LOCUS       NM_019977               1074 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus myo-inositol oxygenase (Miox), mRNA.
ACCESSION   NM_019977
VERSION     NM_019977.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1074)
  AUTHORS   Sharma,I., Liao,Y., Zheng,X. and Kanwar,Y.S.
  TITLE     Modulation of gentamicin-induced acute kidney injury by
            myo-inositol oxygenase via the ROS/ALOX-12/12-HETE/GPR31 signaling
            pathway
  JOURNAL   JCI Insight 7 (6), e155487 (2022)
   PUBMED   35315361
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1074)
  AUTHORS   Zheng,X., Deng,F., Sharma,I. and Kanwar,Y.S.
  TITLE     Myo-inositol oxygenase overexpression exacerbates cadmium-induced
            kidney injury via oxidant stress and necroptosis
  JOURNAL   Am J Physiol Renal Physiol 322 (3), F344-F359 (2022)
   PUBMED   35100813
REFERENCE   3  (bases 1 to 1074)
  AUTHORS   Sharma,I., Deng,F., Liao,Y. and Kanwar,Y.S.
  TITLE     Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression
            of Renal Tubulointerstitial Injury in Diabetes
  JOURNAL   Diabetes 69 (6), 1248-1263 (2020)
   PUBMED   32169892
  REMARK    GeneRIF: Myo-inositol Oxygenase (MIOX) Overexpression Drives the
            Progression of Renal Tubulointerstitial Injury in Diabetes.
REFERENCE   4  (bases 1 to 1074)
  AUTHORS   Deng,F., Sharma,I., Dai,Y., Yang,M. and Kanwar,Y.S.
  TITLE     Myo-inositol oxygenase expression profile modulates pathogenic
            ferroptosis in the renal proximal tubule
  JOURNAL   J Clin Invest 129 (11), 5033-5049 (2019)
   PUBMED   31437128
  REMARK    GeneRIF: these findings indicate that ferroptosis, an integral
            process in the pathogenesis of cisplatin-induced AKI, is modulated
            by the expression profile of MIOX.
REFERENCE   5  (bases 1 to 1074)
  AUTHORS   Tominaga,T., Sharma,I., Fujita,Y., Doi,T., Wallner,A.K. and
            Kanwar,Y.S.
  TITLE     Myo-inositol oxygenase accentuates renal tubular injury initiated
            by endoplasmic reticulum stress
  JOURNAL   Am J Physiol Renal Physiol 316 (2), F301-F315 (2019)
   PUBMED   30539651
  REMARK    GeneRIF: MIOX-induced oxidant stress and tunicamycin-induced
            endoplasmic reticulum stress are interlinked, and both of the
            events may feed into each other to amplify the tubulointerstitial
            injury.
REFERENCE   6  (bases 1 to 1074)
  AUTHORS   Nayak,B., Xie,P., Akagi,S., Yang,Q., Sun,L., Wada,J., Thakur,A.,
            Danesh,F.R., Chugh,S.S. and Kanwar,Y.S.
  TITLE     Modulation of renal-specific oxidoreductase/myo-inositol oxygenase
            by high-glucose ambience
  JOURNAL   Proc Natl Acad Sci U S A 102 (50), 17952-17957 (2005)
   PUBMED   16330753
  REMARK    GeneRIF: RSOR activity is modulated by diverse mechanisms, and it
            is endowed with dual properties to channel glucose intermediaries,
            characteristic of hepatic aldehyde reductases, and to maintain
            osmoregulation, in diabetes.
REFERENCE   7  (bases 1 to 1074)
  AUTHORS   Arner,R.J., Prabhu,K.S. and Reddy,C.C.
  TITLE     Molecular cloning, expression, and characterization of myo-inositol
            oxygenase from mouse, rat, and human kidney
  JOURNAL   Biochem Biophys Res Commun 324 (4), 1386-1392 (2004)
   PUBMED   15504367
  REMARK    GeneRIF: Molecular cloning and characterization of myo-inositol
            oxygenase as a 33kDa protein.
REFERENCE   8  (bases 1 to 1074)
  AUTHORS   Kanwar,Y.S., Yang,Q., Tian,Y., Lin,S., Wada,J., Chugh,S. and
            Srivastava,S.K.
  TITLE     Relevance of renal-specific oxidoreductase in tubulogenesis during
            mammalian nephron development
  JOURNAL   Am J Physiol Renal Physiol 282 (4), F752-F762 (2002)
   PUBMED   11880337
  REMARK    GeneRIF: is developmentally regulated in kidney, exhibits a
            distinct spatiotemporal distribution, and probably plays a role in
            tubulogenesis.
REFERENCE   9  (bases 1 to 1074)
  AUTHORS   Arner,R.J., Prabhu,K.S., Thompson,J.T., Hildenbrandt,G.R.,
            Liken,A.D. and Reddy,C.C.
  TITLE     myo-Inositol oxygenase: molecular cloning and expression of a
            unique enzyme that oxidizes myo-inositol and D-chiro-inositol
  JOURNAL   Biochem J 360 (Pt 2), 313-320 (2001)
   PUBMED   11716759
REFERENCE   10 (bases 1 to 1074)
  AUTHORS   Yang,Q., Dixit,B., Wada,J., Tian,Y., Wallner,E.I., Srivastva,S.K.
            and Kanwar,Y.S.
  TITLE     Identification of a renal-specific oxido-reductase in newborn
            diabetic mice
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 9896-9901 (2000)
   PUBMED   10944187
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC013543.1.
            
            On Mar 17, 2004 this sequence version replaced NM_019977.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013543.1, AF197127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.82 cM"
     gene            1..1074
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /note="myo-inositol oxygenase"
                     /db_xref="GeneID:56727"
                     /db_xref="MGI:MGI:1891725"
     exon            1..45
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..888
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /EC_number="1.13.99.1"
                     /note="renal-specific oxido-reducatse; aldehyde reductase
                     (aldose reductase)-like 6; aldehyde reductase 6, renal; MI
                     oxygenase; aldehyde reductase-like 6; renal-specific
                     oxidoreductase"
                     /codon_start=1
                     /product="inositol oxygenase"
                     /protein_id="NP_064361.2"
                     /db_xref="CCDS:CCDS27745.1"
                     /db_xref="GeneID:56727"
                     /db_xref="MGI:MGI:1891725"
                     /translation="MKVDVGPDPSLVYRPDVDPEMAKSKDSFRNYTSGPLLDRVFTTY
                     KLMHTHQTVDFVSRKRIQYGSFSYKKMTIMEAVGMLDDLVDESDPDVDFPNSFHAFQT
                     AEGIRKAHPDKDWFHLVGLLHDLGKIMALWGEPQWAVVGDTFPVGCRPQASVVFCDST
                     FQDNPDLQDPRYSTELGMYQPHCGLENVLMSWGHDEYLYQMMKFNKFSLPSEAFYMIR
                     FHSFYPWHTGGDYRQLCSQQDLDMLPWVQEFNKFDLYTKCPDLPDVESLRPYYQGLID
                     KYCPGTLSW"
     exon            46..126
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            127..207
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            208..370
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            371..438
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            439..548
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            549..616
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            617..666
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            667..779
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1047
                     /gene="Miox"
                     /gene_synonym="0610009I10Rik; Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctgccgt cgggtgactg ctccctcagg atgaaggtcg atgtgggccc agacccttcc
       61 ctggtctatc gacccgatgt ggacccagag atggccaaaa gcaaggacag cttccgaaac
      121 tatacttcag gcccgctgct ggatcgtgtc tttaccacat acaagctcat gcacactcac
      181 cagactgtgg acttcgtcag caggaagcgc atccagtatg gaagcttctc ttacaagaag
      241 atgaccatca tggaggctgt gggcatgctg gatgatctgg tggacgaatc tgacccagac
      301 gtagatttcc ccaactcctt ccacgcgttc cagaccgcgg agggcatccg gaaagcccac
      361 ccggacaagg actggttcca cctggtcgga cttttgcacg atctggggaa aattatggct
      421 ctgtgggggg aacctcagtg ggctgttgtt ggagacacgt tccccgtggg ctgccgtccc
      481 caggcctctg tggtgttctg tgactctact ttccaggaca atcctgacct ccaggatcct
      541 cgatacagca cagaactcgg catgtaccag cctcactgtg gactagagaa cgtccttatg
      601 tcctggggcc atgatgagta cctataccag atgatgaagt tcaacaagtt ctccctgcct
      661 tcagaggcct tctacatgat ccgattccac tccttctatc cgtggcacac cggcggtgac
      721 taccggcagc tgtgcagcca gcaggacctg gatatgctgc cctgggtgca agagttcaac
      781 aagtttgatc tctacacgaa gtgccctgac ctaccggatg tggagagcct gcggccctac
      841 tatcaagggc tgattgacaa gtactgcccg ggcaccctga gctggtgaat ggtttccaat
      901 accctcccac cactgagcca gtacacctag gctggacaac ttcaggagct ataatagccc
      961 ctcactccag cctggctcag ggttcacagt ccccacccat cacaattgag gtcacgtttg
     1021 ctgggtatca ataaagaatg aaagagaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
