LOCUS       NM_010798                581 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus macrophage migration inhibitory factor
            (glycosylation-inhibiting factor) (Mif), mRNA.
ACCESSION   NM_010798
VERSION     NM_010798.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 581)
  AUTHORS   Zhang,F., Meng,T., Feng,R., Jin,C., Zhang,S., Meng,J., Zhang,M. and
            Liang,C.
  TITLE     MIF aggravates experimental autoimmune prostatitis through
            activation of the NLRP3 inflammasome via the PI3K/AKT pathway
  JOURNAL   Int Immunopharmacol 141, 112891 (2024)
   PUBMED   39153310
  REMARK    GeneRIF: MIF aggravates experimental autoimmune prostatitis through
            activation of the NLRP3 inflammasome via the PI3K/AKT pathway.
REFERENCE   2  (bases 1 to 581)
  AUTHORS   Zhou,L., Zhang,G., Zhang,K., Rao,Z., Tang,Z., Wang,Y. and Zhao,J.
  TITLE     The role of PAR2 in regulating MIF release in house dust
            mite-induced atopic dermatitis
  JOURNAL   Front Immunol 15, 1478292 (2024)
   PUBMED   39416784
  REMARK    GeneRIF: The role of PAR2 in regulating MIF release in house dust
            mite-induced atopic dermatitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 581)
  AUTHORS   Wen,L., Chen,W., Zhu,C., Li,J., Zhou,J., Zhang,M., Zhang,W. and
            Xue,Q.
  TITLE     Overexpression of macrophage migration inhibitory factor protects
            against pressure overload-induced cardiac hypertrophy through
            regulating the miR-29b-3p/HBP1 axis
  JOURNAL   Physiol Rep 12 (12), e16022 (2024)
   PUBMED   38924383
  REMARK    GeneRIF: Overexpression of macrophage migration inhibitory factor
            protects against pressure overload-induced cardiac hypertrophy
            through regulating the miR-29b-3p/HBP1 axis.
REFERENCE   4  (bases 1 to 581)
  AUTHORS   Yang,H., Li,J., Huang,X.R., Bucala,R., Xu,A. and Lan,H.Y.
  TITLE     Macrophage-derived macrophage migration inhibitory factor mediates
            renal injury in anti-glomerular basement membrane
            glomerulonephritis
  JOURNAL   Front Immunol 15, 1361343 (2024)
   PUBMED   38846956
  REMARK    GeneRIF: Macrophage-derived macrophage migration inhibitory factor
            mediates renal injury in anti-glomerular basement membrane
            glomerulonephritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 581)
  AUTHORS   Liu,L., Wang,J., Wang,Y., Chen,L., Peng,L., Bin,Y., Ding,P.,
            Zhang,R., Tong,F. and Dong,X.
  TITLE     Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain
            metastasis in NSCLC via synergistically promoting microglia M1
            polarization
  JOURNAL   J Exp Clin Cancer Res 43 (1), 128 (2024)
   PUBMED   38685050
  REMARK    GeneRIF: Blocking the MIF-CD74 axis augments radiotherapy efficacy
            for brain metastasis in NSCLC via synergistically promoting
            microglia M1 polarization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 581)
  AUTHORS   Bozza,M., Kolakowski,L.F. Jr., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., David,J.R. and Gerard,C.
  TITLE     Structural characterization and chromosomal location of the mouse
            macrophage migration inhibitory factor gene and pseudogenes
  JOURNAL   Genomics 27 (3), 412-419 (1995)
   PUBMED   7558021
REFERENCE   7  (bases 1 to 581)
  AUTHORS   Kozak,C.A., Adamson,M.C., Buckler,C.E., Segovia,L., Paralkar,V. and
            Wistow,G.
  TITLE     Genomic cloning of mouse MIF (macrophage inhibitory factor) and
            genetic mapping of the human and mouse expressed gene and nine
            mouse pseudogenes
  JOURNAL   Genomics 27 (3), 405-411 (1995)
   PUBMED   7558020
REFERENCE   8  (bases 1 to 581)
  AUTHORS   Mitchell,R., Bacher,M., Bernhagen,J., Pushkarskaya,T., Seldin,M.F.
            and Bucala,R.
  TITLE     Cloning and characterization of the gene for mouse macrophage
            migration inhibitory factor (MIF)
  JOURNAL   J Immunol 154 (8), 3863-3870 (1995)
   PUBMED   7706726
REFERENCE   9  (bases 1 to 581)
  AUTHORS   Wistow,G.J., Shaughnessy,M.P., Lee,D.C., Hodin,J. and Zelenka,P.S.
  TITLE     A macrophage migration inhibitory factor is expressed in the
            differentiating cells of the eye lens
  JOURNAL   Proc Natl Acad Sci U S A 90 (4), 1272-1275 (1993)
   PUBMED   7679497
REFERENCE   10 (bases 1 to 581)
  AUTHORS   Lanahan,A., Williams,J.B., Sanders,L.K. and Nathans,D.
  TITLE     Growth factor-induced delayed early response genes
  JOURNAL   Mol Cell Biol 12 (9), 3919-3929 (1992)
   PUBMED   1508193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142499.9.
            
            On Jun 22, 2018 this sequence version replaced NM_010798.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO813136.1, CB202396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN02415134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC142499.9         63941-64157
            218-390             AC142499.9         64359-64531
            391-581             AC142499.9         64675-64865
FEATURES             Location/Qualifiers
     source          1..581
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.59 cM"
     gene            1..581
                     /gene="Mif"
                     /gene_synonym="DER6; GIF; Glif"
                     /note="macrophage migration inhibitory factor
                     (glycosylation-inhibiting factor)"
                     /db_xref="GeneID:17319"
                     /db_xref="MGI:MGI:96982"
     exon            1..217
                     /gene="Mif"
                     /gene_synonym="DER6; GIF; Glif"
                     /inference="alignment:Splign:2.1.0"
     exon            218..390
                     /gene="Mif"
                     /gene_synonym="DER6; GIF; Glif"
                     /inference="alignment:Splign:2.1.0"
     exon            391..581
                     /gene="Mif"
                     /gene_synonym="DER6; GIF; Glif"
                     /inference="alignment:Splign:2.1.0"
     regulatory      559..564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mif"
                     /gene_synonym="DER6; GIF; Glif"
                     /note="hexamer: AATAAA"
     polyA_site      578
                     /gene="Mif"
                     /gene_synonym="DER6; GIF; Glif"
                     /note="major polyA site"
ORIGIN      
        1 agccggcttg gggcggtact gagctgggtc acgtagctca ggtccctggc ttgggtcaca
       61 ccgcgctttg taccgtcctc cggtccacgc tcgcagtctc tccgccacca tgcctatgtt
      121 catcgtgaac accaatgttc cccgcgcctc cgtgccagag gggtttctgt cggagctcac
      181 ccagcagctg gcgcaggcca ccggcaagcc cgcacagtac atcgcagtgc acgtggtccc
      241 ggaccagctc atgactttta gcggcacgaa cgatccctgc gccctctgca gcctgcacag
      301 catcggcaag atcggtggtg cccagaaccg caactacagt aagctgctgt gtggcctgct
      361 gtccgatcgc ctgcacatca gcccggaccg ggtctacatc aactattacg acatgaacgc
      421 tgccaacgtg ggctggaacg gttccacctt cgcttgagtc ctggccccac ttacctgcac
      481 cgctgttctt tgagcctcgc tccacgtagt gttctgtgtt tatccaccgg tagcgatgcc
      541 caccttccag ccgggagaaa taaatggttt ataagagacc a
//
