LOCUS       NM_013729               2294 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus Mix paired-like homeobox (Mixl1), mRNA.
ACCESSION   NM_013729
VERSION     NM_013729.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2294)
  AUTHORS   Chen,S., Hayoun-Neeman,D., Nagar,M., Pinyan,S., Hadad,L.,
            Yaacobov,L., Alon,L., Shachar,L.E., Swissa,T., Kryukov,O.,
            Gershoni-Yahalom,O., Rosental,B., Cohen,S. and Lichtenstein,R.G.
  TITLE     Terminal alpha1,2-fucosylation of glycosphingolipids by FUT1 is a
            key regulator in early cell-fate decisions
  JOURNAL   EMBO Rep 25 (10), 4433-4464 (2024)
   PUBMED   39256596
REFERENCE   2  (bases 1 to 2294)
  AUTHORS   Miura,A., Sarmah,H., Tanaka,J., Hwang,Y., Sawada,A., Shimamura,Y.,
            Otoshi,T., Kondo,Y., Fang,Y., Shimizu,D., Ninish,Z., Suer,J.L.,
            Dubois,N.C., Davis,J., Toyooka,S., Wu,J., Que,J., Hawkins,F.J.,
            Lin,C.S. and Mori,M.
  TITLE     Conditional blastocyst complementation of a defective Foxa2 lineage
            efficiently promotes the generation of the whole lung
  JOURNAL   Elife 12, e86105 (2023)
   PUBMED   37861292
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2294)
  AUTHORS   Hernandez-Martinez,R., Ramkumar,N. and Anderson,K.V.
  TITLE     p120-catenin regulates WNT signaling and EMT in the mouse embryo
  JOURNAL   Proc Natl Acad Sci U S A 116 (34), 16872-16881 (2019)
   PUBMED   31371508
REFERENCE   4  (bases 1 to 2294)
  AUTHORS   Wymeersch,F.J., Skylaki,S., Huang,Y., Watson,J.A., Economou,C.,
            Marek-Johnston,C., Tomlinson,S.R. and Wilson,V.
  TITLE     Transcriptionally dynamic progenitor populations organised around a
            stable niche drive axial patterning
  JOURNAL   Development 146 (1) (2019)
   PUBMED   30559277
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2294)
  AUTHORS   Acharya,D., Nera,B., Milstone,Z.J., Bourke,L., Yoon,Y.,
            Rivera-Perez,J.A., Trivedi,C.M. and Fazzio,T.G.
  TITLE     TIP55, a splice isoform of the KAT5 acetyltransferase, is essential
            for developmental gene regulation and organogenesis
  JOURNAL   Sci Rep 8 (1), 14908 (2018)
   PUBMED   30297694
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2294)
  AUTHORS   Hart,A.H., Hartley,L., Sourris,K., Stadler,E.S., Li,R.,
            Stanley,E.G., Tam,P.P., Elefanty,A.G. and Robb,L.
  TITLE     Mixl1 is required for axial mesendoderm morphogenesis and
            patterning in the murine embryo
  JOURNAL   Development 129 (15), 3597-3608 (2002)
   PUBMED   12117810
  REMARK    GeneRIF: required for the morphogenesis of axial mesoderm, the
            heart and the gut during embryogenesis
REFERENCE   7  (bases 1 to 2294)
  AUTHORS   Sahr,K., Dias,D.C., Sanchez,R., Chen,D., Chen,S.W., Gudas,L.J. and
            Baron,M.H.
  TITLE     Structure, upstream promoter region, and functional domains of a
            mouse and human Mix paired-like homeobox gene
  JOURNAL   Gene 291 (1-2), 135-147 (2002)
   PUBMED   12095687
REFERENCE   8  (bases 1 to 2294)
  AUTHORS   Robb,L., Hartley,L., Begley,C.G., Brodnicki,T.C., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Elefanty,A.G.
  TITLE     Cloning, expression analysis, and chromosomal localization of
            murine and human homologues of a Xenopus mix gene
  JOURNAL   Dev Dyn 219 (4), 497-504 (2000)
   PUBMED   11084649
REFERENCE   9  (bases 1 to 2294)
  AUTHORS   Russ,A.P., Wattler,S., Colledge,W.H., Aparicio,S.A., Carlton,M.B.,
            Pearce,J.J., Barton,S.C., Surani,M.A., Ryan,K., Nehls,M.C.,
            Wilson,V. and Evans,M.J.
  TITLE     Eomesodermin is required for mouse trophoblast development and
            mesoderm formation
  JOURNAL   Nature 404 (6773), 95-99 (2000)
   PUBMED   10716450
REFERENCE   10 (bases 1 to 2294)
  AUTHORS   Pearce,J.J. and Evans,M.J.
  TITLE     Mml, a mouse Mix-like gene expressed in the primitive streak
  JOURNAL   Mech Dev 87 (1-2), 189-192 (1999)
   PUBMED   10495285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC099877.1 and AC167020.3.
            
            On May 1, 2009 this sequence version replaced NM_013729.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF154573.1, AF201959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-818               BC099877.1         1-818
            819-2294            AC167020.3         130493-131968       c
FEATURES             Location/Qualifiers
     source          1..2294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.46 cM"
     gene            1..2294
                     /gene="Mixl1"
                     /gene_synonym="Mm1; Mml"
                     /note="Mix paired-like homeobox"
                     /db_xref="GeneID:27217"
                     /db_xref="MGI:MGI:1351322"
     exon            1..415
                     /gene="Mixl1"
                     /gene_synonym="Mm1; Mml"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..718
                     /gene="Mixl1"
                     /gene_synonym="Mm1; Mml"
                     /note="mMix; homeodomain protein MIX; mix.1 homeobox-like
                     protein; MIX1 homeobox-like protein 1; Mix1 homeobox-like
                     1"
                     /codon_start=1
                     /product="homeobox protein MIXL1"
                     /protein_id="NP_038757.1"
                     /db_xref="CCDS:CCDS15571.1"
                     /db_xref="GeneID:27217"
                     /db_xref="MGI:MGI:1351322"
                     /translation="MAAAGSQQLQFAEGAAFPIFPAAHPGGQLLPAMRPASGLPAAPH
                     DSRAPAATQCFPNRDSSPTAQTPAGLDPPGPSKGSAAPSAPQRRKRTSFSSEQLQLLE
                     LVFRQTMYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQSGKSFQPLSSRRGVFL
                     HCPAPGTEARCLKPQLPLEADVNHVPDPSMTGGGVCTSGSQSFETYSSLSEDIGSKLD
                     SWEEHIFSALGNF"
     exon            416..2294
                     /gene="Mixl1"
                     /gene_synonym="Mm1; Mml"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacagggaag cgtccgggag tcatggccgc agcagggtcc cagcagctcc agttcgcaga
       61 aggcgccgct ttccccatct tccccgccgc gcatcccgga gggcagctgc tcccagccat
      121 gcgcccagcc tctgggctgc ccgcggcgcc ccacgactct cgcgccccag cagccacgca
      181 gtgctttcca aaccgcgact ccagtcccac agcgcagacc cccgccggcc tggatccgcc
      241 cggaccctcc aaaggctcgg ccgccccgtc ggcgccacag cgccgcaagc gcacgtcgtt
      301 cagctcggag cagctgcagt tgctggagct cgtcttccga cagaccatgt acccagacat
      361 ccacttgcgg gagcgcctgg ctgcgctcac gctgctaccc gagtccagga tccaggtgtg
      421 gttccagaac cgacgggcca agtccaggcg ccagagtggg aagtcatttc agcccttatc
      481 ctcaaggcgg ggagttttcc tccattgccc tgctcctggg actgaagcta ggtgtttgaa
      541 gcctcagctg cccctggagg cagatgtgaa ccacgttccg gatcccagca tgactggagg
      601 aggcgtctgc acatctggtt ctcagagttt tgaaacgtat tcgtctctct ctgaagatat
      661 tggctcaaag ttggactcct gggaggagca catcttttct gccttaggta acttctgagg
      721 attctgggag cgttgaggat gcactcaggg agatctggga gattggagct gatctcctga
      781 ctggccatgg cctcggttct ggatcatctc tcacattttg gttcccttct ctgacactga
      841 gcctttactg ctggcttgtt ctcggtagcc accgaaaagt caccgtgact ctccaagact
      901 gcacattata atttggtccg catcccctgg gccttcttac tagggttatt cctatttttc
      961 agactgattg ttcagaactt gttttcttca taagaacctt cggcttgact cagtttcccc
     1021 actttctcgg cagctgctgt cttcttgtag tcctagttgt aagtgggttc acacactcta
     1081 tcccacatcc tgtactctgg actcatcacc aagactcatt actctttttc actgagtctt
     1141 tttgttttgt tcttgacctt gctgtgtaag gaaggaaaga tgcctcaaac tcctgtcctc
     1201 ctagctttat ttgccaccat aactggatgc tgcttttttt tttttttttt ttgcttaaaa
     1261 atgtatatgg tattaacata tatctccaaa ataatggatg tcaatatttt tgtttaaaat
     1321 tttatatggt attaacatac atacccaaat caaactgctt aacacatgca tgacatcact
     1381 cacctttctt tgttctgtga tgatataatc tattagcaat tttcaagtat atgaaatgta
     1441 gatattaact atagccatct ccatcgagtt tttcagcttc tctctcccag ctgactgtgt
     1501 atcctagcca cctcccctgc cctcacttga ctggtttctc atctggcctg tcagctagac
     1561 gctccctcag taacaacgct actttccagc tctttcaaga gccccatgcc tcttgttccc
     1621 cacttttttg ttttgttttt aattactcca tttggaagtc tgtggcagct tccagttaac
     1681 caaactgtaa gaccctgtca agcacgctca cagtcaatgc catcatcttt agcttatgca
     1741 aaccttaaga tcatttaccc aaaatgtgct tctctgtctg tcattccttt ctggttggga
     1801 ctcagtgaaa aagtttctct ttcaaaacag ctcaggaaac agcttccctt tctgaagcct
     1861 gaacttttcg taagtaatct taatttttgt acctgttact tggaccacca tttttcttag
     1921 cacttgttat tatgtttcct gtgcaacatt agtgggttac tgtttctcac tactcttcat
     1981 acataaatcc cattgaagtg agctctgttt tgaattgaac cctgttgtcc cagacctcag
     2041 tgctgggaaa gttggggagt acacaatgaa tgagaaaaca ttccgaagta agcttacttg
     2101 ctgggctgct aagatggctc agtggaggca gacacatgac caccaggcct gacaacctga
     2161 gtttgatccc caagacccac atggtggatg ggagaacggg tttctttaag ttgtcttttt
     2221 gacttccata tgtgtggtat ggtgtgcacc cacataagta cacacataca aaataaatag
     2281 attaaagaaa aaaa
//
