LOCUS       NM_001368955            3002 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus muscular LMNA-interacting protein (Mlip), transcript
            variant 1, mRNA.
ACCESSION   NM_001368955 XM_017313570
VERSION     NM_001368955.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3002)
  AUTHORS   Yan,Y., Long,T., Su,Q., Wang,Y., Chen,K., Yang,T., Zhao,G., Ma,Q.,
            Hu,X., Liu,C., Liao,X., Min,W., Li,S., Zhang,D., Yang,Y., Pu,W.T.,
            Dong,Y., Wang,D.Z., Chen,Y. and Huang,Z.P.
  TITLE     Cardiac ISL1-Interacting Protein, a Cardioprotective Factor,
            Inhibits the Transition From Cardiac Hypertrophy to Heart Failure
  JOURNAL   Front Cardiovasc Med 9, 857049 (2022)
   PUBMED   35369338
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3002)
  AUTHORS   He,X., Liu,J., Gu,F., Chen,J., Lu,Y.W., Ding,J., Guo,H., Nie,M.,
            Kataoka,M., Lin,Z., Hu,X., Chen,H., Liao,X., Dong,Y., Min,W.,
            Deng,Z.L., Pu,W.T., Huang,Z.P. and Wang,D.Z.
  TITLE     Cardiac CIP protein regulates dystrophic cardiomyopathy
  JOURNAL   Mol Ther 30 (2), 898-914 (2022)
   PUBMED   34400329
  REMARK    GeneRIF: Cardiac CIP protein regulates dystrophic cardiomyopathy.
REFERENCE   3  (bases 1 to 3002)
  AUTHORS   Liu,J., Huang,Z.P., Nie,M., Wang,G., Silva,W.J., Yang,Q.,
            Freire,P.P., Hu,X., Chen,H., Deng,Z., Pu,W.T. and Wang,D.Z.
  TITLE     Regulation of myonuclear positioning and muscle function by the
            skeletal muscle-specific CIP protein
  JOURNAL   Proc Natl Acad Sci U S A 117 (32), 19254-19265 (2020)
   PUBMED   32719146
  REMARK    GeneRIF: Regulation of myonuclear positioning and muscle function
            by the skeletal muscle-specific CIP protein.
REFERENCE   4  (bases 1 to 3002)
  AUTHORS   Holmes,G., Gonzalez-Reiche,A.S., Lu,N., Zhou,X., Rivera,J.,
            Kriti,D., Sebra,R., Williams,A.A., Donovan,M.J., Potter,S.S.,
            Pinto,D., Zhang,B., van Bakel,H. and Jabs,E.W.
  TITLE     Integrated Transcriptome and Network Analysis Reveals
            Spatiotemporal Dynamics of Calvarial Suturogenesis
  JOURNAL   Cell Rep 32 (1), 107871 (2020)
   PUBMED   32640236
REFERENCE   5  (bases 1 to 3002)
  AUTHORS   Cattin,M.E., Deeke,S.A., Dick,S.A., Verret-Borsos,Z.J.A.,
            Tennakoon,G., Gupta,R., Mak,E., Roeske,C.L., Weldrick,J.J.,
            Megeney,L.A. and Burgon,P.G.
  TITLE     Expression of murine muscle-enriched A-type lamin-interacting
            protein (MLIP) is regulated by tissue-specific alternative
            transcription start sites
  JOURNAL   J Biol Chem 293 (51), 19761-19770 (2018)
   PUBMED   30389785
  REMARK    GeneRIF: Mlip tissue-specific expression and alternative splicing
            play a critical role in determining MLIP's functions in mice
REFERENCE   6  (bases 1 to 3002)
  AUTHORS   Huang,Z.P., Kataoka,M., Chen,J., Wu,G., Ding,J., Nie,M., Lin,Z.,
            Liu,J., Hu,X., Ma,L., Zhou,B., Wakimoto,H., Zeng,C., Kyselovic,J.,
            Deng,Z.L., Seidman,C.E., Seidman,J.G., Pu,W.T. and Wang,D.Z.
  TITLE     Cardiomyocyte-enriched protein CIP protects against
            pathophysiological stresses and regulates cardiac homeostasis
  JOURNAL   J Clin Invest 125 (11), 4122-4134 (2015)
   PUBMED   26436652
  REMARK    GeneRIF: Deletion of the CIP-encoding gene accelerated progress
            from hypertrophy to heart failure in several cardiomyopathy models.
REFERENCE   7  (bases 1 to 3002)
  AUTHORS   Cattin,M.E., Wang,J., Weldrick,J.J., Roeske,C.L., Mak,E.,
            Thorn,S.L., DaSilva,J.N., Wang,Y., Lusis,A.J. and Burgon,P.G.
  TITLE     Deletion of MLIP (muscle-enriched A-type lamin-interacting protein)
            leads to cardiac hyperactivation of Akt/mammalian target of
            rapamycin (mTOR) and impaired cardiac adaptation
  JOURNAL   J Biol Chem 290 (44), 26699-26714 (2015)
   PUBMED   26359501
  REMARK    GeneRIF: Mlip-deficient hearts showed an impaired capacity to adapt
            to stress (isoproterenol-induced hypertrophy), likely because of
            deregulated Akt/mTOR activity.
REFERENCE   8  (bases 1 to 3002)
  AUTHORS   Huang,Z.P., Young Seok,H., Zhou,B., Chen,J., Chen,J.F., Tao,Y.,
            Pu,W.T. and Wang,D.Z.
  TITLE     CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte
            hypertrophy
  JOURNAL   Circ Res 110 (6), 818-830 (2012)
   PUBMED   22343712
  REMARK    GeneRIF: studies identify cardiac Isl1-interacting protein (CIP) as
            a novel regulator of cardiac hypertrophy.
REFERENCE   9  (bases 1 to 3002)
  AUTHORS   Ahmady,E., Deeke,S.A., Rabaa,S., Kouri,L., Kenney,L., Stewart,A.F.
            and Burgon,P.G.
  TITLE     Identification of a novel muscle A-type lamin-interacting protein
            (MLIP)
  JOURNAL   J Biol Chem 286 (22), 19702-19713 (2011)
   PUBMED   21498514
  REMARK    GeneRIF: MLIP is expressed most highly in striated and smooth
            muscle, it is likely to contribute to the mesenchymal phenotypes of
            laminopathies.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123797.3, AC151731.4 and AC128705.4.
            
            On Mar 11, 2019 this sequence version replaced XM_017313570.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.125267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC123797.3         62044-62149
            107-262             AC123797.3         70169-70324
            263-655             AC123797.3         74112-74504
            656-2125            AC123797.3         82942-84411
            2126-2191           AC123797.3         123159-123224
            2192-2236           AC151731.4         186599-186643       c
            2237-2281           AC151731.4         179206-179250       c
            2282-2410           AC151731.4         170012-170140       c
            2411-2617           AC128705.4         186942-187148       c
            2618-2692           AC128705.4         161566-161640       c
            2693-3002           AC128705.4         150676-150985       c
FEATURES             Location/Qualifiers
     source          1..3002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.67 cM"
     gene            1..3002
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /note="muscular LMNA-interacting protein"
                     /db_xref="GeneID:69642"
                     /db_xref="MGI:MGI:1916892"
     exon            1..106
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2695
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     muscular-enriched A-type laminin-interacting protein;
                     cardiac Isl1-interacting protein"
                     /codon_start=1
                     /product="muscular LMNA-interacting protein isoform 1"
                     /protein_id="NP_001355884.1"
                     /db_xref="GeneID:69642"
                     /db_xref="MGI:MGI:1916892"
                     /translation="MTSCILAGSLETTPKVSPGDPEAKPLIFTFVPTLRRLPTHIQLA
                     DTSKFLVKIPEEPTDKSPETVNRFEYSDHMTFSSESKQERVQRILDYPSEVSGRNSQQ
                     KEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGGPGNIATRPKSLAI
                     SSSLASDVVRPKVRGADLKTSSHPEIPHGIAPQQKHGLKTPPVPANVSGATVLREFHT
                     RRLDVTGASEEETTTYFHSTAHDSPLSAWKGASTLVVSPSAQLSGSSLCGSNVTDHTR
                     GLASEAQKKMSTSNVLNPKEDVRTCPAPASGASLTSPSASYIPVRIVMHSLSPSPKPL
                     TSSSHGSLSTVCSQMSSSGSLSKSGLKSPVPSRLSLLTAILKSNPSHQRPLSPASCPT
                     FSLNSLASSTLALDQKVKQTPPTSKKSLSSGSLTTGSTEQEHQASAASYQPCHLPFFS
                     KTTPLSQAQPLSPLALASNSCASMDIEKIPGSTLRSNTTSPQPQTDTFSLADVPSVTP
                     VLSPLSSSKGRKDGDSRTPEKNRNICIQPSTLASTPPVDESLALSSSGKGFHPSPALS
                     DLIDRSKRACSQQHPGQRPSPSALPTPPVSRAASASHPHLGCSILPLQSSLTQTLQPS
                     PSALRPSCGSATCPSRTQMPENTASNHSSRVSTPSLPVSLTRTKELFSPCALSMSAGP
                     ENKKPKALDEPARTESNSKASVLDLPVETPTTHPRAAGRETKYANLSSSSSTASESQL
                     TKPGVIRPVPVKSKLLLRKDEEVYEPNPFSKYLEDNSGLFSEQDMAIPHKPVSLHPLY
                     QSKLYPPAKSLLHPQTLSHADCLTPGSFSHLSSFSVRDEQEKSPTLLSQDTYNKLGIF
                     SVKLGHPMVTIPEHDTLDSKE"
     exon            107..262
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            263..655
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            656..2125
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2191
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2236
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2281
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2410
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2617
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2692
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..3002
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /note="hexamer: AATAAA"
     polyA_site      3002
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /note="major polyA site"
ORIGIN      
        1 agtcattggt ttgctttcag agcaggggct tctgagtgcc tgcaggaaca attacttcca
       61 aatgacctcc tgcatcttag cggggagcct tgagaccaca cccaaggtct ctcctggaga
      121 tcctgaagcc aaacctctga tcttcacatt tgtccccact ctcagaagac taccaaccca
      181 cattcagttg gctgacactt ccaaatttct cgttaaaatt cccgaggaac caactgataa
      241 gagtccagaa actgtaaata ggtttgagta cagtgatcat atgaccttca gctctgagag
      301 caaacaagag agggtccaga ggatactgga ttatccgtca gaggtcagtg ggaggaattc
      361 acaacaaaag gaattcaata caaaggaacc tcaaggaatg cagaaaggtg atctcttcaa
      421 agcagaatat gtttttattg tggattctga tggggaagat gaagctacat gcagacaagg
      481 tgaacaaggc cccccagggg gaccaggcaa catagctact cggcccaagt ctctggctat
      541 ttcttctagt ctggcttctg acgtggtgcg tcccaaagta cgaggggctg atctcaagac
      601 ctcatcacat cctgaaattc ctcatgggat agcccctcag caaaagcatg ggctgaaaac
      661 accacctgtc ccagctaacg tcagcggagc gactgtgcta cgggagtttc acactcgcag
      721 gctggatgtc actggggcct ctgaggaaga aacaactacg tattttcaca gtactgctca
      781 tgattctccc ctttctgcat ggaagggcgc ttcgacgtta gtagtctctc cttccgctca
      841 actgtcaggt tctagtttat gtggctcaaa tgtcactgat cacacacgtg ggctggcatc
      901 ggaagcccag aagaaaatgt ccacttcgaa tgtccttaat cccaaggaag atgtgagaac
      961 ctgtcctgcg cctgcctctg gtgcttctct gacatcaccc tcagcttcct acataccagt
     1021 ccgtattgtc atgcactcac tgtccccaag tcccaaacca cttacctcct cttcccatgg
     1081 ctctttgtct actgtctgta gccaaatgtc atccagtgga agtctttcaa agtcagggct
     1141 gaagtcccca gtaccctctc ggctttctct cctcaccgct atcctcaagt caaacccttc
     1201 tcaccaaagg cctttatccc ctgcatcctg cccgaccttc tcccttaatt ccctggcttc
     1261 ttctactctt gcacttgatc aaaaagtaaa gcaaactcca cccacatcta agaaatctct
     1321 ctcaagtggc tccttgacaa cggggtctac agagcaagaa caccaggctt ctgcagcgag
     1381 ctaccaaccc tgccacctcc ctttcttttc caagactacc ccactttctc aggcacaacc
     1441 cctctctcca ctagcactgg ccagtaacag ttgtgcttct atggatatag agaaaatacc
     1501 aggaagcaca ctaaggagca acacaacctc accccaacca cagactgata cattcagtct
     1561 tgctgatgtc ccttctgtca caccagtctt gtcccctctt tcctcttcca agggcagaaa
     1621 ggatggtgac tccaggactc cagaaaagaa caggaatatt tgcatacagc cttctacctt
     1681 agcttcgaca ccacctgttg atgagagctt ggccctttcc tcttccggga aaggtttcca
     1741 cccttccccg gccctctcag acctgataga cagatccaaa agagcgtgct cccaacaaca
     1801 cccaggccag cggccaagcc cttcagctct tccgactcct ccagtctcca gggctgcctc
     1861 tgcttctcat ccccatttgg ggtgctctat tctccctctt cagagttcac tcacccagac
     1921 acttcagcct agtccttcag cactgcgccc aagttgtggg agtgctacat gtccttcaag
     1981 aactcagatg cctgaaaata cggcatccaa ccacagctca cgtgtttcaa ctccatcact
     2041 tcctgtctct ctaacaagaa ccaaggagct gttctcgcct tgtgccctgt ccatgtcagc
     2101 aggccctgaa aataagaagc ccaaggcact agatgaacca gccaggactg aaagcaactc
     2161 caaggccagc gtgttagacc taccagtgga gactcctaca actcatccaa gagcagctgg
     2221 tcgagaaacc aaatacgcaa atctttcttc atcatcctca acagcgtctg agagccaact
     2281 gactaagcct ggagtaattc gtccagtacc tgtaaaatcc aaactactcc tgagaaagga
     2341 tgaagaagtt tatgagccca accctttcag taaatacctt gaagacaaca gtggcctgtt
     2401 ttctgagcag gatatggcca tccctcacaa gcctgtctct ctccatcctt tatatcagtc
     2461 taaactctac cctcctgcta agtccctgct acatccacag accctctctc atgctgactg
     2521 tcttacccca ggatccttca gtcatttgtc ttccttctca gtgagggatg aacaggagaa
     2581 atcccccact cttcttagtc aggacacata caataagctg ggcatctttt ctgtgaagct
     2641 gggtcatccc atggtgacaa tacctgaaca tgacactctt gactctaaag agtaaggaag
     2701 ctggagtgga agtggacacc ggtctgctga agagttttgg aatgatgcca tggccaacta
     2761 cttgctaaac ttacctgatg ctttgttaga aggagtgctc tgctcagtcc agcagaagca
     2821 cctgaatggt ttgccacagc cacatagcat taccacactc tgggaaaccc agagcaggat
     2881 catagccctt ctgtttcttg cattgccgtt caagcctata atgccttcta ttaagtcaac
     2941 agcaatacta atgttcccct atatttagca gtcaaataaa gaagaatgat agctgaatac
     3001 aa
//
