LOCUS       NM_001252560            5065 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus myeloid/lymphoid or mixed-lineage leukemia;
            translocated to, 10 (Mllt10), transcript variant 1, mRNA.
ACCESSION   NM_001252560
VERSION     NM_001252560.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5065)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5065)
  AUTHORS   Nishimura,H., Ikawa,Y., Kajikawa,E., Shimizu-Mizuno,N., Hiver,S.,
            Tabata-Okamoto,N., Mori,M., Kitajima,T., Hayashi,T., Yoshimura,M.,
            Umeda,M., Nikaido,I., Kurokawa,M., Watanabe,T. and Hamada,H.
  TITLE     Maternal epigenetic factors in embryonic and postnatal development
  JOURNAL   Genes Cells 28 (6), 422-432 (2023)
   PUBMED   36906847
REFERENCE   3  (bases 1 to 5065)
  AUTHORS   Lin,H., Cossu,I.G., Leu,N.A., Deshpande,A.J., Bernt,K.M., Luo,M.
            and Wang,P.J.
  TITLE     The DOT1L-MLLT10 complex regulates male fertility and promotes
            histone removal during spermiogenesis
  JOURNAL   Development 150 (9) (2023)
   PUBMED   37082953
  REMARK    GeneRIF: The DOT1L-MLLT10 complex regulates male fertility and
            promotes histone removal during spermiogenesis.
REFERENCE   4  (bases 1 to 5065)
  AUTHORS   Klein,B.J., Deshpande,A., Cox,K.L., Xuan,F., Zandian,M.,
            Barbosa,K., Khanal,S., Tong,Q., Zhang,Y., Zhang,P., Sinha,A.,
            Bohlander,S.K., Shi,X., Wen,H., Poirier,M.G., Deshpande,A.J. and
            Kutateladze,T.G.
  TITLE     The role of the PZP domain of AF10 in acute leukemia driven by AF10
            translocations
  JOURNAL   Nat Commun 12 (1), 4130 (2021)
   PUBMED   34226546
  REMARK    GeneRIF: The role of the PZP domain of AF10 in acute leukemia
            driven by AF10 translocations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5065)
  AUTHORS   Jing,X., Wu,H., Cheng,X., Chen,X., Zhang,Y., Shi,M., Zhang,T.,
            Wang,X. and Zhao,R.
  TITLE     MLLT10 promotes tumor migration, invasion, and metastasis in human
            colorectal cancer
  JOURNAL   Scand J Gastroenterol 53 (8), 964-971 (2018)
   PUBMED   30102091
  REMARK    GeneRIF: In lung metastasis sites, the knockdown of MLLT10 in SW620
            cells significantly inhibited Vimentin expression, whereas the
            E-Cadherin was increased. These results indicate that MLLT10
            regulates the metastasis of CRC cells via EMT.
REFERENCE   6  (bases 1 to 5065)
  AUTHORS   Deshpande,A.J., Rouhi,A., Lin,Y., Stadler,C., Greif,P.A.,
            Arseni,N., Opatz,S., Quintanilla-Fend,L., Holzmann,K.,
            Hiddemann,W., Dohner,K., Dohner,H., Xu,G., Armstrong,S.A.,
            Bohlander,S.K. and Buske,C.
  TITLE     The clathrin-binding domain of CALM and the OM-LZ domain of AF10
            are sufficient to induce acute myeloid leukemia in mice
  JOURNAL   Leukemia 25 (11), 1718-1727 (2011)
   PUBMED   21681188
  REMARK    GeneRIF: further suggest that future approaches to antagonize
            CALM-AF10-induced transformation should incorporate strategies,
            which aim at blocking these key domains
REFERENCE   7  (bases 1 to 5065)
  AUTHORS   Mahmoudi,T., Boj,S.F., Hatzis,P., Li,V.S., Taouatas,N., Vries,R.G.,
            Teunissen,H., Begthel,H., Korving,J., Mohammed,S., Heck,A.J. and
            Clevers,H.
  TITLE     The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/beta-catenin
            coactivators essential for intestinal homeostasis
  JOURNAL   PLoS Biol 8 (11), e1000539 (2010)
   PUBMED   21103407
  REMARK    GeneRIF: conclude that Mllt10/Af10-Dot1l are essential, largely
            dedicated activators of Wnt-dependent transcription, critical for
            maintenance of intestinal proliferation and homeostasis
            Erratum:[PLoS Biol. 2017 Feb 7;15(2):e1002596. doi:
            10.1371/journal.pbio.1002596.. PMID: 28170393]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5065)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 5065)
  AUTHORS   Okada,Y., Feng,Q., Lin,Y., Jiang,Q., Li,Y., Coffield,V.M., Su,L.,
            Xu,G. and Zhang,Y.
  TITLE     hDOT1L links histone methylation to leukemogenesis
  JOURNAL   Cell 121 (2), 167-178 (2005)
   PUBMED   15851025
  REMARK    Erratum:[Cell. 2005 Jun 3;121(5):809]
REFERENCE   10 (bases 1 to 5065)
  AUTHORS   Linder,B., Jones,L.K., Chaplin,T., Mohd-Sarip,A., Heinlein,U.A.,
            Young,B.D. and Saha,V.
  TITLE     Expression pattern and cellular distribution of the murine
            homologue of AF10
  JOURNAL   Biochim Biophys Acta 1443 (3), 285-296 (1998)
   PUBMED   9878787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928589.11 and AL928557.6.
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1
            and 2 encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154320.1, AF010135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               AL928589.11        189859-190138
            281-440             AL928589.11        190309-190468
            441-520             AL928589.11        196399-196478
            521-575             AL928557.6         19679-19733
            576-685             AL928557.6         28003-28112
            686-789             AL928557.6         40466-40569
            790-883             AL928557.6         41940-42033
            884-979             AL928557.6         44355-44450
            980-1075            AL928557.6         64998-65093
            1076-1331           AL928557.6         77677-77932
            1332-1901           AL928557.6         80538-81107
            1902-1946           AL928557.6         88475-88519
            1947-1979           AL928557.6         89264-89296
            1980-2158           AL928557.6         104439-104617
            2159-2276           AL928557.6         114804-114921
            2277-2349           AL928557.6         116146-116218
            2350-2504           AL928557.6         121822-121976
            2505-2693           AL928557.6         124222-124410
            2694-2782           AL928557.6         124772-124860
            2783-3147           AL928557.6         125001-125365
            3148-3244           AL928557.6         126004-126100
            3245-3442           AL928557.6         126971-127168
            3443-5065           AL928557.6         128989-130611
FEATURES             Location/Qualifiers
     source          1..5065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 12.84 cM"
     gene            1..5065
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /note="myeloid/lymphoid or mixed-lineage leukemia;
                     translocated to, 10"
                     /db_xref="GeneID:17354"
                     /db_xref="MGI:MGI:1329038"
     exon            1..280
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..3487
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein AF-10; myeloid/lymphoid or mixed lineage-leukemia
                     translocation to 10 homolog; myeloid/lymphoid or
                     mixed-lineage leukemia (trithorax homolog, Drosophila);
                     translocated to, 10"
                     /codon_start=1
                     /product="protein AF-10 isoform 1"
                     /protein_id="NP_001239489.1"
                     /db_xref="CCDS:CCDS15708.1"
                     /db_xref="GeneID:17354"
                     /db_xref="MGI:MGI:1329038"
                     /translation="MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDG
                     HGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAH
                     VVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKH
                     GCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYEQSLSD
                     SSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSIS
                     GSLKRLEDTAARFTNANFQEVSAHTSSGKDVSEARGSEGKGKKSSAHSSGQRGRKPGA
                     GRNPGTAVSASSPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRSDSYTHTQQ
                     PSSTKDVHKGESGSQEAAVNSFSSLVGHPVTSTVISQPKSFDNSPGELGSSSLPTAGY
                     KRAQTSGIEEEAVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAA
                     GSVTSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHN
                     GIYNSNDVAVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAASSVTPAAAT
                     TQANTVSGSSLSQAPAHMYGSRLNQNPSMAVLIAQSESSQTDQDLGDNARSLGGRGSS
                     PRGSLSPRSPVSNLQLRYDQPSNSSLETVPPVAASIEQLLERQWSEGQQFLLEQGTPG
                     DILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPAITTNPSPSHQMH
                     TYTAQTAPPPDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAG
                     QSPAQQSSGVSGVQQVNGVTVGALASGMQTVTSTIPAVSAVGGIIGALPGNQLAINGI
                     VGALNGVIQTPVTISQNPAPLTHTSVPPNAAHPMPAAALTNSASGLGLLSDQQRQMFI
                     QQQQFQQLLNSQQLTPEQHQAFLYQLMQQQHHPPELQQLQLPGPTQIPINNLLAGAQA
                     PPLHTATTNPFLTIHGDSTSQKVTRLSDKTGPVAQEKS"
     exon            281..440
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            441..520
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            521..575
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            576..685
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            686..789
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            790..883
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            884..979
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1075
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1331
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1901
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1946
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..1979
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2158
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2276
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2349
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2504
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2693
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2782
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..3147
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3244
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3442
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..5065
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5043..5048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /note="hexamer: AATAAA"
     polyA_site      5065
                     /gene="Mllt10"
                     /gene_synonym="Af10; B130021D15Rik; D630001B22Rik;
                     mKIAA4140"
                     /note="major polyA site"
ORIGIN      
        1 gcgtacgccg ggtgacgctc ggaggaggaa gcgcagcccc ttcccctccc tcgccgcccc
       61 gggcccagcg ggagcccccc agtgcgcctg tgcggaggcc tgcttgatta tgtgtgccct
      121 cctcgggcgg cggcgttagc ggccgggtgg aggtggggag ggaggacgcc gcggaggagg
      181 aggaggagga ggagacggtg gcggggaggt ggggggagtc agcaaggaca tggctcctga
      241 ctcctgtgcg gaacgtgagt gactgagcgg caaagcccga atggtctcta gcgaccggcc
      301 cgtgtcactg gaggacgagg tctcccatag tatgaaggaa atgattggag gctgttgcgt
      361 ttgctcagac gagagaggct gggccgagaa cccgctggtt tattgcgacg ggcacggctg
      421 cagcgtcgcg gtgcatcaag cttgctatgg cattgttcaa gtacctactg gaccgtggtt
      481 ttgtaggaaa tgtgaatctc aggagagagc agccagagtg agatgtgagc tgtgtcccca
      541 taaagatgga gctttaaaaa gaacagataa tgggggttgg gctcatgtgg tttgtgccct
      601 ctatattcca gaggtacaat ttgccaatgt ttctacaatg gagccaatcg ttttacagtc
      661 tgtcccacat gatcgttata ataagacttg ctatatatgt gatgaacaag gacgagaaag
      721 caaagcagcc actggtgctt gcatgacatg taataaacat ggatgtcgac aggctttcca
      781 tgtaacatgt gctcagtttg ccgggctgct ttgtgaagaa gaagggaatg gcgcagacaa
      841 tgttcaatac tgtggctact gtaaatacca ctttagtaag ctgaaaaaga gcaaacgggg
      901 atctaatagg tcatatgagc aaagtttaag tgactcttcc tctcactctc aggataagca
      961 tcatgagaaa gagaaaaaaa aatataaaga aaaggacaaa cacaaacaaa aacacaagaa
     1021 gcaaccagaa ccgtcacctg ccttggttcc ttctttgact gttactacag aaaaaactta
     1081 tacaagcact agcaacaact ccatatctgg atcattgaag cgcttggaag atactgcagc
     1141 aagatttaca aatgcaaatt tccaggaagt ctctgcccat acctctagtg gaaaagatgt
     1201 ttcagaggct agagggtcag agggcaaagg gaagaaatct tcagctcaca gctcaggtca
     1261 aaggggaagg aagcctggtg caggaagaaa tccaggaaca gctgtgtcag catctagccc
     1321 ctttccacaa ggcagttttt caggaactcc aggcagtgta aagtcatctt ctggaagttc
     1381 agtgcagtct ccccaggact tcttaagctt tacagactca gatctgcgaa gtgacagtta
     1441 cactcacacc cagcagccat catcaaccaa agatgtacat aaaggagagt ctggaagcca
     1501 ggaagcggca gtaaacagtt ttagctcttt agttggtcac cctgtgacct cgactgttat
     1561 ttcacagcct aaaagctttg acaattcacc tggagagttg ggtagttcga gcctccctac
     1621 agcaggatat aagcgggctc agacttctgg tatagaagaa gaagctgtaa aggaaaagaa
     1681 acgaaaagga aataagcaaa gcaaacatgg ccccggccga cccaaaggaa acaaaaatca
     1741 agaaaatgtt tctcacctct cagtttcttc tgcttcacca acatcgtccg tagcatcagc
     1801 tgcaggaagt gtaacaagct ctagtcttca gaaatctcct acgctgctca ggaatggaag
     1861 tttgcagagt cttagtgttg gctcgtctcc agttggctca gaaatttcca tgcagtatcg
     1921 acatgatgga gcttgtccaa caactacctt ctcagagttg ctgaatgcaa tacacaatgg
     1981 tatttataac agcaatgatg tagccgtatc ctttccaaac gtggtgtctg gctcaggatc
     2041 tagtactcct gtctctagct ctcatatacc tcagcagtca tctggtcatt tgcaacaggt
     2101 gggagctctc tccccctcag ctgcgtcatc tgtaacccct gctgctgcta caactcaggc
     2161 aaataccgtt tctggatctt ctctcagtca ggcaccagcc catatgtatg gcagtagatt
     2221 aaatcagaat ccatccatgg cagttctcat agctcagtct gaaagcagcc aaacagatca
     2281 agatcttgga gacaatgccc gtagcctggg tggccgagga agctcgcccc gaggaagcct
     2341 ctctccgaga tcccctgtga gcaacttaca gcttcgctat gatcaaccga gcaatagcag
     2401 tttggaaact gtgcctccag tagcagcaag tattgaacag ctcttggaga ggcagtggag
     2461 tgaaggacag cagtttttac tagagcaggg gactcctggt gacattctag gaatgttaaa
     2521 gtcattacat caacttcaag ttgaaaatcg aagattagaa gaacagatca aaaatttgac
     2581 tgccaagaaa gaacgtcttc agttgttgaa tgcacagctt tcagtgcctt tcccagccat
     2641 aacgacaaac cccagtccgt cccatcagat gcacacatac acagcacaga ctgctcctcc
     2701 tcctgattcc ctgaacagca gtaagagccc acatatagga aacagctttt tacctgacaa
     2761 ttctcttcct gtattaaatc aggacttgac ctccagtgga caaagcacca gcagttcttc
     2821 tgctctttct actccccctc ctgctggcca gagtcctgct cagcagagct ctggagtcag
     2881 tggggttcag caggtgaatg gcgtgacagt gggggcacta gctagtggga tgcagaccgt
     2941 cacatccacc atcccagctg tgtccgcagt gggtggaata attggagctc tgccaggtaa
     3001 ccaactggca attaacggca ttgtgggagc tttaaatggt gtgattcaga ctccagtcac
     3061 aatctcccag aaccctgccc ctctcaccca caccagtgta ccacctaatg cagcgcatcc
     3121 aatgccggcc gccgcactga ccaacagtgc ctcgggacta gggctgctgt cggaccagca
     3181 gagacagatg tttatccagc agcagcagtt ccagcagctg ttaaactccc agcagctcac
     3241 acccgaacag catcaggcct tcctatacca gctgatgcag cagcagcacc acccgcctga
     3301 gctccagcag ctgcagctcc cgggacccac gcagatcccc atcaacaatc tccttgcagg
     3361 tgctcaggcg cctccactcc acacagctac caccaacccc ttcctcacca tccacgggga
     3421 cagcacgagc cagaaggtca caagacttag tgataaaact gggcctgtag ctcaagagaa
     3481 aagttgacac ttgaaaatgg ccagaactcg cctttcctgc tgttctgtgc ttcactggct
     3541 gctgcagtgt ctgccacagc tatgaagaat ggaggcggga acacacaggg gaggatgcca
     3601 cacactccct tgtaaggctc tgattttctt gttgctttgt tgcactgaaa tggaattcct
     3661 atatacccat cccctaccaa agtgtttgaa cttcggaaga aaaattaata actttttgtc
     3721 aatgaaataa ttcatatgca atgagtttat caatccaaga aaaatgtaat gtgcttgctg
     3781 cacagctagt tttgttataa attggaaaca taaaactaaa gactattcta tttggaaacc
     3841 acttggttat atcataaaag ttggaatata actatcttat tgggatagag tgtgcttgtt
     3901 ccacggggca gatcttaagt tttgagaact gtctaatatc ttctcttgga gttgtattca
     3961 ttaaatattg ttattataca gatcctcaac tggggctttg caaatgtttt aaagaattcc
     4021 tttctaatga gatttgtcca tttggagatc aaattaggat ggagacaact gcttctgcta
     4081 acagtagttt tcttttgcaa aagaaaaaaa ttttgtgtgt gtgttaaaac ctactcttga
     4141 gttaagggag ctgtaaggct gctgggagaa ctagatcaat tggatgagaa cagtttcttt
     4201 cagaaagata caccaatgtg gaaactgctg caaggttcta gcatcaaatt gcctgttggg
     4261 acctccctgg atagaaaggg ctctgtactg ccgggcaggc cacttgtgcc agcagcttcc
     4321 ccgtgcttct gtctctgttg aacctttctg tgccaccaga gagagctcag gcaaactgac
     4381 tgtccacaag gaaacaagta gacctgggaa gagtctacat gcttgcttat ctcatcagcc
     4441 tcaaaccacc cactggaaca ggcacaccac cacagttcct aaaacctgtc ccacagcctt
     4501 ccgacttagc catgccccga gtagccatgc tcttgattgt gacaatatgg cagcctagta
     4561 ggttagacag ttggggatat aatcattggt ctgtttctga aacacatgaa ttactggtgg
     4621 gaaaggccca actgcagttc gacctccact gtgtgcttag ctggaagacc atgtgcacgg
     4681 cttagcagtc tgtcttctgt gacactgcac acctcttacc tcacttctgt aaataaggtt
     4741 gtgaatctgt tttgtaatgt gaaaaattca taagataaca ttgatatttt gatttgtaat
     4801 atttctaatt ggtagattta attgaaaagt aaaattaatt tatttttata tgttcagggg
     4861 aattttaaag aaagtcaaac cttttgtaga taatttaaaa gaatcagtgt ggtttatttt
     4921 atatatgtaa cccactggtt gttattctgt aacaatttgt ataaatggta aatttttgaa
     4981 tgtgctgtta ttttacttag atgtaaaatt ccacatgtat taaaatgtac aaagtttttg
     5041 ttaataaaat ttaatgatgt ttata
//
