LOCUS       NM_199475               2850 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus MINDY lysine 48 deubiquitinase 1 (Mindy1), transcript
            variant 1, mRNA.
ACCESSION   NM_199475
VERSION     NM_199475.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2850)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2850)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2850)
  AUTHORS   James,C., Zhao,T.Y., Rahim,A., Saxena,P., Muthalif,N.A., Uemura,T.,
            Tsuneyoshi,N., Ong,S., Igarashi,K., Lim,C.Y., Dunn,N.R. and
            Vardy,L.A.
  TITLE     MINDY1 Is a Downstream Target of the Polyamines and Promotes
            Embryonic Stem Cell Self-Renewal
  JOURNAL   Stem Cells 36 (8), 1170-1178 (2018)
   PUBMED   29644784
  REMARK    GeneRIF: high polyamine levels are required for embryonic stem
            cells self-renewal and that they function, in part, through
            promotion of high MINDY1 levels.
REFERENCE   4  (bases 1 to 2850)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2850)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   6  (bases 1 to 2850)
  AUTHORS   Fock,E.L., Yan,F., Pan,S. and Chong,B.H.
  TITLE     NF-E2-mediated enhancement of megakaryocytic differentiation and
            platelet production in vitro and in vivo
  JOURNAL   Exp Hematol 36 (1), 78-92 (2008)
   PUBMED   17923245
  REMARK    GeneRIF: Early megakaryocyte differentiation, characterized by
            colony-forming unit MK formation, was enhanced by p45-NF-E2
            overexpression at the expense of CFU-granulocyte macrophage
            development. An increased number of acetylcholinesterase(+) MKs was
            observed.
REFERENCE   7  (bases 1 to 2850)
  AUTHORS   Mao,H.Z., Roussos,E.T. and Peterfy,M.
  TITLE     Genetic analysis of the diabetes-prone C57BLKS/J mouse strain
            reveals genetic contribution from multiple strains
  JOURNAL   Biochim Biophys Acta 1762 (4), 440-446 (2006)
   PUBMED   16481151
REFERENCE   8  (bases 1 to 2850)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 2850)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2850)
  AUTHORS   Takahashi,Y., Miyata,M., Zheng,P., Imazato,T., Horwitz,A. and
            Smith,J.D.
  TITLE     Identification of cAMP analogue inducible genes in RAW264
            macrophages
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 385-394 (2000)
   PUBMED   11004510
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ571591.1, BC094388.1 and BC132301.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094388.1, AK169673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BQ571591.1         1-13
            14-262              BQ571591.1         15-263
            263-1959            BC094388.1         80-1776
            1960-1968           BC132301.1         1205-1213
            1969-2850           BC094388.1         1786-2667
FEATURES             Location/Qualifiers
     source          1..2850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..2850
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /note="MINDY lysine 48 deubiquitinase 1"
                     /db_xref="GeneID:75007"
                     /db_xref="MGI:MGI:1922257"
     exon            1..691
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /inference="alignment:Splign:2.1.0"
     exon            692..1447
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /inference="alignment:Splign:2.1.0"
     CDS             995..2401
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1; NF-E2
                     inducible protein; protein FAM63A; deubiquitinating enzyme
                     MINDY-1; ubiquitin carboxyl-terminal hydrolase MINDY-1;
                     family with sequence similarity 63, member A"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-1
                     isoform 1"
                     /protein_id="NP_955769.1"
                     /db_xref="CCDS:CCDS57233.1"
                     /db_xref="GeneID:75007"
                     /db_xref="MGI:MGI:1922257"
                     /translation="MEQPQTENPAPSKATSAETVESENHEALSGPEKHPQDKDGADAD
                     GAAGEQEPGDQTLPPAQDGENLECPPPEASSSPPGPACGTSPKVETAEVCSRPQELPQ
                     SPRIQQPELDFYCVKWIPWKGERTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEV
                     ITSDELLTHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVS
                     DFEYTPECSIFDLLGIPLYHGWLVDPQSPEAVSAVGKLSYNQLVEKIITCKHSSDSNL
                     VTEGLVAEQFLETTAAQLTYHGLCELTAAATEDELSVFFRNNHFSTMTKHKSHLYLLV
                     TDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKSHGAEGGGGSPEKQLQVDQD
                     YLIALSLQQQQQPQGTLGLSDLELAQQLQQEEYQQQQAVQPVRTRAPSPQGRGATSGR
                     PAGERRQRSKTESDCVLL"
     exon            1448..1505
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1570
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1729
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1832
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1975
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2167
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2320
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2834
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2816..2821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /note="hexamer: AATAAA"
     polyA_site      2834
                     /gene="Mindy1"
                     /gene_synonym="1810005H09Rik; 4930504E06Rik; cI-40;
                     Fam63a; mKIAA1390; ni"
                     /note="major polyA site"
ORIGIN      
        1 cgggcatcca gggaggtcta atcaacagcc gctgtcccgc cctgctcctc cgggctctgc
       61 caggccgctt gcttttcccg gttctcacca gagaggcaca cgcgctccgt cccttccagc
      121 ggcaggcgga gggaagagaa agggtctgtt gtttttctct cttcctttct gcggctcacc
      181 gggctgctga ccggctcaga cagccctgat ggaaatcctc ggtagctgag caggcccctc
      241 ctcctcctcc tcctctaggg accgcgtcct tggctaattt gtctttgtcc ggacaggggg
      301 aaaagaggga cagagagaag aaaaagaaaa accacaaact tcctttgaaa gccagtttgt
      361 aggcacggcc tggagcgcac gccggaggct cggtgactcg ggaatcctga agactctggg
      421 aagccaggcg ggaccgcctg cgctgtgcct tgcttgtcct cggccccgac cctgctccag
      481 cgtcccccgt attgggcgtg tgtccggaag tggcagcgac ccaggctgga cgccgcgaga
      541 gtaaacccgt gtcaagccgt gtaagctctg gggctgacag ctgggaggcg gctggcgcag
      601 tcggcgcccc tcaacgatgt ccccacctcc cgcgtagaac cgccagagtt gagtcctctc
      661 ccagtgccgg aacctcatct acctctttga gggaagaagc cagctgcacc cagtatctcc
      721 atcctttcca agcctgataa cccatgtcca gtcggcccca tctggtcaca gcaagtcaga
      781 ggtggaatga gctgaatcct gtttatacac tctgagaaaa acttaatctg gagccagagt
      841 agcctacaca gttctctttg acttttcttg ttccctttgc tctgtaattc agtgaccttg
      901 taggcccagt ctctcttcta cacactagaa tagccatagg caaggtctct gaggtctcag
      961 aacacttcac tcccctcagc tgactgtacc cactatggaa caacctcaga ctgagaaccc
     1021 agcccctagt aaggccacta gtgcagaaac tgttgaatct gaaaaccatg aggccctgtc
     1081 tggaccagag aagcatcctc aggacaagga tggtgcagat gctgatggag cagctggaga
     1141 acaggagcca ggagaccaaa ctttgccacc agcccaggat ggtgaaaatc ttgagtgtcc
     1201 tcctcctgaa gctagctcaa gtcctcctgg gccagcttgt gggacgtcac ctaaggtaga
     1261 gacagcagag gtgtgttcca ggccacagga acttccccag tcccccagga tccaacagcc
     1321 tgagctagat ttctactgtg tcaagtggat cccctggaag ggagaacgga ccccgatcat
     1381 cacccagagc accaatggtc cgtgtcctct tctagccatc atgaacatcc tttttcttca
     1441 gtggaaggtg aagctgcccc ctcagaagga agtgatcaca tcagatgagc tcctgacaca
     1501 ccttggaaac tgccttctgt ccatcaaacc ccaagagaag tctgagggcc ttcaacttaa
     1561 ctttcagcag aatgtggacg atgcaatgac ggtgctcccg aaactggcca caggtctgga
     1621 cgtcaatgtg cgattcacgg gcgtctccga ctttgagtat acgccggaat gcagcatctt
     1681 tgacttgctg ggaatacctc tataccatgg ctggctggtg gatccacaga gtcccgaggc
     1741 tgtgagtgct gttgggaaac tgagttacaa ccagctggta gagaagatca tcacctgtaa
     1801 acactctagt gactccaacc tcgtgacaga aggcttggtt gcggagcagt tcctggagac
     1861 cactgcggca cagttgacct accatggcct gtgcgagctc acagcagctg ccacggaaga
     1921 tgaacttagt gtcttctttc gaaacaacca cttcagcacg atgactaagc acaagagtca
     1981 cctgtaccta ctggtcactg accaaggttt tctacaggag gagcaggtgg tatgggagag
     2041 cttgcataac gtggatggtg acagctgctt ttgtgactcg gacttccacc taagtcattc
     2101 cctaggcaaa agccatggag cagaaggtgg gggtggctct ccagagaagc agctgcaagt
     2161 ggaccaggac taccttattg ccttatccct gcagcagcag cagcagccac aaggcacgtt
     2221 gggcctcagt gacctggaac tggcccaaca acttcaacaa gaagagtatc aacaacagca
     2281 agcagttcaa cctgtgcgaa caagggctcc ttcgccccag gggagaggag ccacatctgg
     2341 acgtccagct ggagagcggc ggcagaggtc aaagactgag tcagactgtg ttctgctctg
     2401 actctgcccc ctacagccag ctcaggctgt gacttgcagg atcccacccc atctcaatcc
     2461 ctgagacaca gagaataacc tatatgcact gttggggatc agaacagaca ataggtgcca
     2521 aggtcagact tggtaccatc tttgcccttg tactgctatc ttctcttcct ctcttccaag
     2581 gccacatagg tgtgggtggg tgaaaatctc tggtgcccca ccccctttcc tggaatagtc
     2641 ccgtggatac atggacccag gctgcttgct ggtcaagaca cctatctgga aagcatctct
     2701 cttgtgtccc tgcctgtttg ctcctgggct accccacaga ccctgccgtc tttgttttag
     2761 ggtttggttt gagtttctat ctttattatt tttaatgcct tcctagaggt ttggaaataa
     2821 aacttctttc ctgaaaaaaa aaaaaaaaaa
//
