LOCUS       NM_175403               5970 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus malectin (Mlec), mRNA.
ACCESSION   NM_175403
VERSION     NM_175403.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5970)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5970)
  AUTHORS   Ramirez,A.S., Kowal,J. and Locher,K.P.
  TITLE     Cryo-electron microscopy structures of human
            oligosaccharyltransferase complexes OST-A and OST-B
  JOURNAL   Science 366 (6471), 1372-1375 (2019)
   PUBMED   31831667
REFERENCE   3  (bases 1 to 5970)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5970)
  AUTHORS   Ryder,E., Gleeson,D., Sethi,D., Vyas,S., Miklejewska,E., Dalvi,P.,
            Habib,B., Cook,R., Hardy,M., Jhaveri,K., Bottomley,J.,
            Wardle-Jones,H., Bussell,J.N., Houghton,R., Salisbury,J.,
            Skarnes,W.C. and Ramirez-Solis,R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Molecular characterization of mutant mouse strains generated from
            the EUCOMM/KOMP-CSD ES cell resource
  JOURNAL   Mamm Genome 24 (7-8), 286-294 (2013)
   PUBMED   23912999
REFERENCE   5  (bases 1 to 5970)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   6  (bases 1 to 5970)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 5970)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 5970)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   9  (bases 1 to 5970)
  AUTHORS   Tchernev,V.T., Barbosa,M.D., Detter,J.C., Patel,T.D., Achey,K.,
            Wakeland,E.K., Gueorguieva,R.V., Yang,M.C., Gossler,A. and
            Kingsmore,S.F.
  TITLE     Genetic mapping of 20 novel expressed sequence tags from
            midgestation mouse embryos suggests chromosomal clustering
  JOURNAL   Genomics 40 (1), 170-174 (1997)
   PUBMED   9070936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ093242.1, AK031525.1, AK129066.1, DV061883.1 and BU703535.1.
            
            On May 16, 2008 this sequence version replaced NM_175403.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.186801.1,
                                           SRR1660815.209029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               CJ093242.1         1-432
            433-1171            AK031525.1         403-1141
            1172-3840           AK031525.1         1146-3814
            3841-4988           AK129066.1         3740-4887
            4989-5441           DV061883.1         44-496
            5442-5970           BU703535.1         55-583
FEATURES             Location/Qualifiers
     source          1..5970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..5970
                     /gene="Mlec"
                     /gene_synonym="2410014A08Rik; ESTM19; mKIAA0152"
                     /note="malectin"
                     /db_xref="GeneID:109154"
                     /db_xref="MGI:MGI:1924015"
     exon            1..374
                     /gene="Mlec"
                     /gene_synonym="2410014A08Rik; ESTM19; mKIAA0152"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1018
                     /gene="Mlec"
                     /gene_synonym="2410014A08Rik; ESTM19; mKIAA0152"
                     /codon_start=1
                     /product="malectin precursor"
                     /protein_id="NP_780612.2"
                     /db_xref="CCDS:CCDS19581.1"
                     /db_xref="GeneID:109154"
                     /db_xref="MGI:MGI:1924015"
                     /translation="MLRPRGAEGTAVALLRLLLLLLLLGPKLRGPGLGVVGAAGAGLP
                     ESVIWAVNAGGEAHVDVHGIHFRKDPLEGRVGRASDYGMKLPILRSTPEDQILYQTER
                     YNEETFGYEVPVKEEGDYVLVLKFAEVYFAQSQQKVFDVRLNGHVVVKDLDIFDRVGH
                     STAHDEIIPMSIRKGKLSVRGEVSTFTGKLYIEFVKGYYDNPKVCALYILAGTVDDVP
                     KLQPHPGLEKKEEEEEEEEYDEGSNLKRQTNKNRVQSGPRTPNPYASDNSSLMFPILV
                     AFGVFIPTLFCLCRL"
     exon            375..553
                     /gene="Mlec"
                     /gene_synonym="2410014A08Rik; ESTM19; mKIAA0152"
                     /inference="alignment:Splign:2.1.0"
     exon            554..730
                     /gene="Mlec"
                     /gene_synonym="2410014A08Rik; ESTM19; mKIAA0152"
                     /inference="alignment:Splign:2.1.0"
     exon            731..788
                     /gene="Mlec"
                     /gene_synonym="2410014A08Rik; ESTM19; mKIAA0152"
                     /inference="alignment:Splign:2.1.0"
     exon            789..5952
                     /gene="Mlec"
                     /gene_synonym="2410014A08Rik; ESTM19; mKIAA0152"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1742..1747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mlec"
                     /gene_synonym="2410014A08Rik; ESTM19; mKIAA0152"
                     /note="hexamer: AACAAA"
     polyA_site      1761
                     /gene="Mlec"
                     /gene_synonym="2410014A08Rik; ESTM19; mKIAA0152"
                     /note="major polyA site"
     regulatory      5932..5937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mlec"
                     /gene_synonym="2410014A08Rik; ESTM19; mKIAA0152"
                     /note="hexamer: AATAAA"
     polyA_site      5952
                     /gene="Mlec"
                     /gene_synonym="2410014A08Rik; ESTM19; mKIAA0152"
                     /note="major polyA site"
ORIGIN      
        1 ggaggaggag gaggaggagg ccctgagagc gacatgtccc gggttgccga ggcagaacgg
       61 tccgctgcgc tgttctcctg agttgggggc ggccggccga ggacgagggt cggcaggggc
      121 tgcccccgcc gtggtggccg ccatgctgag gccccgggga gccgagggaa ccgctgtggc
      181 gcttctccgg ctgcttctgt tgctgctgct gctgggaccg aagctccggg gtccggggct
      241 cggcgtggtc ggcgccgccg gggccggact gccggagagc gtcatctggg cagtgaacgc
      301 aggcggcgag gcgcatgtgg acgtgcacgg gatccacttc cgcaaggacc ctctggaagg
      361 ccgggtgggc cgagcctcgg actatggcat gaaactgccg atcctgcgct ccaccccgga
      421 ggaccagatc ctatatcaga cagagcggta caatgaagag acctttggct acgaagtacc
      481 cgtcaaggag gagggcgact atgtgctggt gttgaagttt gctgaggtct actttgcaca
      541 gtctcagcag aaggtgtttg atgtccggtt gaatggccat gtggtggtga aggacttgga
      601 catctttgac cgtgtcgggc acagcacggc ccatgatgaa atcatcccga tgagcatcag
      661 gaaggggaag ctgagtgtgc ggggggaggt gtccaccttc acagggaagc tatacatcga
      721 gtttgtcaag gggtactatg acaatcccaa agtctgtgca ctctacatcc tggctgggac
      781 agtagacgat gtaccaaagc tgcagcctca tccaggattg gaaaagaaag aagaggagga
      841 ggaggaggag gaatatgatg aggggtctaa tctcaaaaga cagaccaaca agaacagggt
      901 gcagtcaggc ccccgcacgc ctaaccccta tgcctcggac aacagcagcc tcatgttccc
      961 tatcctggtg gccttcggag tgttcattcc aaccctcttc tgcctctgcc gcttgtgaga
     1021 ggacaaatgg ccatcctcag cagggtggag ggagtgtgcg agaaaccaga cactttggtt
     1081 tctgtaatct tcacagtgtt taggaaaaga gaaaacaaat caaacagcgc acacacacac
     1141 acacacacac acacacacac acacacacac aaacacagac acacatgtgc tcacacacac
     1201 acggaaagag ataagaaaag cagagagagt ggggtcaccc caccaacaca ggttgcagag
     1261 tgctcagtcc tgctctgcct agctggcccc accccagctc tctttctctg gggtacttag
     1321 ggagaggatc cttcctctcc gaggatcctc attatatacc tagtaggaag gactctgaac
     1381 tcagagcagt cacacttcct tggttttttt aggttagaca ttaacaaaca gcaggaaaat
     1441 gtcacataac ctggaaagac cgcactggag ttgggtgtgt tctgagtttc tgtccagatg
     1501 tgatttcagc agtcatggta ttccaagtgt gtgtgtggag gtagataagt gggacggtaa
     1561 agacaaaggc gtggaagaga aagtcagcgc ttccttcctg ggaagcctgt cgtctgggtt
     1621 aatctgttga tgtatcttca ttgtcatctc tcatcctgat gtgtgccagt tagaggactg
     1681 tctggtatcc aagacgacta gtgtatgtca ggtcctcaaa tcaccaacag cttgttacta
     1741 caacaaattg ttttgatttt agtgcctgtt gaggacttga tttcttcttg atttttctct
     1801 taatctggtt catttgaaat ttctcacttc ttaaccatag agctaagtta ttgtcaaaac
     1861 tgggcaggag acaggagatt ggagtggtct ctgctggggt gtctgaccct ccaccacctc
     1921 accttgttgg tacctccctc cctgaattcc tgagccagca actcttactg gcccctccat
     1981 agggtcttgc tgccagggac agggatgctt tccagcctgc agcaacagaa cacttgacct
     2041 taaaagtctc ttctggtctt tggattagaa aaggcttatg ttagcaacct cagagacttg
     2101 agccctgcta agtgactgac cactgtttag aatgtccaga atctgatgtc catctgtccc
     2161 tgtgtcttct gtcctctttc agctagttta ggcttatgcc tagagtcacc ccaaagaact
     2221 gagactggct gcagcagccc agctgtgttt ctcattgatg ataatagtag gctctactgc
     2281 cctcccctcc cctatccaag tagcagttaa gttccatcca aatacgtggg actcaaagac
     2341 tcctagtcag ctgtagttct ggaggctctg aatgtctaac tttagcatca aagtgtctgt
     2401 ctcagattcc cagtaaacac ctctgtaggg gatgaagttt ccatgtcccc catcttcctt
     2461 ttggtcacct tcatctgtgt gtcagttaag acacagtgag ggacagccca gctgcaataa
     2521 aagggatttt ctatgtcaga agcagcaggc tttgcttcag cttgagttgg agccgtgtga
     2581 gtctcaggcc aggcccttat ttctgaatgt gtttgaattt taagtttgcc ttatcagata
     2641 tctgagctgt gcgacaagta agtagctctg gggccatgtc ttgactggct cctaatggtg
     2701 actccaggcc agcacttggt catttgagaa ctgtcttctg tgttctctgt gacttaggct
     2761 agccctaggg tactgaggtg gcagctgcat ggctgtggcc tgaagttgca cttgcaaagg
     2821 tcctgcttct acaggacgct gaggtactta ctaccctggt ctcgggaact gcctgcctag
     2881 ggcaacagat gtcctgacta atctggcttc tggttcccgg tccatcccta tttacaaagc
     2941 tatgggccac tgtcagcaca ttaaacaagg tgagggagag tagctgcctc cgtgtcacct
     3001 tgtctgcctg ggtctctgag gaaggagggg tcctgctttc tcacccagct cacccctttg
     3061 gtgactcaga gtccttctca gaaggaaacc ctgactcctg ggccatttcc taatggtact
     3121 gtaagccaag tggctcggct tctgcctctg tttccaagcc caccccttcc cggagggata
     3181 gggacgggtg ctttcctctc tagttgtatc tgagcggaag gaacatcttt ctgtagctaa
     3241 taaaaactaa aagggaagag gaagcagaag ggaaggagtg tggcggaggc tgggatggat
     3301 tccctaagcc aagcctgccc agctaatgag ctgtttgacg ttgaacttga aagctttccc
     3361 ctccctctaa gatgatgtag gtacttgagg tttgggttaa aggggctggg tggggcacgc
     3421 tttattttta tttttgtatt gtgtatgtca agaatcactc cattgttcgt gttgcttttt
     3481 gcactgtttg ttccccgctg tgttttgagc tagaacaagg agttgcctgg gattgggagc
     3541 tgtgggtggt gcaagtcagg gagtgggcca ggagaggccc gggttttctg tttgagctat
     3601 actctgaccc aggatgttag agcacactga tccagccact agagagaaag gtacaagagc
     3661 agagcagagg agcaagcaag gacagctggg ttgagtctgc aggtccagtg tggtttaggt
     3721 cagtcagggg ccagctggcc tctgactgca ttgctttagg tcgtattcaa actctcttaa
     3781 acattgtgcc aagaaacgat ttgtgggatt catgtcccga aaccattaaa tctattgttt
     3841 ggaaagtctg cagtcctgag gagggcttgc tcactggaca cccacagatc tggccctttg
     3901 aaaggcagcc ttcagatgcc catcgtgtga gaggcgctgc ctgttgatga agtgtgtgac
     3961 cttttctcct gctgagtggg agatcccagg gtcccacacg cctcacctcg gtgagtgggc
     4021 agagctgagc cgcactgtgt gcctgggagc aggttacaac tctggtttga ctttcatttt
     4081 gttgagaagc ttctgtttta aggaatttct ccttcttgtc tcattcctgc ctttcctggg
     4141 aagggcctgg ccctgatcta gagtcttagc taaggagctg agaaacagcc acagtactcc
     4201 cttctcttcg cgcacagggc cctctctctt agagactgct cagctttcga gtccagggag
     4261 gagtcagcgg ggagtcagca ggttctctct cctccctggg aactggggac caacccaccc
     4321 cggcagcaca gtgccttttt ttctcctgct ctgagtcagg tgggcgtccc ctctagatcc
     4381 aggtctgggc aggggtctga tggtccactg tgggctgttt ccctatccac ccccctcctt
     4441 gctggcctac tctgacataa tacaagtgtc ttcttgcctt gaggaacctt aatggcattg
     4501 tggccaccac atgtgactct tctccgtgac tctataaaga cctagcagag catgtgagca
     4561 ttctcaaaca agagactaac tgatgctcct gctgttaaaa aggcagaact agggaggtga
     4621 ctttaggcct cctgctgtgg cctctgaaga aggtgactct tcaggtaaga ctgatggagg
     4681 ctacaccgac aaaccgcaga cacgcaggat ctgctcagag attgcagaag agcgtggcct
     4741 ctcttatagg gaagatgtaa ttatggatca aagagtgcta agaaaattgc gaagaagcct
     4801 tactgcttac accagagagc tcagggcagc tttatcttcc aggtttatct aaaactatct
     4861 gtgttgggct tccctgacac gggagagggg caaggataga cgattgacat ggcactgatg
     4921 gtcagttgcc cagggaggcc gcttactctg gatgcagatg gctgctgccg atccactctg
     4981 tctttctcgg gctgcttttg cgtcgttgtc ctaggtggcc agattgtctt gataagagca
     5041 gatctgggga ctgatcggat tggcaggaaa agaacagagt gcatctcttg ggatgggctt
     5101 ctctcggagt gtaaaagcaa ggggccagga ttgtgctggc agccagggag acagtagtgc
     5161 ctgcggaagt tggcagagga ggccttggca tgctcgcatc caggcagtca tgtgtgatgg
     5221 gagcacatag catcgggaga agcagaactc catcctcacc tctattttga gcttagtgct
     5281 ttatttcagt atgaggaaaa acaacaacaa accgaagtgt gctttccgtc ctttcagagg
     5341 acaactgtca ggaaacagtt gaggtgccag gtgggagggg agacttggca aggagagatg
     5401 tcgtggcaaa actaggaaaa gagacattct tggctcttct ctttcctggt gtgccatgat
     5461 ccagggaatg aaaagaaatt tgaccctgga ttagtttctt tgtcggcgct gaggaacact
     5521 gctttttcac aaagttcccc cgggatagaa tggctgtcca gtctaagctc agggcagcct
     5581 cttcaaccac tgttggccca gcctggcttg tgaggaaacc agccctgtcc ctcagtattg
     5641 aacttggctg cttgtgggat ccagtcctgg aggacaggca tcaagttctt agcctctgta
     5701 gctcttagct ttcccatctt tccctgcaag gccacaccgt gcatttacag cagtgtggca
     5761 aggtgtagga gggaccttga acctggctgg ccagggcagc agcaggagta ggtagagctg
     5821 ttgttccttc tgggctgtct ccatccatct ataccccttt catgccccac cccactccca
     5881 ccaaaaagta aaaaatcagg atgtttttca ctgtccattg ctttgtgttt taataaacaa
     5941 tttgcagtga taaaaaaaaa aaaaaaaaaa
//
