LOCUS       NM_177595               3201 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus mohawk homeobox (Mkx), mRNA.
ACCESSION   NM_177595 XM_974986
VERSION     NM_177595.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3201)
  AUTHORS   Wang,Y., Qin,Q., Wang,Z., Negri,S., Sono,T., Tower,R.J., Li,Z.,
            Xing,X., Archer,M., Thottappillil,N., Zhu,M., Suarez,A., Kim,D.H.,
            Harvey,T., Fan,C.M. and James,A.W.
  TITLE     The Mohawk homeobox gene represents a marker and osteo-inhibitory
            factor in calvarial suture osteoprogenitor cells
  JOURNAL   Cell Death Dis 15 (6), 420 (2024)
   PUBMED   38886383
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3201)
  AUTHORS   Lynch,C.A., Acosta,S.A., Anderson,D.M., Rogers,G.E.,
            Wilson-Rawls,J. and Rawls,A.
  TITLE     The Transcription Factor Mohawk Facilitates Skeletal Muscle Repair
            via Modulation of the Inflammatory Environment
  JOURNAL   Int J Mol Sci 25 (9), 5019 (2024)
   PUBMED   38732238
  REMARK    GeneRIF: The Transcription Factor Mohawk Facilitates Skeletal
            Muscle Repair via Modulation of the Inflammatory Environment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3201)
  AUTHORS   Ono,Y., Schlesinger,S., Fukunaga,K., Yambe,S., Sato,T., Sasaki,T.,
            Shukunami,C., Asahara,H. and Inui,M.
  TITLE     Scleraxis-lineage cells are required for correct muscle patterning
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37246520
REFERENCE   4  (bases 1 to 3201)
  AUTHORS   Mechakra,A., Lin,J., Yang,Y., Du,X., Zhang,J., Ewetse,P.M., Zhou,F.
            and Alakpa,E.
  TITLE     Mohawk impedes angiofibrosis by preventing the differentiation of
            tendon stem/progenitor cells into myofibroblasts
  JOURNAL   Sci Rep 12 (1), 20003 (2022)
   PUBMED   36411329
  REMARK    GeneRIF: Mohawk impedes angiofibrosis by preventing the
            differentiation of tendon stem/progenitor cells into
            myofibroblasts.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3201)
  AUTHORS   Adachi,Y., Higuchi,A., Wakai,E., Shiromizu,T., Koiwa,J. and
            Nishimura,Y.
  TITLE     Involvement of homeobox transcription factor Mohawk in
            palatogenesis
  JOURNAL   Congenit Anom (Kyoto) 62 (1), 27-37 (2022)
   PUBMED   34816492
  REMARK    GeneRIF: Involvement of homeobox transcription factor Mohawk in
            palatogenesis.
REFERENCE   6  (bases 1 to 3201)
  AUTHORS   Anderson,D.M., Beres,B.J., Wilson-Rawls,J. and Rawls,A.
  TITLE     The homeobox gene Mohawk represses transcription by recruiting the
            sin3A/HDAC co-repressor complex
  JOURNAL   Dev Dyn 238 (3), 572-580 (2009)
   PUBMED   19235719
  REMARK    GeneRIF: Mohawk can repress transcription through recruitment of
            the Sin3A/HDAC co-repressor complex
REFERENCE   7  (bases 1 to 3201)
  AUTHORS   Takeuchi,J.K. and Bruneau,B.G.
  TITLE     Irxl1, a divergent Iroquois homeobox family transcription factor
            gene
  JOURNAL   Gene Expr Patterns 7 (1-2), 51-56 (2007)
   PUBMED   16824806
  REMARK    GeneRIF: Irxl1 is a newly identified highly divergent member of the
            Irx gene family with specific expression patterns in embryogenesis.
REFERENCE   8  (bases 1 to 3201)
  AUTHORS   Liu,H., Liu,W., Maltby,K.M., Lan,Y. and Jiang,R.
  TITLE     Identification and developmental expression analysis of a novel
            homeobox gene closely linked to the mouse Twirler mutation
  JOURNAL   Gene Expr Patterns 6 (6), 632-636 (2006)
   PUBMED   16426902
  REMARK    GeneRIF: The developmental expression pattern indicates that Irxl1
            is a good candidate gene for the Twirler gene.
REFERENCE   9  (bases 1 to 3201)
  AUTHORS   Anderson,D.M., Arredondo,J., Hahn,K., Valente,G., Martin,J.F.,
            Wilson-Rawls,J. and Rawls,A.
  TITLE     Mohawk is a novel homeobox gene expressed in the developing mouse
            embryo
  JOURNAL   Dev Dyn 235 (3), 792-801 (2006)
   PUBMED   16408284
  REMARK    GeneRIF: Mohawk is an important regulator of vertebrate
            development.
REFERENCE   10 (bases 1 to 3201)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856607.1, AK034675.1, CD544112.1 and BY644476.1.
            
            On Oct 25, 2007 this sequence version replaced NM_177595.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034675.1, BC137728.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               BB856607.1         2-159
            159-1225            AK034675.1         137-1203
            1226-1575           CD544112.1         207-556
            1576-3167           AK034675.1         1551-3142
            3168-3201           BY644476.1         362-395
FEATURES             Location/Qualifiers
     source          1..3201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.53 cM"
     gene            1..3201
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="mohawk homeobox"
                     /db_xref="GeneID:210719"
                     /db_xref="MGI:MGI:2687286"
     exon            1..158
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            159..425
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1302
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="iroquois homeobox protein-like 1"
                     /codon_start=1
                     /product="homeobox protein Mohawk"
                     /protein_id="NP_808263.2"
                     /db_xref="CCDS:CCDS37728.1"
                     /db_xref="GeneID:210719"
                     /db_xref="MGI:MGI:2687286"
                     /translation="MNTIVFNKLGGAVLFEDRGTPDRERGSRTFSGFLDNPHTGPEVG
                     IPDGPPLKDNLSLRHRRTGARQNGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTE
                     KILLALGSQMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVS
                     SDGDSCSEDGENPPRNHMNEEGYSTPAHHTVIKGESSAIKAGGRPESRAAEDYVSPPK
                     YKSSLLNRYLNDSLRHVMATSTAMMGKTRRRNHSGSFSSNEFEEELVSPSSSETEGTF
                     VYRTDTPDIGSTKGDSAANRRGPSKDDTYWKEINAAMALTNLAQGKDEVQGTTTSCII
                     QKSSHIAEVKTVKLPLVQRF"
     exon            426..585
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..742
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1078
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1112
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..3201
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="hexamer: AATAAA"
     polyA_site      3189
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="major polyA site"
ORIGIN      
        1 gggccgcgcg catcagtctg ggtaaataaa gcagagacga ctccggtggc cccggtgaac
       61 gcgtcggagc ctgagccgag aacatgcggt ggggatggga gtgtgcctag tccagagaca
      121 ggagtgtcag ccgctggctg ccgattccgc ggccacagaa cccgagccct gctgcggagc
      181 tcctggtgga ctccgaggct ctgccgcaag gccgcgcgtc cctgccagcc cccaatcatg
      241 aacaccatcg tcttcaacaa gctcggggga gccgtgcttt ttgaagaccg aggcactcca
      301 gatcgggaac gtggcagccg gacgttcagt ggtttcctgg acaatccaca cacagggccg
      361 gaggtgggca taccagacgg cccgcccctc aaggacaacc tcagcctgag acaccggagg
      421 acaggggccc ggcagaatgg agggaaggta aggcataagc gacaggccct gcaagacatg
      481 gcgcgtcctc ttaagcagtg gctttacaag caccgtgaca acccgtaccc tacgaagact
      541 gagaagatac tcttggccct aggctcgcag atgacgctag tgcaggtgtc aaattggttc
      601 gctaatgcta gacgtcggct gaagaacact gtccggcagc cagatttaag ttgggcctta
      661 agaataaagt tatacaacaa gtatgttcag ggcaacgctg aacggctgag tgtgagcagc
      721 gatggcgact cctgctctga agatggagaa aatcccccaa gaaatcacat gaacgaagaa
      781 ggctacagca cccccgccca ccacactgtg attaaagggg aaagctcagc gataaaagct
      841 ggcggcagac cggagtcgag ggctgccgag gattatgtgt caccgcccaa gtataagagc
      901 agcttgttga accgttacct taacgactcc ttgagacatg tcatggccac cagcactgcc
      961 atgatgggga aaacaaggcg aaggaaccat tcggggtctt ttagctccaa cgaatttgaa
     1021 gaagagttgg tgtctccatc atcatcagaa actgaaggca cctttgtcta tcgcacagac
     1081 accccggaca tcggatctac taagggtgac agtgctgcta acagaagggg accaagcaaa
     1141 gatgacacat actggaagga gatcaatgca gccatggcct taacaaacct tgcccaagga
     1201 aaagatgaag tgcaggggac gaccaccagt tgcatcatcc agaagtcttc ccacatagca
     1261 gaagtaaaga cagtcaagct gccactggtg cagcgcttct agagtggcca ggaagtgctg
     1321 agctgtcagt gggttgtttg tttgtttgtg tttgttttta cctaaatcct catcctaaga
     1381 gccaaagcag aggtgaagag gactccctta aaactcctga gttcaactat cgtaaatata
     1441 tcagttgctt ctataaaaag acatataagt tataaaaact cattttaatc aaaaatatta
     1501 acttattttt atgttactga aactatgcat aaagtatctg cattaccatt acagtaagtg
     1561 ccttgctccc tgaggtaagc cccaacgtgg gcacagtgaa gagctgtgcc tcaaaccatc
     1621 aatgccaaca cttgctagac tgcatcattc ccactggtcc aggacagaag ccaatcgccg
     1681 aaagcccatg aaacaatttc attcattcac atgttcaaac ttggaaatct gttcagccca
     1741 gatgaggtga tcttttcttt cttttttctt tccttttctt tttctttttc tctttctttt
     1801 tctttcctct ttcttttttt tttttctttt ccttaacttc cggtgtgatg gtgagaattt
     1861 tatgtgtggg ttttgtttgc atatcagtta gtgcatccaa aatgaaaggt gctgcaggac
     1921 cacatgatgc atacacttaa gaagagatgc tttcaaacta ctttaatatt gtaatgcagt
     1981 caaggattgt tttcccaagc actgctggaa agtatcccaa tgccctttac aactaattgg
     2041 gatttttttt ccctgaagct ttaaaaagag tcttattata taaatctttg aaattttttc
     2101 ctgtgtaaag ctaaacctaa agtttagttt taaatcataa tcttgtttgc attagagctc
     2161 agggttcctg tgtgatggaa gccgctttca tgtggagtga gtaaaagctt tttatttggt
     2221 tcatttcaaa tcccaattca gatggacaat ttgtattgca atgagaacaa gacaacgaag
     2281 aaaaaatctg tgtgtgtata tacatataca tgcagaaaaa ttgatttctt aaaaatttaa
     2341 aatgtacggg tagcaaaata tgttcatgta gcatagactg tttagtctct gatttttgcc
     2401 agataggaca ttcaaataga aattaagtga agtcttgcat taaaagaaag aaagtcttgt
     2461 ttctaaatgt cactaccaca gagtgagagc aatcgctatc aagaaagaaa agtcttttcc
     2521 atcaagcatt aacatcctcc cctgcctggg aagactgcaa accagaggaa tgtggagatg
     2581 cccagtagaa aaggaaatct ggagatggcc tataaaacag agcaaacgtt caacagcaaa
     2641 gtaaaaaaga ctaggctatc gggggaattt ttttctggtt atgtaatgta ttttctaatt
     2701 gttttaggct ggaaagcatt tttgcaagtg tgaatgacat ctggtttcac agcacatgct
     2761 gacgtttttt tctttatttt acaaaatgct tttaatgcca aagttaatct ggttgctgag
     2821 cagacatgac ggccttgatg gccctcgtag gacactttct cctgtatcat agcatagtgg
     2881 ggtgggggtt atctagtgta atgaagataa tttgatatga aaatattttg tacgtatatt
     2941 tttactttgt tttctcaagt gctgttggca gttgcagttg ccctaggtga gatgtgtcag
     3001 tgctgactgt atgaatggat gaagtattgg gttcttctcg tgcagccagc caagtgggga
     3061 tcactacaag acaagcctgc ccagatgtgc atgaggcagt gagaagcaag aacgaatact
     3121 tcactctttc tcatactatt ataagttatt ctggtattaa atattttaat aaaagtgttc
     3181 ttgttttaac atattgtgat t
//
