LOCUS       NM_024185               2333 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus MINDY lysine 48 deubiquitinase 3 (Mindy3), transcript
            variant 1, mRNA.
ACCESSION   NM_024185
VERSION     NM_024185.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2333)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2333)
  AUTHORS   Kole,C., Berdugo,N., Da Silva,C., Ait-Ali,N., Millet-Puel,G.,
            Pagan,D., Blond,F., Poidevin,L., Ripp,R., Fontaine,V., Wincker,P.,
            Zack,D.J., Sahel,J.A., Poch,O. and Leveillard,T.
  TITLE     Identification of an Alternative Splicing Product of the Otx2 Gene
            Expressed in the Neural Retina and Retinal Pigmented Epithelial
            Cells
  JOURNAL   PLoS One 11 (3), e0150758 (2016)
   PUBMED   26985665
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2333)
  AUTHORS   Kalsotra,A., Xiao,X., Ward,A.J., Castle,J.C., Johnson,J.M.,
            Burge,C.B. and Cooper,T.A.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   4  (bases 1 to 2333)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY297479.1 and AK009891.1.
            
            On Jul 19, 2005 this sequence version replaced NM_024185.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009891.1, BC027202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY297479.1         11-32
            23-2333             AK009891.1         2-2312
FEATURES             Location/Qualifiers
     source          1..2333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 9.27 cM"
     gene            1..2333
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /note="MINDY lysine 48 deubiquitinase 3"
                     /db_xref="GeneID:66960"
                     /db_xref="MGI:MGI:1914210"
     exon            1..302
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1543
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /EC_number="3.4.19.12"
                     /note="isoform a is encoded by transcript variant 1;
                     caspase recruitment domain containing protein; protein
                     FAM188A; ubiquitin carboxyl-terminal hydrolase FAM188A;
                     deubiquitinating enzyme MINDY-3; ubiquitin
                     carboxyl-terminal hydrolase MINDY-3; family with sequence
                     similarity 188, member A"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-3
                     isoform a"
                     /protein_id="NP_077147.2"
                     /db_xref="CCDS:CCDS15690.1"
                     /db_xref="GeneID:66960"
                     /db_xref="MGI:MGI:1914210"
                     /translation="MSEVTKELLELVWGTKSSPGLSDTIFCRWTQGFVFSESEGSALE
                     QFEGGPCAVIAPVQAFLLKKLLFSSEKSSWRDCSEEEQKELLCHTLCDIVESAYDSSG
                     SYCLVSWLRGRTPEEAARISGSPAQSSCQVEHSSALAVEELGFERFHALIQKRSFRTV
                     SELKDAVLDQYSMWGNKFGVLLFLYSVLLTKGIENIKNSIEDANEPLIDPVYGHGSQS
                     LINLLLTGHAVSNVWDGDRECSGMQLLGIHEQAAVGFLTLMEALRYCKVGSYLKSPKF
                     PIWIVGSETHLTVFFAKDMALVAPEAPSEQARRVFQTYDPEDNGFIADSLLEDVMKAL
                     DLVSDPEYINLMKNKLDPEGLGIILLGPFLQEFFPDQGSSGPESFTVYHYNGLKQSNY
                     NEKVMYVEGTAVVMGFEDPMLQTDDTPIKRCLQTKWPYIELLWTTDRCPSLN"
     exon            303..382
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            383..443
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            444..614
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            615..666
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            667..781
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            782..855
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            856..935
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1006
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1087
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1160
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1233
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1321
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1393
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..2333
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2055..2060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
                     /note="hexamer: AATAAA"
     polyA_site      2077
                     /gene="Mindy3"
                     /gene_synonym="1810041E18Rik; 2310047O13Rik;
                     5830410F13Rik; Fam188a"
ORIGIN      
        1 gccgcttccg gcaggggaaa ctcctagttg ccgcttcgcc cggcttgaca ggcggtctgt
       61 gccggcagtg tgctgccctc acccatctcg acctcccgtt cgcgtccgac cgctgccgtc
      121 ccgctgccct tttctcgagc ctccccttcc ctatgttccg ggaccggagt ccgagaagca
      181 aagacccact tcttgtccag ttcccatcat gtccgaagtg accaaagagc tgctggagct
      241 ggtgtggggc accaagagca gtcccggact gtcggacacc atcttctgcc gctggacgca
      301 agggtttgtg tttagtgaat cagagggatc tgcattagag cagtttgaag gtggcccctg
      361 tgctgttatt gcacctgtcc aggcgtttct tttgaagaag cttctgttct cctccgagaa
      421 gtcgtcctgg cgggattgct cagaggaaga gcagaaggag ctcctttgtc acaccttgtg
      481 tgatattgta gagagtgctt atgacagctc tggatcatac tgcttggttt catggttgag
      541 aggaaggacc cccgaggaag cggctaggat ttctgggagt cctgcacagt ctagttgcca
      601 agtggaacat tcttctgcct tggctgtcga agagcttggc tttgagcgat ttcatgcatt
      661 aattcaaaaa agatcattca gaactgtatc agaattaaaa gatgctgtct tggaccagta
      721 ttcaatgtgg ggaaacaaat ttggagtctt gctttttctc tattctgtat tactgacaaa
      781 gggcattgaa aacataaaga attcaattga agatgcaaat gagcctttga tagaccctgt
      841 gtacgggcat ggcagccaaa gcttaattaa cctcctactg acggggcatg cagtatctaa
      901 tgtatgggat ggtgatagag agtgctcagg aatgcaactt ctcggtatcc atgaacaagc
      961 agctgtagga ttcttaacac taatggaagc tttacgatat tgtaaggttg gttcttactt
     1021 gaaatctcca aaattcccta tttggattgt tggcagcgaa actcacctca ccgtattttt
     1081 tgccaaggat atggctttag ttgcccctga agcgccttcg gaacaagcca gaagagtttt
     1141 ccaaacctat gatccggaag ataatggatt catagctgac tcccttctag aagatgtcat
     1201 gaaagccttg gaccttgttt cagatcccga gtatataaat ctcatgaaga ataaattaga
     1261 tccagaagga ctaggaatca tattgttggg tccatttctt caagaatttt ttcctgatca
     1321 gggctccagt ggtccagaat cttttactgt ctaccactac aatggattga agcagtcaaa
     1381 ttataatgaa aaggtaatgt atgtggaagg gactgcagtg gttatgggtt ttgaagaccc
     1441 catgctacag acagacgaca ctcctattaa acgctgtctg caaaccaaat ggccatacat
     1501 tgagttactg tggaccacag accgctgtcc ttcgctcaac tgagttgcct gagtatttgt
     1561 aaggaagatt gtcaaaccag gtgttgaaag ggggattcat gactggctac ataaagctaa
     1621 acactggtat tgttaattaa ctataaataa caattaaaaa cacatttttc agtgtttaag
     1681 atacgtttaa attatttgtt ctaaagcttt atgttaaagg ttatcctatt ttactccttt
     1741 ctgtgaaatt tactaacaaa attaagcttt aattaaagtt catcgcttct gcagtcaggg
     1801 aactggttgt taccagatta taaacacaat attatagcat ttttataaat ggaatcagtc
     1861 acaaaaacct gcctggaata tcacttcatt catttcattt tactgtatta ttttagcagc
     1921 ctccatatca aaatgcagaa gtcaattttt gttaattttg tttttcatca gaaatactaa
     1981 taaatcacaa attatagacc ctggctattt ggtaactaat ttaactatag catgtttacc
     2041 aaaaaagaaa ataaaataaa aattttttta aaaaggctac tatgtgggaa cttctatttg
     2101 ttcacaggtg cacaggaatg tggtttttac aacgataggg gaagaatctg tttgctttgt
     2161 gggcttacta ttctcacttt cactgtattg ctaagtacac tctcctgcaa gccagctttc
     2221 ttgtatattt ataagtgtgg taatgcatga gaatctctac tgttacatta gcatattgca
     2281 ttatttatta tggccccagc taataccgta aataaagact tttctttaac tac
//
