LOCUS       NM_025642               1300 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus MIS18 kinetochore protein A (Mis18a), mRNA.
ACCESSION   NM_025642 XM_619410
VERSION     NM_025642.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1300)
  AUTHORS   Das,A., Boese,K.G., Tachibana,K., Baek,S.H., Lampson,M.A. and
            Black,B.E.
  TITLE     Centromere-specifying nucleosomes persist in aging mouse oocytes in
            the absence of nascent assembly
  JOURNAL   Curr Biol 33 (17), 3759-3765 (2023)
   PUBMED   37582374
REFERENCE   2  (bases 1 to 1300)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1300)
  AUTHORS   Park,K.C., Lee,M., Jeon,Y., Jeon,R., Baek,S.H., Lee,H. and Kim,K.I.
  TITLE     Skin-Specific Deletion of Mis18alpha Impedes Proliferation and
            Stratification of Epidermal Keratinocytes
  JOURNAL   J Invest Dermatol 137 (2), 414-421 (2017)
   PUBMED   27670610
  REMARK    GeneRIF: Mis18alpha is important for epidermal cell proliferation
            and stratification, because it is required for the deposition of
            CENP-A at the centromeric nucleosomes.
REFERENCE   4  (bases 1 to 1300)
  AUTHORS   Kim,I.S., Lee,M., Park,K.C., Jeon,Y., Park,J.H., Hwang,E.J.,
            Jeon,T.I., Ko,S., Lee,H., Baek,S.H. and Kim,K.I.
  TITLE     Roles of Mis18alpha in epigenetic regulation of centromeric
            chromatin and CENP-A loading
  JOURNAL   Mol Cell 46 (3), 260-273 (2012)
   PUBMED   22516971
  REMARK    GeneRIF: Mis18alpha interacts with DNMT3A/3B, and this interaction
            is critical for maintaining DNA methylation and hence regulating
            epigenetic states of centromeric chromatin.
REFERENCE   5  (bases 1 to 1300)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
REFERENCE   6  (bases 1 to 1300)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   7  (bases 1 to 1300)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   8  (bases 1 to 1300)
  AUTHORS   Akeson,E.C., Lambert,J.P., Narayanswami,S., Gardiner,K.,
            Bechtel,L.J. and Davisson,M.T.
  TITLE     Ts65Dn -- localization of the translocation breakpoint and trisomic
            gene content in a mouse model for Down syndrome
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 270-276 (2001)
   PUBMED   11528125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012533.1.
            
            On Jul 17, 2005 this sequence version replaced XM_619410.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012533.1, AK163310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1300              AK012533.1         2-1301
FEATURES             Location/Qualifiers
     source          1..1300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 51.87 cM"
     gene            1..1300
                     /gene="Mis18a"
                     /gene_synonym="2610039C10Rik; 2810018N07Rik"
                     /note="MIS18 kinetochore protein A"
                     /db_xref="GeneID:66578"
                     /db_xref="MGI:MGI:1913828"
     exon            1..346
                     /gene="Mis18a"
                     /gene_synonym="2610039C10Rik; 2810018N07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..714
                     /gene="Mis18a"
                     /gene_synonym="2610039C10Rik; 2810018N07Rik"
                     /note="MIS18 kinetochore protein homolog A"
                     /codon_start=1
                     /product="protein Mis18-alpha"
                     /protein_id="NP_079918.1"
                     /db_xref="CCDS:CCDS28316.1"
                     /db_xref="GeneID:66578"
                     /db_xref="MGI:MGI:1913828"
                     /translation="MSSESPLLEKRLSEDSSRYLRLQKWANMSSADALGLEKERPEEK
                     AAAAENPLVFLCARCRRPLGDSLTWVASQEDTNCILLRSVSCNVSVDKEPKLSKCRDE
                     DGCILEALYCTGCSLSLGYVYRCTPKNLDYKRDLFCLSVEAVESYTLGSSEKQIVSED
                     KELFNLESRVEIEKSIKQMEEVLTALQKKLREVESKLSLASRGS"
     exon            347..413
                     /gene="Mis18a"
                     /gene_synonym="2610039C10Rik; 2810018N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            414..536
                     /gene="Mis18a"
                     /gene_synonym="2610039C10Rik; 2810018N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            537..633
                     /gene="Mis18a"
                     /gene_synonym="2610039C10Rik; 2810018N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            634..1300
                     /gene="Mis18a"
                     /gene_synonym="2610039C10Rik; 2810018N07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1271..1276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mis18a"
                     /gene_synonym="2610039C10Rik; 2810018N07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1295
                     /gene="Mis18a"
                     /gene_synonym="2610039C10Rik; 2810018N07Rik"
                     /note="major polyA site"
ORIGIN      
        1 attcccgtga ggttccgggg cgcggcaaat tcgtatgtca tggctgcttc ctggtctctg
       61 ggatgttcct tgaccgcttg tggttaaaac cgcctggcta tgtcgagcga gtcccccctg
      121 ctggagaagc gtctgtcgga agactcgagc cgctacctgc ggctgcagaa gtgggcaaac
      181 atgtcgagcg cagacgcgtt agggctagag aaggaacggc ctgaggagaa ggcggccgcg
      241 gcggagaacc cgctggtgtt cctttgtgcc cgctgtcgcc ggccactggg cgactcgctc
      301 acctgggtgg ccagccagga ggacaccaac tgcatcctgt tgcgcagcgt ctcctgtaac
      361 gtctctgtgg ataaggaacc gaaactgtcc aagtgcagag atgaagacgg ttgcatcctt
      421 gaggcgctgt actgcacggg ctgctccctc agccttggct atgtgtacag atgcactcct
      481 aagaacctgg actacaagcg cgacttgttc tgcctcagcg ttgaagccgt tgaaagttac
      541 accttagggt cctctgagaa gcaaatcgtg tcagaagaca aggagctttt caaccttgaa
      601 agccgagttg aaatagagaa gtctataaag cagatggaag aagtcctgac agccctgcaa
      661 aagaagctac gggaagttga atctaaactg tccttggcca gccggggcag ctgagctgtg
      721 tcccatccgc caccatgccc caccctcatt cctaacaaac tctttctctg cctttaattt
      781 agggtaagag gtaaccgttt cccgtgtttg aattataagg ccagtttatg ggattttaat
      841 gttttaattt taattaaaag accagggtga ttttctgtct tctttttcta ttaaatttgt
      901 tgtttgtatg tatgtatgtg catgtatgta tatatgtatg tatttttata tcttttaaaa
      961 actttgttac ttttaatact ttgagtactt aagagtagag agaaaaatct tgttttaccc
     1021 ttgaaaatta gtgcttaagc ctctctggaa aaattgtcag ttgacttgtt agaatgattt
     1081 aaatttgtgt aaagtatcat tgtgtcatga gacccccatt ttgctgtgtg ctacttcatg
     1141 cttaaagagt ctggaggcta ctcaaccgat agtgcactct ctgggtaaga tattagtgga
     1201 ctgtatttag atttagattt tctataatgc aataccttta taaggaatgt attcattttt
     1261 ataataagag aataaagaat tcaaaagtgc ttgaacgttc
//
