LOCUS       NP_001157842             379 aa            linear   ROD 14-FEB-2025
DEFINITION  mirror-image polydactyly gene 1 protein homolog isoform 2 [Mus
            musculus].
ACCESSION   NP_001157842
VERSION     NP_001157842.1
DBSOURCE    REFSEQ: accession NM_001164370.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 379)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 379)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (residues 1 to 379)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (residues 1 to 379)
  AUTHORS   Cheung,A.K., Lung,H.L., Ko,J.M., Cheng,Y., Stanbridge,E.J.,
            Zabarovsky,E.R., Nicholls,J.M., Chua,D., Tsao,S.W., Guan,X.Y. and
            Lung,M.L.
  TITLE     Chromosome 14 transfer and functional studies identify a candidate
            tumor suppressor gene, mirror image polydactyly 1, in
            nasopharyngeal carcinoma
  JOURNAL   Proc Natl Acad Sci U S A 106 (34), 14478-14483 (2009)
   PUBMED   19667180
REFERENCE   5  (residues 1 to 379)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   6  (residues 1 to 379)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (residues 1 to 379)
  AUTHORS   Kondoh,S., Sugawara,H., Harada,N., Matsumoto,N., Ohashi,H.,
            Sato,M., Kantaputra,P.N., Ogino,T., Tomita,H., Ohta,T., Kishino,T.,
            Fukushima,Y., Niikawa,N. and Yoshiura,K.
  TITLE     A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a
            patient with mirror-image polydactyly of hands and feet
  JOURNAL   J Hum Genet 47 (3), 136-139 (2002)
   PUBMED   11954550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124486.4 and AC122307.4.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077915.1, SRR13422597.1358927.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 24.7 cM"
     Protein         1..379
                     /product="mirror-image polydactyly gene 1 protein homolog
                     isoform 2"
                     /note="mirror-image polydactyly gene 1 protein homolog;
                     mirror-image polydactyly gene 1 homolog"
                     /calculated_mol_wt=43374
     Region          <74..>373
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..379
                     /gene="Mipol1"
                     /gene_synonym="1700081O04Rik; 6030439O22Rik; D12Ertd19e"
                     /coded_by="NM_001164370.2:261..1400"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:73490"
                     /db_xref="MGI:MGI:1920740"
ORIGIN      
        1 mnseqsirel gnevpsedle lpgrkpsnfq vlqpcrdega saecsivecg knyepvishq
       61 vipdlnkets vaylqkelei lrasntklqe klakedkekr rlklklelqe kaaeadiaer
      121 taalveevyf aqrerdeaim crlqlalker deaiahvkhm emslkmleni npeendmtlq
      181 ellnrinnad tgiaiqknga vivdtiyktk ecrkritaee msavleerda alsqckrlhq
      241 elhrlkeqnq tsanntrrpt aennqeralk akllsmqqar etaveqykrl eeeiqtlrvy
      301 yslhkslsqe eslkdqfnha lstyeealkn resvvsitqq qneelatqlq qaltehshme
      361 lqlqcaveas qaanekvqk
//
