LOCUS       NM_029993                461 bp    mRNA    linear   ROD 01-FEB-2024
DEFINITION  Mus musculus melan-A (Mlana), mRNA.
ACCESSION   NM_029993 XM_129166 XM_916895 XM_993504
VERSION     NM_029993.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Raymundo,J.R., Zhang,H., Smaldone,G., Zhu,W., Daly,K.E.,
            Glennon,B.J., Pecoraro,G., Salvatore,M., Devine,W.A., Lo,C.W.,
            Vitagliano,L. and Marneros,A.G.
  TITLE     KCTD1/KCTD15 complexes control ectodermal and neural crest cell
            functions and their impairment causes aplasia cutis
  JOURNAL   J Clin Invest (2023) In press
   PUBMED   38113115
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Sahut-Barnola,I., Lefrancois-Martinez,A.M., Dufour,D., Botto,J.M.,
            Kamilaris,C., Faucz,F.R., Stratakis,C.A., Val,P. and Martinez,A.
  TITLE     Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney
            Complex Syndrome
  JOURNAL   J Invest Dermatol 142 (11), 2949-2957 (2022)
   PUBMED   35568059
REFERENCE   3  (bases 1 to 461)
  AUTHORS   Sun,G., Liang,X., Qin,K., Qin,Y., Shi,X., Cong,P., Mo,D., Liu,X.,
            Chen,Y. and He,Z.
  TITLE     Functional Analysis of KIT Gene Structural Mutations Causing the
            Porcine Dominant White Phenotype Using Genome Edited Mouse Models
  JOURNAL   Front Genet 11, 138 (2020)
   PUBMED   32194624
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 461)
  AUTHORS   Mouriaux,F., Zaniolo,K., Bergeron,M.A., Weidmann,C., De La
            Fouchardiere,A., Fournier,F., Droit,A., Morcos,M.W., Landreville,S.
            and Guerin,S.L.
  TITLE     Effects of Long-term Serial Passaging on the Characteristics and
            Properties of Cell Lines Derived From Uveal Melanoma Primary Tumors
  JOURNAL   Invest Ophthalmol Vis Sci 57 (13), 5288-5301 (2016)
   PUBMED   27723895
  REMARK    GeneRIF: Cell passaging severely reduced the expression of genes
            encoding markers typical of UM, including those of the prognostic
            gene signature. Marked differences between gene expression profiles
            of primary tumors and cell lines could be linked to the
            infiltrating immune and stromal cells in situ.
REFERENCE   5  (bases 1 to 461)
  AUTHORS   DiTommaso,T., Cottle,D.L., Pearson,H.B., Schluter,H., Kaur,P.,
            Humbert,P.O. and Smyth,I.M.
  TITLE     Keratin 76 is required for tight junction function and maintenance
            of the skin barrier
  JOURNAL   PLoS Genet 10 (10), e1004706 (2014)
   PUBMED   25340345
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 461)
  AUTHORS   Giordano,F., Bonetti,C., Surace,E.M., Marigo,V. and Raposo,G.
  TITLE     The ocular albinism type 1 (OA1) G-protein-coupled receptor
            functions with MART-1 at early stages of melanogenesis to control
            melanosome identity and composition
  JOURNAL   Hum Mol Genet 18 (23), 4530-4545 (2009)
   PUBMED   19717472
  REMARK    GeneRIF: OA1 interacts with MART-1 at early stages of melanogenesis
            to control melanosome identity and composition.
REFERENCE   7  (bases 1 to 461)
  AUTHORS   Loftus,S.K., Baxter,L.L., Buac,K., Watkins-Chow,D.E., Larson,D.M.
            and Pavan,W.J.
  TITLE     Comparison of melanoblast expression patterns identifies distinct
            classes of genes
  JOURNAL   Pigment Cell Melanoma Res 22 (5), 611-622 (2009)
   PUBMED   19493314
REFERENCE   8  (bases 1 to 461)
  AUTHORS   Forrest,J.C., Paden,C.R., Allen,R.D. 3rd, Collins,J. and Speck,S.H.
  TITLE     ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and
            p53 in virus replication
  JOURNAL   J Virol 81 (21), 11957-11971 (2007)
   PUBMED   17699571
  REMARK    GeneRIF: mLANA and p53 have roles in virus replication
REFERENCE   9  (bases 1 to 461)
  AUTHORS   Wright,A., Kawakami,Y. and Pavan,W.
  TITLE     Mart1 is located on mouse chromosome 19 and is excluded as a
            candidate for ep and ru
  JOURNAL   Mamm Genome 8 (5), 377-378 (1997)
   PUBMED   9107690
REFERENCE   10 (bases 1 to 461)
  AUTHORS   Zhai,Y., Yang,J.C., Spiess,P., Nishimura,M.I., Overwijk,W.W.,
            Roberts,B., Restifo,N.P. and Rosenberg,S.A.
  TITLE     Cloning and characterization of the genes encoding the murine
            homologues of the human melanoma antigens MART1 and gp100
  JOURNAL   J Immunother 20 (1), 15-25 (1997)
   PUBMED   9101410
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC111114.1.
            
            On or before Jul 24, 2006 this sequence version replaced
            XM_129166.5, XM_916895.2, XM_993504.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111114.1, BB851876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 24.28 cM"
     gene            1..461
                     /gene="Mlana"
                     /gene_synonym="A930034P04Rik; Mart1"
                     /note="melan-A"
                     /db_xref="GeneID:77836"
                     /db_xref="MGI:MGI:108454"
     exon            1..23
                     /gene="Mlana"
                     /gene_synonym="A930034P04Rik; Mart1"
                     /inference="alignment:Splign:2.1.0"
     exon            24..117
                     /gene="Mlana"
                     /gene_synonym="A930034P04Rik; Mart1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..388
                     /gene="Mlana"
                     /gene_synonym="A930034P04Rik; Mart1"
                     /note="melanoma associated antigen recognized by T-cells
                     1"
                     /codon_start=1
                     /product="melanoma antigen recognized by T-cells 1"
                     /protein_id="NP_084269.1"
                     /db_xref="CCDS:CCDS29739.1"
                     /db_xref="GeneID:77836"
                     /db_xref="MGI:MGI:108454"
                     /translation="MPQEDIHFGYPRKGHRRSYVTAEEAAGIGILIVVLGIALLIGCW
                     YCRRRSGYRTLMDKRRHIGIQKTSRERCSCESPDHQDSRLSSQEKSHQPVVPNAPPAY
                     EKLSSPPPYSP"
     exon            118..214
                     /gene="Mlana"
                     /gene_synonym="A930034P04Rik; Mart1"
                     /inference="alignment:Splign:2.1.0"
     exon            215..328
                     /gene="Mlana"
                     /gene_synonym="A930034P04Rik; Mart1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..461
                     /gene="Mlana"
                     /gene_synonym="A930034P04Rik; Mart1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagaagtg ttcctcgggg aaggtgtcct gtgctgagtc cacacaatgc cccaagaaga
       61 cattcacttt ggttatccca ggaaggggca cagacgctcc tatgtcactg ctgaagaggc
      121 cgcagggatc ggcatcctga tcgtggtcct ggggattgct ctgcttatcg gctgctggta
      181 ctgtagaaga cgaagtggat acagaacctt gatggacaaa aggcgtcata ttggtattca
      241 aaaaacctca agggaaagat gctcatgtga gagccctgat caccaggaca gccgactgtc
      301 ttctcaagag aaatcccatc agcccgtggt tcccaacgct ccgcctgcct atgagaagct
      361 ctcttcaccg ccaccttatt caccctgaga gccgggaaac tcctgagaac gctgaacaac
      421 ttccctcaca cttccgcttt aaggctgagt agacgccggt g
//
