LOCUS       NM_019966               2112 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus malonyl-CoA decarboxylase (Mlycd), transcript variant
            1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_019966
VERSION     NM_019966.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2112)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   2  (bases 1 to 2112)
  AUTHORS   Guilherme,A., Rowland,L.A., Wetoska,N., Tsagkaraki,E., Santos,K.B.,
            Bedard,A.H., Henriques,F., Kelly,M., Munroe,S., Pedersen,D.J.,
            Ilkayeva,O.R., Koves,T.R., Tauer,L., Pan,M., Han,X., Kim,J.K.,
            Newgard,C.B., Muoio,D.M. and Czech,M.P.
  TITLE     Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte
            thermogenic program
  JOURNAL   Cell Rep 42 (5), 112488 (2023)
   PUBMED   37163372
REFERENCE   3  (bases 1 to 2112)
  AUTHORS   Fisher-Wellman,K.H., Draper,J.A., Davidson,M.T., Williams,A.S.,
            Narowski,T.M., Slentz,D.H., Ilkayeva,O.R., Stevens,R.D.,
            Wagner,G.R., Najjar,R., Hirschey,M.D., Thompson,J.W., Olson,D.P.,
            Kelly,D.P., Koves,T.R., Grimsrud,P.A. and Muoio,D.M.
  TITLE     Respiratory Phenomics across Multiple Models of Protein
            Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on
            Bioenergetics
  JOURNAL   Cell Rep 26 (6), 1557-1572 (2019)
   PUBMED   30726738
REFERENCE   4  (bases 1 to 2112)
  AUTHORS   Zhou,L., Dai,H., Wu,J., Zhou,M., Yuan,H., Du,J., Yang,L., Wu,X.,
            Xu,H., Hua,Y., Xu,J., Zheng,L. and Shen,B.
  TITLE     Role of FEN1 S187 phosphorylation in counteracting oxygen-induced
            stress and regulating postnatal heart development
  JOURNAL   FASEB J 31 (1), 132-147 (2017)
   PUBMED   27694478
REFERENCE   5  (bases 1 to 2112)
  AUTHORS   Ussher,J.R., Fillmore,N., Keung,W., Zhang,L., Mori,J., Sidhu,V.K.,
            Fukushima,A., Gopal,K., Lopaschuk,D.G., Wagg,C.S., Jaswal,J.S.,
            Dyck,J.R. and Lopaschuk,G.D.
  TITLE     Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase
            Does Not Exacerbate Age-Related Insulin Resistance in Mice
  JOURNAL   Diabetes 65 (7), 1883-1891 (2016)
   PUBMED   27207536
  REMARK    GeneRIF: Decreased fat oxidation in MCD(-/-) mice resulted in the
            accumulation of lipid intermediates in peripheral tissues, but this
            was not associated with a worsening of age-associated insulin
            resistance and, conversely, improved longevity.
REFERENCE   6  (bases 1 to 2112)
  AUTHORS   Sutendra,G., Bonnet,S., Rochefort,G., Haromy,A., Folmes,K.D.,
            Lopaschuk,G.D., Dyck,J.R. and Michelakis,E.D.
  TITLE     Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular
            remodeling of pulmonary hypertension
  JOURNAL   Sci Transl Med 2 (44), 44ra58 (2010)
   PUBMED   20702857
  REMARK    GeneRIF: This study of fatty acid oxidation and malonyl-CoA
            decarboxylase identifies a critical role for metabolism in both the
            normal pulmonary circulation (hypoxic pulmonary vasoconstriction)
            and pulmonary hypertension
REFERENCE   7  (bases 1 to 2112)
  AUTHORS   Ussher,J.R., Koves,T.R., Jaswal,J.S., Zhang,L., Ilkayeva,O.,
            Dyck,J.R., Muoio,D.M. and Lopaschuk,G.D.
  TITLE     Insulin-stimulated cardiac glucose oxidation is increased in
            high-fat diet-induced obese mice lacking malonyl CoA decarboxylase
  JOURNAL   Diabetes 58 (8), 1766-1775 (2009)
   PUBMED   19478144
  REMARK    GeneRIF: Mcd deficiency is not detrimental to the heart in obesity
            in mice.
            Erratum:[Diabetes. 2009 Oct;58(10):2425]
REFERENCE   8  (bases 1 to 2112)
  AUTHORS   Koves,T.R., Ussher,J.R., Noland,R.C., Slentz,D., Mosedale,M.,
            Ilkayeva,O., Bain,J., Stevens,R., Dyck,J.R., Newgard,C.B.,
            Lopaschuk,G.D. and Muoio,D.M.
  TITLE     Mitochondrial overload and incomplete fatty acid oxidation
            contribute to skeletal muscle insulin resistance
  JOURNAL   Cell Metab 7 (1), 45-56 (2008)
   PUBMED   18177724
REFERENCE   9  (bases 1 to 2112)
  AUTHORS   Harada,N., Oda,Z., Hara,Y., Fujinami,K., Okawa,M., Ohbuchi,K.,
            Yonemoto,M., Ikeda,Y., Ohwaki,K., Aragane,K., Tamai,Y. and
            Kusunoki,J.
  TITLE     Hepatic de novo lipogenesis is present in liver-specific
            ACC1-deficient mice
  JOURNAL   Mol Cell Biol 27 (5), 1881-1888 (2007)
   PUBMED   17210641
  REMARK    Erratum:[Mol Cell Biol. 2007 May;27(9):3556]
REFERENCE   10 (bases 1 to 2112)
  AUTHORS   Dyck,J.R., Hopkins,T.A., Bonnet,S., Michelakis,E.D., Young,M.E.,
            Watanabe,M., Kawase,Y., Jishage,K. and Lopaschuk,G.D.
  TITLE     Absence of malonyl coenzyme A decarboxylase in mice increases
            cardiac glucose oxidation and protects the heart from ischemic
            injury
  JOURNAL   Circulation 114 (16), 1721-1728 (2006)
   PUBMED   17030679
  REMARK    GeneRIF: In vivo and ex vivo cardiac function is similar in
            wild-type and mcd-deficient mice; however, deletion of MCD markedly
            increases glucose oxidation and improves functional recovery of the
            heart after ischemia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166781.7.
            
            On Jun 14, 2018 this sequence version replaced NM_019966.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004764.1, AK082479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-577               AC166781.7         85563-86139         c
            578-690             AC166781.7         79440-79552         c
            691-847             AC166781.7         78443-78599         c
            848-997             AC166781.7         73328-73477         c
            998-2112            AC166781.7         69931-71045         c
FEATURES             Location/Qualifiers
     source          1..2112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 67.64 cM"
     gene            1..2112
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /note="malonyl-CoA decarboxylase"
                     /db_xref="GeneID:56690"
                     /db_xref="MGI:MGI:1928485"
     exon            1..577
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1531
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /EC_number="4.1.1.9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; malonyl-CoA decarboxylase, mitochondrial"
                     /codon_start=1
                     /product="malonyl-CoA decarboxylase, mitochondrial isoform
                     1 precursor"
                     /protein_id="NP_064350.2"
                     /db_xref="CCDS:CCDS22703.1"
                     /db_xref="GeneID:56690"
                     /db_xref="MGI:MGI:1928485"
                     /translation="MRGLGPGLRARRLLPLRSPPRPPGPRGRRLCGGLAASAMDELLR
                     RAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAEASQRAELLGRLAQGFGVDHGQVA
                     EQSAGVLQLRQQAREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADL
                     LEAQALKLVEGPHVREMNGVLKSMLSEWFSSGFLNLERVTWHSPCEVLQKISECEAVH
                     PVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISNNIQGIVKECPPTET
                     EERNRIAAAIFYSISLTQQGLQGVELGTFLIKRVVKELQKEFPQLGAFSSLSPIPGFT
                     KWLLGLLNVQGKEHGRNELFTDSECQEISAVTGNPVHESLKGFLSSGEWVKSEKLTQA
                     LQGPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVMWRINWMADSSLKGLTSSCGLM
                     VNYRYYLEETGPNSISYLGSKNIKASEQILSLVAQFQNNSKL"
     exon            578..690
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /inference="alignment:Splign:2.1.0"
     exon            691..847
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /inference="alignment:Splign:2.1.0"
     exon            848..997
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /inference="alignment:Splign:2.1.0"
     exon            998..2112
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /note="hexamer: ATTAAA"
     polyA_site      2098
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /note="major polyA site"
ORIGIN      
        1 agaggcccgc tctccagtgg cgtctcccgc tagcagctgt cgcggagctg tcatgcgagg
       61 cctcgggcca ggcttgaggg ctcggcgcct gctcccactg cggtccccgc cgcggcctcc
      121 ggggccccgg ggacgtcggc tgtgcggcgg gctcgcggcc agcgccatgg acgagctgct
      181 gcggcgagcc gtgcccccga cgccggccta cgagctgcgc gagaagacgc cggcgcccgc
      241 cgagggccag tgcgccgact tcgtgagctt ctacggcggc ctggccgagg cgtcccagcg
      301 cgccgagctg ctcggccgcc tggctcaggg cttcggcgtg gaccacggcc aggtggccga
      361 gcagagcgcc ggggtgctgc agctgcgcca gcaggcgcgc gaggcggccg tgctgctgca
      421 ggcggaggac cggttgcgct acgcgctcgt gccgcggtat cgcggcctct tccatcacat
      481 cagcaagctg gacggcggcg tgcgcttctt ggtgcagctg cgggccgatc tgctggaggc
      541 gcaggccctc aagctggtgg aggggccgca cgtccgggaa atgaacggag tgctcaaaag
      601 catgctgtct gagtggttct cctccggctt cctgaacctg gagcgggtca cctggcactc
      661 accctgtgag gtacttcaga agatcagcga gtgtgaggct gtgcaccctg tgaaaaactg
      721 gatggacatg aagcggcgtg tggggcccta ccggagatgt tacttcttct cccactgctc
      781 cacccccggg gaacccctgg tggttctgca tgtggctctg actggtgaca tttccaacaa
      841 catccagggc attgtgaagg agtgccctcc gactgaaacc gaggagagga acaggatcgc
      901 cgctgccatc ttctactcca tcagcctgac ccagcagggc ctgcaggggg tggagctcgg
      961 gaccttcctc ataaagagag tggtcaagga gctgcagaag gaatttcctc agctgggggc
     1021 cttttcaagc ctgtcgccta tccctggatt caccaagtgg ctgctgggcc tcctgaatgt
     1081 gcaggggaag gagcatggga ggaacgaact attcacagac tcagagtgcc aagaaatctc
     1141 agcggttacc ggcaaccctg ttcacgagag cctcaagggg ttcctgagca gtggtgagtg
     1201 ggtgaagtca gagaagctga cgcaggcgct gcaggggcca ctaatgaggc tgtgtgcctg
     1261 gtacctgtac ggtgagaagc accgaggcta cgccctcaac ccagtggcca acttccatct
     1321 gcagaatggg gctgtgatgt ggcgtatcaa ctggatggct gacagcagcc tcaaaggcct
     1381 caccagctca tgcggcctca tggtcaacta ccgctactac ctggaggaga caggccccaa
     1441 cagtatctcc tacctgggct ccaagaacat caaagcttcc gagcagatcc tcagcctggt
     1501 agcccagttc cagaacaaca gcaaactcta gggacagcct tcccaaagct tgggcccctt
     1561 cttagaaagg aggctgtgtt ctgatgggcc aggcttactt accacagaat ccttttcagg
     1621 gaggccacag cggtgctgtc ctctgacctc agcaggcact caggaggcca caccttggct
     1681 gtcactgtgg tggcccactc actgctagga ggcggtggcg gactgggtgc tggggttccg
     1741 gggatcccac tgtgctgctc ccccacagcc tgtgccttca gaaagctcta cagatgccac
     1801 cacaggccac ccaggacaca gcccagagca cagacctttt ggagtatgaa gagctgacag
     1861 tcatgttctc tctatttggg agaggactaa gatctgtact gtggctaata ccgcagctta
     1921 aagctcagac tagagagagt ttgtgccgtg cacagggtgt gtttggcacc tcagggatgc
     1981 tgctgctgct tgaggccaga gttggcttac agggtttaaa tgagatccca gttcataatg
     2041 aactgaacgg taaagaacag atttgttctg taagcattaa acatgattgt tcactgtaca
     2101 cctttaagtc ta
//
