LOCUS       NM_153761               1120 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus MHC I like leukocyte 2 (Mill2), transcript variant 1,
            mRNA.
ACCESSION   NM_153761 XM_985890
VERSION     NM_153761.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1120)
  AUTHORS   Kajikawa,M., Ose,T., Fukunaga,Y., Okabe,Y., Matsumoto,N.,
            Yonezawa,K., Shimizu,N., Kollnberger,S., Kasahara,M. and Maenaka,K.
  TITLE     Structure of MHC class I-like MILL2 reveals heparan-sulfate binding
            and interdomain flexibility
  JOURNAL   Nat Commun 9 (1), 4330 (2018)
   PUBMED   30337538
  REMARK    GeneRIF: MILL2 has a unique structural architecture and
            physiological role, with binding to heparan sulfate proteoglycans
            on fibroblasts possibly regulating cellular recruitment in
            biological events.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1120)
  AUTHORS   Ritter,C., Fan,K., Paulson,K.G., Nghiem,P., Schrama,D. and
            Becker,J.C.
  TITLE     Reversal of epigenetic silencing of MHC class I chain-related
            protein A and B improves immune recognition of Merkel cell
            carcinoma
  JOURNAL   Sci Rep 6, 21678 (2016)
   PUBMED   26902929
  REMARK    GeneRIF: Reversal of epigenetic silencing of MICA and MICB improves
            immune recognition and killing of Merkel cell carcinoma cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1120)
  AUTHORS   Martinez-Naves,E., Lafuente,E.M. and Reche,P.A.
  TITLE     Recognition of the ligand-type specificity of classical and
            non-classical MHC I proteins
  JOURNAL   FEBS Lett 585 (21), 3478-3484 (2011)
   PUBMED   22001201
REFERENCE   4  (bases 1 to 1120)
  AUTHORS   Rabinovich,B.A., Ketchem,R.R., Wolfson,M., Goldstein,L., Skelly,M.
            and Cosman,D.
  TITLE     A role for the MHC class I-like Mill molecules in nutrient
            metabolism and wound healing
  JOURNAL   Immunol Cell Biol 86 (6), 489-496 (2008)
   PUBMED   18560379
  REMARK    GeneRIF: Our results suggest a role for the Mill proteins in
            cellular metabolism, with possible therapeutic significance.
REFERENCE   5  (bases 1 to 1120)
  AUTHORS   Kajikawa,M., Baba,T., Tomaru,U., Watanabe,Y., Koganei,S.,
            Tsuji-Kawahara,S., Matsumoto,N., Yamamoto,K., Miyazawa,M.,
            Maenaka,K., Ishizu,A. and Kasahara,M.
  TITLE     MHC class I-like MILL molecules are beta2-microglobulin-associated,
            GPI-anchored glycoproteins that do not require TAP for cell surface
            expression
  JOURNAL   J Immunol 177 (5), 3108-3115 (2006)
   PUBMED   16920948
  REMARK    GeneRIF: two members of the mouse MILL family, MILL1 and MILL2, are
            GPI-anchored glycoproteins associated with beta2-microglobulin
            (beta2m)
REFERENCE   6  (bases 1 to 1120)
  AUTHORS   Belov,K., Deakin,J.E., Papenfuss,A.T., Baker,M.L., Melman,S.D.,
            Siddle,H.V., Gouin,N., Goode,D.L., Sargeant,T.J., Robinson,M.D.,
            Wakefield,M.J., Mahony,S., Cross,J.G., Benos,P.V., Samollow,P.B.,
            Speed,T.P., Graves,J.A. and Miller,R.D.
  TITLE     Reconstructing an ancestral mammalian immune supercomplex from a
            marsupial major histocompatibility complex
  JOURNAL   PLoS Biol 4 (3), e46 (2006)
   PUBMED   16435885
REFERENCE   7  (bases 1 to 1120)
  AUTHORS   Zhang,B., Wei,H., Zheng,X., Zhang,J., Sun,R. and Tian,Z.
  TITLE     The inhibitory effects of synthetic short peptides, mimicking MICA
            and targeting at NKG2D receptors, on function of NK cells
  JOURNAL   Peptides 26 (3), 405-412 (2005)
   PUBMED   15652646
  REMARK    GeneRIF: analysis of functional sites in NKG2D-MICA interaction in
            mouse and human
REFERENCE   8  (bases 1 to 1120)
  AUTHORS   Kasahara,M., Watanabe,Y., Sumasu,M. and Nagata,T.
  TITLE     A family of MHC class I-like genes located in the vicinity of the
            mouse leukocyte receptor complex
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13687-13692 (2002)
   PUBMED   12370446
  REMARK    GeneRIF: Mill1 and Mill2 genes are predicted to encode membrane
            glycoproteins with domain organization essentially similar to that
            of MHC class I heavy chains.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153651.4.
            
            On Dec 20, 2007 this sequence version replaced NM_153761.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB086267.1, BC144886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC153651.4         94832-94957         c
            127-171             AC153651.4         93409-93453         c
            172-435             AC153651.4         78720-78983         c
            436-711             AC153651.4         78242-78517         c
            712-990             AC153651.4         76504-76782         c
            991-1120            AC153651.4         76270-76399         c
FEATURES             Location/Qualifiers
     source          1..1120
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.35 cM"
     gene            1..1120
                     /gene="Mill2"
                     /gene_synonym="Micb"
                     /note="MHC I like leukocyte 2"
                     /db_xref="GeneID:243864"
                     /db_xref="MGI:MGI:2179989"
     exon            1..126
                     /gene="Mill2"
                     /gene_synonym="Micb"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1094
                     /gene="Mill2"
                     /gene_synonym="Micb"
                     /note="isoform long precursor is encoded by transcript
                     variant 1; MHC class I-like located near the LRC, 2; VMHC
                     class I polypeptide-related sequence B; MHC class I-like
                     located near the leukocyte receptor complex 2; MHC class
                     I-like protein MILL2"
                     /codon_start=1
                     /product="MHC class I-like protein MILL2 isoform long
                     precursor"
                     /protein_id="NP_715642.2"
                     /db_xref="CCDS:CCDS20880.1"
                     /db_xref="GeneID:243864"
                     /db_xref="MGI:MGI:2179989"
                     /translation="MKASSGKPREFRPAVLLLILGLLLRDSRGSSIQGFLADVEVHGS
                     SRLTRTHTLRYNVRAHSLEGSEKTQLLVLIYVDEELFLKYNGDSRETEPLGCWIKGHG
                     GNETCARETNNLLKVEEKLRGMMAEVINQKSQEEGLHTLQATLGCELLSNGSTRGFWH
                     LGYDGQNFLTFDQKTLTWTVDGPSTQQNKMFWKTHAPRADLVKTFLDDICPAHLQRYL
                     ASLRNGLQDTGPPMVTVTCRNYPVGRVTLTCRAFNLYTREATLVWLQDGKPVQQKTFR
                     SETILPSGDGTYQARVSIRVLPGQEPQFSCNLRHGNHSIMQTAVSGHAAEDSQDVASS
                     ATASAGSALPVVLAVALARAN"
     exon            127..171
                     /gene="Mill2"
                     /gene_synonym="Micb"
                     /inference="alignment:Splign:2.1.0"
     exon            172..435
                     /gene="Mill2"
                     /gene_synonym="Micb"
                     /inference="alignment:Splign:2.1.0"
     exon            436..711
                     /gene="Mill2"
                     /gene_synonym="Micb"
                     /inference="alignment:Splign:2.1.0"
     exon            712..990
                     /gene="Mill2"
                     /gene_synonym="Micb"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1120
                     /gene="Mill2"
                     /gene_synonym="Micb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgcacaaa actccatttg agaaaaatga aagccagttc tggaaagccc agagaattca
       61 gaccagcagt cctactgttg atcttagggc tgctccttag agactcacgg ggatccagca
      121 tccaagggtt tctggctgac gtggaggttc atggttccag caggctgacc agaacccaca
      181 ctctgcgcta taatgtcaga gcccattctc tggaggggtc tgagaagacc cagctcctgg
      241 tcctaatata cgtagatgaa gagctcttcc tgaaatacaa tggagacagc agggagacag
      301 agcccttggg atgctggatt aagggccatg ggggaaatga gacctgtgca agagagacta
      361 acaatctgtt gaaggtggaa gagaaactca gggggatgat ggctgaggtt ataaaccaga
      421 agagtcagga ggaaggcctt cacactctcc aggcaacttt gggctgtgag cttctgagta
      481 atgggagcac tagaggcttc tggcacctgg gctatgatgg gcagaacttc ctcacctttg
      541 accagaagac tctcacgtgg acagtggatg gaccctccac ccagcagaac aagatgttct
      601 ggaagacaca tgcacccaga gctgatctag ttaagacatt cttggatgat atatgtcctg
      661 ctcacctcca gagatacctc gcttccttga gaaacggtct gcaggataca ggacccccaa
      721 tggtaactgt gacctgcagg aactatccag taggtagggt cacactgaca tgccgggctt
      781 ttaatctgta tacccgtgag gccaccctgg tctggcttca ggatgggaag ccagtacagc
      841 agaaaacctt cagatctgag accatcctgc ccagcgggga tgggacctac caggcccggg
      901 tgtccattcg ggttcttcct ggacaggaac cacagttcag ctgcaacctg aggcatggca
      961 accatagcat catgcagaca gctgtctctg ggcatgctgc tgaggacagt caggatgttg
     1021 ctagctctgc tacagcttca gctggatctg cactccctgt tgtattggcg gtggcactgg
     1081 ccagagccaa ctgaatccag aacacaaagg acaggaccag
//
