LOCUS       NM_021462               3448 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus MAP kinase-interacting serine/threonine kinase 2
            (Mknk2), mRNA.
ACCESSION   NM_021462 XM_006513317
VERSION     NM_021462.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3448)
  AUTHORS   Huang,B., Guo,S., Zhang,Y., Lin,P., Lin,C., Chen,M., Zhu,S.,
            Huang,L., He,J., Zhang,L., Zheng,Y. and Wen,Z.
  TITLE     MiR-223-3p alleviates trigeminal neuropathic pain in the male mouse
            by targeting MKNK2 and MAPK/ERK signaling
  JOURNAL   Brain Behav 12 (7), e2634 (2022)
   PUBMED   35608154
  REMARK    GeneRIF: MiR-223-3p alleviates trigeminal neuropathic pain in the
            male mouse by targeting MKNK2 and MAPK/ERK signaling.
REFERENCE   2  (bases 1 to 3448)
  AUTHORS   Liu,D., Li,J., Lin,H., Lorsung,E., Le,N., Singla,R., Mishra,A.,
            Fukunaga,R. and Cao,R.
  TITLE     Circadian activities of the brain MNK-eIF4E signalling axis
            contribute to diurnal rhythms of some cognitive functions
  JOURNAL   Eur J Neurosci 56 (1), 3553-3569 (2022)
   PUBMED   35481869
REFERENCE   3  (bases 1 to 3448)
  AUTHORS   Chen,B.R., Wei,T.W., Tang,C.P., Sun,J.T., Shan,T.K., Fan,Y.,
            Yang,T.T., Li,Y.F., Ma,Y., Wang,S.B., Wang,Z.M., Wang,H., Shi,J.Z.,
            Liu,L., Chen,J.W., Zhou,L.H., Du,C., Sun,R., Wang,Q.M. and
            Wang,L.S.
  TITLE     MNK2-eIF4E axis promotes cardiac repair in the infarcted mouse
            heart by activating cyclin D1
  JOURNAL   J Mol Cell Cardiol 166, 91-106 (2022)
   PUBMED   35235835
  REMARK    GeneRIF: MNK2-eIF4E axis promotes cardiac repair in the infarcted
            mouse heart by activating cyclin D1.
REFERENCE   4  (bases 1 to 3448)
  AUTHORS   Huang,F., Goncalves,C., Bartish,M., Remy-Sarrazin,J., Issa,M.E.,
            Cordeiro,B., Guo,Q., Emond,A., Attias,M., Yang,W., Plourde,D.,
            Su,J., Gimeno,M.G., Zhan,Y., Galan,A., Rzymski,T., Mazan,M.,
            Masiejczyk,M., Faber,J., Khoury,E., Benoit,A., Gagnon,N.,
            Dankort,D., Journe,F., Ghanem,G.E., Krawczyk,C.M., Saragovi,H.U.,
            Piccirillo,C.A., Sonenberg,N., Topisirovic,I., Rudd,C.E.,
            Miller,W.H. Jr. and Del Rincon,S.V.
  TITLE     Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype
            switching and potentiates antitumor immune responses
  JOURNAL   J Clin Invest 131 (8) (2021)
   PUBMED   33690225
  REMARK    GeneRIF: Inhibiting the MNK1/2-eIF4E axis impairs melanoma
            phenotype switching and potentiates antitumor immune responses.
REFERENCE   5  (bases 1 to 3448)
  AUTHORS   Ueda,T., Sasaki,M., Elia,A.J., Chio,I.I., Hamada,K., Fukunaga,R.
            and Mak,T.W.
  TITLE     Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1
            and Mnk2) delays tumor development
  JOURNAL   Proc Natl Acad Sci U S A 107 (32), 13984-13990 (2010)
   PUBMED   20679220
  REMARK    GeneRIF: oncogenic role for Mnk1/2 in tumor development
REFERENCE   6  (bases 1 to 3448)
  AUTHORS   Chrestensen,C.A., Eschenroeder,A., Ross,W.G., Ueda,T.,
            Watanabe-Fukunaga,R., Fukunaga,R. and Sturgill,T.W.
  TITLE     Loss of MNK function sensitizes fibroblasts to serum-withdrawal
            induced apoptosis
  JOURNAL   Genes Cells 12 (10), 1133-1140 (2007)
   PUBMED   17903173
  REMARK    GeneRIF: MNK1 and MNK2 are kinases involved in anti-apoptotic
            signaling in response to serum withdrawal
REFERENCE   7  (bases 1 to 3448)
  AUTHORS   Shenberger,J.S., Zhang,L., Hughlock,M.K., Ueda,T.,
            Watanabe-Fukunaga,R. and Fukunaga,R.
  TITLE     Roles of mitogen-activated protein kinase signal-integrating
            kinases 1 and 2 in oxidant-mediated eIF4E phosphorylation
  JOURNAL   Int J Biochem Cell Biol 39 (10), 1828-1842 (2007)
   PUBMED   17689282
  REMARK    GeneRIF: Roles of mitogen-activated protein kinase
            signal-integrating kinases 1 and 2 in oxidant-mediated eIF4E
            phosphorylation.
REFERENCE   8  (bases 1 to 3448)
  AUTHORS   Parra,J.L., Buxade,M. and Proud,C.G.
  TITLE     Features of the catalytic domains and C termini of the MAPK
            signal-integrating kinases Mnk1 and Mnk2 determine their differing
            activities and regulatory properties
  JOURNAL   J Biol Chem 280 (45), 37623-37633 (2005)
   PUBMED   16162500
  REMARK    GeneRIF: The roles of features in the catalytic domains and C
            termini in determining the regulatory properties and basal
            activities of Mnk1 AND Mnk2 are reported.
REFERENCE   9  (bases 1 to 3448)
  AUTHORS   Ueda,T., Watanabe-Fukunaga,R., Fukuyama,H., Nagata,S. and
            Fukunaga,R.
  TITLE     Mnk2 and Mnk1 are essential for constitutive and inducible
            phosphorylation of eukaryotic initiation factor 4E but not for cell
            growth or development
  JOURNAL   Mol Cell Biol 24 (15), 6539-6549 (2004)
   PUBMED   15254222
  REMARK    GeneRIF: Mnk2 and Mnk1 are essential for constitutive and inducible
            phosphorylation of eukaryotic initiation factor 4E but not for cell
            growth or development
REFERENCE   10 (bases 1 to 3448)
  AUTHORS   Waskiewicz,A.J., Flynn,A., Proud,C.G. and Cooper,J.A.
  TITLE     Mitogen-activated protein kinases activate the serine/threonine
            kinases Mnk1 and Mnk2
  JOURNAL   EMBO J 16 (8), 1909-1920 (1997)
   PUBMED   9155017
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC152410.6, CX243939.1,
            BY732164.1, AK030830.1 and AK164278.1.
            
            [WARNING] On Mar 19, 2024 this sequence was replaced by
            NM_021462.5.
            
            On or before Oct 29, 2014 this sequence version replaced
            XM_006513317.1, NM_021462.3.
            
            Summary: The protein encoded by this gene is a
            serine/threonine-protein kinase, which is targeted by both the
            extracellular signal-regulated kinase and p38 mitogen-activated
            protein kinase pathways. This enzyme targets several substrates
            including eukaryotic translation initiation factor 4E and mammalian
            target of rapamycin, which are negatively regulated by its
            phosphorylation. Null mutant mice do not exhibit developmental or
            reproductive defects. However, mice null for both this protein and
            mitogen-activated protein kinase-interacting serine/threonine
            protein kinase 1 have delayed tumor development in phosphatase and
            tensin homolog mutant mice, indicating an oncogenic function for
            this gene in tumor development. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154235.1, SRR7652917.544145.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC152410.6         102471-102485       c
            16-171              CX243939.1         1-156
            172-213             AC152410.6         102273-102314       c
            214-276             CX243939.1         157-219
            277-728             BY732164.1         1-452
            729-1454            AK030830.1         2-727
            1455-1455           AC152410.6         93503-93503         c
            1456-3434           AK030830.1         729-2707
            3435-3448           AK164278.1         2262-2275
FEATURES             Location/Qualifiers
     source          1..3448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3448
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /note="MAP kinase-interacting serine/threonine kinase 2"
                     /db_xref="GeneID:17347"
                     /db_xref="MGI:MGI:894279"
     exon            1..213
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..330
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..418
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..520
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            521..618
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            619..698
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..772
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..877
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..933
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1029
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1224
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1389
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1433
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..3448
                     /gene="Mknk2"
                     /gene_synonym="2010016G11Rik; Gprk7; Mnk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcctctc ggcggcagcg gcccagtgga ggggtccgtg gtggcggtgg tggcggcggt
       61 ggcggcggcg gcggcggcga cggcggcggc ggcggcggcg gcagcagcag cggtggctgt
      121 ggcggcgctg ttccccgcgc agtcctcgga gcggggtccg ggctgtgcta ggtgaggtga
      181 cggcgctgcg accccggccg gtgtccgacc ccgggtcgcc tcccaagccg ccccccgggc
      241 cccgcgtccc ctcccccgct ggtggggccc ggactgaaga tggtgcagaa gagaacagcc
      301 gaacttcagg gcttccaccg ttcgttcaag gggcagaatc ctttcgagtt ggccttctcc
      361 ttagacctcg cccagcacag ggactctgac ttcagcccac agtgtgaagc ccgacctgac
      421 atgccttcca gccagcccat tgacatccca gatgccaaga agagaggccg gaaaaagaag
      481 cgctgtcggg ctactgacag cttctcaggc aggttcgaag atgtctatca gctgcaggag
      541 gatgtgctgg gggaaggtgc tcacgctcgt gtgcagacct gtgtcaatct catcaccaac
      601 caggaatatg ctgtcaagat cattgagaag cagctgggcc acatccgcag cagggtgttc
      661 cgggaggtgg agatgctgta ccagtgccag ggacatagga atgttctaga actgattgag
      721 ttctttgagg aggaggaccg tttctacctg gtgtttgaga agatgcgtgg cggatccatc
      781 ctaagccaca tccatagaag gcgccacttt aacgagctgg aggccagcgt ggtagtacag
      841 gacgtggcca gtgccctgga cttcctgcat aacaaaggca tcgcccacag ggacctaaag
      901 ccagagaaca tcctatgtga gcaccccaac caggtctcgc cagtgaagat ctgcgacttc
      961 gaccttggca gtggtatcaa actcaatgga gactgctccc ccatctccac accagagctg
     1021 ctcaccccgt gtgggtcagc tgagtacatg gccccagagg tggtggaggc cttcagtgaa
     1081 gaggccagca tctacgacaa gcgctgcgac ctgtggagcc tgggcgtcat cctctacatc
     1141 ctgcttagtg gctacccgcc cttcgtgggc cactgtggca gcgactgtgg ctgggaccgt
     1201 ggggaggcct gtcctgcctg ccagaacatg ctgtttgaga gcatccagga gggcaagtat
     1261 gagttccctg acaaggactg gtcccacatc tcctttgctg ccaaagacct catctccaag
     1321 ctgctggtcc gagatgccaa gcagaggctg agtgctgccc aagtcctgca gcatccctgg
     1381 gtgcaggggt gtgccccaga gaacacccta ccgacaccct tggttctgca gaggaacagc
     1441 tgtgccaaag acctcacgtc ctttgcggct gaggccatcg ccatgaaccg gcagctggcc
     1501 cagtgtgagg aggacgctgg gcaggaccag cctgtggtca tccgagctac ctcacgctgc
     1561 ctgcagctgt ccccaccctc ccagtccaag ctggcccagc ggcgccagag ggctagcctg
     1621 tcggccaccc ctgtggtcct tgtgggggat cgcgcatgac ccccactagc tccttgtaca
     1681 tatgcccctg ccccgcgggg cctgaaggct agggacctgg acaccccacc ccttgccatt
     1741 ccaggtgcca gctcagctgg gtcctctggg ggtgtagggg tctgttaggg ggtgtctcct
     1801 tttctccctg tccttcccct gccctgccca cttggctttg ttttgtttgt ttttctttgc
     1861 cgctattgaa agcaagtgcc cggaggaggg cggagggctc aggccgccca gcctgcaccc
     1921 cacgatgctc acctgccaac tgtgaaggtc ctgccacctg cgcccccacc tccactccag
     1981 ccactctgct gtcttccagg gttggggatc ccgcagggtc agcaccccac acctctccca
     2041 gccctcagtg ttgtcaggga caggccctcc tggtgagcac agtggtggtt gcatctcctc
     2101 accagagcac ccttgggtct ggggtagggc agggctccct gtcttggata gagacctctg
     2161 gggagcaggt ggatggggac agtgcacttg attgaccccg agtccccatc atccacctgc
     2221 agtgtccctt ggagggttga caatcagaaa cccctcccag gctgcttagc tccttgccct
     2281 gggacagacc tactgctccc aaccccactt cccaggggca gagctggaag gggaccctgc
     2341 acccagctag ctccaccaca gcaggagagg tgctggacca ggctttcatc agcaaacatg
     2401 gggctcccac atgtctcccc acccagggca cctgagtgcc ccttctcagg gctcagcctg
     2461 accacggcca cgtcctgccc ctggggttcc taagctctcc tagctgcttc tgttagccag
     2521 agctgaggcc atacccaggg ctctcacctt cctgttgccc ccagagggca gcagctcagg
     2581 cgtgcctgct ttcaggaaag ggaggctggg aagggatgtg gtggccctgc ggtgcccaga
     2641 cctaactgcc cgaggcctgt agactgttct agccgaacta ctatgcaata cgagttccca
     2701 ttttctccat ggccctgctg gtcgggggcg gctgccaggg gccaggccac cctgccctgc
     2761 aactgctcag gtgtctacag ggcagcccct ggcctcaaaa atccttggtc aggattgttt
     2821 gtcgagttta gtttaggctt tttttttttt tttaaagaaa taatttgact tgcttccctg
     2881 ttcttgaaga gtacttgaat gtcggggtct ggtgggtggg ggcctgggac acccactgcc
     2941 cagcatcctc caccctcctc cctagtctca taggatcgtc acagtggagg tgacatgcct
     3001 tctccagtcc tgccccacct gcctctgtgg acacatttcc aaagaacccc tgggggtggg
     3061 acctcctcca tcagtatgac tcagctgttg gccacctgag gactcggccc ccctgcaggt
     3121 tcctgaagca acctgactgg gcagtgagca gcattgaccc ccactcaccc ccaaaacagg
     3181 gctgtgattt ccttagtcct tccaagcccg acctggagga tgggtcagac cccttaactg
     3241 tgaatgagac atgatcctgg gctggcttcg ccacaaacca tgcagaaatc taaaaggcct
     3301 gttgtagagt gggggacatg caagcacttt taactccatc gtaccaggtg aactgacctc
     3361 cggactcctt tcccaccaac tgtcaacgcc aggattttgt attctgtttt gtaaggattt
     3421 aataaaagtc atttaaaaat ttctgtgc
//
