LOCUS       NM_001159385            1830 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus MAX-like protein X (Mlx), transcript variant 2, mRNA.
ACCESSION   NM_001159385
VERSION     NM_001159385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1830)
  AUTHORS   Wang,H., Stevens,T., Lu,J., Airik,M., Airik,R. and Prochownik,E.V.
  TITLE     Disruption of Multiple Overlapping Functions Following Stepwise
            Inactivation of the Extended Myc Network
  JOURNAL   Cells 11 (24), 4087 (2022)
   PUBMED   36552851
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1830)
  AUTHORS   Wang,H., Lu,J., Alencastro,F., Roberts,A., Fiedor,J., Carroll,P.,
            Eisenman,R.N., Ranganathan,S., Torbenson,M., Duncan,A.W. and
            Prochownik,E.V.
  TITLE     Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver
            Regeneration and Neoplasia
  JOURNAL   Cell Mol Gastroenterol Hepatol 13 (6), 1785-1804 (2022)
   PUBMED   35259493
REFERENCE   4  (bases 1 to 1830)
  AUTHORS   Carroll,P.A., Freie,B.W., Cheng,P.F., Kasinathan,S., Gu,H.,
            Hedrich,T., Dowdle,J.A., Venkataramani,V., Ramani,V., Wu,X.,
            Raftery,D., Shendure,J., Ayer,D.E., Muller,C.H. and Eisenman,R.N.
  TITLE     The glucose-sensing transcription factor MLX balances metabolism
            and stress to suppress apoptosis and maintain spermatogenesis
  JOURNAL   PLoS Biol 19 (10), e3001085 (2021)
   PUBMED   34669700
  REMARK    GeneRIF: The glucose-sensing transcription factor MLX balances
            metabolism and stress to suppress apoptosis and maintain
            spermatogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1830)
  AUTHORS   Hunt,L.C., Xu,B., Finkelstein,D., Fan,Y., Carroll,P.A., Cheng,P.F.,
            Eisenman,R.N. and Demontis,F.
  TITLE     The glucose-sensing transcription factor MLX promotes myogenesis
            via myokine signaling
  JOURNAL   Genes Dev 29 (23), 2475-2489 (2015)
   PUBMED   26584623
  REMARK    GeneRIF: MLX promotes myogenesis not via an adjustment of glucose
            metabolism but rather by inducing the expression of several
            myokines, including insulin-like growth factor 2 (IGF2)
REFERENCE   6  (bases 1 to 1830)
  AUTHORS   Stoeckman,A.K., Ma,L. and Towle,H.C.
  TITLE     Mlx is the functional heteromeric partner of the carbohydrate
            response element-binding protein in glucose regulation of lipogenic
            enzyme genes
  JOURNAL   J Biol Chem 279 (15), 15662-15669 (2004)
   PUBMED   14742444
REFERENCE   7  (bases 1 to 1830)
  AUTHORS   Eilers,A.L., Sundwall,E., Lin,M., Sullivan,A.A. and Ayer,D.E.
  TITLE     A novel heterodimerization domain, CRM1, and 14-3-3 control
            subcellular localization of the MondoA-Mlx heterocomplex
  JOURNAL   Mol Cell Biol 22 (24), 8514-8526 (2002)
   PUBMED   12446771
REFERENCE   8  (bases 1 to 1830)
  AUTHORS   Meroni,G., Cairo,S., Merla,G., Messali,S., Brent,R., Ballabio,A.
            and Reymond,A.
  TITLE     Mlx, a new Max-like bHLHZip family member: the center stage of a
            novel transcription factors regulatory pathway?
  JOURNAL   Oncogene 19 (29), 3266-3277 (2000)
   PUBMED   10918583
REFERENCE   9  (bases 1 to 1830)
  AUTHORS   Billin,A.N., Eilers,A.L., Queva,C. and Ayer,D.E.
  TITLE     Mlx, a novel Max-like BHLHZip protein that interacts with the Max
            network of transcription factors
  JOURNAL   J Biol Chem 274 (51), 36344-36350 (1999)
   PUBMED   10593926
REFERENCE   10 (bases 1 to 1830)
  AUTHORS   Bjerknes,M. and Cheng,H.
  TITLE     TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix
            leucine-zipper transcription factor
  JOURNAL   Gene 181 (1-2), 7-11 (1996)
   PUBMED   8973301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK620266.1, AF213671.1, AK142605.1, AK011478.1 and BI202547.1.
            
            Transcript Variant: This variant (2) contains an additional coding
            exon compared to variant 1. The resulting isoform (beta) thus, is
            longer than isoform alpha encoded by variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.57488.1, AK142605.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CK620266.1         5-40
            37-234              AF213671.1         1-198
            235-1194            AK142605.1         201-1160
            1195-1810           AK011478.1         1084-1699
            1811-1830           BI202547.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.18 cM"
     gene            1..1830
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
                     /note="MAX-like protein X"
                     /db_xref="GeneID:21428"
                     /db_xref="MGI:MGI:108398"
     exon            1..78
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
                     /inference="alignment:Splign:2.1.0"
     exon            79..115
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
                     /inference="alignment:Splign:2.1.0"
     exon            116..205
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
                     /inference="alignment:Splign:2.1.0"
     exon            206..312
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
                     /inference="alignment:Splign:2.1.0"
     exon            313..412
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
                     /inference="alignment:Splign:2.1.0"
     exon            413..512
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
                     /inference="alignment:Splign:2.1.0"
     exon            513..714
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1813
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1129
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
                     /note="hexamer: AATAAA"
     polyA_site      1813
                     /gene="Mlx"
                     /gene_synonym="bHLHd13; Tcfl4; Tf4"
                     /note="major polyA site"
ORIGIN      
        1 agtccgctgg cttgtttccg gttcggtagg ttcacgatga cggagccggg cgcctctccg
       61 gaggaccctt gggtcaaggt cgagtatgcc tacagtgaca acagcctgga tcctgggctt
      121 tttgtagaaa gcacccacaa ggggagtgta gtgtccagag ctaatagcat cggctccacc
      181 agtgcctctt ctgtccccaa cacagatgat gaggacagtg attatcagca ggagtcctac
      241 aaggagtcct acaaagaccg gaggcggcgt gcgcacactc aggctgaaca gaagagaagg
      301 gatgctatta agagaggcta tgatgacctt cagaccattg tccctacctg ccagcagcag
      361 gatttctcca ttggctccca aaaactcagc aaagccatcg ttctacagaa gaccattgac
      421 tacatccagt ttttacacaa ggagaagaaa aagcaggagg aagaagtatc cacactgcgc
      481 aaggacgtca cagccttgaa gataatgaaa gtgaactatg agcaaatcgt gaaggcacat
      541 caggacaacc ctcatgaggg agaggaccag gtctctgacc aggtcaagtt caacgtcttt
      601 caaggcatca tggactccct cttccagtct ttcaacgcct ctatctctgt ggccagcttc
      661 caggagctct cagcttgtgt cttcagctgg attgaggaac actgtgagcc acagactcta
      721 cgagagattg tgatcggtgt ccttcatcag ttgaaaaacc aactctactg attgcccatg
      781 gaagcctgca gagcagccaa caagaggcct ttgagagtgt ggccatggaa ctaactgctg
      841 ggcctatgag actggcctgc aacacctcac accggtcagc tggtttctac ttggtgtttg
      901 gttttcccaa ccccacttca gcttcggtgg ggttgagtgt tttgtgaaag cttctgaata
      961 atttattata ttgtccacaa tgttgaacct acccaacctt cccctttcta ggaaaagcct
     1021 ctaggacaag agtctgttca gggagcctca cagaaccctg agcccctcag ccttttctct
     1081 acccactggg ttcctgctca caatctatat acataatttg gaaatcgttt gcctctgctt
     1141 ggtctcttgg gcaacacttg gctcaagttt gggtattttg gcagttctta agttagaaaa
     1201 aaggaaaaga aatagcccta tggccatgaa gggtaaaagg ccaccttgtg cctaggctag
     1261 ggctgtgtgg tcaatactaa gtaaggccag ggtattctag ccagctcagg gtagggctgc
     1321 ctgaccctgc taccctcatg ttctgctgcc cacttcagct gctgtaggtg ctacaggaaa
     1381 cagcgtccca tcagctcttg ccctgtcttc ccaaaggcaa aggcagcatt acatatttga
     1441 atttatcttc taaataccca cagtgcattt ttgttatatg cagtttccca aacttcttag
     1501 cagacctcca aagcagcccc agcctcttct gcataatgtg tgtatctgcc ccaccagtgt
     1561 gttgtctcca tttctcctgg ggcctgggga tagagttagg tgggacagga gatcctcaag
     1621 tcttctgggg gtaggccagg gcgatccctt gggagtctca aatgttggtg tatggcaccc
     1681 tttctgtact cttatcccat gtttcctact gccttcccca ggtttgatat ctgggaggtt
     1741 tgatcatcca gaggaaatta agtattttta tatcaaatta tattacaata aatattacaa
     1801 atactttctt ttaaaaaaaa aaaaaaaaaa
//
