LOCUS       NM_001286221            4781 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus MEIR1 treanscription regulator (Mier1), transcript
            variant 4, mRNA.
ACCESSION   NM_001286221
VERSION     NM_001286221.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4781)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4781)
  AUTHORS   Chen,Y., Chen,L., Wu,X., Zhao,Y., Wang,Y., Jiang,D., Liu,X.,
            Zhou,T., Li,S., Wei,Y., Liu,Y., Hu,C., Zhou,B., Qin,J., Ying,H. and
            Ding,Q.
  TITLE     Acute liver steatosis translationally controls the epigenetic
            regulator MIER1 to promote liver regeneration in a study with male
            mice
  JOURNAL   Nat Commun 14 (1), 1521 (2023)
   PUBMED   36934083
  REMARK    GeneRIF: Acute liver steatosis translationally controls the
            epigenetic regulator MIER1 to promote liver regeneration in a study
            with male mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4781)
  AUTHORS   van der Weyden,L., Swiatkowska,A., Iyer,V., Speak,A.O. and
            Adams,D.J.
  TITLE     A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators
            of Pulmonary Metastatic Colonisation
  JOURNAL   G3 (Bethesda) 10 (6), 1869-1877 (2020)
   PUBMED   32245826
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4781)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4781)
  AUTHORS   Fisher,C.L., Marks,H., Cho,L.T., Andrews,R., Wormald,S.,
            Carroll,T., Iyer,V., Tate,P., Rosen,B., Stunnenberg,H.G.,
            Fisher,A.G. and Skarnes,W.C.
  TITLE     An efficient method for generation of bi-allelic null mutant mouse
            embryonic stem cells and its application for investigating
            epigenetic modifiers
  JOURNAL   Nucleic Acids Res 45 (21), e174 (2017)
   PUBMED   28981838
REFERENCE   6  (bases 1 to 4781)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 4781)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 4781)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4781)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (bases 1 to 4781)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844176.11, BC108273.1, CN538186.1, AK136467.1 and AV322829.1.
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (c).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY769438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL844176.11        90075-90175
            102-178             AL844176.11        92754-92830
            179-203             BC108273.1         88-112
            204-276             AL844176.11        103856-103928
            277-967             BC108273.1         113-803
            968-1261            CN538186.1         438-731
            1262-2057           BC108273.1         1098-1893
            2058-4776           AK136467.1         771-3489
            4777-4781           AV322829.1         200-204
FEATURES             Location/Qualifiers
     source          1..4781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 47.36 cM"
     gene            1..4781
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /note="MEIR1 treanscription regulator"
                     /db_xref="GeneID:71148"
                     /db_xref="MGI:MGI:1918398"
     exon            1..101
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            102..178
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1778
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /note="isoform c is encoded by transcript variant 4;
                     mesoderm induction early response protein 1; early
                     response 1; mesoderm induction early response 1 homolog
                     (Xenopus laevis"
                     /codon_start=1
                     /product="mesoderm induction early response protein 1
                     isoform c"
                     /protein_id="NP_001273150.1"
                     /db_xref="CCDS:CCDS71432.1"
                     /db_xref="GeneID:71148"
                     /db_xref="MGI:MGI:1918398"
                     /translation="MCIRCLCLIGLQTVSGFFSCQITSHLLSLQVQGEYKCGLLCENT
                     SLLIANVRRKVSGGSATSEDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEIED
                     LAREGDMPIHELLSLYGYDSTVRLPEEEEEEEEEEEGEDDEDADNDDNSGCSGENKEE
                     NIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSEIEEESEEDEDYIP
                     SEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPECLPEEKVVVFLKDAS
                     RRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFNVKAAREELSVWTE
                     EECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKK
                     KYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSNSQSEKEDGAVSSRNQNGVS
                     SNGPGEILNKEEVKVEGLHVNGPTGGNKKPLLTDMDTNGYEANNLTTDPKLAHMTARN
                     ENDFDEKNERPAKRRRINSSGKESPGSSEFFQEAVSHGKFEEHENTND"
     exon            179..203
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..276
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..422
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..581
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..714
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..779
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..852
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1004
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1086
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1181
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1309
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1449
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..4781
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4759..4764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /note="hexamer: ATTAAA"
     polyA_site      4781
                     /gene="Mier1"
                     /gene_synonym="4933425I22Rik; 5830411K19Rik; er1"
                     /note="major polyA site"
ORIGIN      
        1 atggtgtggt ggctcgattc tcccagtgcc tggctgagtt tcggacgtgg ttaagaacca
       61 actggttgag gttcaatgca gacaagacgg atgtgatgct gtagaaaatg tgcatcagat
      121 gtttatgttt aattggttta cagactgtct ctggattctt ttcctgtcaa attacaagcc
      181 atctgttgag tcttcaagtc cagggtgaat ataagtgtgg cctgctctgt gaaaacactt
      241 cattgttgat tgctaatgtc agaagaaaag tttcaggagg ctcagcaaca tcagaggacc
      301 atgagtttga tccatcagct gacatgctgg ttcatgattt tgatgatgag cgaacattag
      361 aagaagaaga aatgatggaa ggagagacaa acttcagttc tgaaatagag gatcttgcga
      421 gggaaggcga catgccaatc cacgagctgc tcagcctcta tggttatgac agcactgttc
      481 ggttacctga ggaagaggag gaggaagagg aggaggagga aggtgaagat gatgaagatg
      541 ctgataatga tgataacagt ggctgtagtg gagaaaataa agaagagaat ataaaggatt
      601 catcgggtca ggaggatgaa actcagtctt ccaatgatga tccctcacag tctgttactt
      661 cccaagatgc tcaggaaata atccgcccac gtcgatgtaa atattttgat acaaatagtg
      721 aaatagaaga agaatctgaa gaagatgaag attatattcc ctcagaagac tggaaaaagg
      781 aaatcatggt gggctccatg tttcaagctg agattccagt tggtgtttgt agatacaaag
      841 aaaatgaaaa agtgtatgaa aatgatgatc agcttctgtg ggatccagag tgtttaccag
      901 aagagaaagt ggttgtcttt cttaaggatg cgtctagaag gacaggggat gagaaaggtg
      961 tggaagcaat ccctgaaggc tcgcatatca aagacaatga gcaggcttta tatgagttgg
     1021 ttaaatgcag ctttgatacg gaagaagcct tgagaagact gagatttaat gtcaaagcag
     1081 ctcgagagga gttatctgtg tggacagagg aagagtgtag aaattttgag caagggctga
     1141 aggcctatgg aaaagatttt catctgattc aggctaataa agtccgaaca agatcagttg
     1201 gtgaatgtgt agcattctat tacatgtgga aaaagtctga gcgctatgat ttctttgctc
     1261 agcaaacaag gtttggaaaa aagaaatata atcttcatcc tggtgtaacg gattacatgg
     1321 atcgtctttt ggatgaaagt gaaagtgctg cttctagccg agcaccatcc ccccctccca
     1381 ctgcctcaaa tagcagtaac agccagtccg agaaagaaga tggcgctgtc agcagtagga
     1441 atcagaacgg tgtctcatct aatggaccag gagaaatact aaacaaagaa gaagtaaaag
     1501 ttgaagggtt acatgttaat ggaccaacag gtggaaataa gaaaccactt cttacagata
     1561 tggacactaa tggttatgaa gcaaataacc tgaccactga cccaaaactt gcccatatga
     1621 ctgcaagaaa tgaaaatgat tttgatgaaa aaaatgagag acctgccaaa aggcggcgga
     1681 taaacagcag tgggaaagaa agtccgggct catctgagtt tttccaggaa gcagtctcac
     1741 atgggaagtt tgaggaacat gaaaacacga atgactaact cttaggcctg tttcactttc
     1801 tttgcagtaa agtctggttt gactacaatt ttcagggttg gggggtgacc tttagaaagc
     1861 tgatttcctt aaagcagttg gttaactctt gaaatttgaa ttaagtccta acttttaaga
     1921 aatgggattc ataattctac cttttacaag ttcttttact tcaaattttt gaagccctct
     1981 ttaaggatat aaaaacattg gtaaatttga atgacccaaa gacttaactg caccttctcc
     2041 tttgaaaacc aaatcatata tttgattaaa aggtaatctt tccttattct ttatgaggaa
     2101 gaaaagagtt tgtgtttctg ctcaacatca aattttttat tatctggaaa tgtctttaca
     2161 acagacattt ttctctccat acaaattgaa catcgttact aaggaaaccc tcatgaatcc
     2221 tgaaggttat gctagcatga tttttatatg tagaagttta aaaataaacc aagtcaggtt
     2281 tgtatttgta aaattgttga catcaatgat gtctttccat attcttatct gggcttaaga
     2341 aatacattct gtatttttcc agattctttg tagcctttga aagattttta cagtacatat
     2401 gtcttgactg agctgtcttt tcttaataca aaaagcttgt ataattttct taacttgtac
     2461 agttggtaaa cttttatgag aggaactgat attctgagtc tgtcagcttt cattttattt
     2521 tgctaagatt tttctaatga ctttttaagt gtgtgtgtag ttaaccaagt catgtttctt
     2581 atccaggtgg taaaagcatt cataaagaat tatgaacatg cgttattttc aaacttctac
     2641 ttactgacaa ataatttggg atgtctaaat ttcagcatga tactcagatt acaagcttgt
     2701 ttgcatttgc tataatttta taaattaatt ttgaaacaaa acaaaaactt accgtcagct
     2761 taagtgcgta gatgtatcat gctgaataga atcctgttca gttgctctca tgtgccctat
     2821 aagatttctc atcgtttcca ttaagtcaac agaaggggaa gaccaggtga tgttgcaata
     2881 ttgccacatc caaggagtaa ctgttgacag gtagcaatat tcatttttat gagaaaataa
     2941 tggttttaag aattttcaga tttttccagt tgtaatccag tttgtcagat ttgatagttt
     3001 ttccaaaatg aaacacatac aaaataatca ttgttctgtg tgatttttaa aaagggttat
     3061 ctgcactagc cttgtatgga tgggtgccat tttattttta gtgcaaaatt cttcttaaaa
     3121 aatgtagttt tttacagctg atagaccaat ctatctccag actgtttttt agcgaatgat
     3181 tattagctat gttttctcac acaggcacat ccccaaatgc tgctttcagt ttgatctcag
     3241 ccatcagttc aagagccaat gctctcaaag gcagatctgt gctcctttca caggctcagt
     3301 tgtctgatgc aggttgggta aaggttcgca ctgagaatga tcgcccaggc ctctccctca
     3361 gagtattctt agatttgtcc agactgcttc ctttccctcg accagtattg gaaggcactt
     3421 tgacagtaca tcacataata tgcatttatt gtttttgcag aaatatccca gtaagtcagt
     3481 ttcagatgga agtgctaaga agcatgagag gattttgttt gtttgtttgt tttattgaaa
     3541 accattaatt tatccagaat ggcagtaggt caagtagctt tagcagatgg atcatagcct
     3601 ctgtttccct gcccaccccc acccatttct attatctctc ttttttctgt gttttttttt
     3661 ttttttttta aaaacaacaa aaacaaaaca gagtctcact gtgtagccca ggctggcctg
     3721 gaacttaaca atccttctac ctcagccctc taatgctgag attgaaggtg tttcccacca
     3781 cacccagcaa caatctattc tctaaagcag gttttattaa atgagttcaa accattctaa
     3841 ctctttgtca cagatggtct ctaggaatgt ttttttaaaa aacagtgatg ctttttaatc
     3901 attacactat tggaggtgtc agcccacctt ttaaaggcta caactgctgg gcaagttcct
     3961 agagttcttg aaactgttgt tacaggaact ttttaaggaa tttctcaggc atgttgggaa
     4021 atgtgccagg tgtatatgtg ttcatatatc ttacttttct ttttaaagta tgcataatga
     4081 aacatttctc taatacacga tgctcagctt ttccaaacta cattgttctg tgtttgtaca
     4141 ggtatttcac cctttgttca aaactgcagc cactgaaact taagtcattg cacttttaaa
     4201 caacttggca atatcatgag taatttgtta aaggtttagt atatttcata actcttgagc
     4261 acttaagtaa ttgagatgag aaaataagcc ttcaggagta gggatgtagc tcagtagttt
     4321 gactgttttg cccaacgtgc atatgaagcc tgggttccat gcccagtacc acataaactg
     4381 ggtgtggtgg cacatgcctg tcatcctaag cacttgggag gtggaggcag gaggatcaga
     4441 agttcaaggc cgtcctcacc tacatagtga gttggaggca agcctgagat acctgagatg
     4501 ctgcctcaaa cagaaatgtc tctgttggta gttagcattg tcattttcct ttgaaacaca
     4561 atgtttatga tgtattctca gtaaggttca gaatctgtaa ctcagctcaa cgcggatctg
     4621 ttgagcttta aaatgtattt gaagtaattt aagtaggcat tcaaaattat aaattagatg
     4681 tttttaaatt tctgcataat aatttgcact gtaaaatatg tccttcctcc catttccttc
     4741 tgccattctg atatgctcat taaaatattt ttgtaaacat a
//
