LOCUS       NM_010799               2619 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus multiple inositol polyphosphate histidine phosphatase
            1 (Minpp1), mRNA.
ACCESSION   NM_010799
VERSION     NM_010799.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2619)
  AUTHORS   Ucuncu,E., Rajamani,K., Wilson,M.S.C., Medina-Cano,D., Altin,N.,
            David,P., Barcia,G., Lefort,N., Banal,C., Vasilache-Dangles,M.T.,
            Pitelet,G., Lorino,E., Rabasse,N., Bieth,E., Zaki,M.S., Topcu,M.,
            Sonmez,F.M., Musaev,D., Stanley,V., Bole-Feysot,C., Nitschke,P.,
            Munnich,A., Bahi-Buisson,N., Fossoud,C., Giuliano,F., Colleaux,L.,
            Burglen,L., Gleeson,J.G., Boddaert,N., Saiardi,A. and Cantagrel,V.
  TITLE     MINPP1 prevents intracellular accumulation of the chelator inositol
            hexakisphosphate and is mutated in Pontocerebellar Hypoplasia
  JOURNAL   Nat Commun 11 (1), 6087 (2020)
   PUBMED   33257696
  REMARK    GeneRIF: MINPP1 prevents intracellular accumulation of the chelator
            inositol hexakisphosphate and is mutated in Pontocerebellar
            Hypoplasia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2619)
  AUTHORS   Chi,H., Yang,X., Kingsley,P.D., O'Keefe,R.J., Puzas,J.E.,
            Rosier,R.N., Shears,S.B. and Reynolds,P.R.
  TITLE     Targeted deletion of Minpp1 provides new insight into the activity
            of multiple inositol polyphosphate phosphatase in vivo
  JOURNAL   Mol Cell Biol 20 (17), 6496-6507 (2000)
   PUBMED   10938126
REFERENCE   3  (bases 1 to 2619)
  AUTHORS   Chi,H., Tiller,G.E., Dasouki,M.J., Romano,P.R., Wang,J.,
            O'keefe,R.J., Puzas,J.E., Rosier,R.N. and Reynolds,P.R.
  TITLE     Multiple inositol polyphosphate phosphatase: evolution as a
            distinct group within the histidine phosphatase family and
            chromosomal localization of the human and mouse genes to
            chromosomes 10q23 and 19
  JOURNAL   Genomics 56 (3), 324-336 (1999)
   PUBMED   10087200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115752.8, AK151486.1 and AV297692.1.
            
            On Dec 11, 2007 this sequence version replaced NM_010799.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF046908.1, AK128911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC115752.8         39928-40083         c
            157-2578            AK151486.1         2-2423
            2579-2619           AV297692.1         233-273
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 27.25 cM"
     gene            1..2619
                     /gene="Minpp1"
                     /note="multiple inositol polyphosphate histidine
                     phosphatase 1"
                     /db_xref="GeneID:17330"
                     /db_xref="MGI:MGI:1336159"
     exon            1..791
                     /gene="Minpp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1618
                     /gene="Minpp1"
                     /EC_number="3.1.3.62"
                     /EC_number="3.1.3.80"
                     /note="multiple inositol polyphosphate phosphatase 1;
                     ins(1,3,4,5)P(4) 3-phosphatase; inositol
                     (1,3,4,5)-tetrakisphosphate 3-phosphatase; 2,3-BPG
                     phosphatase; 2,3-bisphosphoglycerate 3-phosphatase"
                     /codon_start=1
                     /product="multiple inositol polyphosphate phosphatase 1
                     precursor"
                     /protein_id="NP_034929.1"
                     /db_xref="CCDS:CCDS29751.1"
                     /db_xref="GeneID:17330"
                     /db_xref="MGI:MGI:1336159"
                     /translation="MLRGARSHLPASVAPAAVLAAALLSSFARCSLPGRGDPVASVLS
                     PYFGTKTRYEDANPWLLVDPVAPRRDPELLAGTCTPVQLVALIRHGTRYPTTKQIRKL
                     KQLQGLLQTRESRDGGSQVAAALAEWPLWYGDWMDGQLVEKGRQDMRQLALRLAALFP
                     DLFSRENYDRLRLITSSKHRCVDSSAAFLQGLWQHYHPGLPPPDVSDMECGPPRINDK
                     LMRFFDHCEKFLTDVERNETALYHVEAFKTGPEMQKVLKKVAATLQVPMNSLNADLIQ
                     VAFFTCSFDLAIKGVHSPWCDVFDVDDARVLEYLNDLKQYWKRSYGYTINSRSSCNLF
                     QDIFLHLDKAVEQKQRSQPVSSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNFEEQ
                     VNRKFRSGHIVPYASNLIFVLYHCDNAQSPEEQFQIQLLLNEKVLPLAHSQRPVGLYE
                     ELKTHYRDILQSCQTSKECSPPKANITSDEL"
     exon            792..989
                     /gene="Minpp1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1087
                     /gene="Minpp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1221
                     /gene="Minpp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..2619
                     /gene="Minpp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2485..2490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Minpp1"
                     /note="hexamer: AATAAA"
     polyA_site      2506
                     /gene="Minpp1"
     regulatory      2583..2588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Minpp1"
                     /note="hexamer: AATAAA"
     polyA_site      2610
                     /gene="Minpp1"
                     /note="major polyA site"
ORIGIN      
        1 acaccgaagc tccgagacga tcggccacac tcgctcggtg acagcaccgg agaccacgct
       61 tgccttctga ggttcccggg ccggaagtgc gctctgctcc cgcccccgcc ggcggatccg
      121 gaagtggggg tcggcaagcg gcgcgccgcc ctccgcgggg cccccgggca cgatgcttcg
      181 cggcgcgcgc agccacctcc cggcctcggt agcgcccgcc gcggtcctgg ctgcggcgct
      241 gctctcgtcg ttcgcgcgct gctctctccc ggggcgcggc gacccggtgg cttcggtgct
      301 cagcccctac ttcggcacga agacacgcta cgaagatgcc aacccctggc tgctggtcga
      361 tccggtggcg ccgcggcggg acccggagct gctggcgggg acctgcaccc cggtgcagct
      421 ggtcgccctc atccgtcacg gcacccgcta ccctacgacc aagcagatcc gcaagctgaa
      481 gcagctgcag gggctgctgc agacccgcga gtcccgggat ggcgggagcc aagtggccgc
      541 cgcgctggcc gagtggccgc tgtggtacgg tgactggatg gacgggcagc tggtggagaa
      601 ggggcggcag gacatgcgac agctggccct gcgtctggct gccctcttcc cagacctctt
      661 cagccgggag aactacgacc gcctgcggct gatcaccagc tccaagcacc gctgtgtgga
      721 cagcagcgcc gccttcctcc aggggttgtg gcagcattac cacccaggac tgccacctcc
      781 cgacgtctca gatatggagt gtggccctcc aagaattaat gataaactaa tgaggttctt
      841 cgatcattgt gagaagttct taactgatgt ggaaagaaac gagacggctc tttatcatgt
      901 ggaagctttc aaaactggac cagaaatgca gaaggtctta aagaaagttg cagctactct
      961 gcaagtgcca atgaacagtt taaatgcaga cttaattcag gtagcttttt tcacctgttc
     1021 atttgacctg gcaattaaag gtgtccattc tccctggtgt gatgtgtttg acgtagatga
     1081 tgcaagggtt ctggaatact taaacgacct gaaacagtac tggaaacgaa gctatggcta
     1141 caccattaac agccggtcca gctgcaacct atttcaggac atttttctac acctggacaa
     1201 agcagtggag cagaagcaaa ggtctcagcc agtctcctct ccagtcatcc tccagtttgg
     1261 acacgcggag acgctcctgc cgctcctctc cctcatgggc tacttcaagg acaaggagcc
     1321 tctgaccgct tacaatttcg aggagcaagt taatcgcaag ttccgaagtg gtcacatcgt
     1381 accttatgcc tcaaacctaa tcttcgtgct ttaccactgt gacaacgcgc agagccccga
     1441 agaacaattc cagatacagc tgctgctgaa tgagaaggtg ctgcccctgg ctcactcgca
     1501 gagacccgtc gggttgtatg aggagctcaa gacccactac cgggacattc ttcagagctg
     1561 ccaaaccagt aaggagtgca gcccgcccaa agcgaacatc acgtccgatg agctctgagg
     1621 accttcggct gtgccatact gaggggtggt tgtgtttgca ggaggtagcc actctagagg
     1681 ccgcggcaga aggagctctg tgagtccaag gccagcctgt tctacatagt gagttccagg
     1741 ccagccaaga ctacatagag caataaagcc tggtctttct gtcttttcac agaaaataat
     1801 agttcctttt aggatctaga catacgggta agacatgact ctccctggag cagctctctg
     1861 cagaacaaaa actaattcaa tgaagcagct gtccctccca gtgtttgcag agctgagatt
     1921 ttcctaatga cctaagaaga tactgacgta gaacggtatt agaaaatgac acttcaaaaa
     1981 tgttggatac caaagcacgg tagctgccgg gtgagcggca gtgattggca gagatgggga
     2041 cttgagtgac catgttgggt tcccttcttc tccttcttgc aggacacaaa tgatatcgct
     2101 tagtcataag tgtggtagac tggatcctga ccagaaggag gtctgatata atatccatcc
     2161 agacaagaaa tcaacatgct atcaagaacc aggttgaagc aaaactgaaa gtgtgtgata
     2221 tttttgttga cgttatttat aaaaatattt caacgctgtc aataattgtc tttaacctcc
     2281 aagtaggtct tgcagaatcg tcttcatttc atcagaccta ttgggggtga acagtaatta
     2341 ataggaggcc cagcctggca gacgcttgct gacgctcctt ggctcttgcc tgcttgtctt
     2401 tttcattcca tcatggcttc ccttttcata gctggatctt ccgtgaagtg ttccttttgg
     2461 tggtttggat tttttttttt tttaaataaa gaccttatct gccgaattta attgtagaga
     2521 tttgaacccg atcaaagaaa ttttgagttc tctcaaatac cataaaagtg tttgctacaa
     2581 taaataaaat tcttgtgact ttactaccaa gtcatctct
//
