LOCUS       NM_027326               6059 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus myeloid/lymphoid or mixed-lineage leukemia;
            translocated to, 3 (Mllt3), transcript variant 1, mRNA.
ACCESSION   NM_027326
VERSION     NM_027326.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6059)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6059)
  AUTHORS   Yu,H., He,J., Liu,W., Feng,S., Gao,L., Xu,Y., Zhang,Y., Hou,X.,
            Zhou,Y., Yang,L. and Wang,X.
  TITLE     The Transcriptional Coactivator, ALL1-Fused Gene From Chromosome 9,
            Simultaneously Sustains Hypoxia Tolerance and Metabolic Advantages
            in Liver Cancer
  JOURNAL   Hepatology 74 (4), 1952-1970 (2021)
   PUBMED   33928666
  REMARK    GeneRIF: The Transcriptional Coactivator, ALL1-Fused Gene From
            Chromosome 9, Simultaneously Sustains Hypoxia Tolerance and
            Metabolic Advantages in Liver Cancer.
REFERENCE   3  (bases 1 to 6059)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6059)
  AUTHORS   Young,K., Loberg,M.A., Eudy,E., Schwartz,L.S., Mujica,K.D. and
            Trowbridge,J.J.
  TITLE     Heritable genetic background alters survival and phenotype of
            Mll-AF9-induced leukemias
  JOURNAL   Exp Hematol 89, 61-67 (2020)
   PUBMED   32768438
  REMARK    GeneRIF: Heritable genetic background alters survival and phenotype
            of Mll-AF9-induced leukemias.
REFERENCE   5  (bases 1 to 6059)
  AUTHORS   Sarrou,E., Richmond,L., Carmody,R.J., Gibson,B. and Keeshan,K.
  TITLE     CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells
            Induces MLL-AF9 Chromosomal Translocation and MLL-AF9
            Leukaemogenesis
  JOURNAL   Int J Mol Sci 21 (12), 4266 (2020)
   PUBMED   32549410
  REMARK    GeneRIF: CRISPR Gene Editing of Murine Blood Stem and Progenitor
            Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9
            Leukaemogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6059)
  AUTHORS   Srinivasan,R.S., de Erkenez,A.C. and Hemenway,C.S.
  TITLE     The mixed lineage leukemia fusion partner AF9 binds specific
            isoforms of the BCL-6 corepressor
  JOURNAL   Oncogene 22 (22), 3395-3406 (2003)
   PUBMED   12776190
REFERENCE   7  (bases 1 to 6059)
  AUTHORS   Collins,E.C., Appert,A., Ariza-McNaughton,L., Pannell,R., Yamada,Y.
            and Rabbitts,T.H.
  TITLE     Mouse Af9 is a controller of embryo patterning, like Mll, whose
            human homologue fuses with Af9 after chromosomal translocation in
            leukemia
  JOURNAL   Mol Cell Biol 22 (20), 7313-7324 (2002)
   PUBMED   12242306
  REMARK    GeneRIF: Af9 gene is required for normal embryogenesis in mice by
            controlling pattern formation, apparently via control of Hox gene
            regulation
REFERENCE   8  (bases 1 to 6059)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   9  (bases 1 to 6059)
  AUTHORS   Hemenway,C.S., de Erkenez,A.C. and Gould,G.C.
  TITLE     The polycomb protein MPc3 interacts with AF9, an MLL fusion partner
            in t(9;11)(p22;q23) acute leukemias
  JOURNAL   Oncogene 20 (29), 3798-3805 (2001)
   PUBMED   11439343
REFERENCE   10 (bases 1 to 6059)
  AUTHORS   Collins,E.C., Pannell,R., Simpson,E.M., Forster,A. and
            Rabbitts,T.H.
  TITLE     Inter-chromosomal recombination of Mll and Af9 genes mediated by
            cre-loxP in mouse development
  JOURNAL   EMBO Rep 1 (2), 127-132 (2000)
   PUBMED   11265751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831756.8, AL806533.8 and AL929524.16.
            
            On Apr 15, 2022 this sequence version replaced NM_027326.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.74025.1,
                                           SRR10223970.6459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AL831756.8         43237-43507         c
            272-452             AL831756.8         41677-41857         c
            453-535             AL806533.8         91439-91521         c
            536-679             AL806533.8         85211-85354         c
            680-1387            AL806533.8         52055-52762         c
            1388-1463           AL806533.8         5309-5384           c
            1464-1593           AL806533.8         3226-3355           c
            1594-1693           AL929524.16        157767-157866       c
            1694-1765           AL929524.16        152129-152200       c
            1766-1837           AL929524.16        150767-150838       c
            1838-6059           AL929524.16        138405-142626       c
FEATURES             Location/Qualifiers
     source          1..6059
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 41.06 cM"
     gene            1..6059
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /note="myeloid/lymphoid or mixed-lineage leukemia;
                     translocated to, 3"
                     /db_xref="GeneID:70122"
                     /db_xref="MGI:MGI:1917372"
     exon            1..271
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1969
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein AF-9; myeloid/lymphoid or mixed-lineage leukemia
                     translocated to chromosome 3 protein homolog;
                     myeloid/lymphoid or mixed lineage-leukemia translocation
                     to 3 homolog; myeloid/lymphoid or mixed-lineage leukemia
                     (trithorax homolog, Drosophila); translocated to, 3"
                     /codon_start=1
                     /product="protein AF-9 isoform 1"
                     /protein_id="NP_081602.3"
                     /db_xref="CCDS:CCDS38796.1"
                     /db_xref="GeneID:70122"
                     /db_xref="MGI:MGI:1917372"
                     /translation="MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNI
                     QHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDY
                     DLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSS
                     SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAF
                     KEPSRDHNKSSKDSSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKADSNLLTVTSGQ
                     QDKKAPSKRPPASDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHV
                     KMGKVKIESETSEKKKSMLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSSS
                     FTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSD
                     GSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDEL
                     VELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETS
                     GTS"
     exon            272..452
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /inference="alignment:Splign:2.1.0"
     exon            453..535
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /inference="alignment:Splign:2.1.0"
     exon            536..679
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /inference="alignment:Splign:2.1.0"
     exon            680..1387
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1463
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1593
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1693
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1765
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1837
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..6059
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2722..2727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /note="hexamer: AATAAA"
     polyA_site      2743
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /note="major polyA site"
     regulatory      3321..3326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /note="hexamer: AAGAAA"
     polyA_site      3339
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /note="major polyA site"
     regulatory      5809..5814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /note="hexamer: AATAAA"
     polyA_site      5835
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
     polyA_site      6059
                     /gene="Mllt3"
                     /gene_synonym="2210011H10Rik; 2610012I03Rik;
                     3830408D16Rik; Af9; D4Ertd321e"
                     /note="major polyA site"
ORIGIN      
        1 atgctccgga ctcatcctct ggccccggag ctgctgctgc tgctgctgct gctgcttttg
       61 cttttggggc tgagtttaat aagcgagcga gagagcgagc acggggtggg gtgggggcca
      121 aggcagagca tgtccgccat ctaccctcag ctcccgggcg cgctctcatt catagcagcc
      181 tcttcatgaa ttacagctga agggggcggg ggaggggggg taccacacaa caccccggca
      241 aacctccggg cccccaggca tggctagctc gtgtgccgtg caggtgaagc tggagctggg
      301 gcaccgcgcc caggtgagga agaaacccac agtggagggc ttcacccacg actggatggt
      361 gttcgtgcgc ggcccggagc acagtaacat tcagcacttt gtggagaaag tcgtcttcca
      421 cttgcacgaa agcttcccta ggccaaaaag agtgtgcaaa gacccacctt acaaggtaga
      481 agagtccggg tacgctggct tcatcttgcc aattgaagtt tattttaaaa acaaggaaga
      541 acctaagaaa gtccgctttg attatgactt attcctgcat cttgaaggcc acccaccagt
      601 gaatcacctc cgctgtgaga aactaacttt caataacccc acggaggact ttagaagaaa
      661 gttgctgaag gcaggagggg accctaacag gagcattcat accagcagta gcagcagcag
      721 cagcagcagt agcagcagca gcagcagcag cagtagtagt agcagcagca gcagcagcag
      781 tagcagcagc agcagcagca gtagcagcag cagcagcagc agcagtagta ccagtttttc
      841 aaagcctcac aaattaatga aggagcacaa ggaaaaacct tctaaggact ccagagaaca
      901 taaaagtgcc ttcaaagaac cttccaggga tcacaacaaa tcttccaaag actcctccaa
      961 gaaacccaaa gaaaacaaac cactgaaaga agaaaaaata gttcctaaga tggccttcaa
     1021 ggaacctaaa cccatgtcaa aagagccaaa agcagacagt aacttactca ccgtcaccag
     1081 tgggcagcag gacaagaagg cgcccagcaa aaggccccct gcttcagatt ctgaagaact
     1141 ctcagccaaa aaaaggaaaa agagtagctc ggaggcttta tttaaaagtt tttctagtgc
     1201 gcccccactg atactcactt gttctgctga caaaaaacag ataaaagata aatctcatgt
     1261 caagatggga aaggtcaaaa ttgagagtga gacttcagag aagaagaagt caatgttgcc
     1321 accgtttgat gacatcgtgg atcccaatga ctcagacgtg gaggagaaca tgtcctcgaa
     1381 atctgactca gagcaaccca gtcctgccag ctccagctcc agttccagct ccagcttcac
     1441 accatcccag accaggcaac aaggtccttt aaggtcgatc atgaaagatc tgcattctga
     1501 tgacaacgag gaggagtctg atgaggcaga ggacaatgac aatgactcgg agatggaaag
     1561 acctgtaaat agaggaggaa gccgaagtcg cagggtcagc ttgagtgacg gcagtgacag
     1621 tgaaagcagc tccgcctctt cccctctcca tcatgaaccc ccgccaccat tattgaaaac
     1681 taacaacaac cagatccttg aagtgaaaag tccaataaaa caaagcaaat cagataagca
     1741 aataaagaat ggtgaatgtg acaaggcata tctagatgag ttggtagagc tccacagaag
     1801 gttaatgaca ctgagggaac gacacattct gcagcagatc gtgaacctta tagaggaaac
     1861 tggacacttt catattacga atacaacatt tgattttgat ctttgctcgc tggacaaaac
     1921 tacagtccgt aaattacaga gttacctgga aacatctgga acatcctgag gatacaacag
     1981 ctggacgcat caaaaactat tttttttttt ggttgtgatt tttttttgtt gttgttgttt
     2041 atatgaaaac actcggaatg atacaaccaa aagggaaaaa aataaaaatg aaacaacctt
     2101 cagctttatt tttctttaaa gccagtcatc atctcttgat aaaggagagg ttacctaaac
     2161 cagcctcagc ggacactcct ctgcaaggaa atccccagga agaattagcc tggatagcct
     2221 tgaaaacaag cagacacaac acaagaaaac ttaaaagaat gtgtatggta ccgtggatct
     2281 ttctgtggtg gttcattcca caggacgaat gcatattcaa cacactgcct tattacataa
     2341 ctgatctatt tattaccaca tacagataaa gttgtgaggg aatgacacca ccagacgtcc
     2401 taaatactcg gtcccgcgga tgctctttca atgcagcgcc cttgccgtcc caagcccagt
     2461 gaccttattc gtatactgtg ccactttcca ccaactcttc ccaggtcctt taacttgttg
     2521 cagtctatgg tttccatctt tgttttccca gttccaggac atagttacca actgggggga
     2581 ccaaatagcc accttgattt tcttccttgt ggtcttcttt cctaaaggtt gaggcccagt
     2641 ccttggctgt atccatgtaa tgatcttgga catggtagat gtaccaaata ggatcatttg
     2701 aattgctgtc tagccttagt caataaacct gtaggacttt gaacaaaagt gtccctgtga
     2761 tgtccacagc ccagcagtgc cgagctgtca ccaacactcg tgtctctatt ttactgttgc
     2821 aatattaggt gaatatggag gtaaaggcat tccacagact cagcatctta aatgggattc
     2881 gggtcctgtt ttctaaaaca gcagtgtaga tgttcttaat ttgaatctat ttattagtga
     2941 gcatttcact tgtctcccgc agccagtgtg gtactcattt cttcttaaaa acaaaacaaa
     3001 aacaggactc agaatttttt tgtttgtttg tttgttctca tacgactctc ttagacgatt
     3061 ttatttttga aaaattaaaa cctttctttg gggaaaaatt cttggttatt ctgccatgag
     3121 agactatgta ttcacttgta gatttggtaa ctttgtatct gtgtagtctc ttgctgatgt
     3181 gtccagaagg atttcctgta taggtgaaag gtaaaggtgg ttgggagggg ggagtttctt
     3241 gtccttgttg tacctttgtt ttgaaactag aaatctgtcc tgtggcatgc aaaagaaggc
     3301 aaattatttt caaaagaaaa aagaaaaaaa aaacccaaag gactttggtg tcatttttct
     3361 acagtctctg tagtagagga attcagagtt aggacagcca actttccaag ttgttaccag
     3421 agctcaactg aaaagaaaag gaatgaagaa gacttctgga tccaaagcct taagagagtc
     3481 tacgtgtgct aacagcctag tgtcccccac atctgttccc acaacagatg ctgtcctttc
     3541 attcagagat taactagtgt ctgtacagaa aatggtcttc cggacccgtt ctttcaagcg
     3601 gtgatgtaaa tgcagattaa taatggagtg gtttctgcat tttaaaaagg agattttttt
     3661 acactgtttc tttctatcca aagaaactat tttttttctt ttttaaaaaa aaaatgataa
     3721 aacagccatg gtctttgtag attgcgttcc tgcagtgtcc tcctcgagga gcaggatcca
     3781 cattttcaag aatgtcctga ctcctcgtga cgatgggcat gagccgtact tgaagcattt
     3841 ggtgtgtagt cctcttcttg gtgtgcagtt gcatagatac gtatcctgtc attttggaca
     3901 gtaggtggtt ggtgaacggt gtgtttttag ttgtgtttca tttctaactt cacaggtgaa
     3961 aagagacaat gtttcaacat tcagaaacct ttttaaattt ctatctgcaa ttccacatac
     4021 tctcattaaa ctaaaaaagt aagtggttta actaatgttt ctgtataatt taatgagaag
     4081 caatgcagtt tgggccattt ttatttttat aaccaaattg agtgatgaaa tatatgcttt
     4141 ggcttctttt attcctaaag ttacaaaacc caagaaacta agataagaaa gtatcccccc
     4201 tcttcatgcc caaagaaata aaatttaaga gaggggtaag aagaaaggca gctattgtaa
     4261 tgataacatt agagctagaa aaattagcta atgcagatgt cttcagtata tcatgaaatg
     4321 taagtttgta catgggtaac aaaattcaga acaactaact tcttacctgg acagcaaaat
     4381 ttcctgtaaa cgtttcctgg caggctaaga gtcatgctgt agagtcagtc tttcaaatgg
     4441 tcctcctgct cttagcacat gatctgaaaa tacagaagtc atgaattccc ttcagctcca
     4501 ctcaaagaat gtgccacatt tctctagcag cagaccactc ctgccacatc tatgtacact
     4561 cactcttgga ccctgttaag aatattttga cacatgtgta ccctaacagt ggctttgggg
     4621 ttttaagcac aaagagggaa tggcagggtt taacttcttt agtgtgtgta tatattaaat
     4681 aaataaataa ataaataaat aaataggtgt ttcaaataaa attaattggg tgaatgtgaa
     4741 tatgttttga accagcaaga gtatgataaa ctatcattaa atttttttct tctaaaaact
     4801 atatgtacag accacacaca cacacacaca cattaacttt tgattttgtg tgtagtgtgt
     4861 ggagggctcc ttctgttgaa ggatacaatg atcatgttag tgaaaatgta tacagttact
     4921 tcatattgtc accgtactct gccccctttt ttaggtagca gaacatctgt gtcaagatta
     4981 gggagaacat taaaaaaaaa tcagatgagt ttcagatgaa aaacatttta aaaattgcaa
     5041 caaaatctct gatctgaata attacctgtt ttgaggaaag ggccaataaa tttgggggga
     5101 tttatttttc ctttatcaag accaattttt gctaatccct tttgtagtcc aacctaatcc
     5161 taaaaacaac agttattagg cctgcataac atcccattac catatcaagc cctacaaatg
     5221 taattaacac acttgtttaa gagcggttta attcttaaat gctttaactc tacctattta
     5281 atgagttggt tgttcaatgt tgaaatggtc aatgtctgtg tttggtggct tgtgttcatt
     5341 tttctcactg tggaagtggt cagctctaga gtaatttgct gtatgcttat tactttccac
     5401 ctttagtgtt ttgtgtacca atgctatgta ttcctatatt tatatatata tatatacata
     5461 tattatcaga atgatcttgc tctggactgt tgttctcaaa ctatggctat gatgtagaga
     5521 tgacaacggc tgctgggaat gtggtggaat caattcccac ggtgcaggtt aatcatgggc
     5581 tggaagatct ttcaacctca tctgttttct atgatgcttt ttgttatgta ggcactgcca
     5641 tcctgaatct accttgtaaa gatgcagtca atttcaaagg aagacaaagc cactgctgtc
     5701 tgtacactgt aaatatgtat tttggcactt gtactccagt attctgaaag cagagctatg
     5761 atggaaatgc tgacagatct ttgatggtgg ccaaagctac cctacaaaaa taaattaagt
     5821 aaaaatgtat tctgagatta gcagtgcaag gccaacatgt tttacaaatc tgtcagtatc
     5881 tttctaatgg agtgtgtatg tgtagttatg ttgaaagata cactgtgtat gtgtgtacat
     5941 gcttttatgt gaactacaag gcacatagaa aatgtatttc ccatctctaa atcccatgtg
     6001 gaaatgttaa gtacagatgg acagaaatag gtgttttact taaattcata cccaatcta
//
