LOCUS       NM_026810               2598 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus mutL homolog 1 (Mlh1), transcript variant 1, mRNA.
ACCESSION   NM_026810
VERSION     NM_026810.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2598)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell (2025) In press
   PUBMED   39938516
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2598)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   3  (bases 1 to 2598)
  AUTHORS   Yoshimura,S., Shimada,R., Kikuchi,K., Kawagoe,S., Abe,H.,
            Iisaka,S., Fujimura,S., Yasunaga,K.I., Usuki,S., Tani,N., Ohba,T.,
            Kondoh,E., Saio,T., Araki,K. and Ishiguro,K.I.
  TITLE     Atypical heat shock transcription factor HSF5 is critical for male
            meiotic prophase under non-stress conditions
  JOURNAL   Nat Commun 15 (1), 3330 (2024)
   PUBMED   38684656
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2598)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2598)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2598)
  AUTHORS   Prolla,T.A., Baker,S.M., Harris,A.C., Tsao,J.L., Yao,X.,
            Bronner,C.E., Zheng,B., Gordon,M., Reneker,J., Arnheim,N.,
            Shibata,D., Bradley,A. and Liskay,R.M.
  TITLE     Tumour susceptibility and spontaneous mutation in mice deficient in
            Mlh1, Pms1 and Pms2 DNA mismatch repair
  JOURNAL   Nat Genet 18 (3), 276-279 (1998)
   PUBMED   9500552
REFERENCE   7  (bases 1 to 2598)
  AUTHORS   Baker,S.M., Plug,A.W., Prolla,T.A., Bronner,C.E., Harris,A.C.,
            Yao,X., Christie,D.M., Monell,C., Arnheim,N., Bradley,A., Ashley,T.
            and Liskay,R.M.
  TITLE     Involvement of mouse Mlh1 in DNA mismatch repair and meiotic
            crossing over
  JOURNAL   Nat Genet 13 (3), 336-342 (1996)
   PUBMED   8673133
REFERENCE   8  (bases 1 to 2598)
  AUTHORS   Edelmann,W., Cohen,P.E., Kane,M., Lau,K., Morrow,B., Bennett,S.,
            Umar,A., Kunkel,T., Cattoretti,G., Chaganti,R., Pollard,J.W.,
            Kolodner,R.D. and Kucherlapati,R.
  TITLE     Meiotic pachytene arrest in MLH1-deficient mice
  JOURNAL   Cell 85 (7), 1125-1134 (1996)
   PUBMED   8674118
REFERENCE   9  (bases 1 to 2598)
  AUTHORS   Zechmeister-Machhart,M., Hufnagl,P., Uhrin,P., Xu,J., Geiger,M. and
            Binder,B.R.
  TITLE     Molecular cloning and tissue distribution of mouse protein C
            inhibitor (PCI)
  JOURNAL   Immunopharmacology 32 (1-3), 96-98 (1996)
   PUBMED   8796278
REFERENCE   10 (bases 1 to 2598)
  AUTHORS   Bronner,C.E., Baker,S.M., Morrison,P.T., Warren,G., Smith,L.G.,
            Lescoe,M.K., Kane,M., Earabino,C., Lipford,J., Lindblom,A. et al.
  TITLE     Mutation in the DNA mismatch repair gene homologue hMLH1 is
            associated with hereditary non-polyposis colon cancer
  JOURNAL   Nature 368 (6468), 258-261 (1994)
   PUBMED   8145827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY327218.1, AK145646.1 and AK163861.1.
            
            On Aug 14, 2009 this sequence version replaced NM_026810.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021815.1, AK145646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BY327218.1         1-54
            55-553              AK145646.1         1-499
            554-2571            AK145646.1         501-2518
            2572-2598           AK163861.1         3738-3764
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.92 cM"
     gene            1..2598
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /note="mutL homolog 1"
                     /db_xref="GeneID:17350"
                     /db_xref="MGI:MGI:101938"
     exon            1..200
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2367
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     mismatch repair protein MLH1; mutL protein homolog 1;
                     colon cancer, nonpolyposis type 2"
                     /codon_start=1
                     /product="DNA mismatch repair protein Mlh1 isoform 1"
                     /protein_id="NP_081086.2"
                     /db_xref="CCDS:CCDS40784.1"
                     /db_xref="GeneID:17350"
                     /db_xref="MGI:MGI:101938"
                     /translation="MAFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKS
                     TNIQVVVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQTFEDLASISTYGFRGE
                     ALASISHVAHVTITTKTADGKCAYRASYSDGKLQAPPKPCAGNQGTLITVEDLFYNII
                     TRRKALKNPSEEYGKILEVVGRYSIHNSGISFSVKKQGETVSDVRTLPNATTVDNIRS
                     IFGNAVSRELIEVGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESAALRKAI
                     ETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILQRVQQHIESKL
                     LGSNSSRMYFTQTLLPGLAGPSGEAARPTTGVASSSTSGSGDKVYAYQMVRTDSREQK
                     LDAFLQPVSSLGPSQPQDPAPVRGARTEGSPERATREDEEMLALPAPAEAAAESENLE
                     RESLMETSDAAQKAAPTSSPGSSRKRHREDSDVEMVENASGKEMTAACYPRRRIINLT
                     SVLSLQEEISERCHETLREMLRNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQ
                     ILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEDDGPKEGLAEYIVEFLKKKAE
                     MLADYFSVEIDEEGNLIGLPLLIDSYVPPLEGLPIFILRLATEVNWDEEKECFESLSK
                     ECAMFYSIRKQYILEESTLSGQQSDMPGSTSKPWKWTVEHIIYKAFRSHLLPPKHFTE
                     DGNVLQLANLPDLYKVFERC"
     exon            201..291
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            292..390
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            391..464
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            465..537
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            538..629
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            630..672
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            673..761
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            762..874
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            875..968
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1122
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1505
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1654
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1763
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1827
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1992
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2085
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2199
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2598
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2552..2557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2576
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggactgcag tcggccgaag ctgaaggaag aacttgagcg tgaggagctc gagtgattgg
       61 ctgactggga actcgggcgc caatatggcg tttgtagcag gagttattcg gcgtctggac
      121 gagacggtag tgaaccgcat agcggcgggg gaagtcattc agcggccggc caatgctatc
      181 aaagagatga tagaaaactg tttagatgca aaatctacaa atattcaagt ggttgttaag
      241 gaaggtggcc tgaagctaat tcagatccaa gacaatggca ctggaatcag gaaggaagat
      301 ctggatattg tgtgtgagag gttcactacg agtaaactgc agacttttga ggatttagcc
      361 agtatttcta cctatggctt tcgtggtgag gcattggcaa gcataagcca tgtggcccat
      421 gtcactatta caaccaaaac agctgatggg aaatgtgcgt acagagcaag ttactcagat
      481 ggaaagctgc aagcccctcc taaaccctgt gcaggcaacc agggcaccct gatcacggtg
      541 gaagaccttt tttacaacat aatcacaagg aggaaagctt taaaaaatcc aagtgaagag
      601 tacggaaaaa ttttggaagt tgttggcagg tattcaatac acaattcagg cattagtttc
      661 tcagttaaaa aacaaggtga gacagtatct gatgtcagaa cactgcccaa tgccacaacc
      721 gtggacaaca ttcgctccat ctttggaaat gcggttagtc gagaactgat agaagttggg
      781 tgtgaggata aaaccctagc tttcaaaatg aatggctata tatcgaatgc aaactattca
      841 gtgaagaagt gcattttcct actcttcatc aaccaccgtc tggtagaatc agctgccttg
      901 agaaaagcca ttgaaactgt atatgcagca tacttgccca aaaacacaca cccattcctg
      961 tacctcagtt tggaaatcag ccctcagaac gtggacgtca atgtacaccc caccaagcac
     1021 gaagttcact ttctgcacga ggagagcatt ctgcagcgtg tgcagcagca cattgagagc
     1081 aagctgctgg gctccaattc ctccaggatg tatttcaccc agaccttgct tccaggactt
     1141 gctgggcctt ctggggaggc agctagaccc acgacagggg tggcttcctc atccactagt
     1201 ggaagtggcg acaaggtcta cgcttaccag atggtccgta cggactcccg ggagcagaag
     1261 cttgacgcct ttctgcagcc tgtaagcagc cttgggccca gccagcccca ggaccctgcc
     1321 cctgtccgag gggccaggac ggagggatct cctgaaaggg ccacgcggga ggacgaggag
     1381 atgcttgctc tcccagcccc cgctgaagca gctgctgaga gtgagaactt ggagagggaa
     1441 tcactaatgg agacttcaga cgcagcccag aaggcggcac ccacttccag tccaggaagc
     1501 tccagaaaga gacatcggga ggactctgat gtggaaatgg tggaaaatgc ttccgggaag
     1561 gaaatgacag ctgcttgcta ccccaggagg aggatcatta acctcaccag cgtcttgagt
     1621 ctccaggaag agattagtga gcggtgccat gagactctcc gggagatgct ccgtaaccat
     1681 tcctttgtgg gctgtgtgaa tcctcagtgg gccttggcac agcaccagac caagctctac
     1741 ctcctcaaca ctaccaagct cagtgaagag ctgttctacc agatactcat ttatgatttt
     1801 gccaactttg gtgttctgag gttatcggaa ccagcgccac tcttcgacct ggccatgctg
     1861 gccttagaca gtcctgaaag tggctggaca gaggacgacg gcccgaagga agggcttgca
     1921 gagtacattg ttgagtttct gaagaagaaa gcggagatgc ttgcagacta tttctctgtg
     1981 gagatcgatg aggaagggaa cctgattgga ttacctcttc tgattgacag ctatgtgcca
     2041 cctttggagg gactgcctat cttcattctt cgactggcca ctgaggtgaa ttgggatgaa
     2101 gaaaaggagt gttttgaaag tctcagtaaa gaatgtgcta tgttttactc cattcggaag
     2161 cagtatatac tggaggagtc gaccctctca ggccagcaga gtgacatgcc tggctccacg
     2221 tcaaagccct ggaagtggac tgtggagcac attatctata aagccttccg ctcacacctc
     2281 ctacctccga agcatttcac agaagatggc aatgtcctgc agcttgccaa cctgccagat
     2341 ctatacaaag tctttgagcg gtgttaaata caatcatagc caccgtagag actgcatgac
     2401 catccaaggc gaagtgtatg gtactaatct ggaagccaca gaataggaca cttggtttcc
     2461 aagctccagg gtttccagtg ctcactattc ttgttctgta tcccagtatt ggtgctgcaa
     2521 cttaatgtac ttcacctgtg gattggctgc aaataaactc acgtgtattg gtgtgatttt
     2581 ttttttttat ataaccgc
//
