LOCUS       NM_145374               3724 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus meiosis regulator for oocyte development (Mios), mRNA.
ACCESSION   NM_145374
VERSION     NM_145374.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3724)
  AUTHORS   Yu,Z., Yang,Z., Ren,G., Wang,Y., Luo,X., Zhu,F., Yu,S., Jia,L.,
            Chen,M., Worley,P.F. and Xiao,B.
  TITLE     GATOR2 complex-mediated amino acid signaling regulates brain
            myelination
  JOURNAL   Proc Natl Acad Sci U S A 119 (3) (2022)
   PUBMED   35022234
REFERENCE   2  (bases 1 to 3724)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   3  (bases 1 to 3724)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   4  (bases 1 to 3724)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY064617.1, BU510538.1, CX565910.1, CD807728.1, BQ876300.1,
            AK079844.1, AK034623.1 and BP765255.1.
            
            On Nov 15, 2008 this sequence version replaced NM_145374.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020002.1, SRR1660819.145003.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               BY064617.1         1-340
            341-924             BU510538.1         191-774
            925-1520            CX565910.1         113-708
            1521-1910           CD807728.1         7-396
            1911-2148           BQ876300.1         466-703
            2149-2939           AK079844.1         74-864
            2940-3699           AK034623.1         2269-3028
            3700-3724           BP765255.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..3724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 3.51 cM"
     gene            1..3724
                     /gene="Mios"
                     /note="meiosis regulator for oocyte development"
                     /db_xref="GeneID:252875"
                     /db_xref="MGI:MGI:2182066"
     exon            1..185
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     exon            186..244
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     exon            245..1578
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..2912
                     /gene="Mios"
                     /note="WD repeat-containing protein mio; GATOR complex
                     protein MIOS; missing oocyte, meiosis regulator, homolog"
                     /codon_start=1
                     /product="GATOR2 complex protein MIOS"
                     /protein_id="NP_663349.2"
                     /db_xref="CCDS:CCDS39425.1"
                     /db_xref="GeneID:252875"
                     /db_xref="MGI:MGI:2182066"
                     /translation="MSGTKPDILWAPHQVDRFVVCDSELSLYHVESAVNSELKAGSLR
                     LSEDSAATLLSINSDTPYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKD
                     LIGKEFVPKHARQCNTLAWNPLDSNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEK
                     VRLSAGEAETTLLVTKPLYELGQNDASLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQ
                     KMFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWC
                     PTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSVQPCDNYIASFAWHPTS
                     QNRMIVVTPNRTMSDFTVFERISLAWSPITSLMWACGRHLYECAEEESDNSLEKDIAT
                     KMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDNDQKSPGNKGS
                     LVYAGIKSIVKSSLGMVESSRHNWSGLDKQTDIQNLNEERILALQLCGWIKKGTDVDV
                     GPFLNSLVQEGEWERAAAVALFNLDIRRAIQILNEGASSEKGDLNLNVVAMALSGYTD
                     EKNSLWREMCSTLRLQLNNPYLCVMFAFLTSEAGAYDGVLYENKVAVRDRVAFACKFL
                     GDAQLNKYIEKLTNEMKEAGNLEGILLTGLTKDGVDLMESYVDRTGDVQTASYCMLQG
                     SPLDVLKDERVQYWIENYRNLLDAWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFC
                     GKSISYSCSSVPHQGRGFSQYGVSGSPTKSKVTSCPGCRKPLPRCALCLINMGTPVSS
                     CPGGSKSDEKVDLSKDKKLAQFNNWFTWCHNCRHGGHAGHMLSWFRDHAECPVSACTC
                     KCMQLDTTGNLVPAETVQP"
     exon            1579..1677
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1932
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2102
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2168
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2327
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2480
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2685
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2815
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..3705
                     /gene="Mios"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2979..2984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mios"
                     /note="hexamer: AATAAA"
     regulatory      3013..3018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mios"
                     /note="hexamer: AATAAA"
     polyA_site      3034
                     /gene="Mios"
                     /note="major polyA site"
     polyA_site      3038
                     /gene="Mios"
     regulatory      3192..3197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mios"
                     /note="hexamer: AATAAA"
     polyA_site      3230
                     /gene="Mios"
     regulatory      3681..3686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mios"
                     /note="hexamer: AATAAA"
     polyA_site      3701
                     /gene="Mios"
ORIGIN      
        1 gaaggcgggg ctcgcggcga ggaggtctgc ttcggaggcg gcagggtggt ttggtcgggg
       61 gcccagcggg tggcccgggt caccgcccgt gcttcggcgg ccatcttgcc cgcgcccgtc
      121 tcccgcggcg ggaggggcgg cgtacaggcc ggaaacgtct gtgtggcgac aggccacctc
      181 ctcagggaca tagcaagaat ctcaagacat gtttcagaag ctccctctat ttgtgagaat
      241 ctagtgaatg gacctgactg gactttttaa gcccatcaat aaacatgagc ggtaccaagc
      301 ccgatatttt gtgggcacca caccaagttg atagatttgt tgtatgtgac tcagaattga
      361 gcctttatca tgtggaatcg gctgtgaatt cagaactcaa agctggatcg ttacgtttat
      421 ctgaagactc tgcagcgaca ttgctgtcaa taaactcaga tacaccctat atgaaatgtg
      481 ttgcgtggta tctcaattat gatcctgaat gtctcctagc agttggacaa gcaaatggtc
      541 gagttgtact tacaagtctt ggtcaagatc ataactctaa gttcaaagat ttgataggaa
      601 aagaatttgt tccaaagcat gctcgccaat gcaataccct tgcatggaat ccactggata
      661 gtaactggct tgctgctggt ctcgacaaac acagagctga cttttcagtt ctaatatggg
      721 atatctgcag caaatatact cctgatattg ttcccatgga aaaagtgaga ctttcagcag
      781 gtgaagctga aacaacatta ctagtgacaa aaccgctgta tgagttaggg cagaatgacg
      841 cttctctatc tctgtgttgg cttccacgag accagaaact tcttcttgct ggcatgcatc
      901 gtaatctagc aatatttgat ctccggaaca caagccagaa gatgtttgta aatacaaaag
      961 ctgttcaagg agtgacagta gacccttact tccacgatcg tgttgcttcc ttctatgaag
     1021 gtcaggttgc aatatgggat cttagaaaat ttgagaagcc agttttgact ttgactgaac
     1081 aaccaaagcc cttgacaaag gtcgcatggt gtccaaccag gacaggcctg cttgctactt
     1141 taacaaggga tagtaatatt attaggctgt atgatatgca gcatacaccc actcccatcg
     1201 gggatgaaac cgaacccaca ataattgaaa gaagtgtgca gccttgtgac aattacattg
     1261 cttcctttgc atggcatcca acgagtcaaa atcgaatgat agttgtgact cccaaccgaa
     1321 caatgtctga cttcactgta tttgaaagga tatctcttgc ctggagccca attacatctt
     1381 taatgtgggc ttgtggtcgc catttgtatg agtgtgcaga agaagaaagt gataactcct
     1441 tagaaaaaga tatagcaaca aaaatgcgcc ttcgggcttt atcaaggtat ggacttgata
     1501 cagaacaggt ttggagaaac cacattttag ctggcaatga agacccacag ctcaagtcac
     1561 tctggtatac tctgcacttt atgaagcaat atacagaaga taatgatcaa aaatctccag
     1621 gcaacaaagg atcattggtt tatgcaggaa ttaaatcaat agtaaaatca tctttgggaa
     1681 tggtagaaag cagcagacat aattggagtg gcttggataa acaaactgat attcagaact
     1741 taaatgaaga aaggatttta gcattacagc tttgtgggtg gataaagaaa ggaacggatg
     1801 tagatgtagg gccatttttg aactcccttg tgcaagaagg agaatgggaa agagctgctg
     1861 ctgtggcttt gttcaacttg gatattcggc gagcaatcca aatcctgaat gaaggggcgt
     1921 cttcagaaaa aggagatctg aatctcaatg tggtggcaat ggctttatcg gggtatacgg
     1981 acgagaagaa ctcgctgtgg cgggagatgt gcagcaccct gcgcctgcag ctcaacaacc
     2041 cctatctgtg tgtcatgttt gcgttcctga cgagtgaagc gggggcatat gatggagtgt
     2101 tgtatgaaaa caaagttgct gtacgtgaca gagtggcatt cgcttgtaaa ttccttggtg
     2161 atgctcagtt aaataaatac attgaaaagc tgaccaatga aatgaaagag gctggaaatt
     2221 tggaggggat cttgcttaca ggcctcacta aagatggagt ggacctgatg gagagctatg
     2281 tggatagaac tggagatgtt caaacagcaa gttactgcat gttacagggt tcacctttag
     2341 atgttctgaa agatgaaagg gttcaatatt ggattgagaa ttacagaaat ttattagatg
     2401 cctggaggtt ttggcacaaa agggcagaat ttgatattca taggagtaag ctggatccca
     2461 gttccaagcc tttagcacag gtgtttgtga gttgtaattt ttgtggcaaa tcaatctcct
     2521 acagctgttc ctctgtgcct catcagggca gagggtttag tcagtatggt gtgagtggct
     2581 caccaacaaa atccaaagtc acaagctgcc ctggctgtcg gaaacccctt cctcgatgtg
     2641 cactttgcct cattaatatg ggaacacctg tttctagctg tcctggtgga tccaaatcag
     2701 atgaaaaggt ggacttgagc aaggacaaaa agttagctca gtttaacaac tggtttacct
     2761 ggtgtcacaa ctgtcggcat ggtgggcatg ccggacatat gctgagttgg ttcagggacc
     2821 atgcagagtg tcctgtatct gcatgcacgt gtaaatgtat gcagttggat acaacaggaa
     2881 atctggtgcc agcagagact gtccagccat gaaatgttcc acctaaagaa aaatcttcac
     2941 atgtggagtt tttaaaggat gtccttcata gttcaggaaa taaagtcact catggctttg
     3001 ctgtcgtgga aaaataaagc attctgtcag ctcagcaatg tgatgtttga gtgactttga
     3061 cgtactcctc agaggccaac gctgctgata ggaacattag aacatgaata ttggtgctgt
     3121 ttagtaggtt aaagttcatt tgaaagaact gtctaggctt ttgtcaaaat tatgtttata
     3181 gatggtttta gaataaaaac aggccttgtg cctgcatctt caatctgaaa ttgatatctt
     3241 ttgataaaat ctgtacatat ctaaaaccaa atgccaattc attgtttcat atatcaattt
     3301 aagcttattc atgcttaaat atgctttcag agaaaatgtc aattttacat tggtaattag
     3361 ctcctggccc atgctggaga atacatgcat gtgtgcatat gtgcacacac acgtttaagg
     3421 aacgttctcc ctcatacatt tatattttaa tataaaagat ttgacatagg tcattcttgt
     3481 cttcctcaaa actccaagtt aaaagcaggc tggtgagctg gttcagcatg cgaggaggct
     3541 tgcagccaat cctgatgacc taagtgcggt cccatgtgtt ggaagcagtg attcaactca
     3601 tctccagaac cttgctgcag catggggcga gcacgtacac atgtgcgcgc tcgtgagcac
     3661 tcgagcacac gcagacaata aataaaaaaa atttaaaacg ataaaaaaaa aaaaaaaaaa
     3721 aaaa
//
