LOCUS       NP_001355884             877 aa            linear   ROD 08-JUN-2024
DEFINITION  muscular LMNA-interacting protein isoform 1 [Mus musculus].
ACCESSION   NP_001355884 XP_017169059
VERSION     NP_001355884.1
DBSOURCE    REFSEQ: accession NM_001368955.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 877)
  AUTHORS   Yan,Y., Long,T., Su,Q., Wang,Y., Chen,K., Yang,T., Zhao,G., Ma,Q.,
            Hu,X., Liu,C., Liao,X., Min,W., Li,S., Zhang,D., Yang,Y., Pu,W.T.,
            Dong,Y., Wang,D.Z., Chen,Y. and Huang,Z.P.
  TITLE     Cardiac ISL1-Interacting Protein, a Cardioprotective Factor,
            Inhibits the Transition From Cardiac Hypertrophy to Heart Failure
  JOURNAL   Front Cardiovasc Med 9, 857049 (2022)
   PUBMED   35369338
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 877)
  AUTHORS   He,X., Liu,J., Gu,F., Chen,J., Lu,Y.W., Ding,J., Guo,H., Nie,M.,
            Kataoka,M., Lin,Z., Hu,X., Chen,H., Liao,X., Dong,Y., Min,W.,
            Deng,Z.L., Pu,W.T., Huang,Z.P. and Wang,D.Z.
  TITLE     Cardiac CIP protein regulates dystrophic cardiomyopathy
  JOURNAL   Mol Ther 30 (2), 898-914 (2022)
   PUBMED   34400329
  REMARK    GeneRIF: Cardiac CIP protein regulates dystrophic cardiomyopathy.
REFERENCE   3  (residues 1 to 877)
  AUTHORS   Liu,J., Huang,Z.P., Nie,M., Wang,G., Silva,W.J., Yang,Q.,
            Freire,P.P., Hu,X., Chen,H., Deng,Z., Pu,W.T. and Wang,D.Z.
  TITLE     Regulation of myonuclear positioning and muscle function by the
            skeletal muscle-specific CIP protein
  JOURNAL   Proc Natl Acad Sci U S A 117 (32), 19254-19265 (2020)
   PUBMED   32719146
  REMARK    GeneRIF: Regulation of myonuclear positioning and muscle function
            by the skeletal muscle-specific CIP protein.
REFERENCE   4  (residues 1 to 877)
  AUTHORS   Holmes,G., Gonzalez-Reiche,A.S., Lu,N., Zhou,X., Rivera,J.,
            Kriti,D., Sebra,R., Williams,A.A., Donovan,M.J., Potter,S.S.,
            Pinto,D., Zhang,B., van Bakel,H. and Jabs,E.W.
  TITLE     Integrated Transcriptome and Network Analysis Reveals
            Spatiotemporal Dynamics of Calvarial Suturogenesis
  JOURNAL   Cell Rep 32 (1), 107871 (2020)
   PUBMED   32640236
REFERENCE   5  (residues 1 to 877)
  AUTHORS   Cattin,M.E., Deeke,S.A., Dick,S.A., Verret-Borsos,Z.J.A.,
            Tennakoon,G., Gupta,R., Mak,E., Roeske,C.L., Weldrick,J.J.,
            Megeney,L.A. and Burgon,P.G.
  TITLE     Expression of murine muscle-enriched A-type lamin-interacting
            protein (MLIP) is regulated by tissue-specific alternative
            transcription start sites
  JOURNAL   J Biol Chem 293 (51), 19761-19770 (2018)
   PUBMED   30389785
  REMARK    GeneRIF: Mlip tissue-specific expression and alternative splicing
            play a critical role in determining MLIP's functions in mice
REFERENCE   6  (residues 1 to 877)
  AUTHORS   Huang,Z.P., Kataoka,M., Chen,J., Wu,G., Ding,J., Nie,M., Lin,Z.,
            Liu,J., Hu,X., Ma,L., Zhou,B., Wakimoto,H., Zeng,C., Kyselovic,J.,
            Deng,Z.L., Seidman,C.E., Seidman,J.G., Pu,W.T. and Wang,D.Z.
  TITLE     Cardiomyocyte-enriched protein CIP protects against
            pathophysiological stresses and regulates cardiac homeostasis
  JOURNAL   J Clin Invest 125 (11), 4122-4134 (2015)
   PUBMED   26436652
  REMARK    GeneRIF: Deletion of the CIP-encoding gene accelerated progress
            from hypertrophy to heart failure in several cardiomyopathy models.
REFERENCE   7  (residues 1 to 877)
  AUTHORS   Cattin,M.E., Wang,J., Weldrick,J.J., Roeske,C.L., Mak,E.,
            Thorn,S.L., DaSilva,J.N., Wang,Y., Lusis,A.J. and Burgon,P.G.
  TITLE     Deletion of MLIP (muscle-enriched A-type lamin-interacting protein)
            leads to cardiac hyperactivation of Akt/mammalian target of
            rapamycin (mTOR) and impaired cardiac adaptation
  JOURNAL   J Biol Chem 290 (44), 26699-26714 (2015)
   PUBMED   26359501
  REMARK    GeneRIF: Mlip-deficient hearts showed an impaired capacity to adapt
            to stress (isoproterenol-induced hypertrophy), likely because of
            deregulated Akt/mTOR activity.
REFERENCE   8  (residues 1 to 877)
  AUTHORS   Huang,Z.P., Young Seok,H., Zhou,B., Chen,J., Chen,J.F., Tao,Y.,
            Pu,W.T. and Wang,D.Z.
  TITLE     CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte
            hypertrophy
  JOURNAL   Circ Res 110 (6), 818-830 (2012)
   PUBMED   22343712
  REMARK    GeneRIF: studies identify cardiac Isl1-interacting protein (CIP) as
            a novel regulator of cardiac hypertrophy.
REFERENCE   9  (residues 1 to 877)
  AUTHORS   Ahmady,E., Deeke,S.A., Rabaa,S., Kouri,L., Kenney,L., Stewart,A.F.
            and Burgon,P.G.
  TITLE     Identification of a novel muscle A-type lamin-interacting protein
            (MLIP)
  JOURNAL   J Biol Chem 286 (22), 19702-19713 (2011)
   PUBMED   21498514
  REMARK    GeneRIF: MLIP is expressed most highly in striated and smooth
            muscle, it is likely to contribute to the mesenchymal phenotypes of
            laminopathies.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123797.3, AC151731.4 and AC128705.4.
            
            On Mar 11, 2019 this sequence version replaced XP_017169059.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.125267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.67 cM"
     Protein         1..877
                     /product="muscular LMNA-interacting protein isoform 1"
                     /note="muscular-enriched A-type laminin-interacting
                     protein; cardiac Isl1-interacting protein"
                     /calculated_mol_wt=93318
     Region          113..>197
                     /region_name="MLIP"
                     /note="Muscular LMNA-interacting protein; pfam15274"
                     /db_xref="CDD:405866"
     Region          451..>722
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          624..783
                     /region_name="MLIP"
                     /note="Muscular LMNA-interacting protein; pfam15274"
                     /db_xref="CDD:405866"
     CDS             1..877
                     /gene="Mlip"
                     /gene_synonym="2310046A06Rik; CIP"
                     /coded_by="NM_001368955.1:62..2695"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:69642"
                     /db_xref="MGI:MGI:1916892"
ORIGIN      
        1 mtscilagsl ettpkvspgd peakpliftf vptlrrlpth iqladtskfl vkipeeptdk
       61 spetvnrfey sdhmtfsses kqervqrild ypsevsgrns qqkefntkep qgmqkgdlfk
      121 aeyvfivdsd gedeatcrqg eqgppggpgn iatrpkslai ssslasdvvr pkvrgadlkt
      181 sshpeiphgi apqqkhglkt ppvpanvsga tvlrefhtrr ldvtgaseee tttyfhstah
      241 dsplsawkga stlvvspsaq lsgsslcgsn vtdhtrglas eaqkkmstsn vlnpkedvrt
      301 cpapasgasl tspsasyipv rivmhslsps pkpltssshg slstvcsqms ssgslsksgl
      361 kspvpsrlsl ltailksnps hqrplspasc ptfslnslas stlaldqkvk qtpptskksl
      421 ssgslttgst eqehqasaas yqpchlpffs kttplsqaqp lsplalasns casmdiekip
      481 gstlrsntts pqpqtdtfsl advpsvtpvl splssskgrk dgdsrtpekn rniciqpstl
      541 astppvdesl alsssgkgfh pspalsdlid rskracsqqh pgqrpspsal ptppvsraas
      601 ashphlgcsi lplqssltqt lqpspsalrp scgsatcpsr tqmpentasn hssrvstpsl
      661 pvsltrtkel fspcalsmsa gpenkkpkal departesns kasvldlpve tptthpraag
      721 retkyanlss ssstasesql tkpgvirpvp vksklllrkd eevyepnpfs kylednsglf
      781 seqdmaiphk pvslhplyqs klyppaksll hpqtlshadc ltpgsfshls sfsvrdeqek
      841 sptllsqdty nklgifsvkl ghpmvtipeh dtldske
//
