LOCUS       NM_001081117           10098 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus antigen identified by monoclonal antibody Ki 67
            (Mki67), mRNA.
ACCESSION   NM_001081117 XM_133912
VERSION     NM_001081117.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10098)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
REFERENCE   2  (bases 1 to 10098)
  AUTHORS   Hrncir,H.R., Goodloe,B., Bombin,S., Hogan,C.B., Jadi,O. and
            Gracz,A.D.
  TITLE     Sox9 inhibits Activin A to promote biliary maturation and branching
            morphogenesis
  JOURNAL   Nat Commun 16 (1), 1667 (2025)
   PUBMED   39955269
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10098)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10098)
  AUTHORS   Allen,R.S., Biswas,S.K. and Seifert,A.W.
  TITLE     Ear pinna growth and differentiation is conserved in murids and
            requires BMP signaling for chondrocyte proliferation
  JOURNAL   Development 152 (3) (2025)
   PUBMED   39846506
REFERENCE   5  (bases 1 to 10098)
  AUTHORS   Chen,X., Tober,J., Dominguez,M., Tang,A.T., Bockman,J., Yang,J.,
            Mani,S., Lee,C.N., Chen,M., Thillaikumaran,T., Mericko-Ishizuka,P.,
            Mainigi,M., Speck,N.A. and Kahn,M.L.
  TITLE     Lineage tracing studies suggest that the placenta is not a de novo
            source of hematopoietic stem cells
  JOURNAL   PLoS Biol 23 (1), e3003003 (2025)
   PUBMED   39874373
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10098)
  AUTHORS   Murgia,C., Blaikie,P., Kim,N., Dans,M., Petrie,H.T. and
            Giancotti,F.G.
  TITLE     Cell cycle and adhesion defects in mice carrying a targeted
            deletion of the integrin beta4 cytoplasmic domain
  JOURNAL   EMBO J 17 (14), 3940-3951 (1998)
   PUBMED   9670011
REFERENCE   7  (bases 1 to 10098)
  AUTHORS   Oesterreicher,T.J., Leeper,L.L., Finegold,M.J., Darlington,G.J. and
            Henning,S.J.
  TITLE     Intestinal maturation in mice lacking CCAAT/enhancer-binding
            protein alpha (C/EPBalpha)
  JOURNAL   Biochem J 330 (Pt 3) (Pt 3), 1165-1171 (1998)
   PUBMED   9494081
REFERENCE   8  (bases 1 to 10098)
  AUTHORS   Kaestner,K.H., Silberg,D.G., Traber,P.G. and Schutz,G.
  TITLE     The mesenchymal winged helix transcription factor Fkh6 is required
            for the control of gastrointestinal proliferation and
            differentiation
  JOURNAL   Genes Dev 11 (12), 1583-1595 (1997)
   PUBMED   9203584
REFERENCE   9  (bases 1 to 10098)
  AUTHORS   Mitsuyoshi,S., Igarashi,H., Sakata,A., Koseki,H., Taniguchi,M. and
            Sakaguchi,N.
  TITLE     Expression of the proliferation-related Ki-67 mRNA in the early
            development of murine embryo
  JOURNAL   Biochem Biophys Res Commun 235 (1), 191-196 (1997)
   PUBMED   9196061
REFERENCE   10 (bases 1 to 10098)
  AUTHORS   Starborg,M., Gell,K., Brundell,E. and Hoog,C.
  TITLE     The murine Ki-67 cell proliferation antigen accumulates in the
            nucleolar and heterochromatic regions of interphase cells and at
            the periphery of the mitotic chromosomes in a process essential for
            cell cycle progression
  JOURNAL   J Cell Sci 109 (Pt 1), 143-153 (1996)
   PUBMED   8834799
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143677.1, AK052772.1, AC123047.3 and BC053453.1.
            
            On Mar 1, 2008 this sequence version replaced NM_001081117.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164134,
                              SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-974               AK143677.1         40-1013
            975-3065            AK052772.1         895-2985
            3066-7627           AC123047.3         130293-134854       c
            7628-10098          BC053453.1         254-2724
FEATURES             Location/Qualifiers
     source          1..10098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 81.32 cM"
     gene            1..10098
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /note="antigen identified by monoclonal antibody Ki 67"
                     /db_xref="GeneID:17345"
                     /db_xref="MGI:MGI:106035"
     exon            1..332
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..9774
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /note="antigen Ki67 homolog; antigen KI-67 homolog;
                     antigen identified by monoclonal antibody Ki-67 homolog"
                     /codon_start=1
                     /product="proliferation marker protein Ki-67"
                     /protein_id="NP_001074586.2"
                     /db_xref="CCDS:CCDS52421.1"
                     /db_xref="GeneID:17345"
                     /db_xref="MGI:MGI:106035"
                     /translation="MASSAHLVTIKRSGDDGAHFPLSLSSCLFGRSIECDIRIQLPVV
                     SKRHCKIEVKEQEAILYNFSSTNPTQVNGVTIDEPVRLRHGDIITIIDRSFRYEDGNH
                     EDGSKPTEFPGKSLGKEPSRRASRDSFCADPDGEGQDTKASKMTASRRSFVYAKGLSA
                     DSPASDGSKNSVSQDSSGHVEQHTGRNIVEPTSGDLFKKSRSTGSSYREPKSSPTQSL
                     SNSNEKESPFEKLYQSMKEELDVKSQKSCRKSEPQPDRAAEESRETQLLVSGRARAKS
                     SGSTPVTAASSPKVGKIWTERWRGGMVPVQTSTETAKMKTPVRHSQQLKDEDSRVTGR
                     RHSVNLDEGESAQAVHKTVTPGKLATRNQAAVEAGDVASPADTPEHSSSKKRSIPAKV
                     EAPSAETQKRLSLTQRLVPGEKKTPKGSFSKPEKLATAAEQTCSGLPGLSSVDISNFG
                     DSINKSEGMPMKRRRVSFGGHLRPELFDENLPPNTPLKRGETPTKRKSLGTHSPAVLK
                     TIIKERPQSPGKQESPGITPPRTNDQRRRSGRTSSGSKFLCETDIPKKAGRKSGNLPA
                     KRASISRSQHGILQMICSKRRSGASEANLIVAKSWADVVKLGVKQTQTKVAKHVPQKQ
                     TSKRQRRPSTPKKPTSNLHNQFTTGHANSPCTIVVGRAQIEKVSVPARPYKMLNNLML
                     NRKVDFSEDLSGLTEMFKTPVKEKQQQMSDTGSVLSNSANLSERQLQVTNSGDIPEPI
                     TTEILGEKVLSSTRNAAKQQSDRYSASPTLRRRSIKHENTVQTPKNVHNITDLEKKTP
                     VSETEPLKTASSVSKLRRSRELRHTLVETMNEKTEAVLAENTTARHLRGTFREQKVDQ
                     QVQDNENAPQRCKESGELSEGSEKTSARRSSARKQKPTKDLLGSQMVTQTADYAEELL
                     SQGQGTIQNLEESMHMQNTSISEDQGITEKKVNIIVYATKEKHSPKTPGKKAQPLEGP
                     AGLKEHFETPNPKDKPITEDRTRVLCKSPQVTTENITTNTKPQTSTSGKKVDMKEESS
                     ALTKRIHMPGESRHNPKILKLECEDIKALKQSENEMLTSTVNGSKRTLEKSKKKAQPL
                     EDLTCFQELFISPVPTNIIKKIPSKSPHTQPVRTPASTKRLSKTGLSKVDVRQEPSTL
                     GKRTKSPGRAPGTPAPVQEENDSTAFMETPKQKLDFAGNSSGSKRRSRTSKNRSQPLE
                     DLDGFQELFQTPAGASDSVTVEESAKISLESSQAEPVKTPASTKRRSKMSLMKVDMKE
                     LSILEKQTQSRGRDAGTPAPMQEGNGTTAIMETPKQKLDFTGNSTGHKRRPRTPKIRA
                     QPLEDLDGFQELFQTPAGANDSVTVEESAKMSLESSQAEPVKTPASTKRLSKTDLSKV
                     DVREDPSILGKKTKSPGRAPGTPAPVQEENDCTAYMETPKQKLESIENLTGLRKQSRT
                     PKDITGFQDSFQIPDHANGPLVVVKTKKMFFNSPQPESAITRKSRERQSRASISKIDV
                     KEELLESEEHLQLGEGVDTFQVSTNKVIRSSRKPAKRKLDSTAGMPNSKRMRCSSKDN
                     TPCLEDLNGFQELFQMPGYANDSLTTGISTMLARSPQLGPVRTQINKKSLPKIILRKM
                     DVTEEISGLWKQSLGRVHTTQEQEDNAIKAIMEIPKETLQTAADGTRLTRQPQTPKEK
                     VQPLEDHSVFQELFQTSRYCSDPLIGNKQTRMSLRSPQPGFVRTPRTSKRLAKTSVGN
                     IAVREKISPVSLPQCATGEVVHIPIGPEDDTENKGVKESTPQTLDSSASRTVSKRQQG
                     AHEERPQFSGDLFHPQELFQTPASGKDPVTVDETTKIALQSPQPGHIINPASMKRQSN
                     MSLRKDMREFSILEKQTQSRGRDAGTPAPMQEENGTTAIMETPKQKLDFIGNSTGHKR
                     RPRTPKNRAQPLEDLDGFQELFQTPAGASDPVSVEESAKISLASSQAEPVRTPASTKR
                     RSKTGLSKVDVRQEPSTLGKRMKSLGRAPGTPAPVQEENDSTAFMETPKQKLDFTGNS
                     SGHKRRPQTPKIRAQPLEDLDGFQELFQTPAGANDSVTVEESVKMSLESSQAEPVKTP
                     ASTKRLSKTGLSKVDVREDPSILEKKTKSPGTPAPVQEENDCTAFMETPKQKLDFTGN
                     SSGHKRRPRTPKIRAQPLEDLDGFQELFQTPAGASDSVTVEESAKMSLESSQAKPVKT
                     PASTKRLSKTGLSKVDVREDPSTLGKKTKSPGRAPGTPAPVQEENDSTAFMETPKQKL
                     DFAENSSGSKRRSRTSKNRSQPLEDLDGFQELFQTPAGASNPVSVEESAKISLESSQA
                     EPVRTRASTKRLSKTGLNKMDVREGHSPLSKSSCASQKVMQTLTLGEDHGRETKDGKV
                     LLAQKLEPAIYVTRGKRQQRSCKKRSQSPEDLSGVQEVFQTSGHNKDSVTVDNLAKLP
                     SSSPPLEPTDTSVTSRRQARTGLRKVHVKNELSGGIMHPQISGEIVDLPREPEGEGKV
                     IKTRKQSVKRKLDTEVNVPRSKRQRITRAEKTLEDLPGFQELCQAPSLVMDSVIVEKT
                     PKMPDKSPEPVDTTSETQARRRLRRLVVTEEPIPQRKTTRVVRQTRNTQKEPISDNQG
                     MEEFKESSVQKQDPSVSLTGRRNQPRTVKEKTQPLEELTSFQEETAKRISSKSPQPEE
                     KETLAGLKRQLRIQLINDGVKEEPTAQRKQPSRETRNTLKEPVGDSINVEEVKKSTKQ
                     KIDPVASVPVSKRPRRVPKEKAQALELAGLKGPIQTLGHTDESASDKGPTQMPCNSLQ
                     PEQVDSFQSSPRRPRTRRGKVEADEEPSAVRKTVSTSRQTMRSRKVPEIGNNGTQVSK
                     ASIKQTLDTVAKVTGSRRQLRTHKDGVQPLEVLGDSKEITQISDHSEKLAHDTSILKS
                     TQQQKPDSVKPLRTCRRVLRASKEDPKEVLVDTRDHATLQSKSNPLLSPKRKSARDGS
                     IVRTRALRSLAPKQEATDEKPVPEKKRAASSKRHVSPEPVKMKHLKIVSNKLESVEEQ
                     VSTVMKTEEMEAKRENPVTPDQNSRYRKKTNVKQPRPKFDASAENVGIKKNEKTMKTA
                     SQETELQNPDDGAKKSTSRGQVSGKRTCLRSRGTTEMPQPCEAEEKTSKPAAEILIKP
                     QEEKGVSGESDVRCLRSRKTRVALDSEPKPRVTRGTKKDAKTLKEDEDIVCTKKLRTR
                     S"
     exon            333..411
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            412..527
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            528..594
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            595..640
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            641..1600
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1776
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2029
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2148
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2320
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2476
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..9312
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            9313..9729
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
     exon            9730..10075
                     /gene="Mki67"
                     /gene_synonym="D630048A14Rik; Ki-67; Ki67"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgggacgcg ggcggcggga gtgcgggtct ggtcggggcg gagcgaaggc cgcgggtggc
       61 cgtggtcggt cctccgcggc taaggagccg agggctccga cgcgggctgc gcccggtgag
      121 cggcggccag agctaacttg cgctgactgg accagctgag gagcggcccg gcggggcgac
      181 tgcgagcttc accgagaggc ttctccgccc tggtccgcag tcccgacggc cgggcggacc
      241 atggcgtcct cggctcacct ggtcaccatc aagcggagcg gcgatgacgg cgcacacttc
      301 ccgctgagcc tcagctcctg cctgtttgga aggagtattg aatgtgacat tcgtatccag
      361 ctgcctgtag tgtcaaaaag acattgcaaa attgaagtca aagagcaaga ggcaatatta
      421 tataatttca gttctaccaa tccaactcaa gtaaacgggg ttactataga tgagcctgtg
      481 aggctgagac atggagacat aataaccatc attgaccgct cctttaggta tgaagatgga
      541 aatcatgagg atggaagcaa gccaacagaa tttccaggaa agtcccttgg aaaggaacca
      601 tcaaggcgag cctcaagaga tagcttctgt gctgaccctg atggggaagg tcaagatacc
      661 aaagcttcaa aaatgactgc ttcaagaaga tcttttgtgt atgccaaggg cctttctgca
      721 gatagccctg cctcagatgg ctcaaagaac agtgttagcc aagactcatc agggcatgta
      781 gaacagcaca ctggcagaaa catagtagag cccacttctg gggatctctt taagaagtcc
      841 aggtctacag ggagcagtta cagggaaccg aagtcttctc ctacacagag ccttagcaat
      901 agcaacgaaa aggaatctcc ctttgagaaa ctttatcaat caatgaagga agagttggat
      961 gtaaaatccc agaaatcttg taggaaatca gaaccccaac ctgaccgtgc agcagaggaa
     1021 tcgcgggaga cacagctatt ggtgtcaggc agggcaagag caaagtctag tggaagcacc
     1081 cctgttactg cagcctcttc acccaaagta ggaaagatct ggactgagag atggcgcggt
     1141 ggaatggtgc ctgtccagac ttccacagag acagctaaaa tgaagacccc tgtgcggcat
     1201 tcacagcaac ttaaggatga agactctcgt gttactggca gacgacattc tgtgaatctg
     1261 gatgaaggtg aaagtgccca ggcagtccat aaaacagtca ctcctgggaa actggcgact
     1321 agaaaccaag ctgcggtgga ggctggggat gttgccagcc ccgctgatac accagaacat
     1381 tcctcttcca aaaagagaag tattcctgca aaggtagagg ctccatctgc agagacacaa
     1441 aagcggctct ctttaactca gcgccttgtt ccaggtgaaa agaaaactcc caagggttcc
     1501 ttcagcaagc ctgagaaact ggccacagcc gccgaacaga cttgctctgg cctacctggt
     1561 cttagttccg ttgatatcag caactttggt gattccatta acaagagtga gggaatgcct
     1621 atgaagagaa gacgtgtatc ctttggtgga catctaagac ctgaattatt tgatgaaaac
     1681 ttgcctccta atacaccact gaaaagagga gaaacgccaa ccaagaggaa gtctcttggc
     1741 actcacagcc cagctgtcct caagacaatc atcaaggaac ggccccagtc tccagggaaa
     1801 caagagtctc ctgggataac gccaccgagg acaaatgatc aaagacgcag atcaggcagg
     1861 acttccagtg gaagcaaatt cttatgtgag acagacattc ccaagaaagc aggcaggaag
     1921 agcggtaacc tgcctgcgaa gagagcatcc atcagccgga gtcagcatgg cattctacag
     1981 atgatttgct ccaaaaggcg aagtggagct tctgaagcca acttgattgt tgcaaaatca
     2041 tgggctgatg ttgtaaaact tggcgtgaaa caaacacaaa cgaaagttgc gaaacatgtc
     2101 cctcaaaagc agacgagcaa gagacaaaga agacccagca ctccaaagaa acccacaagc
     2161 aatcttcaca atcaatttac tacaggccat gcaaactctc cctgtaccat tgtagtaggt
     2221 agagcgcaga ttgaaaaagt aagtgtgcct gcccgaccct acaaaatgct gaataacttg
     2281 atgctaaacc gaaaagtgga cttcagtgaa gatctgtcag gactaactga aatgttcaag
     2341 actccagtga aggagaagca gcagcagatg agtgatacag gctccgtact ttccaattca
     2401 gcgaatttgt ctgaaagaca attgcaagta actaattcag gagacatacc tgagcccatc
     2461 accacagaga ttttgggaga aaaagtgcta tccagtactc ggaatgcagc aaagcagcag
     2521 tctgatagat attctgcaag tcctacctta agacggcgga gcatcaaaca tgaaaacaca
     2581 gtgcaaactc ctaagaatgt ccataacatt actgaccttg agaagaagac tccggtctct
     2641 gagacagagc ccctgaagac tgcatcgagt gtgagcaagt taagaagatc tagagagctc
     2701 agacataccc ttgtggaaac tatgaatgaa aaaacagaag cagtccttgc tgagaacacc
     2761 acagcaagac atttaagggg gacatttcga gaacaaaaag tagatcaaca ggtgcaggac
     2821 aatgaaaacg ctcctcaaag atgcaaggaa agtggtgaat taagtgaagg ttcagaaaag
     2881 acatcagcta ggagatcaag tgccaggaag cagaagccga caaaagactt actaggaagt
     2941 cagatggtca cccaaacagc agactatgct gaggaactac ttagtcaagg acaaggaacc
     3001 atacaaaacc tagaggaatc catgcacatg caaaacacat caataagtga ggatcaagga
     3061 attacagaaa agaaagtgaa cataatagta tatgcaacca aagagaagca ctcgccaaag
     3121 acccctggca aaaaggcaca acctctagaa gggccagctg gtctcaagga acactttgaa
     3181 acaccaaacc ccaaagataa acctataacg gaagacagaa ctagagtcct ttgcaaatca
     3241 ccacaagtca caacagagaa tatcacaaca aacacaaagc cacagactag cacatctggg
     3301 aagaaagtag acatgaagga agaaagctct gccttgacaa aacgtataca tatgccaggg
     3361 gaatccaggc ataatcccaa aattttaaaa cttgagtgtg aggatatcaa agctttgaag
     3421 caatctgaaa atgaaatgct gacctcaaca gtaaatggaa gcaagaggac tttagaaaaa
     3481 tctaaaaaaa aggctcagcc cctggaagac ctgacttgtt tccaggaact ctttatatca
     3541 ccagttccta ctaacataat caaaaaaatt cccagcaaat ctccacacac acaaccagtc
     3601 agaaccccag cgagcacaaa gagactctcc aagacaggtc tcagtaaagt ggatgtgaga
     3661 caagaacctt caacacttgg gaaaagaacg aagtcaccag gcagagcccc aggcacacca
     3721 gcaccagtgc aggaagaaaa tgacagcaca gccttcatgg aaactccaaa gcagaaactg
     3781 gattttgcag ggaattcatc agggagtaag agaaggtcac gaacatctaa gaacaggtct
     3841 cagcccctag aagacctgga tggcttccaa gaactcttcc aaacaccagc tggtgccagt
     3901 gactcagtga ctgttgagga aagtgcaaag atatctttgg aatcttcaca agcagaacca
     3961 gtcaaaaccc cggcaagcac aaagagacgg tctaagatga gtctcatgaa agtggatatg
     4021 aaagaacttt ccatacttga gaaacaaaca cagtcacgag gcagagacgc aggcacacca
     4081 gcaccaatgc aggaaggaaa tggcaccaca gccattatgg aaactccaaa gcagaaactg
     4141 gatttcacag gaaattcaac aggacataag aggaggccac ggacacctaa gatcagagct
     4201 cagcccctag aagacctgga tggcttccaa gaactcttcc aaacaccagc tggtgctaat
     4261 gactcagtga ctgttgagga aagtgcaaag atgtctttgg aatcttcaca agcagaacca
     4321 gtcaaaaccc cggcaagcac aaagagactc tccaagacag atctcagtaa ggtggatgtg
     4381 agagaagacc cttcaatact tgggaaaaaa acaaagtcac caggcagagc cccaggtaca
     4441 ccagcaccag tgcaggaaga aaatgactgc acagcctaca tggaaactcc aaagcagaaa
     4501 ctggagtcta tagaaaattt aacagggctt aggaaacagt ccagaacacc taaagacatc
     4561 actggtttcc aggatagttt ccaaatacca gatcatgcta atggcccatt agtggttgtc
     4621 aaaaccaaaa aaatgttctt taattctcca caaccagaaa gtgccataac ccgaaagagc
     4681 agagagagac agtctagggc aagtataagt aaaatagatg ttaaagaaga acttttagaa
     4741 tcagaggaac acctacaatt aggagaaggt gtagacacat ttcaggtatc caccaacaaa
     4801 gtcattagat catctaggaa acctgcaaag cgtaaactgg attcaacagc tggtatgcct
     4861 aacagcaaga ggatgcgctg ttcttcaaag gataacacac catgcctaga agacctgaat
     4921 ggcttccaag agctcttcca aatgccaggc tatgctaatg actctttgac cactggaatc
     4981 tcaacaatgc ttgctagatc accacaatta ggaccagtta gaacccaaat caacaaaaag
     5041 agtctgccca agatcatctt gagaaaaatg gatgtgacag aagaaatttc aggtctctgg
     5101 aagcagtcac tgggcagagt ccacaccaca caagagcagg aggataatgc aatcaaagca
     5161 attatggaga ttccaaagga aacactgcag actgcagcag atggaactag gcttaccaga
     5221 cagccacaaa cacctaagga aaaagttcaa ccgctggaag atcacagtgt cttccaagaa
     5281 ctcttccaaa catcacgcta ctgttctgat ccattaattg gtaacaaaca aacaagaatg
     5341 tccttgagat ctccacaacc aggatttgtt agaactccac gaacctcaaa gagactggct
     5401 aagacaagtg ttgggaatat tgctgtgaga gaaaagatct ctccagtgag tctgccacag
     5461 tgtgctacag gggaggttgt acacataccc atagggccag aagatgacac agagaacaaa
     5521 ggtgtgaagg aatccacacc tcagacactg gactcatcag caagtcgaac tgtcagcaag
     5581 aggcagcaag gggcacatga ggaaaggcct cagttctcag gagacttatt tcatccccaa
     5641 gagctctttc aaacaccagc cagtggcaaa gacccagtaa ctgttgatga aactacaaaa
     5701 atagctctgc agtctccaca accaggacat atcataaacc cagcaagcat gaagagacag
     5761 tccaacatga gtctcaggaa agacatgaga gaattttcca tacttgaaaa acaaacacag
     5821 tcacgaggca gagacgcagg cacaccagca ccaatgcagg aagaaaatgg caccacagcc
     5881 attatggaaa caccaaagca gaaactggat ttcataggaa attcaacagg acataagagg
     5941 aggcctcgga cacccaaaaa cagggctcag cccctagaag acctggatgg cttccaagaa
     6001 ctctttcaaa caccagctgg tgccagtgac cctgtgagtg ttgaagaaag tgcaaagata
     6061 tctttggcat cttcacaagc agaaccagtc agaaccccag caagtacaaa gagacgctcc
     6121 aagacaggtc tcagtaaagt ggatgtgaga caagaacctt caacacttgg gaaaagaatg
     6181 aagtcactag gcagagcccc aggcacacca gcaccagtgc aggaagaaaa tgacagcaca
     6241 gccttcatgg aaactccaaa gcagaaactg gatttcacag gaaattcatc aggacataag
     6301 aggaggccac agacacctaa gatcagggct cagcccctag aagacctgga tggcttccaa
     6361 gaactcttcc aaacaccagc tggtgccaat gactcagtga ctgttgagga aagtgtaaag
     6421 atgtctttgg aatcttcaca agcagaacca gtcaaaaccc cggcaagcac aaagagactc
     6481 tccaagacag gtctcagtaa ggtggatgtg agagaagacc cttcaatact tgagaaaaaa
     6541 acaaagtcac caggcacacc agcaccagtg caggaagaaa atgactgcac agccttcatg
     6601 gaaactccaa agcagaaact ggatttcaca ggaaattcat caggacataa gaggaggcca
     6661 cggacaccta agatcagagc tcagccccta gaagacctgg atggcttcca agaactcttc
     6721 caaacaccag ctggtgctag tgactcagtg actgttgagg aaagtgcaaa gatgtctttg
     6781 gaatcttcac aagcaaaacc agtcaaaacc ccggcaagca caaagagact ctccaagaca
     6841 ggtctcagta aggtggatgt gagagaagac ccttcaacac ttgggaaaaa aacaaagtca
     6901 ccaggcagag ccccaggcac accagcacca gtgcaggaag aaaatgacag cacagccttc
     6961 atggaaactc caaagcagaa actggatttt gcagagaatt catcagggag taagagaagg
     7021 tcacgaacat ctaagaacag gtctcagccc ctagaagacc tggatggctt ccaagaactc
     7081 ttccaaacac cagctggtgc cagtaaccct gtgagtgttg aagaaagtgc aaagatatct
     7141 ttggaatctt cacaagcaga accagtcaga acccgggcaa gcacaaagag actttccaag
     7201 acaggtctca ataagatgga tgtgagagaa gggcactctc cgctcagtaa gtcaagctgt
     7261 gcatcacaga aagtcatgca aaccctcaca cttggagaag atcatggcag agagaccaaa
     7321 gatgggaagg tattgttagc tcagaaattg gaaccagcaa tatatgttac tcgtggcaag
     7381 aggcagcaaa ggtcatgtaa gaaaaggtcc cagtccccag aagacctctc tggtgttcag
     7441 gaggtcttcc aaacatcagg ccataacaag gattcagtga cagtggacaa tcttgcaaaa
     7501 ctgcccagct cgtctccacc actagagcca acagacactt cagtaacctc acggagacag
     7561 gccagaactg gtctgaggaa agttcacgtg aaaaatgaac tttcaggagg cataatgcat
     7621 ccacaaatat caggggaaat tgtggactta cctagagaac cagaaggtga aggcaaagtc
     7681 attaaaacaa ggaagcaatc tgtaaaacgg aaattggaca cagaagtcaa tgtgcctcgc
     7741 agtaagaggc aaagaattac aagagcagaa aagaccctag aggatctgcc tggcttccaa
     7801 gagctctgcc aagctccaag cttggtaatg gactcagtta ttgttgagaa aaccccaaag
     7861 atgcccgaca aatctccaga acctgtggat acaacttcag agacacaggc aagaagaaga
     7921 ctcaggagac tggttgttac tgaagagccc ataccacaaa gaaagactac aagagttgta
     7981 aggcaaacca gaaacacaca gaaagagccc ataagtgaca atcaaggtat ggaagagttt
     8041 aaggaatctt cagtacagaa acaagaccca agtgtaagtt taactggcag gaggaaccaa
     8101 ccaaggacag ttaaggagaa aacccaaccc ttagaagaac tcaccagttt ccaagaggaa
     8161 actgccaaaa gaatatcttc caaatctcca caaccggaag agaaggaaac cttagcaggt
     8221 ttaaagaggc agctcagaat acaactaatc aacgatggtg taaaagaaga gcccacagca
     8281 cagagaaagc aaccatccag ggaaaccagg aacacactca aagagcctgt aggtgacagt
     8341 ataaatgttg aagaggttaa gaagtctaca aagcagaaaa ttgatccagt agcaagtgtg
     8401 cctgtcagca agaggccacg gagggtaccc aaggaaaagg cacaggccct agaattggct
     8461 ggtctcaaag gaccaatcca aaccctaggc cacactgatg aatcagcaag tgataaagga
     8521 cccacacaga tgccctgtaa ttctctacaa ccagagcaag ttgacagctt ccaaagctca
     8581 ccaaggcgac ccaggacaag acgtgggaaa gtagaggcag atgaagagcc ttcagcagta
     8641 agaaagacag tatcaacatc aaggcaaact atgcgatccc gcaaggtccc tgaaattggt
     8701 aacaatggta cccaagtttc aaaggcctcc ataaagcaga cattagatac agtagccaaa
     8761 gtaactggca gcaggaggca gctaaggaca cataaggatg gggttcaacc tcttgaagtg
     8821 ttaggtgact ccaaagaaat aacccaaata tcagatcact ctgagaaact agcacatgac
     8881 accagtatcc ttaagagcac tcaacagcaa aagccagact cagtaaaacc tctgagaaca
     8941 tgcagaagag tgctgagggc ctctaaagag gaccccaagg aagtgttggt ggacaccaga
     9001 gaccatgcaa cattacaaag caaaagcaac cctttgctgt ccccgaagag gaagtctgca
     9061 agagatggaa gcattgtgag aaccagggct ttgcgctctt tagcaccaaa gcaggaagca
     9121 acagatgaga agcctgtacc tgagaaaaaa agggctgctt ccagcaagag gcatgtatca
     9181 cctgagcctg tgaagatgaa acacctgaaa atcgtgtcaa acaaacttga atctgtggaa
     9241 gagcaggtta gcactgttat gaaaacagaa gaaatggaag ccaaaagaga aaatcctgtc
     9301 actccagatc agaactctag gtaccgaaag aaaaccaatg taaaacagcc aaggcccaag
     9361 tttgatgcat ctgcagagaa tgtcgggata aagaaaaacg agaagactat gaagactgcc
     9421 tcccaggaga cagagctgca gaatccagat gatggagcca agaaatctac atctcggggc
     9481 caagtcagtg ggaaaagaac atgcttgagg tctagaggaa cgactgagat gccccagcct
     9541 tgtgaagcag aagagaaaac aagcaaacca gctgcagaaa tcttgataaa gcctcaggaa
     9601 gagaaaggag tctctggaga gtctgatgtt aggtgtttga ggtccagaaa aactagagtc
     9661 gctttggaca gtgaacctaa gccaagggta actcgtggaa ccaagaaaga tgcaaaaact
     9721 ctgaaggagg atgaagacat tgtatgcacc aagaagttaa gaacaagaag ttaagaacaa
     9781 gaagttacca gaaaagtgaa actatgtagc aaagacattt aagaaggaaa agtaaatttg
     9841 acttagtgat aagttccagt gtggttttca cctccagtgt aaagatgaac tgtaaatact
     9901 actgctactg cctgagttta aggaaggaag ctttgagctt tcctggtcat actctcttca
     9961 gacgccaatg gaggtcatga ggaagatcac cagggatctc agcgcaatta cagtttaggg
    10021 gtgagcaggc agaaatgtgg ccctctgtcc tatccaataa agctctgaaa ttcgcaaaaa
    10081 aaaaaaaaaa aaaaaaaa
//
