LOCUS       NM_010797               3860 bp    mRNA    linear   ROD 31-OCT-2023
DEFINITION  Mus musculus midline 1 (Mid1), transcript variant 1, mRNA.
ACCESSION   NM_010797 XM_911174 XM_921917
VERSION     NM_010797.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3860)
  AUTHORS   Cheffer A, Garcia-Miralles M, Maier E, Akol I, Franz H, Srinivasan
            VSV and Vogel T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   2  (bases 1 to 3860)
  AUTHORS   Rao X, Razavi M, Mihai G, Wei Y, Braunstein Z, Frieman MB, Sun XJ,
            Gong Q, Chen J, Zhao G, Liu Z, Quon MJ, Dong L, Rajagopalan S and
            Zhong J.
  TITLE     Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte
            Motility in Atherosclerosis
  JOURNAL   Adv Sci (Weinh) 10 (9), e2204194 (2023)
   PUBMED   36683148
  REMARK    GeneRIF: Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T
            Lymphocyte Motility in Atherosclerosis.
REFERENCE   3  (bases 1 to 3860)
  AUTHORS   Liang Y, Song C, Li J, Li T, Zhang C and Zou Y.
  TITLE     Morphometric analysis of the size-adjusted linear dimensions of the
            skull landmarks revealed craniofacial dysmorphology in Mid1-cKO
            mice
  JOURNAL   BMC Genomics 24 (1), 68 (2023)
   PUBMED   36759768
  REMARK    GeneRIF: Morphometric analysis of the size-adjusted linear
            dimensions of the skull landmarks revealed craniofacial
            dysmorphology in Mid1-cKO mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3860)
  AUTHORS   Du F, Hawez A, Ding Z, Wang Y, Ronnow CF, Rahman M and Thorlacius
            H.
  TITLE     E3 Ubiquitin Ligase Midline 1 Regulates Endothelial Cell ICAM-1
            Expression and Neutrophil Adhesion in Abdominal Sepsis
  JOURNAL   Int J Mol Sci 24 (1), 705 (2022)
   PUBMED   36614145
  REMARK    GeneRIF: E3 Ubiquitin Ligase Midline 1 Regulates Endothelial Cell
            ICAM-1 Expression and Neutrophil Adhesion in Abdominal Sepsis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3860)
  AUTHORS   Fang M, Zhang A, Du Y, Lu W, Wang J, Minze LJ, Cox TC, Li XC, Xing
            J and Zhang Z.
  TITLE     TRIM18 is a critical regulator of viral myocarditis and organ
            inflammation
  JOURNAL   J Biomed Sci 29 (1), 55 (2022)
   PUBMED   35909127
  REMARK    GeneRIF: TRIM18 is a critical regulator of viral myocarditis and
            organ inflammation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3860)
  AUTHORS   Perry J and Ashworth A.
  TITLE     Evolutionary rate of a gene affected by chromosomal position
  JOURNAL   Curr Biol 9 (17), 987-989 (1999)
   PUBMED   10508587
REFERENCE   7  (bases 1 to 3860)
  AUTHORS   Van den Veyver IB, Cormier TA, Jurecic V, Baldini A and Zoghbi HY.
  TITLE     Characterization and physical mapping in human and mouse of a novel
            RING finger gene in Xp22
  JOURNAL   Genomics 51 (2), 251-261 (1998)
   PUBMED   9722948
REFERENCE   8  (bases 1 to 3860)
  AUTHORS   Dal Zotto L, Quaderi NA, Elliott R, Lingerfelter PA, Carrel L,
            Valsecchi V, Montini E, Yen CH, Chapman V, Kalcheva I, Arrigo G,
            Zuffardi O, Thomas S, Willard HF, Ballabio A, Disteche CM and
            Rugarli EI.
  TITLE     The mouse Mid1 gene: implications for the pathogenesis of Opitz
            syndrome and the evolution of the mammalian pseudoautosomal region
  JOURNAL   Hum Mol Genet 7 (3), 489-499 (1998)
   PUBMED   9467009
REFERENCE   9  (bases 1 to 3860)
  AUTHORS   Quaderi NA, Schweiger S, Gaudenz K, Franco B, Rugarli EI, Berger W,
            Feldman GJ, Volta M, Andolfi G, Gilgenkrantz S, Marion RW, Hennekam
            RC, Opitz JM, Muenke M, Ropers HH and Ballabio A.
  TITLE     Opitz G/BBB syndrome, a defect of midline development, is due to
            mutations in a new RING finger gene on Xp22
  JOURNAL   Nat Genet 17 (3), 285-291 (1997)
   PUBMED   9354791
REFERENCE   10 (bases 1 to 3860)
  AUTHORS   Palmer S, Perry J, Kipling D and Ashworth A.
  TITLE     A gene spans the pseudoautosomal boundary in mice
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 12030-12035 (1997)
   PUBMED   9342357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671865.11, AL672015.7 and CR478112.2.
            
            [WARNING] On Nov 29, 2023 this sequence was replaced by
            NM_010797.4.
            
            On Mar 13, 2014 this sequence version replaced NM_010797.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AL671865.11        123712-123885
            175-890             AL672015.7         140996-141711
            891-986             AL672015.7         180105-180200
            987-1094            AL672015.7         190964-191071
            1095-1243           CR478112.2         3640-3788
            1244-1371           CR478112.2         5711-5838
            1372-1515           CR478112.2         6754-6897
            1516-1716           CR478112.2         7652-7852
            1717-1924           CR478112.2         9314-9521
            1925-3860           CR478112.2         10618-12553
FEATURES             Location/Qualifiers
     source          1..3860
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 79.19 cM"
     gene            1..3860
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /note="midline 1"
                     /db_xref="GeneID:17318"
                     /db_xref="MGI:MGI:1100537"
     exon            1..174
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /inference="alignment:Splign:2.1.0"
     exon            175..890
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..2273
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     midin; tripartite motif-containing protein 18; RING finger
                     protein Midline-1; E3 ubiquitin-protein ligase Midline-1;
                     RING-type E3 ubiquitin transferase Midline-1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Midline-1 isoform 1"
                     /protein_id="NP_034927.2"
                     /db_xref="CCDS:CCDS41215.1"
                     /db_xref="GeneID:17318"
                     /db_xref="MGI:MGI:1100537"
                     /translation="METLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCAT
                     NEPVESINAFQCPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRR
                     ERAFDANTMSSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHR
                     LIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDK
                     LKQNLESNLTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECDLLIEIIQQR
                     RQIIGTKIKEGKVIRLRKLAQQIANCKQCLERSASLISQAEHSLKENDHARFLQTAKN
                     ITERVSMATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYLTAPNPPAIREELC
                     TASYDTITVHWTSEDEFSVVSYELQYTIFTGQANVVNVACDGTCLLGSAGLCNSADSW
                     MIVPNIKQNHYTVHGLQSGTKYIFTVKAINQAGSRSSEPGKLKTNSQPFRLDPKSAHR
                     KLKVSHDNLTVERDESSSKKSHAPERFAGQGSYGVAGNVFIDSGRHYWEVVTSGSTWY
                     AIGLAYRSAPKHEWIGKNAASWALCRCHNHWAVRHDGKETPIAPAPHLRRVGVLLDYD
                     NGSIAFYDALSSVHLHTFHAALAQPVCPTFTVWNKCLTIVTGLPIPDHLDCTEQRP"
     exon            891..986
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1094
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1243
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1371
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1515
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1716
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1924
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..3860
                     /gene="Mid1"
                     /gene_synonym="61B3-R; DXHXS1141; Fxy; Trim18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gattcccagc tggacagagc aagcttcctg aacgccccag ccattcagct gatccgaggc
       61 gaagagcagt ctgtacttgc cccggagcag cctccttgga ggacccacag gtttgattct
      121 tccagctccc aactgagaaa caaacctgcg atcctgggaa agatggggaa gccgatagct
      181 gatcagcttc cttggacttt gctgatgacc ccggagagtt ttgcctgaag atggaaacac
      241 tggagtcgga gctgacctgt cctatttgtc tggagctttt tgaggaccct ctcctgcttc
      301 cctgcgcaca tagcctctgc ttcaactgtg cccaccgaat cctggtctct cactgtgcca
      361 ccaacgagcc tgtggagtcc atcaacgcct tccagtgccc cacctgccgg catgtcatca
      421 cgctcagcca gcgaggtcta gacgggctca agcgcaacgt caccctccaa aacatcattg
      481 acagatttca gaaagcatct gtgagcgggc ccaactctcc cagtgagacc cgcagggaac
      541 gggcctttga cgccaacacc atgtcctctg ccgagaaggt tctctgccag ttctgtgacc
      601 aggatcctgc ccaggatgct gtgaagactt gcgttacttg tgaagtgtcc tactgtgatg
      661 agtgcctgaa agccactcat ccgaacaaga agccctttac aggccatcgt ctgattgagc
      721 caatcccgga ctcgcacatc cgggggctga tgtgcctgga gcacgaggat gagaaggtga
      781 atatgtactg tgtgaccgat gaccagttaa tctgtgcctt gtgtaaactg gttgggcggc
      841 accgcgatca tcaggtggca gctttgagtg agcgctatga caaattgaag caaaacttgg
      901 agagtaatct caccaatctt attaagagaa acacagaact ggagactctt ttggctaaac
      961 tcatccaaac ttgtcaacat gttgaagtca atgcatcccg tcaagaagcc aaactgacag
     1021 aagaatgtga tcttctcatt gaaatcattc agcaacgaag acaaattatt ggaacaaaga
     1081 ttaaagaagg caaggtgatc aggctccgca agttagctca gcagattgca aactgtaaac
     1141 agtgccttga gaggtctgca tcgctcatct cgcaagcgga gcactcgctg aaggaaaatg
     1201 accacgcccg ttttctacag acagcaaaga atatcactga gagagtctcc atggcaactg
     1261 catcctccca ggtcctaatt cccgaaatca acctcaatga cacgtttgac acttttgcct
     1321 tggatttttc ccgggagaag aaactgctag aatgtctgga ttacctaaca gctcccaacc
     1381 ctcccgcgat tagagaagag ctctgcaccg cttcctacga caccatcacc gtccactgga
     1441 cctcagagga cgagttcagc gtggtctcct acgagctcca gtacaccata ttcaccggac
     1501 aagccaatgt tgtcaacgtg gcctgtgacg gcacctgtct cctcggctcc gcaggtctgt
     1561 gtaactcggc ggacagctgg atgatcgtgc ccaacatcaa gcagaaccac tacaccgtgc
     1621 acggcctgca aagtggcacc aagtatatct tcacggtgaa ggccatcaac caggcgggca
     1681 gccgtagcag cgagcccgga aagctgaaga ccaacagtca gccgtttaga ctggatccca
     1741 aatcggctca tcgcaagctg aaggtgtccc acgacaacct gactgtcgag cgcgacgagt
     1801 cgtcctctaa gaagagtcac gcgccggagc gcttcgctgg tcaggggagc tacggagtgg
     1861 ctggcaacgt gttcatcgac agcggccgtc actactggga agtggtcacc agcggaagca
     1921 catggtacgc catcggcctg gcgtacagat cggcgccgaa acacgagtgg atcgggaaga
     1981 acgcggcgtc ctgggccctc tgccgctgcc acaaccactg ggcggtgcga cacgacggca
     2041 aggagacccc catcgcgccg gcccctcacc tcaggcgcgt cggcgtcctg ctggactacg
     2101 acaacggctc catcgccttc tacgacgctc tgagctccgt ccacctccac accttccacg
     2161 cggcgctcgc gcagcccgtg tgccccacct tcaccgtgtg gaacaagtgt ctgaccatcg
     2221 tcacgggtct gcccatcccg gaccatctgg actgtacgga gcagcgacct tgagggaccc
     2281 ggccccacag cggccccggg gagggacaca ggtggaggcc gctgtttatg gggtcgagaa
     2341 actcaggctt ccagagcgtc gtgacatctt ccccaatctg tccagaaaat cactcacagt
     2401 catccccctg cctcacacgg tcactcaggg tcatccccct gcctcagaaa atcactcaca
     2461 atcatccccc tgcctcagaa aatcattcac agtgatcacc cccgcttcag aaaatcactc
     2521 acagtcatcc ttctgcctca gaaaatcact cacagtcatc ccactgcctc agaaaatcac
     2581 tcatactcat cccccagcat cataaaatca ctcacagtca ccccctgcct cagaaaatca
     2641 ctcacagtca tccccctgtc tcacacggtc actcagggtc atccccctgc ctcacacggt
     2701 cactcagggt catccccctg cctcagaaaa tcattcacag tcatcccccc gcctcagaaa
     2761 atcactcaca gtcatccccc tgcctcagaa aatcactcac agtcatcccc ctgcctcaca
     2821 cggtcactca gggtcatccc cctgcctcag aaaatcactc acagtcatcc ccctgtctca
     2881 cacggtcact cagggtcatc cccctgcttc agaaaattct attccatact gaggccaggc
     2941 tgggcacgac cgcttagaag aaccggatag acggctaaag cagaagccgt cttgagccta
     3001 ataaggaagc ccgcgggctt cctcactccg atgtgagtgg agacatttca gctgtgactg
     3061 tatcattgat acccagatga atattttgat agcgacttaa aacgacttca catcttaaac
     3121 acggacacct cggtggaaaa tgtttcattt tcctctgaaa atttgtgaga acgtctcgac
     3181 gacgacgacg ccagcaagag aaacgtttgg aaaacagcgc ttctcgtcac gttctcgatt
     3241 ctgccacccc ggaagacatc tggcctcatc tggagtcgat ctcgggcgtc tgtcccctcc
     3301 tcgtcgcttt cccctcgcag actccgaccc ctgggaggac tcccggagcg gaggtttttc
     3361 ccggcgtgct ctctgtcgcc acccggtggt gacagaggag aatgcggcgg tcgtgaccgg
     3421 cgacacggaa attctttttt atagttttct tagactgtca ttgactgctc gtcgctgttt
     3481 gcgtatgtgt gaaccgtagg cacagttttt tcacacgttg cacttgttct tctgtggcct
     3541 gacccccctg ggtcgggccg gtgcttgggg gtcacccgcc caggttggat gtcaccacca
     3601 caagggaaaa caaacacatg ggtttttccc caacatgatt atttttttat gtcactcgcc
     3661 tgctgtttgc gtgtgggtga accccgggcc aaacatccca tgtcagccat cgtttctgtt
     3721 tttatcacat cgttgggctg gggttagggg tcggggtcgg gagggtgggg attcgttttg
     3781 tcatccgggt ccgatgtcgg tggtgtgcgc gggggggggg ggtggggggg gagaataaag
     3841 gagaagcagc gacgtggaaa
//
