LOCUS       NM_013791               3973 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus muskelin 1, intracellular mediator containing kelch
            motifs (Mkln1), mRNA.
ACCESSION   NM_013791
VERSION     NM_013791.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3973)
  AUTHORS   Zhu,Y., Meng,X., Zhu,X., Zhang,J., Lv,H., Wang,F., Wang,J.,
            Chen,C., Chen,M., Wang,D., Jin,W., Tian,R. and Wang,R.
  TITLE     Circular RNA MKLN1 promotes epithelial-mesenchymal transition in
            pulmonary fibrosis by regulating the miR-26a/b-5p/CDK8 axis in
            human alveolar epithelial cells and mice models
  JOURNAL   Arch Toxicol 98 (5), 1399-1413 (2024)
   PUBMED   38460002
  REMARK    GeneRIF: Circular RNA MKLN1 promotes epithelial-mesenchymal
            transition in pulmonary fibrosis by regulating the
            miR-26a/b-5p/CDK8 axis in human alveolar epithelial cells and mice
            models.
REFERENCE   2  (bases 1 to 3973)
  AUTHORS   Heisler,F.F., Pechmann,Y., Wieser,I., Altmeppen,H.C.,
            Veenendaal,L., Muhia,M., Schweizer,M., Glatzel,M., Krasemann,S. and
            Kneussel,M.
  TITLE     Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and
            Impacts Prion Disease Progression
  JOURNAL   Neuron 99 (6), 1155-1169 (2018)
   PUBMED   30174115
REFERENCE   3  (bases 1 to 3973)
  AUTHORS   Delto,C.F., Heisler,F.F., Kuper,J., Sander,B., Kneussel,M. and
            Schindelin,H.
  TITLE     The LisH motif of muskelin is crucial for oligomerization and
            governs intracellular localization
  JOURNAL   Structure 23 (2), 364-373 (2015)
   PUBMED   25579817
REFERENCE   4  (bases 1 to 3973)
  AUTHORS   Kim,K.H., Hong,S.K., Hwang,K.Y. and Kim,E.E.
  TITLE     Structure of mouse muskelin discoidin domain and biochemical
            characterization of its self-association
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 11), 2863-2874 (2014)
   PUBMED   25372678
  REMARK    GeneRIF: The first crystal structure of mouse muskelin discoidin
            domain (MK-DD) is reported at 1.55 A resolution, which reveals a
            distorted eight-stranded beta-barrel with two short alpha-helices
            at one end of the barrel.
REFERENCE   5  (bases 1 to 3973)
  AUTHORS   Debenedittis,P., Harmelink,C., Chen,Y., Wang,Q. and Jiao,K.
  TITLE     Characterization of the novel interaction between muskelin and
            TBX20, a critical cardiogenic transcription factor
  JOURNAL   Biochem Biophys Res Commun 409 (2), 338-343 (2011)
   PUBMED   21586270
  REMARK    GeneRIF: This novel interaction between TBX20b and MKLN1 may help
            elucidate new regulatory mechanisms within heart development.
REFERENCE   6  (bases 1 to 3973)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3973)
  AUTHORS   Adams,J.C.
  TITLE     Characterization of a Drosophila melanogaster orthologue of
            muskelin
  JOURNAL   Gene 297 (1-2), 69-78 (2002)
   PUBMED   12384287
  REMARK    Erratum:[Gene. 2003 Mar 27;307:213-4]
REFERENCE   8  (bases 1 to 3973)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3973)
  AUTHORS   Adams,J.C. and Zhang,L.
  TITLE     cDNA cloning of human muskelin and localisation of the muskelin
            (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2
            by physical mapping and FISH
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 19-21 (1999)
   PUBMED   10640805
REFERENCE   10 (bases 1 to 3973)
  AUTHORS   Adams,J.C., Seed,B. and Lawler,J.
  TITLE     Muskelin, a novel intracellular mediator of cell adhesive and
            cytoskeletal responses to thrombospondin-1
  JOURNAL   EMBO J 17 (17), 4964-4974 (1998)
   PUBMED   9724633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD550341.1, AK077541.1, AK136123.1, CF161946.1, AV321114.1 and
            AC153837.4.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_013791.3.
            
            On Dec 19, 2006 this sequence version replaced NM_013791.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U72194.1, SRR1660815.214643.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CD550341.1         94-98
            6-823               AK077541.1         2-819
            824-940             AK136123.1         508-624
            941-1710            AK077541.1         936-1705
            1711-2220           CF161946.1         51-560
            2221-2455           AK077541.1         2216-2450
            2456-2468           AV321114.1         229-241
            2469-3973           AC153837.4         148412-149916       c
FEATURES             Location/Qualifiers
     source          1..3973
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.57 cM"
     gene            1..3973
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /note="muskelin 1, intracellular mediator containing kelch
                     motifs"
                     /db_xref="GeneID:27418"
                     /db_xref="MGI:MGI:1351638"
     exon            1..127
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..2237
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /codon_start=1
                     /product="muskelin"
                     /protein_id="NP_038819.1"
                     /db_xref="CCDS:CCDS19982.1"
                     /db_xref="GeneID:27418"
                     /db_xref="MGI:MGI:1351638"
                     /translation="MAAGGAVAVAPECRLLPYALHKWSSFSSTYLPENILVDKPNDQS
                     SRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELL
                     SSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDI
                     VQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDMHDKLVL
                     KGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQM
                     VIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCID
                     IQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQM
                     CMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGP
                     EDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGM
                     VPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQ
                     ATKDNLSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLC
                     RPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLA
                     SALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL"
     exon            128..197
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            198..340
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            341..429
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            430..539
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            540..732
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            733..810
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            811..876
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..989
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1202
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1424
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1554
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1702
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1817
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1957
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2060
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2115
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..3973
                     /gene="Mkln1"
                     /gene_synonym="A130067F06Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcggtggtgg ccgctacggt gctgacaaga tggcggctgg cggggctgtt gctgtggcgc
       61 cggagtgccg gcttctgccc tacgcgctgc ataagtggag ctccttctcc tccacctacc
      121 ttcccgagaa cattttagtg gataaaccaa atgatcagtc ttccagatgg tcttcagaga
      181 gcaactatcc tccccaatac ttgattctga agcttgaaag gcctgctatc gttcagaata
      241 ttacatttgg aaaatatgag aaaactcatg tctgcaattt gaagaaattc aaagtttttg
      301 gtggaatgaa tgaagaaaat atgacagagc tgttgtccag tggcctgaag aatgattata
      361 acaaagagac atttaccttg aaacataaaa ttgatgaaca gatgttccct tgtcgattca
      421 ttaaaattgt tccacttttg tcctgggggc ccagctttaa ctttagcatc tggtatgttg
      481 aacttagtgg cattgatgat cctgatatcg tgcagccctg tctgaactgg tacagcaagt
      541 accgtgaaca ggaagccatt cgcctttgcc taaaacactt cagacaacat aactatacag
      601 aggcttttga atccctgcag aagaaaacca agattgcact ggaacatcca atgttgacag
      661 atatgcatga caaattggtg ttaaagggtg actttgatgc ttgcgaggag ttgattgaaa
      721 aagctgtaaa tgatggcttg ttcaatcagt atatcagtca acaggagtat aagccacggt
      781 ggagtcagat tattcctaag agcaccaaag gcgatggaga agataacaga ccaggaatga
      841 gagggggcca tcaaatggtc attgacgtcc agacagagac tgtttatttg tttggtggct
      901 gggatggaac acaagatctt gctgacttct gggcatacag tgtgaaggag aaccagtgga
      961 catgtatttc tagagacact gagaaagaga atggtccgag tgccagatcg tgtcataaga
     1021 tgtgcattga cattcagcgg agacaaatct acacattggg ccgttacttg gattcctctg
     1081 tgaggaacag caaatctctg aaaagtgatt tctaccgtta cgacattgac actaatacct
     1141 ggatgttact aagtgaagat actgctgccg acggtggacc aaagttggtg tttgatcatc
     1201 agatgtgtat ggactcagaa aaacatatga tctacacgtt tggtggcagg attttgacgt
     1261 gtaatggcag tgtagatgac agcagagcca gtgagccaca attcagtggg ttgtttgcgt
     1321 tcaactgcca gtgtcaaact tggaaacttc ttcgagagga ttcctgtaat gctggccctg
     1381 aggacatcca gtctcggatt ggacactgca tgctgttcca ctcaaaaaac cgttgcttat
     1441 atgtgtttgg tggccagaga tccaagacct atttgaatga tttctttagt tatgatgtgg
     1501 actcagatca tgtagacata atttcagatg gcaccaagaa agactctgga atggttccaa
     1561 tgaccggatt cacacagaga gcaactattg atccagaact gaatgaaata catgtcttat
     1621 ccggacttag caaagacaaa gaaaagaggg aagagaatgt cagaaattca ttctggattt
     1681 atgacattgt gaggaatagc tggtcttgtg tctataagaa tgatcaagct acaaaagata
     1741 atctgagtaa aagtcttcag gaggaagaac catgtccaag gtttgcccat caactcgttt
     1801 atgatgaatt acacaaggtt cattatttat ttggtggaaa tccaggaaaa tcttgctctc
     1861 caaagatgag actagatgac ttctggtcac tgaagttgtg tagaccttca aaagactact
     1921 tactgaggca ttgcaagtac ctcataagaa aacacaggtt tgaagaaaag gcccaaatgg
     1981 atccccttag tgctctgaag tatttacaaa atgatcttta tataactgtg gatcattcgg
     2041 acccagaaga gacaaaagag tttcaactcc tagcctcagc tctgttcaaa tctggctcag
     2101 atttcacagc tctaggcttt tcagatgtgg atcataccta tgctcaaaga actcagctct
     2161 ttgacacctt agtaaatttc tttcctgaca gcatgactcc tcctaaaggc aacctggtag
     2221 acctgatcac actgtagact ggggagtggg attgaagaat tactgggctc agacatggag
     2281 aaggaaccag ctgttctgtg ggcagaggtg acgctgcagg tactgaggac ggcaccagag
     2341 ttttgaagga tccttattat cacaagtttt aaccctcttc cttcatacct gacctcaatc
     2401 cccttttcct cttatttctg cattaggcta ataaagtgaa attgatatac ttcccattta
     2461 attatgtata tttttcttta gcctttaaga attagtaagt attaatgaaa attagccttt
     2521 tttctggctt ccaagttttc aaagtttatt tttagttagg agaacagcac tactggtaga
     2581 cttggtgctg taggaatttg gggttttgct gctgggtgtt tagcctttgt ttcccttttc
     2641 ttctcttccc ccttcacttt ccccacatca ccgctgttgt ggtgccgact ctgactccct
     2701 ccctcatcct taactggctc tgtgtggctc tgtgggacac acacaggtgg tgtatgttta
     2761 ggtgatgtgt ggctgttgac ttttcgtgta ttaaacatag agcagttaga gggcttgaat
     2821 ttatactttt tgccatacta ccaaaagcaa aactcaagat tggcccagac acctgatcaa
     2881 gaattgatat ttctgtattg aaattctgta gtggacatta cagtagccat tggcatagaa
     2941 tcacagaaac ctgaaaccca gcctcctacc cagaaataag agtgttccag gtgaccagca
     3001 ggagaggtgc tgtccttccc cctattttta ctgatatctc tgttgggatt ttaaaggaaa
     3061 tgactgctgg tagagctatg cagaacctac gctctcactc tcctctgagt gaactttttg
     3121 tcatagtttt atctggacaa taggttccag agctgtgctt tcatattttt ctgatatgtg
     3181 accctactat tttgaagagt aatagtttgt ggttgtcttt tggcatacaa tttacaggca
     3241 ttttagtaat aagcatgtgg gccagacttt tttttaaatg gataaaaaga aaaatatgta
     3301 acaccaagag tttttcatta aacagaaaag tataagagtt tgcccttttc attgttctgg
     3361 ttttgtacat acaggaatag gagcatacct tcacatcaga tgctggggaa tgtagcatat
     3421 gaaacccaca tctggctagt tagcattcac gtttgttcaa gtgtgccata ggcagctggt
     3481 accactgtgt tgaaaacagg atctgcccta tccgtgtgcc agctgttagg agtgtgtgac
     3541 tatgaaattg acctggactt ccaaaagtgt catgtgtagg aaggagacct tgatccatcc
     3601 ttccctctgt ccttactgac ttttctgggt ttgcttttga ggatgaatgg gaatatattt
     3661 ttgcagttgt agacttttta gcttcataag catcccaagg taatcagtag tgacttaata
     3721 aacatgtatg ccaataccta ccctgtcaga agtatgcagt ataaattagg aggtaccaaa
     3781 ttgtataaga gacagaataa tcacttacct gtacatttga gtaaatccat tctattcaaa
     3841 gacttcgcag cttcctaacg tgattctcct aagtaacagc caagaacaag aacaaaaact
     3901 gtgtagctaa cagcgtagcc tgctgagtct catttcaaga agacagctgc aaatcagtag
     3961 gtgaccaaaa aaa
//
