LOCUS       NM_172578               4026 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus MIS18 binding protein 1 (Mis18bp1), transcript variant
            1, mRNA.
ACCESSION   NM_172578
VERSION     NM_172578.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4026)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4026)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4026)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4026)
  AUTHORS   Naiman,N., Fujioka,K., Fujino,M., Valerius,M.T., Potter,S.S.,
            McMahon,A.P. and Kobayashi,A.
  TITLE     Repression of Interstitial Identity in Nephron Progenitor Cells by
            Pax2 Establishes the Nephron-Interstitium Boundary during Kidney
            Development
  JOURNAL   Dev Cell 41 (4), 349-365 (2017)
   PUBMED   28535371
REFERENCE   5  (bases 1 to 4026)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   6  (bases 1 to 4026)
  AUTHORS   Kim,I.S., Lee,M., Park,K.C., Jeon,Y., Park,J.H., Hwang,E.J.,
            Jeon,T.I., Ko,S., Lee,H., Baek,S.H. and Kim,K.I.
  TITLE     Roles of Mis18alpha in epigenetic regulation of centromeric
            chromatin and CENP-A loading
  JOURNAL   Mol Cell 46 (3), 260-273 (2012)
   PUBMED   22516971
REFERENCE   7  (bases 1 to 4026)
  AUTHORS   Dambacher,S., Deng,W., Hahn,M., Sadic,D., Frohlich,J., Nuber,A.,
            Hoischen,C., Diekmann,S., Leonhardt,H. and Schotta,G.
  TITLE     CENP-C facilitates the recruitment of M18BP1 to centromeric
            chromatin
  JOURNAL   Nucleus 3 (1), 101-110 (2012)
   PUBMED   22540025
  REMARK    GeneRIF: CENP-C works as an important factor for centromeric M18BP1
            recruitment
REFERENCE   8  (bases 1 to 4026)
  AUTHORS   Qiu,H., Nomiyama,R., Moriguchi,K., Fukada,T. and Sugimoto,K.
  TITLE     Identification of novel nuclear protein interactions with the
            N-terminal part of filamin A
  JOURNAL   Biosci Biotechnol Biochem 75 (1), 145-147 (2011)
   PUBMED   21228480
REFERENCE   9  (bases 1 to 4026)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   10 (bases 1 to 4026)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159885.2 and AC159621.2.
            
            On Mar 29, 2023 this sequence version replaced NM_172578.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052175.1, SRR17253012.7213828.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC159885.2         165941-166081
            142-767             AC159621.2         1177-1802
            768-1234            AC159621.2         4344-4810
            1235-1308           AC159621.2         6140-6213
            1309-1439           AC159621.2         8356-8486
            1440-1527           AC159621.2         9312-9399
            1528-1670           AC159621.2         10375-10517
            1671-2499           AC159621.2         13655-14483
            2500-2669           AC159621.2         19813-19982
            2670-2827           AC159621.2         22315-22472
            2828-2979           AC159621.2         24409-24560
            2980-3079           AC159621.2         26356-26455
            3080-3134           AC159621.2         29347-29401
            3135-4026           AC159621.2         29580-30471
FEATURES             Location/Qualifiers
     source          1..4026
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 27.21 cM"
     gene            1..4026
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /note="MIS18 binding protein 1"
                     /db_xref="GeneID:217653"
                     /db_xref="MGI:MGI:2145099"
     exon            1..141
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            142..767
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..3229
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinetochore-associated protein KNL-2 homolog;
                     mis18-binding protein 1"
                     /codon_start=1
                     /product="mis18-binding protein 1 isoform 1"
                     /protein_id="NP_766166.2"
                     /db_xref="CCDS:CCDS25942.1"
                     /db_xref="GeneID:217653"
                     /db_xref="MGI:MGI:2145099"
                     /translation="MIVTPLKHSGIHLSSGTLQRRNMPLDAVFIDSIPSGTLTPLKDL
                     VKYQKSSLKVNGHKKNQLLEIRTSNNKDLFQSTMLSEATLPNSSLDISVIKPSMDRLR
                     NEMIYESPGKIFQRMKAKVQRDKQEQLTRSSSMLGSPQGEHTKDFPPNTDKKAQLQQT
                     YICEEKQTSVQSNDPSLGDPPILNQEQKNVSASCISKKALTRAQFGGQVLHSKESPVR
                     ITVSKKNTFVLGGIDCTYEKFENTDVNTISSLCVPIKNHSQSITSDNDVTTERTAKED
                     ITEPNEEMMSRRTILQDPIKNTSKIKRSSPRPNLTLSGRSQRKCTKLETVVKEVKKYQ
                     AVHLQEWMIKVINNNTAICVEGKLVDMTDVYWHSNVIIERIKHNELRTLSGNIYILKG
                     LIDSVSMKEAGYPCYLTRKFMFGFPHNWKEHIDKFLEQLRAEKKNKTRQETARVQEKQ
                     KSKKKDAEDKETYVLQKASITYDLNDNSLERTEVPTDPLNSLEQPTSGKERRHPLLSQ
                     KRAYVLITPLRNKKLIEQRCIDYSLSIEGISDFFKAKHQEESDSDIHGTPSSTSKSQE
                     TFEHRVGFEGNTKEDCNECDIITARHIQIPCPKSKQMLTNDFMKKNKLPSKLQKTENQ
                     IGVSQYCRSSSHLSSEENEVEIKSRTRARNTKERLNRERENTNHITKDILLISETEGE
                     RACYITPKRPRSCYITPKRPRSSAKESHYKSAVSKDFLTEGKASDRTSRQLLDHLPGL
                     TDDEEWSEQELQKLHCAFTSLPKHKPGFWSDVAMAVGSRTADECQKKYTEEPQGQGSR
                     KHGSKKKQANKVQNGEKDSADAKTIKITAKVGTLKRKRQMRDCLEHLAKDNHDDFFTA
                     TPLQKQRIQLPSFQYSQDDDFLLDMDRDPASPSSIITSPLRSTTPQCQHFSPSMLAAI
                     ERNNCDRYVYQMQKNAKKYGKSNGGLVWGNIRKKTVKTDLSSPPPTRKALFNKDLGKN
                     TDISKYFIDDTESDEEEKDYYFSNSD"
     exon            768..1234
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1308
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1439
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1527
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1670
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..2499
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2669
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2827
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2979
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3079
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3134
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..4026
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4004..4009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /note="hexamer: AATAAA"
     polyA_site      4026
                     /gene="Mis18bp1"
                     /gene_synonym="6720403H11; Knl2; mKIAA1903"
                     /note="major polyA site"
ORIGIN      
        1 gtccgtgctg gggaagtgga cgaggaaggc gagcggagtt tcagtctgcg gacacgcgtg
       61 gagcccttgc ccgggcctcc gtgggtctga ggcgctgcga gccctgggta accacggcct
      121 cgagctgctg tcctcaccaa ggtttctctg gactccttct gaagttctgt ctgaaatttt
      181 gtgttgaatg aattttctat aaaaagaatt ttgttgccac tctcctatca agatgattgt
      241 aacacctttg aagcattcag gaattcattt gtcttctgga acattgcaaa gaagaaatat
      301 gcctctagat gcagtcttta ttgacagcat cccttcaggc acactcactc ctttgaaaga
      361 tttggtaaaa tatcagaagt cctctctaaa agttaatggt cataaaaaga atcagttatt
      421 agaaataaga acttctaaca ataaagatct atttcaatcc accatgttat cagaggctac
      481 ccttccaaac agctctcttg atatcagtgt tataaagccc agcatggata gattaagaaa
      541 tgaaatgatt tatgaatcac caggtaaaat ctttcaaaga atgaaagcaa aagtacagcg
      601 tgacaaacaa gaacaactga caaggagcag tagcatgttg ggatcaccac agggtgaaca
      661 caccaaagac tttcctccta acacggataa gaaagctcag ttgcaacaaa cctatatctg
      721 tgaggaaaaa caaacgtcgg tccaatccaa tgacccttca ttgggagatc ctccaattct
      781 gaaccaagaa caaaaaaatg tttcagcttc gtgcatttca aagaaggcat taactagagc
      841 ccagtttggc ggacaagttc ttcattcaaa agagagtcct gttaggatca ctgtgtccaa
      901 aaagaacaca tttgttttgg gaggcattga ttgtacttat gaaaagtttg aaaatactga
      961 tgttaacacc attagttctc tttgtgttcc tattaagaat catagccaat ctattacttc
     1021 tgataatgat gtgacaacag aaaggactgc aaaagaggat attacagaac caaatgaaga
     1081 gatgatgtcc agaagaacta ttcttcaaga tcccataaag aatacatcta aaattaaacg
     1141 ttcaagtcca agacctaatt taacactatc tggccggtct caaagaaaat gtacaaagct
     1201 tgaaactgtt gtaaaagaag taaaaaaata tcaggcagtc cacctacagg aatggatgat
     1261 taaagtcatc aataataata ctgctatatg tgtagaagga aagctggtag atatgactga
     1321 tgtttattgg catagcaatg taattataga gcggattaaa cacaatgaac ttaggacctt
     1381 atcaggcaac atttatatct taaaaggatt gatagactcg gtctccatga aagaagcagg
     1441 atatccctgt tatctcacaa gaaaatttat gtttggattt ccccacaact ggaaggaaca
     1501 cattgataaa tttctagaac aattaagggc tgaaaaaaag aacaagacca gacaggaaac
     1561 agcaagagtc caagaaaaac aaaaatcaaa aaaaaaagat gcagaagata aagaaactta
     1621 tgtcctccaa aaggccagca tcacgtatga ccttaatgat aatagcttag agagaactga
     1681 agtacccact gatcccttga actcactgga acagcctacc tccggcaaag aaagaagaca
     1741 cccgcttctc agtcagaaga gagcttatgt tttaataaca ccacttagaa acaaaaagtt
     1801 gatagagcaa agatgtatag actacagtct ctctattgaa ggaatatcgg actttttcaa
     1861 agcaaagcat caagaagaaa gtgactcaga tatacatgga actccaagtt ctaccagtaa
     1921 gtctcaagag acctttgaac atagagtggg atttgaaggc aataccaagg aggactgcaa
     1981 tgaatgtgac ataatcactg ccagacatat tcagatacct tgcccgaaaa gtaaacaaat
     2041 gctcaccaat gattttatga aaaagaacaa gttgccctca aaactgcaga aaactgaaaa
     2101 tcaaataggt gtatcacagt attgccggtc ctcatcacat ttgtcaagtg aagagaatga
     2161 agtagaaatt aaaagtagaa ccagagcaag aaatacaaaa gaaaggctga atcgggagag
     2221 agaaaacaca aaccacatca caaaagatat cctcctcatt tcagaaactg aaggtgagag
     2281 agcttgttat atcacaccaa agagacctcg atcttgttat atcacaccaa agagacctcg
     2341 atcttctgct aaagagtcac attacaaatc tgctgttagc aaggactttc tcactgaagg
     2401 aaaggcatct gatagaacta gcagacagct gttagaccat ctacctggtt taactgatga
     2461 tgaagaatgg agtgagcaag agttacagaa gctacattgt gcttttacat ctcttccaaa
     2521 gcacaaacct ggcttttggt cagatgtggc tatggcagta ggttctcgaa ctgctgatga
     2581 gtgccagaag aaatacacag aagaacccca aggccaagga tcccgaaaac atggctctaa
     2641 gaaaaagcaa gccaacaagg tccaaaatgg tgagaaagac agtgctgatg ccaagactat
     2701 taagataact gccaaagtgg gaactcttaa aaggaaacga caaatgaggg attgcctaga
     2761 acatttggca aaagacaacc atgatgattt tttcactgca acacccttgc agaaacaaag
     2821 aattcagttg ccaagttttc aatacagtca agatgatgat tttctgctag atatggacag
     2881 ggatccagca tctccatcat caattattac ttcaccattg agaagcacta ctccacaatg
     2941 tcagcatttc agccccagca tgctagccgc tatagaaagg aataattgtg atagatatgt
     3001 ttaccaaatg caaaaaaatg ctaaaaaata tggcaagagt aatggtggcc ttgtctgggg
     3061 caacattagg aaaaaaacag ttaaaactga tctctcatct ccaccaccaa cacggaaagc
     3121 cctgtttaac aaagatttag gtaaaaacac tgatatttca aagtatttca ttgatgatac
     3181 agaatcagat gaagaagaga aagattatta cttttccaat tctgactgat agacgacttg
     3241 caggaatttt accatcaagc agaatatact tttatcctca ttgatgacta ttttctttgt
     3301 aataagggaa tgcagatttg tttcccaatg tcttatgttt gtatgcaccc tatagagcat
     3361 tcctcagaac tacagcttac aaatactttg cctatgtgtg catttgtaaa ttttatgttt
     3421 gtaatattaa agtatataaa gttcagtctc ttgagaacat ccaagcctgt tttctttagt
     3481 aatcatgtct caagtagaat tttaattgaa cttttaaaag gaggccttaa atgaggagag
     3541 gtaaggggcc agagttaaga ttgtggactg gaagatacta gaatgaaaac ttttagcatc
     3601 atgcagcctg aaattacaag ccagggttcc ttctgtttaa attatgtcat tcaaactgtt
     3661 ttacctggtt tttatgtttt acctgctttc tcttctgata gtttttctta aattttttac
     3721 tgtatgttgg tctgtttgtg aaaacttcac ctctaattca ttgttcttta ttattttata
     3781 aagaaagctg tggacaggtt ctgttgtatt cttcagccct gctatatcta tctgatagat
     3841 ccacccttac aaggacttac aatgccataa tgagcagggt ttccctttct taccgcttca
     3901 aaaggtaact tgccttctgc cgttgtttta acatttcccc taagttattt gtcctctgct
     3961 atagtagtat tcatccaccc tttaaatcta gttagactgc gcaaataaaa atgtacattt
     4021 gtgaaa
//
