LOCUS       NM_027436               2423 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial intermediate peptidase (Mipep),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_027436 XM_914415 XM_923236
VERSION     NM_027436.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2423)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2423)
  AUTHORS   Kobayashi,M., Takeda,K., Narita,T., Nagai,K., Okita,N., Sudo,Y.,
            Miura,Y., Tsumoto,H., Nakagawa,Y., Shimano,H. and Higami,Y.
  TITLE     Mitochondrial intermediate peptidase is a novel regulator of
            sirtuin-3 activation by caloric restriction
  JOURNAL   FEBS Lett 591 (24), 4067-4073 (2017)
   PUBMED   29151261
  REMARK    GeneRIF: MIPEP may contribute to the maintenance of mitochondrial
            quality during caloric restriction (CR) via activation of SIRT3.
            This novel mechanism of SIRT3 activation through MIPEP facilitates
            the elucidation of additional molecular pathways of CR.
REFERENCE   3  (bases 1 to 2423)
  AUTHORS   Gomez-Del Arco,P., Perdiguero,E., Yunes-Leites,P.S., Acin-Perez,R.,
            Zeini,M., Garcia-Gomez,A., Sreenivasan,K., Jimenez-Alcazar,M.,
            Segales,J., Lopez-Maderuelo,D., Ornes,B., Jimenez-Borreguero,L.J.,
            D'Amato,G., Enshell-Seijffers,D., Morgan,B., Georgopoulos,K.,
            Islam,A.B., Braun,T., de la Pompa,J.L., Kim,J., Enriquez,J.A.,
            Ballestar,E., Munoz-Canoves,P. and Redondo,J.M.
  TITLE     The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle
            Identity and Metabolic Homeostasis
  JOURNAL   Cell Metab 23 (5), 881-892 (2016)
   PUBMED   27166947
REFERENCE   4  (bases 1 to 2423)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA460475.1, AK017491.1, AI606287.1 and BE995975.1.
            
            On Nov 15, 2007 this sequence version replaced NM_027436.2.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110358.1, AK038479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                CA460475.1         38-62
            26-2403             AK017491.1         2-2379
            2404-2405           AI606287.1         1-2                 c
            2406-2423           BE995975.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2423
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 31.95 cM"
     gene            1..2423
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /note="mitochondrial intermediate peptidase"
                     /db_xref="GeneID:70478"
                     /db_xref="MGI:MGI:1917728"
     exon            1..305
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            306..479
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            480..568
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            569..655
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            656..719
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            720..902
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1059
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1108
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1169
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1222
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1376
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1454
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1659
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1769
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1844
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1964
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2086
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2160
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2406
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2382..2387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /note="hexamer: AATAAA"
     polyA_site      2404
                     /gene="Mipep"
                     /gene_synonym="5730405E07Rik; MIP"
                     /note="major polyA site"
ORIGIN      
        1 cttcctaacg attgttagcg tgctcaagtc cgggtctgcc ctgcgagttc cgcggcgtgg
       61 gctgctgcct tggaaacgcg gggcgcgcgc ttcccgagcc tggcagagcc ggggtccgga
      121 ggatgctgct ggcggccggg gcacggtacg cccgccggct gtgcggccgg ggagccgcgg
      181 cggctctgca gggacgcaca ggccggagct gcgcccggga cgtcagtact agctggtccc
      241 cggtgggcgc cgccttcaac gtcaagcccc agagccacct atggaacctg ttgggggagc
      301 gccggggtct ttttggagtt cctgagctca gcacccctga aggattccaa gttgcccaag
      361 aggaagcctt gaagaagacg gagtggctgg tagagcgagc atgttccaca cccccagggc
      421 cacagacagt cctcattttt gacgaactct cggattgcct gtgcagagtg gctgacttgg
      481 cggactttgt gaaaattgga cacccagacc ctgcattcag agaggctgcg caagaggcct
      541 gcagaagtat tggcaccatg gtggaaaagt tgaatacaaa cgtggagctg tatcagagtc
      601 tgcaaaggtt actgggtgat aagaagctta tggagtccct tgatgcggaa accaggcgag
      661 tggccgaact atttatgttt gattttgaaa tcagtggaat ccatctagat gaagaaaagc
      721 gcagaagagc agtggacctc aatgttaaga tcttggactt gagcaatgct ttcctcatga
      781 gaaccaactt tcccaacaag atccggaaga gtctcttacc agagcacatt cagcaccact
      841 ttgcccgtga cggaagccac ttaatcattg acggcctgca tgcagaagcc tccgatgact
      901 tggttcggga ggctgcttat aaaattttcc tttatcccaa tgccgatcag ttgaaatgtt
      961 tagaggaatt gctaagcagc agagaccttc tggcaaaatt agtaggttat tctacatttt
     1021 cccacagggc cctccaagga accatagctc agactccaga gactgtcatg cagttccttg
     1081 agaagctatc tgaaaagctc tctgaaagaa ctagaaaaga tttcaagatg atgcaaggaa
     1141 tgaaaacaaa actaaatcct caaaattcta aactaatgcc ttgggaccct ccctactaca
     1201 gcggtgtgat tcgtgcagag aggtataata ttgagcccag tttatactgc ccgtttttat
     1261 cccttggagc ttgcatggaa ggcctgaatg tcttatttaa caaactgctg ggcatcacct
     1321 tatatgcaga gcagaccttc aaaggagagg tgtggtgtaa tgacatccgg aagctggctg
     1381 ttgttcatga atctgaaggg ctgctggggt acatttactg tgattttttc cagagagcaa
     1441 acaagccaca gcaggattgc cacttcacca tccgaggagg cagattaaag gaagatggca
     1501 gctatcagct tccagtggtc gttctcatgc tgaatcttcc tcatgcttcc agggatttcc
     1561 ctacattatt aactccagga atgatggaaa atctcttcca tgaaatgggc catgccatgc
     1621 attcaatgct tggacgaact cggtaccaac atgtcactgg gaccaggtgc cctactgact
     1681 ttgctgaagt tccatctatt ctgatggagt acttttcaaa tgattaccga gtagtcagcc
     1741 agttcgccaa gcattatcag actggtcagc cactcccgaa agctatggtg tctcgtctct
     1801 gtgagtctaa gaaggtttgc acagcagcag aaatgcagct tcaggtcttt tatgccgccc
     1861 tggatcaaat ctaccatggc cagcatcccc tgaagaagtc aaccacagat atcctcatgg
     1921 aaacacaaga gcagttctat ggcttgccct atgttcctga cactgcctgg cagctgaggt
     1981 tcagccacct cgtgggatat ggtgccaagt attactcata cctgatgtcc agggctgtgg
     2041 catccatgat ctggaaggag tgcttcctac aggatccttt taacagggcc gctggggaac
     2101 gctaccgcag agagatgttg gcccatggtg gaggcaagga gcccatgctt atgattcaag
     2161 gcatgctgca gaagtgtcct tccatcgatg actttgtgga tgccctcgtg tctgacatga
     2221 atctggactt tgaaacgttc ttcctggatt ctaaatagca gcagcatggc tcccgtggat
     2281 aagaaccttg tcaccagacc ctccagctag gaaagctcgc tccagcttca gcgatcactg
     2341 aggagacatt ttctgacaag ccttaaattg acaggactca gaataaatag taatgtttta
     2401 attacaaaaa aaaaaaaaaa aaa
//
