LOCUS       NM_001411092            2363 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus myeloid/lymphoid or mixed-lineage leukemia;
            translocated to, 11 (Mllt11), transcript variant 4, mRNA.
ACCESSION   NM_001411092 XM_030252728
VERSION     NM_001411092.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2363)
  AUTHORS   Blommers,M., Stanton-Turcotte,D., Witt,E.A., Heidari,M. and
            Iulianella,A.
  TITLE     Cerebellar granule cell migration and folia development require
            Mllt11/Af1q/Tcf7c
  JOURNAL   Dev Neurobiol 84 (2), 74-92 (2024)
   PUBMED   38509451
REFERENCE   2  (bases 1 to 2363)
  AUTHORS   Blommers,M., Stanton-Turcotte,D. and Iulianella,A.
  TITLE     Retinal neuroblast migration and ganglion cell layer organization
            require the cytoskeletal-interacting protein Mllt11
  JOURNAL   Dev Dyn 252 (2), 305-319 (2023)
   PUBMED   36131367
  REMARK    GeneRIF: Retinal neuroblast migration and ganglion cell layer
            organization require the cytoskeletal-interacting protein Mllt11.
REFERENCE   3  (bases 1 to 2363)
  AUTHORS   Stanton-Turcotte,D., Hsu,K., Moore,S.A., Yamada,M., Fawcett,J.P.
            and Iulianella,A.
  TITLE     Mllt11 Regulates Migration and Neurite Outgrowth of Cortical
            Projection Neurons during Development
  JOURNAL   J Neurosci 42 (19), 3931-3948 (2022)
   PUBMED   35379703
  REMARK    GeneRIF: Mllt11 Regulates Migration and Neurite Outgrowth of
            Cortical Projection Neurons during Development.
REFERENCE   4  (bases 1 to 2363)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2363)
  AUTHORS   Zhang,H., Ren,R., Du,J., Sun,T., Wang,P. and Kang,P.
  TITLE     AF1q Contributes to Adriamycin-Induced Podocyte Injury by
            Activating Wnt/beta-Catenin Signaling
  JOURNAL   Kidney Blood Press Res 42 (5), 794-803 (2017)
   PUBMED   29069662
  REMARK    GeneRIF: aberrant expression of AF1q may activate Wnt/beta-catenin
            signaling and result in podocyte injury
REFERENCE   6  (bases 1 to 2363)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   7  (bases 1 to 2363)
  AUTHORS   Heanue,T.A. and Pachnis,V.
  TITLE     Expression profiling the developing mammalian enteric nervous
            system identifies marker and candidate Hirschsprung disease genes
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 6919-6924 (2006)
   PUBMED   16632597
REFERENCE   8  (bases 1 to 2363)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 2363)
  AUTHORS   Lin,H.J., Shaffer,K.M., Sun,Z., Jay,G., He,W.W. and Ma,W.
  TITLE     AF1q, a differentially expressed gene during neuronal
            differentiation, transforms HEK cells into neuron-like cells
  JOURNAL   Brain Res Mol Brain Res 131 (1-2), 126-130 (2004)
   PUBMED   15530661
  REMARK    GeneRIF: The mouse Af1q, homologue of human AF1q, was found to be
            significantly up-regulated during the neuronal production from
            neural stem cells
REFERENCE   10 (bases 1 to 2363)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140190.3.
            
            On Aug 22, 2022 this sequence version replaced XM_030252728.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.146358.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AC140190.3         116045-116330       c
            287-440             AC140190.3         115488-115641       c
            441-2363            AC140190.3         104977-106899       c
FEATURES             Location/Qualifiers
     source          1..2363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..2363
                     /gene="Mllt11"
                     /gene_synonym="Af1q; Zfp692"
                     /note="myeloid/lymphoid or mixed-lineage leukemia;
                     translocated to, 11"
                     /db_xref="GeneID:56772"
                     /db_xref="MGI:MGI:1929671"
     exon            1..286
                     /gene="Mllt11"
                     /gene_synonym="Af1q; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            287..440
                     /gene="Mllt11"
                     /gene_synonym="Af1q; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            441..2363
                     /gene="Mllt11"
                     /gene_synonym="Af1q; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..719
                     /gene="Mllt11"
                     /gene_synonym="Af1q; Zfp692"
                     /note="zinc finger protein 692; ALL1-fused gene from
                     chromosome 1q; myeloid/lymphoid or mixed-lineage leukemia
                     (trithorax homolog, Drosophila); translocated to, 11"
                     /codon_start=1
                     /product="protein AF1q"
                     /protein_id="NP_001398021.1"
                     /db_xref="GeneID:56772"
                     /db_xref="MGI:MGI:1929671"
                     /translation="MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDTPTYESKDSS
                     SVGKMNGQASGTEQKNPEGDPLLEYSTFNFWRAPIASIHSVDLDLL"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mllt11"
                     /gene_synonym="Af1q; Zfp692"
                     /note="hexamer: AATAAA"
     polyA_site      1769
                     /gene="Mllt11"
                     /gene_synonym="Af1q; Zfp692"
                     /note="major polyA site"
     regulatory      2326..2331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mllt11"
                     /gene_synonym="Af1q; Zfp692"
                     /note="hexamer: ATTAAA"
     polyA_site      2363
                     /gene="Mllt11"
                     /gene_synonym="Af1q; Zfp692"
ORIGIN      
        1 actcctcttc aaagcagcca acgaatgggc tgggaacaaa taaagcctga gctggctagc
       61 tggggagggt gggatgctga atccatggcc cactacttca tccccacagt aaaaaggaag
      121 ccaggaggga tcagggacaa aagcgcagaa agccacatcc ttgacaggag ggcccctctc
      181 acttccacca gaaacccaga acttgaaatg acaaacccta aaccaccgtc atcgtcccgg
      241 tgggccttac acacttcaga gctgtagagg ggcgagcagg agagagactc cagctccgtc
      301 ccccacccac tgcgacccag gatgggaact tcgatgaatt gtactggctc tgtcaatgtt
      361 ctccgtggct gcttcactct ggcttagacc ttccggggcc cagcaccact tcggattctc
      421 tagcacagca gatctctcag gggatcatga gggaccctgt aagtagccag tacagctcct
      481 ttcttttctg gaggatgccc atcccagaac tggatctgtc ggagctggaa ggcctgggcc
      541 tgtcagatac acctacctac gagagcaagg atagcagcag cgttggcaaa atgaacgggc
      601 aggcatctgg gacggagcag aagaaccctg aaggtgaccc cctccttgag tacagcacct
      661 tcaacttctg gagagcgcct attgccagca tccactctgt cgacctggac ttgctttaag
      721 gccaagatct ctctcccacc ccgtaccttc attatcttcc ctcttaagtc ccttcctctc
      781 taagccttcc actttaatct tgttctcttc cctctattgt gctggtggtg ctgatgaatc
      841 tgccaattga attgtaggtt tgtatgtatg tacgtactta tttatctatc tatatttatt
      901 tatttattta tttatctgcc tactccgttt ctctcaaaag ccctctaggc acaaagtcaa
      961 gggtttaatc aatggagtac tagatcatag gatttcctcc cgtcagcccg gagaatatta
     1021 actaatccca gaaaagaatc acccttattt gaggcaccac agagaggtac agttgtgcaa
     1081 aatgggagac caattatttt gtttgtttgt tacattttaa tcaacttcaa agattacttg
     1141 agcctcccta atgtcctcta ccaggccagt aagcaaatac tgcttcaaga agtaatgaga
     1201 acctggaagt tttgagacac tttctacaaa acaggatttc taaaaggcta agataagaaa
     1261 tgctgctgct gcttacaatg cattctcttc cccagaaaca cgcaggcagt taaaggtggg
     1321 aaacaaagga gtgggatgag gaaaaacatc gcaccgtttc agaggtagct cctttaatat
     1381 ccagctctgc ttccagctgt gggtagaaat gctcagaaaa tcagatttga gtcttcacag
     1441 ggaaacttca ctatgaggat aattcctaaa agacaaaaga tgtatctgat ctaaagaaac
     1501 accagagtat tattagggga atttatataa aattgtgatt ttgtcatgga acaggcagat
     1561 gttttggtcc taagtatttt agctttgcct ttctgtagtt gcagtatgtg ataggaatca
     1621 gtgattcctg acacagttct ttggccgcca taagaccgtg aagtaagcag ttatgttcag
     1681 accctacccg tccccattcc ttccaaagct attgcagatg aattgcggag ctgtttattc
     1741 atttatggaa taaagacgtt aaatcctaag tctggggctt agttttttcc attccaatga
     1801 agtactacag attttactca cacttccgaa tccagctttc ccttttatct ttttttcttt
     1861 cttttttttt ttaagtgaag cttttctttt tattttaaaa agatttacta tactatatat
     1921 gagtacactg ttgcactctt cagacacacc agaagagggc attgggtccc attacaagtg
     1981 agccaacatg tggttggtgg ggattgaact caggacctct ggaagagcag tcagtgctct
     2041 taaccactga gtcatctctc cagcgcttcc ttctgtctgt ctaatatttg actttgaaga
     2101 acaatttagg atttggacat agctcaatgg tagaagggct tgccaagcat ctacaaggcc
     2161 ctgctagggt tcccctgtaa gcagccagtg ctcagagatt agccacgccc cccagcccat
     2221 tattaacttt taaatttgtg tggttttctt cggaggcggg ccttgaactc agagaaatcc
     2281 acctgactct gctggactct gctagggtgg gcctagcact ttggtattaa attaggagac
     2341 ctgtgcctcc tgctgtgatc aaa
//
