LOCUS       NM_008600               2183 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus major intrinsic protein of lens fiber (Mip), mRNA.
ACCESSION   NM_008600
VERSION     NM_008600.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2183)
  AUTHORS   Zhang,L., Liu,X., Li,W., Liu,K., Zhang,J., Liu,X. and Wang,J.
  TITLE     Integrative transcriptomic profiling of ncRNAs and mRNAs in
            developing mouse lens
  JOURNAL   Front Genet 15, 1405715 (2024)
   PUBMED   38933921
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2183)
  AUTHORS   Petrova,R.S., Francis,N., Schey,K.L. and Donaldson,P.J.
  TITLE     Verification of the gene and protein expression of the
            aquaglyceroporin AQP3 in the mammalian lens
  JOURNAL   Exp Eye Res 240, 109828 (2024)
   PUBMED   38354944
REFERENCE   3  (bases 1 to 2183)
  AUTHORS   Martin,J.B., Herman,K., Houssin,N.S., Rich,W., Reilly,M.A. and
            Plageman,T.F. Jr.
  TITLE     Arvcf Dependent Adherens Junction Stability is Required to Prevent
            Age-Related Cortical Cataracts
  JOURNAL   Front Cell Dev Biol 10, 840129 (2022)
   PUBMED   35874813
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2183)
  AUTHORS   Okada,N., Kawakita,T., Ito,M. and Tsubota,K.
  TITLE     Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal
            Gland Cells
  JOURNAL   Biomed Res Int 2021, 6888494 (2021)
   PUBMED   34540996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2183)
  AUTHORS   Varadaraj,K., FitzGerald,P.G. and Kumari,S.S.
  TITLE     Deletion of beaded filament proteins or the C-terminal end of
            Aquaporin 0 causes analogous abnormal distortion aberrations in
            mouse lens
  JOURNAL   Exp Eye Res 209, 108645 (2021)
   PUBMED   34087204
  REMARK    GeneRIF: Deletion of beaded filament proteins or the C-terminal end
            of Aquaporin 0 causes analogous abnormal distortion aberrations in
            mouse lens.
REFERENCE   6  (bases 1 to 2183)
  AUTHORS   Kratochvilova,J. and Favor,J.
  TITLE     Allelism tests of 15 dominant cataract mutations in mice
  JOURNAL   Genet Res 59 (3), 199-203 (1992)
   PUBMED   1511869
REFERENCE   7  (bases 1 to 2183)
  AUTHORS   Griffin,C.S. and Shiels,A.
  TITLE     Localisation of the gene for the major intrinsic protein of
            eye-lens-fibre cell membranes to mouse chromosome 10 by in situ
            hybridisation
  JOURNAL   Cytogenet Cell Genet 59 (4), 300-302 (1992)
   PUBMED   1544329
REFERENCE   8  (bases 1 to 2183)
  AUTHORS   Griffin,C.S. and Shiels,A.
  TITLE     In situ hybridisation localises the gene for the major intrinsic
            protein of eye lens fibre cell membranes to human chromosome 12q14
  JOURNAL   Cytogenet Cell Genet 61 (1), 8-9 (1992)
   PUBMED   1505237
REFERENCE   9  (bases 1 to 2183)
  AUTHORS   Shiels,A., Griffin,C.S. and Muggleton-Harris,A.L.
  TITLE     Restriction fragment length polymorphisms associated with the gene
            for the major intrinsic protein of eye-lens fibre cell membranes in
            mice with hereditary cataracts
  JOURNAL   Biochim Biophys Acta 1097 (1), 81-85 (1991)
   PUBMED   1677593
REFERENCE   10 (bases 1 to 2183)
  AUTHORS   Koniukhov,B.V. and Kolesova,N.A.
  TITLE     [Ultrastructural analysis of the effects of dominant cataract-Fr
            gene in mouse embryos]
  JOURNAL   Ontogenez 7 (3), 271-277 (1976)
   PUBMED   1026873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB651737.1, AK136287.1 and AI323353.1.
            
            On Sep 1, 2015 this sequence version replaced NM_008600.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136287.1, AK053490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BB651737.1         4-31
            29-1941             AK136287.1         2-1914
            1942-2183           AI323353.1         1-242               c
FEATURES             Location/Qualifiers
     source          1..2183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.49 cM"
     gene            1..2183
                     /gene="Mip"
                     /gene_synonym="Aqp0; Cat; Cts; Hfi; Lop; MIP26; MP26;
                     shrivelled; Svl"
                     /note="major intrinsic protein of lens fiber"
                     /db_xref="GeneID:17339"
                     /db_xref="MGI:MGI:96990"
     exon            1..432
                     /gene="Mip"
                     /gene_synonym="Aqp0; Cat; Cts; Hfi; Lop; MIP26; MP26;
                     shrivelled; Svl"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..864
                     /gene="Mip"
                     /gene_synonym="Aqp0; Cat; Cts; Hfi; Lop; MIP26; MP26;
                     shrivelled; Svl"
                     /EC_number="1.11.1.6"
                     /note="aquaporin-0; lens opacity; dominant cataract;
                     hydropic fibers; cataract and small eye; major intrinsic
                     protein of eye lens fiber"
                     /codon_start=1
                     /product="lens fiber major intrinsic protein"
                     /protein_id="NP_032626.2"
                     /db_xref="CCDS:CCDS24265.1"
                     /db_xref="GeneID:17339"
                     /db_xref="MGI:MGI:96990"
                     /translation="MWELRSASFWRAIFAEFFATLFYVFFGLGASLRWAPGPLHVLQV
                     ALAFGLALATLVQTVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYIAAQLLGAVAGAA
                     VLYSVTPPAVRGNLALNTLHAGVSVGQATTVEIFLTLQFVLCIFATYDERRNGRMGSV
                     ALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFSNHWVYWVGPIIGGGLGSLL
                     YDFLLFPRLKSVSERLSILKGARPSDSNGQPEGTGEPVELKTQAL"
     exon            433..597
                     /gene="Mip"
                     /gene_synonym="Aqp0; Cat; Cts; Hfi; Lop; MIP26; MP26;
                     shrivelled; Svl"
                     /inference="alignment:Splign:2.1.0"
     exon            598..678
                     /gene="Mip"
                     /gene_synonym="Aqp0; Cat; Cts; Hfi; Lop; MIP26; MP26;
                     shrivelled; Svl"
                     /inference="alignment:Splign:2.1.0"
     exon            679..2172
                     /gene="Mip"
                     /gene_synonym="Aqp0; Cat; Cts; Hfi; Lop; MIP26; MP26;
                     shrivelled; Svl"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1038
                     /gene="Mip"
                     /gene_synonym="Aqp0; Cat; Cts; Hfi; Lop; MIP26; MP26;
                     shrivelled; Svl"
     regulatory      2149..2154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mip"
                     /gene_synonym="Aqp0; Cat; Cts; Hfi; Lop; MIP26; MP26;
                     shrivelled; Svl"
                     /note="hexamer: AATAAA"
     polyA_site      2172
                     /gene="Mip"
                     /gene_synonym="Aqp0; Cat; Cts; Hfi; Lop; MIP26; MP26;
                     shrivelled; Svl"
                     /note="major polyA site"
ORIGIN      
        1 aaaggggact gtcaacccag gcaggtccag ggggttatta gggacccagg cactgtgttc
       61 acccccactg ccatgtggga acttcggtct gcctcctttt ggagggccat atttgctgag
      121 ttctttgcca ccctcttcta tgtcttcttt gggcttggag cctcgctacg ttgggcccct
      181 gggcccctac atgtcttgca agtggctttg gcctttggcc tggccttggc tacattggtg
      241 cagactgtgg gtcacatcag tggagcccat gtcaaccctg cggtcacttt tgccttcctt
      301 gtgggctccc agatgtcctt gctccgggct ttctgctata tagcagccca gcttctggga
      361 gctgtggctg gggcggctgt gctgtacagt gtcaccccac cagctgtccg aggaaaccta
      421 gcgctcaaca cgctgcatgc tggggtgagc gtgggccagg ccaccactgt ggagatcttc
      481 ttgacgctcc agttcgtgct ctgcatcttt gctacatacg acgagaggcg gaatggccgc
      541 atgggctctg tagccctggc tgttggcttc tccctcaccc tggggcacct ctttgggatg
      601 tattacactg gtgcggggat gaacccagcc cgctcctttg ctcctgccat cctcacccgg
      661 aacttcagca accactgggt gtactgggtg ggcccgatca tcggaggggg cctgggcagc
      721 ctactctatg actttctcct cttcccccgg ctcaagagtg tttctgagag actgtctatc
      781 ctgaagggag ccagacccag tgactccaat ggacagccag agggtacagg ggaacctgtc
      841 gaactgaaga ctcaggccct gtaaaagctc cagttggaga gagccgcaga aagccgctgg
      901 gtttcaggga gggccaaacc ggcccttgga tgaagaaaga gactgtgggg agggtcatgt
      961 acttctttat tttttaactt acgtttttca tttttttccc ccttttgctg tgtgaaatct
     1021 ttcaagttgc attcacgact ggttagtgca aacttccctt cctccccgct ccagctaccc
     1081 tcgccgtgtg tgcacgactg ttcatatgaa tgtgggtgcg tgtggccgtg tctgagtttg
     1141 cgggcacaga agctagggga ggggaaagag gtgtcaacat gtatgtcatt tcccacccca
     1201 gtttggtgag cacagggaac ccgagtttct ggcctttacc ctgcttccat tcaagtatat
     1261 gcaccttgat ttttgaaggg tcacgggggt gggtggggtg tcgttcctct caggaagcag
     1321 acagcagaaa gaaaggagga gggaaggcat tccaggggtt aggaggtctg gtgggagagg
     1381 aatccaagat tttatttcca gatcaccaca caagtgtacc taagttttga gggagttaat
     1441 gggagactat aggctacgga tctcatggat gctcatccca gagaaaagta aacacgggcc
     1501 ttgagttgtt ctgtaaagcc acataagcct gcctacatcc accggctggg ctgtgtgttc
     1561 agaagccttg agccacggac cttccaatag aaacaggggt taggcaagtt taaaaggccc
     1621 tgcctaatag ccccagacag aaggtgctga agcccagaat tgctctctga ggctaaaaca
     1681 ggaaatctgg tgtctgaagc aaatttacag gagttgaggg gcaagacggg ggtggggtga
     1741 gtgggtgggg gaagattcat ttagagcaaa ctgaactttg caaatggcat ctctgtactt
     1801 ttatcactag ctccatagtc ttttattttt gtatgtcttt tcacttttct ctcggctatc
     1861 ctttctgcta actctccctc atgacccaga tatcgatctc ctcaatctaa acgcttaatt
     1921 cagagatgat tttttttttt tcttttggag ccctatcttg tatttgttcg taaaacagca
     1981 tcgtctcaac aggggcgcag gtgaccctga acgaacaagg aatatttatt tcagatcttt
     2041 ctattctgag cttcctgtat ataccttgcc agctttaaaa catatgcctg taagaagaca
     2101 gacaacccaa aactccaccc caaacatcaa actctccact tcctcccaaa taaaacacat
     2161 cttttctaac taaaaaaaaa aaa
//
