LOCUS       NM_010801               1133 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus myeloid leukemia factor 1 (Mlf1), transcript variant
            2, mRNA.
ACCESSION   NM_010801
VERSION     NM_010801.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1133)
  AUTHORS   Sah,R.K., Ma,J., Bah,F.B., Xing,Z., Adlat,S., Oo,Z.M., Wang,Y.,
            Bahadar,N., Bohio,A.A., Nagi,F.H., Feng,X., Zhang,L. and Zheng,Y.
  TITLE     Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung
            Development and Prenatal Lethality
  JOURNAL   Int J Mol Sci 21 (21), 8223 (2020)
   PUBMED   33153107
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1133)
  AUTHORS   Johnson,J.A., Watson,J.K., Nikolic,M.Z. and Rawlins,E.L.
  TITLE     Fank1 and Jazf1 promote multiciliated cell differentiation in the
            mouse airway epithelium
  JOURNAL   Biol Open 7 (4) (2018)
   PUBMED   29661797
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1133)
  AUTHORS   Sun,Y., Chao,J.R., Xu,W., Pourpak,A., Boyd,K., Moshiach,S.,
            Qi,G.Y., Fu,A., Shao,H.R., Pounds,S. and Morris,S.W.
  TITLE     MLF1 is a proapoptotic antagonist of HOP complex-mediated survival
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (4), 719-727 (2017)
   PUBMED   28137643
  REMARK    GeneRIF: The data indicate that MLF1 serves as a proapoptotic
            antagonist that interacts with the HAX1/HtrA2-OMI/PARL (HOP)
            mitochondrial complex to modulate cell survival.
REFERENCE   4  (bases 1 to 1133)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   5  (bases 1 to 1133)
  AUTHORS   Sun,Y., Fu,A., Xu,W., Chao,J.R., Moshiach,S. and Morris,S.W.
  TITLE     Myeloid leukemia factor 1 interfered with Bcl-XL to promote
            apoptosis and its function was regulated by 14-3-3
  JOURNAL   J Physiol Biochem 71 (4), 807-821 (2015)
   PUBMED   26563351
  REMARK    GeneRIF: Ectopically expressed MLF1 could be responsible for the
            pathological apoptosis in early myelodysplastic syndrome (MDS)
            patients.
REFERENCE   6  (bases 1 to 1133)
  AUTHORS   Hanissian,S.H., Akbar,U., Teng,B., Janjetovic,Z., Hoffmann,A.,
            Hitzler,J.K., Iscove,N., Hamre,K., Du,X., Tong,Y., Mukatira,S.,
            Robertson,J.H. and Morris,S.W.
  TITLE     cDNA cloning and characterization of a novel gene encoding the
            MLF1-interacting protein MLF1IP
  JOURNAL   Oncogene 23 (20), 3700-3707 (2004)
   PUBMED   15116101
REFERENCE   7  (bases 1 to 1133)
  AUTHORS   Lim,R., Winteringham,L.N., Williams,J.H., McCulloch,R.K.,
            Ingley,E., Tiao,J.Y., Lalonde,J.P., Tsai,S., Tilbrook,P.A., Sun,Y.,
            Wu,X., Morris,S.W. and Klinken,S.P.
  TITLE     MADM, a novel adaptor protein that mediates phosphorylation of the
            14-3-3 binding site of myeloid leukemia factor 1
  JOURNAL   J Biol Chem 277 (43), 40997-41008 (2002)
   PUBMED   12176995
REFERENCE   8  (bases 1 to 1133)
  AUTHORS   Williams,J.H., Daly,L.N., Ingley,E., Beaumont,J.G., Tilbrook,P.A.,
            Lalonde,J.P., Stillitano,J.P. and Klinken,S.P.
  TITLE     HLS7, a hemopoietic lineage switch gene homologous to the
            leukemia-inducing gene MLF1
  JOURNAL   EMBO J 18 (20), 5559-5566 (1999)
   PUBMED   10523300
REFERENCE   9  (bases 1 to 1133)
  AUTHORS   Hitzler,J.K., Witte,D.P., Jenkins,N.A., Copeland,N.G.,
            Gilbert,D.J., Naeve,C.W., Look,A.T. and Morris,S.W.
  TITLE     cDNA cloning, expression pattern, and chromosomal localization of
            Mlf1, murine homologue of a gene involved in myelodysplasia and
            acute myeloid leukemia
  JOURNAL   Am J Pathol 155 (1), 53-59 (1999)
   PUBMED   10393836
REFERENCE   10 (bases 1 to 1133)
  AUTHORS   Yoneda-Kato,N., Look,A.T., Kirstein,M.N., Valentine,M.B.,
            Raimondi,S.C., Cohen,K.J., Carroll,A.J. and Morris,S.W.
  TITLE     The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid
            leukemia produces a novel fusion gene, NPM-MLF1
  JOURNAL   Oncogene 12 (2), 265-275 (1996)
   PUBMED   8570204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133448.1 and BC027526.1.
            
            On Dec 7, 2007 this sequence version replaced NM_010801.2.
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region, compared to variant 1. This results in a shorter protein
            (isoform b) compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133448.1, AF009515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1114              AK133448.1         2-1115
            1115-1133           BC027526.1         1108-1126
FEATURES             Location/Qualifiers
     source          1..1133
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 30.91 cM"
     gene            1..1133
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /note="myeloid leukemia factor 1"
                     /db_xref="GeneID:17349"
                     /db_xref="MGI:MGI:1341819"
     exon            1..166
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..923
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /note="isoform b is encoded by transcript variant 2;
                     hematopoietic lineage switch 7; myelodysplasia-myeloid
                     leukemia factor 1"
                     /codon_start=1
                     /product="myeloid leukemia factor 1 isoform b"
                     /protein_id="NP_034931.2"
                     /db_xref="CCDS:CCDS17396.1"
                     /db_xref="GeneID:17349"
                     /db_xref="MGI:MGI:1341819"
                     /translation="MFRMLSSSFEDDPFFADSFLAHRESMRNMMRSFSEPLGRDLLSI
                     SDGRGRTHNRRERDDGEDSLTHADVNPFQTMDRMMANMRSGIQELQRNFGQLSMDPNG
                     HSFCSSSVMTYSKVGDEPPKVFQASTQTRRAPGGVKETRKAMRDSDSGLERMAVGHHI
                     HDRGHVIRKSKNNKTGDEEVNQEFINMNESDAHAFDDEWQNEVLKYKSIGRSGNTGMR
                     SVGHEHPGSRELKRREKIHRNSAIESGRRSNVFVDKLNVKGSPVKITKK"
     exon            167..314
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /inference="alignment:Splign:2.1.0"
     exon            315..398
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /inference="alignment:Splign:2.1.0"
     exon            399..527
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /inference="alignment:Splign:2.1.0"
     exon            528..687
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /inference="alignment:Splign:2.1.0"
     exon            688..817
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1116
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      919..924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /note="hexamer: AATAAA"
     polyA_site      939
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
     regulatory      1096..1101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /note="hexamer: AATAAA"
     polyA_site      1116
                     /gene="Mlf1"
                     /gene_synonym="HLS7"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgggc gcggcgattg ccgccggcag acgcgcgaag caagcgggaa gcaggctggt
       61 ggcggcgcag agagctgcgc ccatttccat ccgcgcccgc cgcccgccgc aggatcacga
      121 tgttccggat gctgagcagc agctttgagg atgacccctt cttcgctgat tcttttcttg
      181 cacaccgaga aagtatgcgc aacatgatga gaagtttctc tgaacctctt ggaagagact
      241 tgctcagtat ctctgatggt agaggaagaa cccataatcg tcgagaacgt gatgatggcg
      301 aagattcctt aactcatgca gatgtcaacc cttttcagac aatggatcgg atgatggcaa
      361 atatgcgaag tggtatacag gagttacaaa gaaactttgg ccaactttca atggatccaa
      421 atgggcattc attttgttct tcctctgtta tgacctattc caaagtagga gatgaaccac
      481 caaaggtgtt ccaggcctca actcaaaccc gaagggctcc aggaggagta aaagaaacca
      541 gaaaagcaat gagagattct gacagtggac tagaaagaat ggctgttggt catcacatcc
      601 atgaccgagg tcatgtcatt aggaagtcaa agaacaacaa gactggagat gaagaagtca
      661 accaagagtt catcaatatg aatgaaagtg acgctcatgc ttttgatgat gagtggcaaa
      721 atgaagttct gaagtacaag tctattggac ggtcaggaaa cactggaatg cgaagtgtgg
      781 gtcatgagca tccagggtca cgggaactca aaaggagaga gaaaattcat cgaaattcag
      841 ccattgagag tggaagaaga tcaaacgttt ttgtggacaa actcaatgtg aaaggatcac
      901 ctgtgaaaat caccaaaaaa taaatagccc tgcatttcat ttgtttagtt ggttatttta
      961 acaaagtcat ggcatggtgc tagaaaatac acaaaagacc aatctcctgt tgttaaatca
     1021 atgctgtact ttgcaacttt cttccaaata tgaatgttct tgtaagtttt agctttacat
     1081 tgttcatact ttaggaataa aatattggat gttcaaaaaa aaaaaaaaaa aaa
//
