LOCUS       NM_153749               2489 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus MHC I like leukocyte 1 (Mill1), mRNA.
ACCESSION   NM_153749 XM_985454
VERSION     NM_153749.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2489)
  AUTHORS   Ritter,C., Fan,K., Paulson,K.G., Nghiem,P., Schrama,D. and
            Becker,J.C.
  TITLE     Reversal of epigenetic silencing of MHC class I chain-related
            protein A and B improves immune recognition of Merkel cell
            carcinoma
  JOURNAL   Sci Rep 6, 21678 (2016)
   PUBMED   26902929
  REMARK    GeneRIF: Reversal of epigenetic silencing of MICA and MICB improves
            immune recognition and killing of Merkel cell carcinoma cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2489)
  AUTHORS   Martinez-Naves,E., Lafuente,E.M. and Reche,P.A.
  TITLE     Recognition of the ligand-type specificity of classical and
            non-classical MHC I proteins
  JOURNAL   FEBS Lett 585 (21), 3478-3484 (2011)
   PUBMED   22001201
REFERENCE   3  (bases 1 to 2489)
  AUTHORS   Rabinovich,B.A., Ketchem,R.R., Wolfson,M., Goldstein,L., Skelly,M.
            and Cosman,D.
  TITLE     A role for the MHC class I-like Mill molecules in nutrient
            metabolism and wound healing
  JOURNAL   Immunol Cell Biol 86 (6), 489-496 (2008)
   PUBMED   18560379
  REMARK    GeneRIF: Our results suggest a role for the Mill proteins in
            cellular metabolism, with possible therapeutic significance.
REFERENCE   4  (bases 1 to 2489)
  AUTHORS   Kajikawa,M., Baba,T., Tomaru,U., Watanabe,Y., Koganei,S.,
            Tsuji-Kawahara,S., Matsumoto,N., Yamamoto,K., Miyazawa,M.,
            Maenaka,K., Ishizu,A. and Kasahara,M.
  TITLE     MHC class I-like MILL molecules are beta2-microglobulin-associated,
            GPI-anchored glycoproteins that do not require TAP for cell surface
            expression
  JOURNAL   J Immunol 177 (5), 3108-3115 (2006)
   PUBMED   16920948
  REMARK    GeneRIF: two members of the mouse MILL family, MILL1 and MILL2, are
            GPI-anchored glycoproteins associated with beta2-microglobulin
            (beta2m)
REFERENCE   5  (bases 1 to 2489)
  AUTHORS   Belov,K., Deakin,J.E., Papenfuss,A.T., Baker,M.L., Melman,S.D.,
            Siddle,H.V., Gouin,N., Goode,D.L., Sargeant,T.J., Robinson,M.D.,
            Wakefield,M.J., Mahony,S., Cross,J.G., Benos,P.V., Samollow,P.B.,
            Speed,T.P., Graves,J.A. and Miller,R.D.
  TITLE     Reconstructing an ancestral mammalian immune supercomplex from a
            marsupial major histocompatibility complex
  JOURNAL   PLoS Biol 4 (3), e46 (2006)
   PUBMED   16435885
REFERENCE   6  (bases 1 to 2489)
  AUTHORS   Kasahara,M., Watanabe,Y., Sumasu,M. and Nagata,T.
  TITLE     A family of MHC class I-like genes located in the vicinity of the
            mouse leukocyte receptor complex
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13687-13692 (2002)
   PUBMED   12370446
  REMARK    GeneRIF: Mill1 and Mill2 genes are predicted to encode membrane
            glycoproteins with domain organization essentially similar to that
            of MHC class I heavy chains.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029010.1 and AC151983.3.
            
            On May 1, 2009 this sequence version replaced NM_153749.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029010.1, AK030695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1391              AK029010.1         2-1392
            1392-1956           AC151983.3         85218-85782         c
            1957-2489           AK029010.1         1958-2490
FEATURES             Location/Qualifiers
     source          1..2489
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.15 cM"
     gene            1..2489
                     /gene="Mill1"
                     /gene_synonym="5530400I18Rik"
                     /note="MHC I like leukocyte 1"
                     /db_xref="GeneID:266815"
                     /db_xref="MGI:MGI:2179988"
     exon            1..354
                     /gene="Mill1"
                     /gene_synonym="5530400I18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1451
                     /gene="Mill1"
                     /gene_synonym="5530400I18Rik"
                     /note="MHC class I-like located near the leukocyte
                     receptor complex 1; MHC class I-like protein MILL1"
                     /codon_start=1
                     /product="MHC class I-like protein MILL1 precursor"
                     /protein_id="NP_715630.3"
                     /db_xref="CCDS:CCDS20868.1"
                     /db_xref="GeneID:266815"
                     /db_xref="MGI:MGI:2179988"
                     /translation="MLLSRNLRALAAIHLWIVYLLLEDLLGTCAEGDNQRLVASAPYQ
                     DIEITLEKPRVQAVAEPHTLRYDLMALSLEVPGLPQFLTLRYFDDEPFLPYKKNSSIT
                     DSQEPRIKDHLRAETWGRETDDLQEEEEQLKGMLAEITAQNGQNTDLHILQATFGCEL
                     QRNGSTRGFWKLGYDGQNFLTFDQKTLTWTVDGPSTQKNKTFWKTRAPRADLVKTFLD
                     DICPAQLQRYLASLRNGLLNTGFPKVIVTFRNYPVGRITLTCRAFRLYTRVATLTWLQ
                     YRKPVQQKTFGSETILPSGDGTYQAWVSIRVLPGQESQFSCNLKHGNHNINEPAATEA
                     PVYGARREQPPTSGVGSRVGKSLWSAMTTALVVISWTLSQKLMGPLLWFCSGGFCSFL
                     QCW"
     exon            355..441
                     /gene="Mill1"
                     /gene_synonym="5530400I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            442..705
                     /gene="Mill1"
                     /gene_synonym="5530400I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            706..981
                     /gene="Mill1"
                     /gene_synonym="5530400I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            982..2489
                     /gene="Mill1"
                     /gene_synonym="5530400I18Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatttgaat cagggctgcc tgagcccaaa gcatcctgag cacctctgtg tttctcagct
       61 tctctgtaca gggaccagca gccctccagc cagcccagac actttcagga tcccctttca
      121 gcctcttagg atccccctcc acctgaagtc ccagtgatac ccttaagttc tccttggatt
      181 cctgaggttg gtagagctag taagaggagc tcatctggct tgggatcttc aaagtaaact
      241 cagaagtctc aggcagagag aagatgctgc tgtccaggaa cctcagagcc ctagctgcga
      301 tccacctgtg gatagtgtac ctgctcctgg aggatttact gggcacctgc gcagagggtg
      361 acaaccaaag actggtggct tctgctccct accaagatat tgagatcact ctggagaagc
      421 ctagagtaca ggcggtagca gaaccccaca ctctgcgcta tgacctcatg gccttgtctc
      481 tggaggtgcc tgggttgccc cagttcctga ccctgagata cttcgatgat gagcccttcc
      541 tgccctataa gaaaaacagc agcataacag actcccagga acccaggatc aaagaccatc
      601 tgagagctga gacctgggga agagagactg acgatcttca ggaagaagag gagcaactca
      661 aagggatgct agctgagatc acagcccaga acggccagaa tacggatctt cacatcctcc
      721 aggcaacctt cggctgtgag cttcaaagaa atggaagcac tagaggcttc tggaaactgg
      781 gctatgatgg gcagaacttc ctcacctttg accagaagac tctcacatgg acagtggatg
      841 gaccttccac ccagaagaac aagacattct ggaagacacg tgcacccaga gctgatctag
      901 ttaagacatt cttggatgac atatgtcctg ctcagctcca gagatacctt gcttccttga
      961 gaaatggtct gctgaataca ggtttcccaa aggtgattgt gaccttcagg aactatccag
     1021 tgggcaggat cacactgaca tgccgggctt ttcgtctgta tacccgtgtg gccaccctga
     1081 cctggcttca gtatagaaag ccagtacagc agaaaacctt tggatctgaa actatcctgc
     1141 ccagtgggga tggcacctac caggcctggg tgtccattcg ggttcttcct ggacaggaat
     1201 cacagttcag ctgcaacttg aagcacggca accacaatat caatgaacct gctgccactg
     1261 aggcccctgt ctatggtgcg agaagagaac aacctcccac ctcaggtgtg ggaagcaggg
     1321 tcgggaaaag cctgtggagt gcaatgacta cagctctcgt ggtgatctcc tggacattaa
     1381 gccagaaact gatggggcct ctactctggt tctgctctgg tggcttctgc tcttttctac
     1441 agtgttggta gttcaaaccc ttgcctagag cagcaagaac acgcaggagg acagcaagag
     1501 accaggtgaa cattcctgcg ggctgtagca gaaggtggca ggagtggtga gaggcctttt
     1561 cttctttttg taaattgtac agatagaaag gtagtcacac aagcaccatt ttaccacact
     1621 ggtgaatgga gagccctaaa gagttaccat accgtaccct aacctgccct gctgttggga
     1681 ggcaccgccc cctggtggaa gtgcaatgct acttccgatg tgttcttata tatattatga
     1741 aatacagggg caaagaagca ggctagacat ccacaacaaa gtacgagttg tggcaaacta
     1801 cacatgcccc tgcctcttca ccaaatacat agaaaacaaa cagccaaaca agacagagga
     1861 aaaactgaga gtccaagaga tgatcgagag tcattttacc agatgatgat aactattcca
     1921 gttttatctt gattcaaaca cgggaatttc tcctcaaaag atatccatga agcatctggg
     1981 ggagatagtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtacacg
     2041 tacacaaaca cacatatata agcatttaaa agattttgaa gatatcttat tctctatggt
     2101 ctctttaaat acatactaat aatcaaaagg attcttagta tcccgagata caggatttct
     2161 gctctgtctt ctaaattaaa ctactattct tctgccttca ttgtgccagc ctaaaatgat
     2221 cacagcaaaa cttgttaaat gttaatatgc ctccacaata aaagaagaac aagttatccc
     2281 aaccaatttt atttttaaaa taaaatataa attaaaatta gaaattatat tactataatg
     2341 gttttaaaaa ataaaaatgt tacaaaaata aagatatata gtataaaaat aataaaatgt
     2401 tataaaaata ttaaaattta ttttagtaaa gtttatgcat gaagattaaa tggatatatg
     2461 gttacagaat aaaacactga aatattttt
//
