LOCUS       NM_001368968            2498 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus muscular LMNA-interacting protein (Mlip), transcript
            variant 14, mRNA.
ACCESSION   NM_001368968 XM_017313586
VERSION     NM_001368968.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2498)
  AUTHORS   Yan,Y., Long,T., Su,Q., Wang,Y., Chen,K., Yang,T., Zhao,G., Ma,Q.,
            Hu,X., Liu,C., Liao,X., Min,W., Li,S., Zhang,D., Yang,Y., Pu,W.T.,
            Dong,Y., Wang,D.Z., Chen,Y. and Huang,Z.P.
  TITLE     Cardiac ISL1-Interacting Protein, a Cardioprotective Factor,
            Inhibits the Transition From Cardiac Hypertrophy to Heart Failure
  JOURNAL   Front Cardiovasc Med 9, 857049 (2022)
   PUBMED   35369338
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2498)
  AUTHORS   He,X., Liu,J., Gu,F., Chen,J., Lu,Y.W., Ding,J., Guo,H., Nie,M.,
            Kataoka,M., Lin,Z., Hu,X., Chen,H., Liao,X., Dong,Y., Min,W.,
            Deng,Z.L., Pu,W.T., Huang,Z.P. and Wang,D.Z.
  TITLE     Cardiac CIP protein regulates dystrophic cardiomyopathy
  JOURNAL   Mol Ther 30 (2), 898-914 (2022)
   PUBMED   34400329
  REMARK    GeneRIF: Cardiac CIP protein regulates dystrophic cardiomyopathy.
REFERENCE   3  (bases 1 to 2498)
  AUTHORS   Liu,J., Huang,Z.P., Nie,M., Wang,G., Silva,W.J., Yang,Q.,
            Freire,P.P., Hu,X., Chen,H., Deng,Z., Pu,W.T. and Wang,D.Z.
  TITLE     Regulation of myonuclear positioning and muscle function by the
            skeletal muscle-specific CIP protein
  JOURNAL   Proc Natl Acad Sci U S A 117 (32), 19254-19265 (2020)
   PUBMED   32719146
  REMARK    GeneRIF: Regulation of myonuclear positioning and muscle function
            by the skeletal muscle-specific CIP protein.
REFERENCE   4  (bases 1 to 2498)
  AUTHORS   Holmes,G., Gonzalez-Reiche,A.S., Lu,N., Zhou,X., Rivera,J.,
            Kriti,D., Sebra,R., Williams,A.A., Donovan,M.J., Potter,S.S.,
            Pinto,D., Zhang,B., van Bakel,H. and Jabs,E.W.
  TITLE     Integrated Transcriptome and Network Analysis Reveals
            Spatiotemporal Dynamics of Calvarial Suturogenesis
  JOURNAL   Cell Rep 32 (1), 107871 (2020)
   PUBMED   32640236
REFERENCE   5  (bases 1 to 2498)
  AUTHORS   Cattin,M.E., Deeke,S.A., Dick,S.A., Verret-Borsos,Z.J.A.,
            Tennakoon,G., Gupta,R., Mak,E., Roeske,C.L., Weldrick,J.J.,
            Megeney,L.A. and Burgon,P.G.
  TITLE     Expression of murine muscle-enriched A-type lamin-interacting
            protein (MLIP) is regulated by tissue-specific alternative
            transcription start sites
  JOURNAL   J Biol Chem 293 (51), 19761-19770 (2018)
   PUBMED   30389785
  REMARK    GeneRIF: Mlip tissue-specific expression and alternative splicing
            play a critical role in determining MLIP's functions in mice
REFERENCE   6  (bases 1 to 2498)
  AUTHORS   Huang,Z.P., Kataoka,M., Chen,J., Wu,G., Ding,J., Nie,M., Lin,Z.,
            Liu,J., Hu,X., Ma,L., Zhou,B., Wakimoto,H., Zeng,C., Kyselovic,J.,
            Deng,Z.L., Seidman,C.E., Seidman,J.G., Pu,W.T. and Wang,D.Z.
  TITLE     Cardiomyocyte-enriched protein CIP protects against
            pathophysiological stresses and regulates cardiac homeostasis
  JOURNAL   J Clin Invest 125 (11), 4122-4134 (2015)
   PUBMED   26436652
  REMARK    GeneRIF: Deletion of the CIP-encoding gene accelerated progress
            from hypertrophy to heart failure in several cardiomyopathy models.
REFERENCE   7  (bases 1 to 2498)
  AUTHORS   Cattin,M.E., Wang,J., Weldrick,J.J., Roeske,C.L., Mak,E.,
            Thorn,S.L., DaSilva,J.N., Wang,Y., Lusis,A.J. and Burgon,P.G.
  TITLE     Deletion of MLIP (muscle-enriched A-type lamin-interacting protein)
            leads to cardiac hyperactivation of Akt/mammalian target of
            rapamycin (mTOR) and impaired cardiac adaptation
  JOURNAL   J Biol Chem 290 (44), 26699-26714 (2015)
   PUBMED   26359501
  REMARK    GeneRIF: Mlip-deficient hearts showed an impaired capacity to adapt
            to stress (isoproterenol-induced hypertrophy), likely because of
            deregulated Akt/mTOR activity.
REFERENCE   8  (bases 1 to 2498)
  AUTHORS   Huang,Z.P., Young Seok,H., Zhou,B., Chen,J., Chen,J.F., Tao,Y.,
            Pu,W.T. and Wang,D.Z.
  TITLE     CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte
            hypertrophy
  JOURNAL   Circ Res 110 (6), 818-830 (2012)
   PUBMED   22343712
  REMARK    GeneRIF: studies identify cardiac Isl1-interacting protein (CIP) as
            a novel regulator of cardiac hypertrophy.
REFERENCE   9  (bases 1 to 2498)
  AUTHORS   Ahmady,E., Deeke,S.A., Rabaa,S., Kouri,L., Kenney,L., Stewart,A.F.
            and Burgon,P.G.
  TITLE     Identification of a novel muscle A-type lamin-interacting protein
            (MLIP)
  JOURNAL   J Biol Chem 286 (22), 19702-19713 (2011)
   PUBMED   21498514
  REMARK    GeneRIF: MLIP is expressed most highly in striated and smooth
            muscle, it is likely to contribute to the mesenchymal phenotypes of
            laminopathies.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123797.3, AC151731.4 and AC128705.4.
            
            On Mar 11, 2019 this sequence version replaced XM_017313586.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.68082.1,
                                           SRR1660825.102445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC123797.3         62044-62149
            107-499             AC123797.3         74112-74504
            500-1969            AC123797.3         82942-84411
            1970-2014           AC151731.4         186599-186643       c
            2015-2059           AC151731.4         179206-179250       c
            2060-2188           AC151731.4         170012-170140       c
            2189-2498           AC128705.4         150676-150985       c
FEATURES             Location/Qualifiers
     source          1..2498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.67 cM"
     gene            1..2498
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /note="muscular LMNA-interacting protein"
                     /db_xref="GeneID:69642"
                     /db_xref="MGI:MGI:1916892"
     exon            1..106
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2191
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /note="isoform 14 is encoded by transcript variant 14;
                     muscular-enriched A-type laminin-interacting protein;
                     cardiac Isl1-interacting protein"
                     /codon_start=1
                     /product="muscular LMNA-interacting protein isoform 14"
                     /protein_id="NP_001355897.1"
                     /db_xref="GeneID:69642"
                     /db_xref="MGI:MGI:1916892"
                     /translation="MTSCILAGSLETTPKFEYSDHMTFSSESKQERVQRILDYPSEVS
                     GRNSQQKEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGGPGNIATR
                     PKSLAISSSLASDVVRPKVRGADLKTSSHPEIPHGIAPQQKHGLKTPPVPANVSGATV
                     LREFHTRRLDVTGASEEETTTYFHSTAHDSPLSAWKGASTLVVSPSAQLSGSSLCGSN
                     VTDHTRGLASEAQKKMSTSNVLNPKEDVRTCPAPASGASLTSPSASYIPVRIVMHSLS
                     PSPKPLTSSSHGSLSTVCSQMSSSGSLSKSGLKSPVPSRLSLLTAILKSNPSHQRPLS
                     PASCPTFSLNSLASSTLALDQKVKQTPPTSKKSLSSGSLTTGSTEQEHQASAASYQPC
                     HLPFFSKTTPLSQAQPLSPLALASNSCASMDIEKIPGSTLRSNTTSPQPQTDTFSLAD
                     VPSVTPVLSPLSSSKGRKDGDSRTPEKNRNICIQPSTLASTPPVDESLALSSSGKGFH
                     PSPALSDLIDRSKRACSQQHPGQRPSPSALPTPPVSRAASASHPHLGCSILPLQSSLT
                     QTLQPSPSALRPSCGSATCPSRTQMPENTASNHSSRVSTPSLPVSLTRTKELFSPCAL
                     SMSAGPENKKPKTPTTHPRAAGRETKYANLSSSSSTASESQLTKPGVIRPVPVKSKLL
                     LRKDEEVYEPNPFSKYLEDNSGLFSEQ"
     exon            107..499
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            500..1969
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2014
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2059
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2188
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2498
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2471..2476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /note="hexamer: AATAAA"
     polyA_site      2498
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /note="major polyA site"
ORIGIN      
        1 agtcattggt ttgctttcag agcaggggct tctgagtgcc tgcaggaaca attacttcca
       61 aatgacctcc tgcatcttag cggggagcct tgagaccaca cccaagtttg agtacagtga
      121 tcatatgacc ttcagctctg agagcaaaca agagagggtc cagaggatac tggattatcc
      181 gtcagaggtc agtgggagga attcacaaca aaaggaattc aatacaaagg aacctcaagg
      241 aatgcagaaa ggtgatctct tcaaagcaga atatgttttt attgtggatt ctgatgggga
      301 agatgaagct acatgcagac aaggtgaaca aggcccccca gggggaccag gcaacatagc
      361 tactcggccc aagtctctgg ctatttcttc tagtctggct tctgacgtgg tgcgtcccaa
      421 agtacgaggg gctgatctca agacctcatc acatcctgaa attcctcatg ggatagcccc
      481 tcagcaaaag catgggctga aaacaccacc tgtcccagct aacgtcagcg gagcgactgt
      541 gctacgggag tttcacactc gcaggctgga tgtcactggg gcctctgagg aagaaacaac
      601 tacgtatttt cacagtactg ctcatgattc tcccctttct gcatggaagg gcgcttcgac
      661 gttagtagtc tctccttccg ctcaactgtc aggttctagt ttatgtggct caaatgtcac
      721 tgatcacaca cgtgggctgg catcggaagc ccagaagaaa atgtccactt cgaatgtcct
      781 taatcccaag gaagatgtga gaacctgtcc tgcgcctgcc tctggtgctt ctctgacatc
      841 accctcagct tcctacatac cagtccgtat tgtcatgcac tcactgtccc caagtcccaa
      901 accacttacc tcctcttccc atggctcttt gtctactgtc tgtagccaaa tgtcatccag
      961 tggaagtctt tcaaagtcag ggctgaagtc cccagtaccc tctcggcttt ctctcctcac
     1021 cgctatcctc aagtcaaacc cttctcacca aaggccttta tcccctgcat cctgcccgac
     1081 cttctccctt aattccctgg cttcttctac tcttgcactt gatcaaaaag taaagcaaac
     1141 tccacccaca tctaagaaat ctctctcaag tggctccttg acaacggggt ctacagagca
     1201 agaacaccag gcttctgcag cgagctacca accctgccac ctccctttct tttccaagac
     1261 taccccactt tctcaggcac aacccctctc tccactagca ctggccagta acagttgtgc
     1321 ttctatggat atagagaaaa taccaggaag cacactaagg agcaacacaa cctcacccca
     1381 accacagact gatacattca gtcttgctga tgtcccttct gtcacaccag tcttgtcccc
     1441 tctttcctct tccaagggca gaaaggatgg tgactccagg actccagaaa agaacaggaa
     1501 tatttgcata cagccttcta ccttagcttc gacaccacct gttgatgaga gcttggccct
     1561 ttcctcttcc gggaaaggtt tccacccttc cccggccctc tcagacctga tagacagatc
     1621 caaaagagcg tgctcccaac aacacccagg ccagcggcca agcccttcag ctcttccgac
     1681 tcctccagtc tccagggctg cctctgcttc tcatccccat ttggggtgct ctattctccc
     1741 tcttcagagt tcactcaccc agacacttca gcctagtcct tcagcactgc gcccaagttg
     1801 tgggagtgct acatgtcctt caagaactca gatgcctgaa aatacggcat ccaaccacag
     1861 ctcacgtgtt tcaactccat cacttcctgt ctctctaaca agaaccaagg agctgttctc
     1921 gccttgtgcc ctgtccatgt cagcaggccc tgaaaataag aagcccaaga ctcctacaac
     1981 tcatccaaga gcagctggtc gagaaaccaa atacgcaaat ctttcttcat catcctcaac
     2041 agcgtctgag agccaactga ctaagcctgg agtaattcgt ccagtacctg taaaatccaa
     2101 actactcctg agaaaggatg aagaagttta tgagcccaac cctttcagta aataccttga
     2161 agacaacagt ggcctgtttt ctgagcagta aggaagctgg agtggaagtg gacaccggtc
     2221 tgctgaagag ttttggaatg atgccatggc caactacttg ctaaacttac ctgatgcttt
     2281 gttagaagga gtgctctgct cagtccagca gaagcacctg aatggtttgc cacagccaca
     2341 tagcattacc acactctggg aaacccagag caggatcata gcccttctgt ttcttgcatt
     2401 gccgttcaag cctataatgc cttctattaa gtcaacagca atactaatgt tcccctatat
     2461 ttagcagtca aataaagaag aatgatagct gaatacaa
//
