LOCUS       NM_001403555            5074 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus misshapen-like kinase 1 (zebrafish) (Mink1),
            transcript variant 5, mRNA.
ACCESSION   NM_001403555 XM_006533679
VERSION     NM_001403555.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5074)
  AUTHORS   Zhan,K., Zhu,K., Gu,B., Yao,S., Fu,F., Zeng,H., Tian,K., Ji,W.,
            Jin,H., Tong,P., Wu,C., Yue,M. and Ruan,H.
  TITLE     MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and
            exacerbates intervertebral disc degeneration
  JOURNAL   Int Immunopharmacol 134, 112202 (2024)
   PUBMED   38723371
  REMARK    GeneRIF: MINK1 deficiency stimulates nucleus pulposus cell
            pyroptosis and exacerbates intervertebral disc degeneration.
REFERENCE   2  (bases 1 to 5074)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5074)
  AUTHORS   Yu,D., Hu,J., Sheng,Z., Fu,G., Wang,Y., Chen,Y., Pan,Z., Zhang,X.,
            Wu,Y., Sun,H., Dai,J., Lu,L. and Ouyang,H.
  TITLE     Dual roles of misshapen/NIK-related kinase (MINK1) in
            osteoarthritis subtypes through the activation of TGFbeta signaling
  JOURNAL   Osteoarthritis Cartilage 28 (1), 112-121 (2020)
   PUBMED   31647983
  REMARK    GeneRIF: Dual roles of misshapen/NIK-related kinase (MINK1) in
            osteoarthritis subtypes through the activation of TGFbeta
            signaling.
REFERENCE   4  (bases 1 to 5074)
  AUTHORS   Fu,G., Xu,Q., Qiu,Y., Jin,X., Xu,T., Dong,S., Wang,J., Ke,Y.,
            Hu,H., Cao,X., Wang,D., Cantor,H., Gao,X. and Lu,L.
  TITLE     Suppression of Th17 cell differentiation by misshapen/NIK-related
            kinase MINK1
  JOURNAL   J Exp Med 214 (5), 1453-1469 (2017)
   PUBMED   28400474
  REMARK    GeneRIF: a critical regulator of Th17 cell differentiation
REFERENCE   5  (bases 1 to 5074)
  AUTHORS   Diril,M.K., Bisteau,X., Kitagawa,M., Caldez,M.J., Wee,S.,
            Gunaratne,J., Lee,S.H. and Kaldis,P.
  TITLE     Loss of the Greatwall Kinase Weakens the Spindle Assembly
            Checkpoint
  JOURNAL   PLoS Genet 12 (9), e1006310 (2016)
   PUBMED   27631493
  REMARK    GeneRIF: using in vitro dephosphorylation assays, we demonstrate
            that Mastl promotes persistent MPS1 phosphorylation by inhibiting
            PP2A/B55-mediated MPS1 dephosphorylation rather than affecting Cdk1
            kinase activity. Our findings establish a key regulatory function
            of the Greatwall kinase/Mastl - PP2A/B55 pathway in preventing
            premature SAC silencing
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5074)
  AUTHORS   Hu,Y., Leo,C., Yu,S., Huang,B.C., Wang,H., Shen,M., Luo,Y.,
            Daniel-Issakani,S., Payan,D.G. and Xu,X.
  TITLE     Identification and functional characterization of a novel human
            misshapen/Nck interacting kinase-related kinase, hMINK beta
  JOURNAL   J Biol Chem 279 (52), 54387-54397 (2004)
   PUBMED   15469942
  REMARK    Erratum:[J Biol Chem. 2005 Feb 11;280(6):5128]
REFERENCE   7  (bases 1 to 5074)
  AUTHORS   Dan,I., Watanabe,N.M., Kajikawa,E., Ishida,T., Pandey,A. and
            Kusumi,A.
  TITLE     Overlapping of MINK and CHRNE gene loci in the course of mammalian
            evolution
  JOURNAL   Nucleic Acids Res 30 (13), 2906-2910 (2002)
   PUBMED   12087176
REFERENCE   8  (bases 1 to 5074)
  AUTHORS   Dan,I., Watanabe,N.M., Kobayashi,T., Yamashita-Suzuki,K.,
            Fukagaya,Y., Kajikawa,E., Kimura,W.K., Nakashima,T.M.,
            Matsumoto,K., Ninomiya-Tsuji,J. and Kusumi,A.
  TITLE     Molecular cloning of MINK, a novel member of mammalian GCK family
            kinases, which is up-regulated during postnatal mouse cerebral
            development
  JOURNAL   FEBS Lett 469 (1), 19-23 (2000)
   PUBMED   10708748
REFERENCE   9  (bases 1 to 5074)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 5074)
  AUTHORS   Osada,S., Izawa,M., Saito,R., Mizuno,K., Suzuki,A., Hirai,S. and
            Ohno,S.
  TITLE     YSK1, a novel mammalian protein kinase structurally related to
            Ste20 and SPS1, but is not involved in the known MAPK pathways
  JOURNAL   Oncogene 14 (17), 2047-2057 (1997)
   PUBMED   9160885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592547.9.
            
            On Mar 31, 2022 this sequence version replaced XM_006533679.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.528983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AL592547.9         71511-71769         c
            260-325             AL592547.9         37404-37469         c
            326-382             AL592547.9         35739-35795         c
            383-508             AL592547.9         35532-35657         c
            509-619             AL592547.9         32913-33023         c
            620-710             AL592547.9         32580-32670         c
            711-841             AL592547.9         31824-31954         c
            842-896             AL592547.9         31318-31372         c
            897-975             AL592547.9         31089-31167         c
            976-1151            AL592547.9         30694-30869         c
            1152-1221           AL592547.9         30384-30453         c
            1222-1432           AL592547.9         29432-29642         c
            1433-1549           AL592547.9         28473-28589         c
            1550-1636           AL592547.9         27920-28006         c
            1637-1861           AL592547.9         27493-27717         c
            1862-2035           AL592547.9         27122-27295         c
            2036-2299           AL592547.9         26617-26880         c
            2300-2385           AL592547.9         26211-26296         c
            2386-2496           AL592547.9         25938-26048         c
            2497-2615           AL592547.9         25679-25797         c
            2616-2704           AL592547.9         25383-25471         c
            2705-2868           AL592547.9         24920-25083         c
            2869-2974           AL592547.9         24454-24559         c
            2975-3112           AL592547.9         24234-24371         c
            3113-3221           AL592547.9         23928-24036         c
            3222-3389           AL592547.9         23160-23327         c
            3390-3533           AL592547.9         22908-23051         c
            3534-3668           AL592547.9         22266-22400         c
            3669-3769           AL592547.9         22056-22156         c
            3770-3919           AL592547.9         21822-21971         c
            3920-4079           AL592547.9         21571-21730         c
            4080-4219           AL592547.9         21343-21482         c
            4220-5074           AL592547.9         20154-21008         c
FEATURES             Location/Qualifiers
     source          1..5074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.0 cM"
     gene            1..5074
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /note="misshapen-like kinase 1 (zebrafish)"
                     /db_xref="GeneID:50932"
                     /db_xref="MGI:MGI:1355329"
     exon            1..259
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..4303
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /EC_number="2.7.11.1"
                     /note="isoform 5 is encoded by transcript variant 5; MEKKK
                     6; MEK kinase kinase 6; GCK family kinase MiNK;
                     misshapen/NIK-related kinase; MAPK/ERK kinase kinase
                     kinase 6; Yeast Sps1/Ste20-related kinase 2;
                     Misshapen/NIKs-related kinase"
                     /codon_start=1
                     /product="misshapen-like kinase 1 isoform 5"
                     /protein_id="NP_001390484.1"
                     /db_xref="GeneID:50932"
                     /db_xref="MGI:MGI:1355329"
                     /translation="MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRH
                     VKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLW
                     LVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVL
                     LTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWS
                     LGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLS
                     RPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHG
                     EEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLH
                     QRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQE
                     YIRHRLEEEQRQLEILQQQLLQEQALLLEYKRKQLEEQRQSERLQRQLQQEHAYLKSL
                     QQQQQQQQLQKQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERARMNKQQNS
                     PLAKAKPSSAGPEPPISQASPSPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYA
                     APVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQNSDPTSEGPGP
                     SPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQ
                     RRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLER
                     NRNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPADFVLLKERTLDEAPKPPKKAMD
                     YSSSSEEVESSEEEEEEGDGEPSEGSRDTPGGRSDGDTDSVSTMVVHDVEEISGTQPS
                     YGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPTENSKGQSPPTKDGGSDYQ
                     SRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQFDVRKGSVVN
                     VNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGL
                     IGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD
                     MEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLT
                     VEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLL
                     CYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDG
                     VFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW"
     exon            260..325
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..382
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..508
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..619
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..710
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            711..841
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..896
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..975
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1151
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1221
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1432
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1549
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1636
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1861
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2035
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2299
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2385
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2496
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2615
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2704
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2868
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2974
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3112
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3221
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3389
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3533
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..3668
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3769
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3919
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..4079
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            4080..4219
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     exon            4220..5074
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5046..5051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /note="hexamer: AATAAA"
     polyA_site      5074
                     /gene="Mink1"
                     /gene_synonym="B55; Map4k6; MINK; Ysk2"
                     /note="major polyA site"
ORIGIN      
        1 agggcagccg gcgactcggg ttgcaggcgc gcgggtgaga gcgcctgtca gccgctgggt
       61 cggtcctccc gctggccctc cccctccccg gccttcgggg caggcgcggt ggagcccgcc
      121 cctcgagtcc cccgatgggg gagaagcggc gacggcggca gcggagtgag cgagccggag
      181 cgtgagtggc cccgcggcgg ccatgggcga cccagccccc gcccgcagcc tggacgacat
      241 cgacctgtct gccctgcggg accctgcagg aatctttgag ctggtggagg tggttggcaa
      301 tggaacctat ggacaggtat acaaggggcg gcacgtcaag actgggcagc tggctgccat
      361 taaggtcatg gatgtcacag aggatgagga ggaagagatc aaacaggaaa tcaacatgtt
      421 aaagaagtac tctcaccatc gcaatattgc cacctactat ggggccttta tcaagaagag
      481 ccctcctggg aacgatgacc agctctggct ggtgatggag ttctgcggtg ctggttcagt
      541 gaccgacctg gtaaagaaca caaaagggaa cgcactgaag gaggattgca ttgcttacat
      601 ctgcagggag attctcaggg gtcttgccca tctccatgcc cacaaggtga tccacagaga
      661 tatcaaggga caaaatgtgc tgctgacaga gaatgctgaa gtcaagctag tggattttgg
      721 ggtgagtgct cagctggacc gcactgtggg caggcggaac actttcattg gaaccccata
      781 ctggatggct ccagaagtca ttgcctgtga cgagaacccc gatgccacct atgactacag
      841 gagtgacatt tggtctctag gaatcacagc cattgaaatg gcagagggag ccccccctct
      901 gtgtgacatg caccctatgc gggccctctt cctcatccct cggaaccctc cccccaggct
      961 caagtcaaag aaatggtcta agaagttcac tgacttcatc gacacgtgtc tcatcaagac
     1021 ttacctgagc cgcccaccca ccgaacagtt actcaaattc cccttcatcc gagaccagcc
     1081 cacggagcgg caggtccgca tccagctcaa ggaccacatc gaccgctcgc ggaagaagcg
     1141 gggtgagaaa gaggagacag agtatgagta cagcggcagt gaggaggaag acgacagcca
     1201 tggagaggaa ggcgagccaa gctccatcat gaatgtgccc ggtgagtcca cactgcgcag
     1261 agaattcctc agactccagc aggagaataa gagcaactct gaggctttaa agcagcagca
     1321 gcagctgcag caacagcagc agcgggaccc ggaggcacac atcaaacacc tgctgcacca
     1381 gcggcagcgt cgcatagagg agcagaagga ggagcggcga cgtgtggagg agcaacagcg
     1441 gcgagagcga gaacagcgta agctacaaga gaaggagcag cagcggcgat tggaagacat
     1501 gcaagcccta cgacgagagg aagagaggcg gcaagcagag cgggaacagg aatatatccg
     1561 tcacaggcta gaggaggagc agcgacagct cgagatcctt cagcaacagc tgctccagga
     1621 acaggccttg ctgctggaat acaagcggaa gcagctggag gagcagcggc agtcagagcg
     1681 gctgcagaga cagctgcagc aggagcacgc ctacctcaag tccctgcagc agcagcagca
     1741 gcagcagcag ctccagaagc agcagcagca gcagcagcag atcctgcctg gagacaggaa
     1801 gcccctgtat cattacggtc ggggcattaa tcctgctgac aagccagcat gggcccgcga
     1861 ggtggaagag agagcacgga tgaacaagca gcagaactct cccttggcga aggcgaagcc
     1921 aagcagtgcg gggccagagc cccccatctc ccaggcctct cctagccccc caggacctct
     1981 ttcccagact cctcctatgc agaggcctgt ggagccccag gaaggaccgc acaagagcct
     2041 ggtggcacac cgggtcccac tgaagccata tgcagcacct gtaccccgat cccagtccct
     2101 gcaggaccag ccgactcgaa acctggctgc cttcccagcc tcccacgacc ctgaccctgc
     2161 tgctgtccct acacccactg ccacacccag tgcccgagga gctgtcatcc gccagaattc
     2221 agaccccacc tctgaagggc cagggcctag cccaaaccct ccatcctggg ttcggcctga
     2281 taatgaggct ccacctaagg ttccacagag gacctcttct atcgccactg cccttaacac
     2341 cagtggggcc ggagggtccc ggccagctca ggctgtccgt gccagacctc gcagtaactc
     2401 cgcctggcaa atctatctgc agaggcgggc agagcggggc acccccaagc ctcccgggcc
     2461 cccagctcag ccccctggcc cgcccaacgc ctctagtaac cctgacctca ggaggagtga
     2521 ccctggctgg gagcgctcag acagtgtcct cccggcctcc cacggccacc tccctcaggc
     2581 tggctccttg gagcggaacc gaaaccgtgt gggagcctcc acaaaactgg atagctctcc
     2641 agtgctctcc cctgggaaca aagccaagcc tgaagaccac cgctcaaggc caggccggcc
     2701 cgcagacttt gtgttgctca aagagcggac tctggatgag gcccctaagc ctcccaagaa
     2761 ggccatggac tactcctcat ccagtgagga ggtggaaagc agtgaagagg aggaggagga
     2821 aggcgatggg gagccgtcag aggggagcag agacactccc gggggccgca gtgatggtga
     2881 tacagacagc gtcagcacca tggtggttca tgatgttgag gagatatccg ggacccagcc
     2941 ctcatatggc ggcggcacca tggtggtcca gcgtactcct gaagaggaac gaagcctgct
     3001 gcttgctgat agcaatggct acacaaacct gcctgatgtg gtccagccca gccactcacc
     3061 tactgagaac agcaaaggtc aaagccctcc aacaaaggat ggaggcagtg attaccagtc
     3121 tcgtgggctg gtaaaggccc caggaaagag ctcattcacc atgtttgtgg atctagggat
     3181 ctaccagcct ggaggcagtg gggacaccat ccctatcaca gccctagtgg gtggagaagg
     3241 tggtcgcctt gatcaactgc agttcgatgt gaggaagggc tctgtggtca acgtcaatcc
     3301 caccaacacc cgagctcata gtgaaactcc tgaaattcgc aagtacaaga agcgattcaa
     3361 ctcagagatc ctatgtgcag ctctctgggg ggtcaacctc ctagtgggca cagagaatgg
     3421 gctgatgttg ctggaccgaa gtgggcaggg caaggtgtat ggacttattg ggcgacgacg
     3481 cttccagcaa atggatgtct tagaagggct caacttgctc atcaccatct cagggaaaag
     3541 gaacaaactg cgggtatatt acctgtcctg gcttcggaac aagatcctac acaatgaccc
     3601 agaggtggaa aagaagcagg ggtggaccac cgtgggggac atggagggct gcggccacta
     3661 ccgtgttgtg aaatatgaac ggattaagtt cctggtcatt gccctgaaga actccgtgga
     3721 ggtttatgcc tgggctccca aaccctacca caaattcatg gccttcaagt cctttgctga
     3781 cctccctcac cgccctctac tggtggacct gacagtagag gagggacagc ggctcaaggt
     3841 catctatggc tccagtgctg gcttccatgc tgtggatgtt gattctggga acagctatga
     3901 catctacatc cctgtacata tccagagcca gatcacaccc cacgccatca tcttcctccc
     3961 caacactgat ggcatggaga tgctgctgtg ctatgaagat gagggtgtct atgtcaacac
     4021 ttacgggcgg atcatcaagg atgtggtgct gcagtgggga gagatgccca cctctgtggc
     4081 ctacatctgc tccaaccaga taatgggctg gggtgagaag gccatagaga tccgctctgt
     4141 ggagacaggc cacctagatg gggtcttcat gcacaaacga gcccagaggc tcaagttcct
     4201 gtgtgagcgc aatgacaagg tgttttttgc ctctgtccgc tctggaggaa gcagccaagt
     4261 ttactttatg actctgaacc gtaactgcat catgaactgg tgacgaggcc cctgggctgg
     4321 ggctccccac atggacccag ctctcttccc acagccagac tacccaggcc gcccctgccc
     4381 tcccaccccc ttgggctttt gcttttactg gtttgattca ctggagcctg ctgggaacgt
     4441 gacctcatat ccctgaagct ttcgtgatca cgtgaccacc ctttccccca acattctcaa
     4501 aactgtgcct ttccccaact tgtggggaat gacacagctt ccttcccctt accaggaatt
     4561 gagtgggact tgctcctccc cttttctcca cagaagagga gagcgcttgg ggcttggacc
     4621 ccttacccca ttgctgctga atgagcaggg ccctgacccc tttatttgca cgccagggga
     4681 gccggctccc cccttgaatg taccagactc tggggggggg gtgttcactg ggccctgggt
     4741 tctggaggcg gggcggtcac cagccactcc aggggcaggg accattcctc attttctgaa
     4801 agcactttaa tgattccccc ccaaccccca gggaatggag gagggacccc atagccaaaa
     4861 cattcccccc tttcctcccc actcccaccc cttctagcct ctccccttcc ctagaaggag
     4921 agagctcaga gctcccagcc tttatcctcc cttgcttgca tctgtatata gtgtgagcag
     4981 caagtagccc ttctccctcc tgtatccttt ctcaatgtag tggccttgga tatatcccct
     5041 ttgttaataa agacaattca accagcttcc acca
//
