LOCUS       NM_001407284            3611 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus mitoguardin 2 (Miga2), transcript variant 7, mRNA.
ACCESSION   NM_001407284 XM_006497593
VERSION     NM_001407284.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3611)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3611)
  AUTHORS   Yan,M.Q., Zhu,B.H., Liu,X.H., Yang,Y.M., Duan,X.Y., Wang,Y.,
            Sun,H., Feng,M., Li,T. and Liu,X.M.
  TITLE     Mitoguardin 1 and 2 promote granulosa cell proliferation by
            activating AKT and regulating the Hippo-YAP1 signaling pathway
  JOURNAL   Cell Death Dis 14 (11), 779 (2023)
   PUBMED   38012141
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3611)
  AUTHORS   Fan,K.Q., Li,Y.Y., Wang,H.L., Mao,X.T., Guo,J.X., Wang,F.,
            Huang,L.J., Li,Y.N., Ma,X.Y., Gao,Z.J., Chen,W., Qian,D.D.,
            Xue,W.J., Cao,Q., Zhang,L., Shen,L., Zhang,L., Tong,C., Zhong,J.Y.,
            Lu,W., Lu,L., Ren,K.M., Zhong,G., Wang,Y., Tang,M., Feng,X.H.,
            Chai,R.J. and Jin,J.
  TITLE     Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads
            to Anxiety-like Behavior
  JOURNAL   Cell 179 (4), 864-879 (2019)
   PUBMED   31675497
REFERENCE   4  (bases 1 to 3611)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3611)
  AUTHORS   Gao,Z., Li,Y., Wang,F., Huang,T., Fan,K., Zhang,Y., Zhong,J.,
            Cao,Q., Chao,T., Jia,J., Yang,S., Zhang,L., Xiao,Y., Zhou,J.Y.,
            Feng,X.H. and Jin,J.
  TITLE     Mitochondrial dynamics controls anti-tumour innate immunity by
            regulating CHIP-IRF1 axis stability
  JOURNAL   Nat Commun 8 (1), 1805 (2017)
   PUBMED   29180626
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3611)
  AUTHORS   Zhang,Y., Liu,X., Bai,J., Tian,X., Zhao,X., Liu,W., Duan,X.,
            Shang,W., Fan,H.Y. and Tong,C.
  TITLE     Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is
            Required for Neuronal Homeostasis
  JOURNAL   Mol Cell 61 (1), 111-124 (2016)
   PUBMED   26711011
  REMARK    GeneRIF: Propose that MIGA1/2 proteins promote mitochondrial fusion
            by regulating mitochondrial phospholipid metabolism via MitoPLD.
REFERENCE   7  (bases 1 to 3611)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   8  (bases 1 to 3611)
  AUTHORS   Podrini,C., Koffas,A., Chokshi,S., Vinciguerra,M., Lelliott,C.J.,
            White,J.K., Adissu,H.A., Williams,R. and Greco,A.
  TITLE     MacroH2A1 isoforms are associated with epigenetic markers for
            activation of lipogenic genes in fat-induced steatosis
  JOURNAL   FASEB J 29 (5), 1676-1687 (2015)
   PUBMED   25526730
REFERENCE   9  (bases 1 to 3611)
  AUTHORS   Bassett,J.H., Gogakos,A., White,J.K., Evans,H., Jacques,R.M., van
            der Spek,A.H., Ramirez-Solis,R., Ryder,E., Sunter,D., Boyde,A.,
            Campbell,M.J., Croucher,P.I. and Williams,G.R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Rapid-throughput skeletal phenotyping of 100 knockout mice
            identifies 9 new genes that determine bone strength
  JOURNAL   PLoS Genet 8 (8), e1002858 (2012)
   PUBMED   22876197
REFERENCE   10 (bases 1 to 3611)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954388.5.
            
            On May 27, 2022 this sequence version replaced XM_006497593.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.17448.1,
                                           ERR3363658.177476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               AL954388.5         88268-88572
            306-541             AL954388.5         91577-91812
            542-752             AL954388.5         92902-93112
            753-865             AL954388.5         94320-94432
            866-983             AL954388.5         95140-95257
            984-1120            AL954388.5         95558-95694
            1121-1238           AL954388.5         99698-99815
            1239-1339           AL954388.5         100671-100771
            1340-1455           AL954388.5         101504-101619
            1456-1528           AL954388.5         101996-102068
            1529-1615           AL954388.5         102199-102285
            1616-1714           AL954388.5         105663-105761
            1715-1849           AL954388.5         105964-106098
            1850-1903           AL954388.5         106991-107044
            1904-2020           AL954388.5         107615-107731
            2021-3611           AL954388.5         107954-109544
FEATURES             Location/Qualifiers
     source          1..3611
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.63 cM"
     gene            1..3611
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /note="mitoguardin 2"
                     /db_xref="GeneID:108958"
                     /db_xref="MGI:MGI:1922035"
     exon            1..305
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2227
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /note="isoform 4 is encoded by transcript variant 7;
                     ortholog of family with sequence similarity 73, member B
                     FAM73B; mFLJ00199 protein; protein FAM73B"
                     /codon_start=1
                     /product="mitoguardin 2 isoform 4"
                     /protein_id="NP_001394213.1"
                     /db_xref="GeneID:108958"
                     /db_xref="MGI:MGI:1922035"
                     /translation="MSGSPGPGGSRGCVAPWVERERSWVREETPGPGTLRASKTLWKD
                     LLCVPLSCWGVDGTQDPARDQLKTFSLQALTPGGPVSGGGPTMAFRRTEGMSMIQALA
                     MTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRKKKQ
                     VGPEMGGEQLGTVPMPILMARKVPSVKKGCSSRRVQSPSSKSNDTLSGISSIEPSKHS
                     GSSHSLASMVVVNSSSPTAACSGSWEARGMEESVPTTDGSAESLYVQGMELFEEALQK
                     WEQALSVGQRGDGGSTPTPGDSLQNPDTASEALSEPESQRREFAEKLESLLHRAYHLQ
                     EEFGSTFPSDSMLLDLERTLMLPLTEGSLRLRADDEDSLTSEDSFFSATEIFESLQIG
                     EYPLPLSRPAAAYEEALQLVKEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLL
                     EERSNQIFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELEGR
                     GVACMSFFDIVLDFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKA
                     KRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLSEVCAFFKHQIVQYLRDMFDL
                     DNVRYTSVPALAEDILQLSRRRSEILLGYLGAPVASSIGLNGPLPRENGPLEELQ"
     exon            306..541
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            542..752
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            753..865
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            866..983
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1120
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1238
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1339
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1455
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1528
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1615
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1714
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1849
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1903
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2020
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..3611
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3593..3598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /note="hexamer: GATAAA"
     polyA_site      3611
                     /gene="Miga2"
                     /gene_synonym="5730472N09Rik; C9orf54; Fam73b"
                     /note="major polyA site"
ORIGIN      
        1 gtggtttggt tgtattgccg cctggaaagg agacgctgcc cttccccagc gatgggatcc
       61 ctggtgagtg acggccactg cgcgggcgac cagatcagca gggctagaag cgaggcttgc
      121 ggagcatgga acccggccca cgccggggtc tgcgatccag ccagcccgcg aaggtgtcca
      181 aggtgggatg agtggatccc ctggaccagg cggctcgaga ggatgcgtgg ctccgtgggt
      241 ggaacgagaa aggagctggg tcagagagga gactcccggg cctggaacgc tgcgagcatc
      301 taaaactttg tggaaggacc tgttatgtgt gcccctgtcc tgctggggag tggatggtac
      361 ccaggaccca gccagagacc agctgaagac attctccttg caagctctca ccccaggagg
      421 tcccgtctcg ggtggtggac ctaccatggc attccggagg actgagggta tgtccatgat
      481 ccaggctctg gccatgactg tggctgagat tccagtgttc ctgtacacaa cttttggtca
      541 gtccgcgttc tcccagctgc ggttgacacc gggcctgagg aaggttcttt ttgccacagc
      601 ccttgggact gtggccttgg ccctggctgc ccaccagctg aaaaggcgcc ggcggaagaa
      661 gaagcaggtg ggccctgaga tgggaggtga gcagctgggc acggtgccca tgcccatcct
      721 catggcccgc aaggtccctt cggtgaagaa aggctgctcc agcaggaggg ttcagagccc
      781 cagcagcaag agcaacgaca ctcttagtgg catctcctcc atcgagccca gcaagcactc
      841 aggctcctcc cacagcctgg cctcgatggt agtggtcaat tcatccagcc ctacagctgc
      901 gtgctcaggt tcatgggaag cccgagggat ggaggagtct gtgcccacca ctgatggcag
      961 tgccgagagc ctctatgtgc aaggcatgga gctgtttgag gaagccctgc agaaatggga
     1021 gcaggcactg agtgtgggcc agagagggga tggaggcagc acccccacac caggcgacag
     1081 cctccagaac ccagacaccg catcagaagc actgtcagag ccagagtccc aacgaaggga
     1141 gtttgctgag aagctggagt ccctgctgca ccgggcctac cacctgcagg aagagtttgg
     1201 ctctaccttc ccctctgaca gcatgctgtt ggatcttgag aggaccctaa tgctgccact
     1261 gactgagggc tcactgcgac ttcgagctga cgatgaggac agcctgacct ctgaagactc
     1321 ctttttctca gccactgaga tctttgagtc cctgcagatc ggcgagtacc cgcttcctct
     1381 ctccaggcct gctgctgcct acgaggaggc tctgcagctg gtgaaggaag gaagagtccc
     1441 ttgccgaaca ctcaggacag agctgctggg ctgctacagt gaccaggact tcctagccaa
     1501 gctgcattgt gtacggcagg cctttgaggg gcttctagaa gaaagaagca accagatctt
     1561 ctttggggag gtcggccggc agatggtgac gggcctgatg accaaggctg agaagagtcc
     1621 caaaggcttc ctggagagct atgaggagat gctgagctac gccctgcggc ctgagacctg
     1681 ggctaccacc cggctggagc tggagggcag aggggtggcc tgcatgagct tcttcgacat
     1741 cgtgctggac ttcatcctca tggatgcctt tgaggaccta gagaaccctc cgtcttcggt
     1801 gcttgctgtc ctgaggaacc gctggctgtc tgacagcttc aaagaaacag ccctagccac
     1861 cgcgtgctgg tctgtcctga aagccaagag gaggctcctg atggtgcctg atggcttcat
     1921 ctcccatttc tactccgtat cggagcatgt tagccctgtg ttggcctttg gcttcctcgg
     1981 acccaagccc cagctctcgg aagtctgtgc tttcttcaag caccagattg tacaatacct
     2041 gagggacatg ttcgacctgg acaacgtgcg ctacacatct gtgccagccc tagcagaaga
     2101 catcctacag ctgtcccggc ggcgcagcga gattctattg ggctacctgg gggcacctgt
     2161 ggctagtagc atcgggctga atgggccact gcctcgagaa aatgggcccc tggaagagct
     2221 gcagtaacag gggatgggct ggaggggaga ggtggctgtt tgggcctcag atacaaggtg
     2281 ataggagaga gaaagctgcc actcccttcc tttgggttgg tatccaaggg ccatggtggc
     2341 caagggccat tgcccctaag cttgctccac ttcctcacct gggaattccc aacacccagg
     2401 ggacaaattt ccatggagag gaaccactag aagcactgat agcagctgcc cttggggttc
     2461 cctgagcagc agaggcaggc cagagtcagc agggactggc caggggcagg tagcaagaga
     2521 gaaaggtgtg ggagcaaatg gctcttgagt atggaccaca gaaccccagt ccccccctgc
     2581 tgctgaggga gggcaaggga tagttgaggg atagaacata cagggctagg tggtgacagt
     2641 cacagggtcc tgcaattagc agccaccaat agctacatta agtcccagca cctaggcttc
     2701 tggccagtat ggaaagccat gtctgggcca tccagaggtg ggcttgcccc atgtgtgctc
     2761 acatctgagc aggtactcac ccttcacaaa cccttggcgc tgttctccac attcccacac
     2821 cctgccaaag attgttttta tcccctctgt caccaaagat ggaggaggca ggactggccg
     2881 cttcctgctc tctggtgagc caggagctcc tgggcagtgc tgggccccag tcagagctca
     2941 cagtggccca tctactgctc caaaagtgag cacggaacca tggcagggtg ggcatgggct
     3001 gcacagcggg cagctccccc ttcccctttc tgacaggaag ctggactcag cactttgcct
     3061 tcaactccat gcacacgtgc tttggggctg ccaccaccca cgtcctgcag acagttggca
     3121 tttgtcacgg cagctgcagt agtcctggca gccctccttt tgcctgagct gggaagtttt
     3181 tatttattgc cttaatactt tatttggctg ttccatccct tccaggttgt gacaccagga
     3241 gaaaagactc ctggtctgga gttgagcact ggctcctgga accaagttcc tctccctgga
     3301 agggaaaagg gttccccagg gtcagcagga tgcagtaaag agagggcagc catggctctg
     3361 ggtcctctct gaggcttgtg ctcagaaggg agcagccctc atgcactgtc ttgacattcc
     3421 attcatttgc acttaccctg agctgtgaat gtgaccctgg gctaaggcct gctctgctct
     3481 gcccctgacc catacagtgt ggtattttca tttttgtcct gttcatgtgt ctatgcccca
     3541 ccctctagca ctcaaccagc agtggtagag tgtgtgtaag gcctgtgagt cagataaagg
     3601 accgaagcga c
//
