LOCUS       NM_022328               3718 bp    mRNA    linear   ROD 08-NOV-2023
DEFINITION  Mus musculus myeloid/lymphoid or mixed-lineage leukemia;
            translocated to, 1 (Mllt1), transcript variant 1, mRNA.
ACCESSION   NM_022328 XM_974773
VERSION     NM_022328.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3718)
  AUTHORS   Yu N, Tian W, Liu C, Zhang P, Zhao Y, Nan C, Jin Q, Li X and Liu Y.
  TITLE     miR-122-5p Promotes Peripheral and Central Nervous System
            Inflammation in a Mouse Model of Intracerebral Hemorrhage via
            Disruption of the MLLT1/PI3K/AKT Signaling
  JOURNAL   Neurochem Res 48 (12), 3665-3682 (2023)
   PUBMED   37594575
  REMARK    GeneRIF: miR-122-5p Promotes Peripheral and Central Nervous System
            Inflammation in a Mouse Model of Intracerebral Hemorrhage via
            Disruption of the MLLT1/PI3K/AKT Signaling.
REFERENCE   2  (bases 1 to 3718)
  AUTHORS   Liu C, Li X, Xiong F, Wang L, Chen K, Wu P, Hua L and Zhang Z.
  TITLE     Down-regulation of MLLT1 super elongation complex subunit impairs
            the anti-tumor activity of natural killer cells in esophageal
            cancer
  JOURNAL   Immunobiology 227 (4), 152238 (2022)
   PUBMED   35763909
  REMARK    GeneRIF: Down-regulation of MLLT1 super elongation complex subunit
            impairs the anti-tumor activity of natural killer cells in
            esophageal cancer.
REFERENCE   3  (bases 1 to 3718)
  AUTHORS   Zhao Z, Wang L, Volk AG, Birch NW, Stoltz KL, Bartom ET, Marshall
            SA, Rendleman EJ, Nestler CM, Shilati J, Schiltz GE, Crispino JD
            and Shilatifard A.
  TITLE     Regulation of MLL/COMPASS stability through its proteolytic
            cleavage by taspase1 as a possible approach for clinical therapy of
            leukemia
  JOURNAL   Genes Dev 33 (1-2), 61-74 (2019)
   PUBMED   30573454
  REMARK    GeneRIF: direct regulation of the stability of MLL1 through its
            cleavage by taspase1
REFERENCE   4  (bases 1 to 3718)
  AUTHORS   Hetzner K, Garcia-Cuellar MP, Buttner C and Slany RK.
  TITLE     The interaction of ENL with PAF1 mitigates polycomb silencing and
            facilitates murine leukemogenesis
  JOURNAL   Blood 131 (6), 662-673 (2018)
   PUBMED   29217648
  REMARK    GeneRIF: ENL overcomes polycomb silencing through recruitment of
            PAF1 via the conserved YEATS domain, which recognizes acetylated
            histone H3.
REFERENCE   5  (bases 1 to 3718)
  AUTHORS   Wan L, Wen H, Li Y, Lyu J, Xi Y, Hoshii T, Joseph JK, Wang X, Loh
            YE, Erb MA, Souza AL, Bradner JE, Shen L, Li W, Li H, Allis CD,
            Armstrong SA and Shi X.
  TITLE     ENL links histone acetylation to oncogenic gene expression in acute
            myeloid leukaemia
  JOURNAL   Nature 543 (7644), 265-269 (2017)
   PUBMED   28241141
  REMARK    GeneRIF: data identify ENL as a histone acetylation reader that
            regulates oncogenic transcriptional programs in acute myeloid
            leukaemia, and suggest that displacement of ENL from chromatin may
            be a promising epigenetic therapy, alone or in combination with BET
            inhibitors, for aggressive leukaemia
REFERENCE   6  (bases 1 to 3718)
  AUTHORS   Drynan LF, Pannell R, Forster A, Chan NM, Cano F, Daser A and
            Rabbitts TH.
  TITLE     Mll fusions generated by Cre-loxP-mediated de novo translocations
            can induce lineage reassignment in tumorigenesis
  JOURNAL   EMBO J 24 (17), 3136-3146 (2005)
   PUBMED   16096649
REFERENCE   7  (bases 1 to 3718)
  AUTHORS   Hirano M, Kikuchi Y, Nisitani S, Yamaguchi A, Satoh A, Ito T, Iba H
            and Takatsu K.
  TITLE     Bruton's tyrosine kinase (Btk) enhances transcriptional
            co-activation activity of BAM11, a Btk-associated molecule of a
            subunit of SWI/SNF complexes
  JOURNAL   Int Immunol 16 (5), 747-757 (2004)
   PUBMED   15096481
  REMARK    GeneRIF: demonstrate BAM11 transcriptional co-activation activity
            and its functional interaction with Btk
REFERENCE   8  (bases 1 to 3718)
  AUTHORS   Forster A, Pannell R, Drynan LF, McCormack M, Collins EC, Daser A
            and Rabbitts TH.
  TITLE     Engineering de novo reciprocal chromosomal translocations
            associated with Mll to replicate primary events of human cancer
  JOURNAL   Cancer Cell 3 (5), 449-458 (2003)
   PUBMED   12781363
REFERENCE   9  (bases 1 to 3718)
  AUTHORS   Doty RT, Vanasse GJ, Disteche CM and Willerford DM.
  TITLE     The leukemia-associated gene Mllt1/ENL: characterization of a
            murine homolog and demonstration of an essential role in embryonic
            development
  JOURNAL   Blood Cells Mol Dis 28 (3), 407-417 (2002)
   PUBMED   12367585
  REMARK    GeneRIF: characterization of gene structure, mapping to chromosome
            17, and demonstration of an essential role in embryonic development
REFERENCE   10 (bases 1 to 3718)
  AUTHORS   Kikuchi Y, Hirano M, Seto M and Takatsu K.
  TITLE     Identification and characterization of a molecule, BAM11, that
            associates with the pleckstrin homology domain of mouse Btk
  JOURNAL   Int Immunol 12 (10), 1397-1408 (2000)
   PUBMED   11007757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073683.3.
            
            On Jul 29, 2022 this sequence version replaced NM_022328.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053005.1, AK156820.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AC073683.3         72335-72569
            236-416             AC073683.3         80660-80840
            417-499             AC073683.3         87850-87932
            500-643             AC073683.3         101977-102120
            644-769             AC073683.3         105144-105269
            770-1297            AC073683.3         107536-108063
            1298-1385           AC073683.3         110365-110452
            1386-1494           AC073683.3         111515-111623
            1495-1594           AC073683.3         112734-112833
            1595-1666           AC073683.3         112930-113001
            1667-1738           AC073683.3         113094-113165
            1739-3718           AC073683.3         113242-115221
FEATURES             Location/Qualifiers
     source          1..3718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.56 cM"
     gene            1..3718
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /note="myeloid/lymphoid or mixed-lineage leukemia;
                     translocated to, 1"
                     /db_xref="GeneID:64144"
                     /db_xref="MGI:MGI:1927238"
     exon            1..235
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1867
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     trithorax; leukemia-associated protein MLLT1;
                     myeloid/lymphoid or mixed lineage-leukemia translocation
                     to 1 homolog; myeloid/lymphoid or mixed lineage-leukemia
                     translocation to 4 homolog; myeloid/lymphoid or
                     mixed-lineage leukemia (trithorax homolog, Drosophila);
                     translocated to, 1"
                     /codon_start=1
                     /product="protein ENL isoform 1"
                     /protein_id="NP_071723.1"
                     /db_xref="CCDS:CCDS28918.1"
                     /db_xref="GeneID:64144"
                     /db_xref="MGI:MGI:1927238"
                     /translation="MDNQCTVQVKLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDI
                     QHFVEKVIFRLHDSFPKPKRVCKEPPYKVEESGYAGFIMLIEVYFKNKEEPRKVCFTY
                     DLFLNLEGNPPVNHLRCEKLTFNNPTTEFRCKLLMAGGVMVMPEGADTVSRPSPDYPM
                     LPTIPLSAFSDPKKNKPSHGSKDANKESGKASKPHKVAREHRERPRKDSESRSCSKEP
                     EREPKSAKDAARKLPKEEKAPVPKAAFKEPKMALKETKLESLSPKGVPQPPTLPKASS
                     KRPAATDSPKLSAKKPKKSGSKGTRRAPGTSPRASSFPDKKVARDKNSKGDKGKAESE
                     PREAKRTLQTEDSNSEDEASFRSESAQSSPANASSSSDSSSDSDFEPSQNHSQGPLRS
                     MVEDLQSEGSDEDDSSSGEENTGKANPGRESRLSFSDSESDNSADSCLPGREPLPPQK
                     PPPPSSKVSGRRSPEPCSKPEKMLKKATYDKAYTDELVELHRRLMALRERNVLQQIVN
                     LIEETGHFNVTNTTFDFDLFSLDESTVRKLQSCLEAVAT"
     exon            236..416
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
     exon            417..499
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
     exon            500..643
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
     exon            644..769
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1297
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1385
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1494
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1594
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1666
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1738
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..3718
                     /gene="Mllt1"
                     /gene_synonym="BAM11; ENL; LTG19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccatcggc gaggccgggc ccgagtcggc ggctgggggc ccgcggtcgc tgagccgccc
       61 gggctggcgg cggtttccgg ttcagcgcgg ctggcgggcg ggcgggcggc ccggaacggc
      121 ggcggcggcg gtgcggcccc cgacagacaa tgagagcggc ggggcgttgc tgagcggcgg
      181 cagcgagagc gacgcgggcc cgggggcggg gcgggcgcca gtcatggaca atcagtgcac
      241 tgtccaggtg aagttagagc tggggcaccg tgcccagcta cggaagaagc ccaccaccga
      301 gggcttcacc catgactgga tggtcttcgt gcgtggccct gagcagtgtg acatccagca
      361 ctttgtggag aaggtcatct tccggctgca tgacagcttc cctaaaccca agcgtgtgtg
      421 caaggagccc ccctacaaag tggaggagtc gggctatgca ggcttcatca tgctcattga
      481 agtgtacttc aaaaacaagg aggagccgag gaaggtctgc ttcacctacg acctgtttct
      541 caacctggag ggcaaccctc ctgtcaacca cctgcgctgt gagaagctca ccttcaataa
      601 ccccaccacc gagtttcgct gcaagctgct catggctgga ggggtgatgg taatgcccga
      661 aggagcggac acggtgtcca ggcccagccc tgactacccc atgttaccca caattccact
      721 ctctgccttc tctgacccca agaagaacaa accatcccac ggctccaagg atgccaacaa
      781 ggagagtggc aaggcttcca aaccacacaa ggtggccagg gagcaccgtg agcggccgcg
      841 caaggactca gagagcagga gttgctccaa ggagccggag cgtgagccca agagtgccaa
      901 ggatgctgca cgcaagctgc ccaaggagga gaaggcccca gtgcccaagg ctgccttcaa
      961 ggagcccaag atggccctaa aggaaaccaa gctggagagc ctgtccccca agggggtgcc
     1021 ccagcctcct accctgccca aggcctccag caagaggcca gctgccacgg actcaccgaa
     1081 gctcagcgcc aaaaagccta aaaagagtgg gtcaaagggg acacggcgtg caccaggcac
     1141 ctcaccccga gcttcctcct ttcctgacaa gaaggtggcc agggacaaga acagcaaagg
     1201 tgacaagggg aaggcagaga gtgagcctcg ggaggccaag cggactctgc agactgaaga
     1261 ctcaaactca gaggatgagg cctccttccg gtcagagtcg gcccagtcaa gcccagctaa
     1321 tgccagctcc agctctgact ccagctctga ctcagacttt gagccgtctc agaaccacag
     1381 ccaaggaccc ctgcgctcca tggtggagga cctgcagtct gagggctctg atgaggatga
     1441 ctcatcgtca ggagaggaga acaccggcaa ggccaaccca ggccgggagt ccaggctaag
     1501 cttcagtgac agcgagagtg acaacagcgc agactcctgc ctgcctggcc gtgagcccct
     1561 gcctccccag aagccgcccc ctcccagcag caaggtgtct ggtcggagga gccccgagcc
     1621 ctgcagcaag cccgaaaaga tgctgaagaa ggctacctat gacaaggctt acacggatga
     1681 gctggtggag ctgcaccgga gactgatggc tctgcgcgag cgcaatgtgc tgcagcagat
     1741 tgtcaatctg atcgaggaga ctggccactt caatgtcacc aacaccacct tcgactttga
     1801 ccttttctcc ttggatgaaa gcactgttcg caagctgcag agctgcctgg aggccgtggc
     1861 cacatgaccc cggctgccac tgtggagcca cggtgggcat ggtgggcacg ggaggggctg
     1921 ggcatgaggg ctggcccgcc atggcttccg ctcccggtac cacccccaac taaccatggt
     1981 gccccagtac ccctcagtgg ttggtgatga aggggtgctg caggccacac acagggtggg
     2041 gtgacatagg acacacgtgg cctgcagccc ctcacttagt ccctgccagt tgtccattgt
     2101 gggtgggact gaatggcaga ttactgcctg ggcctctctg ggtggccagg atgaccacag
     2161 tcttccacac agttcacagg cctctctcag ctggcctgcc tcctagactt gagggtccgt
     2221 tagcctggcc agagccagct atgtgcacct gcttctgcca tgcagccttg tgcatgtgtg
     2281 tgctccaggt gcagccagca gccggggggc tcaggccacc cctctgctgg aggcacagag
     2341 gatctcccct ctagatccta ggatgccact gcctctcgag gccccaggcc agagaacact
     2401 acaatgggca ccaatcttgg gaccccaagg gccaccactg cagccatgtg ccagctaagc
     2461 acccacagtt ccaaggctag ctggactggc agcactcctg ggccaccatt ccccgtgggc
     2521 ctcctcctct gctctctcac tgatcaagtc tttgaacttt gaaaacatga gcttttgcca
     2581 aatatgatag gatggtgtgt gtgaggccgg cccaacccta gactgcctct gttcctggcc
     2641 acatgtgcgc ctggagaggc tttggacctg tgccctgcaa actgccaggg gtcaagccag
     2701 cccccttccc ctgtctgagc ctggagtgcc accccttccc caacttcagt tgtcggtgtt
     2761 tgtgccccaa ccaaggtgtt tgaaagaggc ctgagctgaa gccagctcac agttgcctcg
     2821 atgtgttgct tcctccccat tgtgggttca cccctggagg cctggcctcc cagctccctc
     2881 tccctgtctg tcccactccc aaactatctg tcaggaagat cctgaacact cctggggacc
     2941 ccagcctcta aggcttcctt tacccccaga gaaaggaaaa ggcctctgcc tgtagcccct
     3001 gttcacactc cctatagctg ggaggaaaca gggctcgtgc cccaacctct ttccacacag
     3061 gccgacaata ctctccatca ggtgttctgc agcctctaag ccttttcata gaaggccctg
     3121 gcatcgtggc agctgttggc ctccacatgg agtgcgccag ggtcccaaac agcctcagcc
     3181 cagggcacca ttcttcctct catggtcgct agcggcccag cccttctgct gccctgggcc
     3241 ttggtgtcta gtccttccag atgcttccag ggtcgtcctg aaaacaccca cccatctctt
     3301 cagttacctc ctctggccag aaggtcacac cactgtcctc cagagccact ctggggccca
     3361 tactggctgt ctggaagcct aaagcagcag cctgcagcca gagccgaggg ttctagggac
     3421 ttgtccatag gaaggggtgg cactatgtat accctcagtg agtccctttg ctgcagcctc
     3481 ctgaaccagt tcatgacact gagtgcaaaa ggtattggat acctatccct ccccagggct
     3541 tcacaagaca tgtctccatg aatagacacg tcactggccc agacgagccc tggacagagg
     3601 gaccaggaga gctgtgtttg taacaagctg cagggccatt tgtcccgcat tttaaacttt
     3661 tttgttaaat tgtgaaatga tggaggagtt ttatagaaaa taaagtgaga tgggagca
//
