LOCUS       NP_034929                481 aa            linear   ROD 04-JUN-2024
DEFINITION  multiple inositol polyphosphate phosphatase 1 precursor [Mus
            musculus].
ACCESSION   NP_034929
VERSION     NP_034929.1
DBSOURCE    REFSEQ: accession NM_010799.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 481)
  AUTHORS   Ucuncu,E., Rajamani,K., Wilson,M.S.C., Medina-Cano,D., Altin,N.,
            David,P., Barcia,G., Lefort,N., Banal,C., Vasilache-Dangles,M.T.,
            Pitelet,G., Lorino,E., Rabasse,N., Bieth,E., Zaki,M.S., Topcu,M.,
            Sonmez,F.M., Musaev,D., Stanley,V., Bole-Feysot,C., Nitschke,P.,
            Munnich,A., Bahi-Buisson,N., Fossoud,C., Giuliano,F., Colleaux,L.,
            Burglen,L., Gleeson,J.G., Boddaert,N., Saiardi,A. and Cantagrel,V.
  TITLE     MINPP1 prevents intracellular accumulation of the chelator inositol
            hexakisphosphate and is mutated in Pontocerebellar Hypoplasia
  JOURNAL   Nat Commun 11 (1), 6087 (2020)
   PUBMED   33257696
  REMARK    GeneRIF: MINPP1 prevents intracellular accumulation of the chelator
            inositol hexakisphosphate and is mutated in Pontocerebellar
            Hypoplasia.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 481)
  AUTHORS   Chi,H., Yang,X., Kingsley,P.D., O'Keefe,R.J., Puzas,J.E.,
            Rosier,R.N., Shears,S.B. and Reynolds,P.R.
  TITLE     Targeted deletion of Minpp1 provides new insight into the activity
            of multiple inositol polyphosphate phosphatase in vivo
  JOURNAL   Mol Cell Biol 20 (17), 6496-6507 (2000)
   PUBMED   10938126
REFERENCE   3  (residues 1 to 481)
  AUTHORS   Chi,H., Tiller,G.E., Dasouki,M.J., Romano,P.R., Wang,J.,
            O'keefe,R.J., Puzas,J.E., Rosier,R.N. and Reynolds,P.R.
  TITLE     Multiple inositol polyphosphate phosphatase: evolution as a
            distinct group within the histidine phosphatase family and
            chromosomal localization of the human and mouse genes to
            chromosomes 10q23 and 19
  JOURNAL   Genomics 56 (3), 324-336 (1999)
   PUBMED   10087200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115752.8, AK151486.1 and AV297692.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF046908.1, AK128911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 27.25 cM"
     Protein         1..481
                     /product="multiple inositol polyphosphate phosphatase 1
                     precursor"
                     /EC_number="3.1.3.62"
                     /EC_number="3.1.3.80"
                     /note="multiple inositol polyphosphate phosphatase 1;
                     ins(1,3,4,5)P(4) 3-phosphatase; inositol
                     (1,3,4,5)-tetrakisphosphate 3-phosphatase; 2,3-BPG
                     phosphatase; 2,3-bisphosphoglycerate 3-phosphatase"
                     /calculated_mol_wt=51547
     sig_peptide     1..30
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2L6.3)"
                     /calculated_mol_wt=3009
     mat_peptide     31..481
                     /product="Multiple inositol polyphosphate phosphatase 1.
                     /id=PRO_0000019583"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2L6.3)"
                     /calculated_mol_wt=51547
     Region          82..429
                     /region_name="HP_HAP_like"
                     /note="Histidine phosphatase domain found in histidine
                     acid phosphatases and phytases; contains a His residue
                     which is phosphorylated during the reaction; cd07061"
                     /db_xref="CDD:132717"
     Site            order(88..89,92,180,364..365)
                     /site_type="active"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132717"
     Site            236
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2L6.3)"
     Site            475
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2L6.3)"
     Region          478..481
                     /region_name="Prevents secretion from ER.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU10138,
                     ECO:0000269|PubMed:10938126"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2L6.3)"
     CDS             1..481
                     /gene="Minpp1"
                     /coded_by="NM_010799.2:173..1618"
                     /db_xref="CCDS:CCDS29751.1"
                     /db_xref="GeneID:17330"
                     /db_xref="MGI:MGI:1336159"
ORIGIN      
        1 mlrgarshlp asvapaavla aallssfarc slpgrgdpva svlspyfgtk tryedanpwl
       61 lvdpvaprrd pellagtctp vqlvalirhg trypttkqir klkqlqgllq tresrdggsq
      121 vaaalaewpl wygdwmdgql vekgrqdmrq lalrlaalfp dlfsrenydr lrlitsskhr
      181 cvdssaaflq glwqhyhpgl pppdvsdmec gpprindklm rffdhcekfl tdvernetal
      241 yhveafktgp emqkvlkkva atlqvpmnsl nadliqvaff tcsfdlaikg vhspwcdvfd
      301 vddarvleyl ndlkqywkrs ygytinsrss cnlfqdiflh ldkaveqkqr sqpvsspvil
      361 qfghaetllp llslmgyfkd kepltaynfe eqvnrkfrsg hivpyasnli fvlyhcdnaq
      421 speeqfqiql llnekvlpla hsqrpvglye elkthyrdil qscqtskecs ppkanitsde
      481 l
//
