LOCUS       NM_144822               2358 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus mitochondrial calcium uptake 1 (Micu1), transcript
            variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_144822
VERSION     NM_144822.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2358)
  AUTHORS   Hasan,P., Berezhnaya,E., Rodriguez-Prados,M., Weaver,D.,
            Bekeova,C., Cartes-Saavedra,B., Birch,E., Beyer,A.M., Santos,J.H.,
            Seifert,E.L., Elrod,J.W. and Hajnoczky,G.
  TITLE     MICU1 and MICU2 control mitochondrial calcium signaling in the
            mammalian heart
  JOURNAL   Proc Natl Acad Sci U S A 121 (35), e2402491121 (2024)
   PUBMED   39163336
  REMARK    GeneRIF: MICU1 and MICU2 control mitochondrial calcium signaling in
            the mammalian heart.
REFERENCE   2  (bases 1 to 2358)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2358)
  AUTHORS   Roman,B., Mastoor,Y., Zhang,Y., Gross,D., Springer,D., Liu,C.,
            Glancy,B. and Murphy,E.
  TITLE     Loss of mitochondrial Ca2+ uptake protein 3 impairs skeletal muscle
            calcium handling and exercise capacity
  JOURNAL   J Physiol 602 (1), 113-128 (2024)
   PUBMED   38018177
REFERENCE   4  (bases 1 to 2358)
  AUTHORS   Li,X., Sun,B., Li,J., Ye,W., Li,M., Guan,F., Wu,S., Luo,X.,
            Feng,J., Jia,J., Liu,X., Li,T. and Liu,L.
  TITLE     SEPSIS LEADS TO IMPAIRED MITOCHONDRIAL CALCIUM UPTAKE AND SKELETAL
            MUSCLE WEAKNESS BY REDUCING THE MICU1:MCU PROTEIN RATIO
  JOURNAL   Shock 60 (5), 698-706 (2023)
   PUBMED   37695737
  REMARK    GeneRIF: SEPSIS LEADS TO IMPAIRED MITOCHONDRIAL CALCIUM UPTAKE AND
            SKELETAL MUSCLE WEAKNESS BY REDUCING THE MICU1:MCU PROTEIN RATIO.
REFERENCE   5  (bases 1 to 2358)
  AUTHORS   Shi,X., Liu,C., Chen,J., Zhou,S., Li,Y., Zhao,X., Xing,J., Xue,J.,
            Liu,F. and Li,F.
  TITLE     Endothelial MICU1 alleviates diabetic cardiomyopathy by attenuating
            nitrative stress-mediated cardiac microvascular injury
  JOURNAL   Cardiovasc Diabetol 22 (1), 216 (2023)
   PUBMED   37592255
  REMARK    GeneRIF: Endothelial MICU1 alleviates diabetic cardiomyopathy by
            attenuating nitrative stress-mediated cardiac microvascular injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2358)
  AUTHORS   Csordas,G., Golenar,T., Seifert,E.L., Kamer,K.J., Sancak,Y.,
            Perocchi,F., Moffat,C., Weaver,D., Perez,S.F., Bogorad,R.,
            Koteliansky,V., Adijanto,J., Mootha,V.K. and Hajnoczky,G.
  TITLE     MICU1 controls both the threshold and cooperative activation of the
            mitochondrial Ca(2) uniporter
  JOURNAL   Cell Metab 17 (6), 976-987 (2013)
   PUBMED   23747253
REFERENCE   7  (bases 1 to 2358)
  AUTHORS   Plovanich,M., Bogorad,R.L., Sancak,Y., Kamer,K.J., Strittmatter,L.,
            Li,A.A., Girgis,H.S., Kuchimanchi,S., De Groot,J., Speciner,L.,
            Taneja,N., Oshea,J., Koteliansky,V. and Mootha,V.K.
  TITLE     MICU2, a paralog of MICU1, resides within the mitochondrial
            uniporter complex to regulate calcium handling
  JOURNAL   PLoS One 8 (2), e55785 (2013)
   PUBMED   23409044
REFERENCE   8  (bases 1 to 2358)
  AUTHORS   De Stefani,D., Raffaello,A., Teardo,E., Szabo,I. and Rizzuto,R.
  TITLE     A forty-kilodalton protein of the inner membrane is the
            mitochondrial calcium uniporter
  JOURNAL   Nature 476 (7360), 336-340 (2011)
   PUBMED   21685888
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2358)
  AUTHORS   Baughman,J.M., Perocchi,F., Girgis,H.S., Plovanich,M.,
            Belcher-Timme,C.A., Sancak,Y., Bao,X.R., Strittmatter,L.,
            Goldberger,O., Bogorad,R.L., Koteliansky,V. and Mootha,V.K.
  TITLE     Integrative genomics identifies MCU as an essential component of
            the mitochondrial calcium uniporter
  JOURNAL   Nature 476 (7360), 341-345 (2011)
   PUBMED   21685886
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2358)
  AUTHORS   Aichberger,K.J., Mittermann,I., Reininger,R., Seiberler,S.,
            Swoboda,I., Spitzauer,S., Kopp,T., Stingl,G., Sperr,W.R.,
            Valent,P., Repa,A., Bohle,B., Kraft,D. and Valenta,R.
  TITLE     Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily
            of calcium-binding proteins, can induce Th cell type 1-mediated
            autoreactivity
  JOURNAL   J Immunol 175 (2), 1286-1294 (2005)
   PUBMED   16002733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155827.10, AK050113.1 and AC155939.6.
            
            On Apr 16, 2014 this sequence version replaced NM_144822.2.
            
            Transcript Variant: This variant (3) lacks two alternate exons in
            the coding region compared to variant 1. The resulting protein
            (isoform 3) is shorter but has the same N- and C-termini compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050113.1, BC018320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC155827.10        86624-86636         c
            14-2344             AK050113.1         1-2331
            2345-2358           AC155939.6         128879-128892
FEATURES             Location/Qualifiers
     source          1..2358
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.6 cM"
     gene            1..2358
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /note="mitochondrial calcium uptake 1"
                     /db_xref="GeneID:216001"
                     /db_xref="MGI:MGI:2384909"
     exon            1..125
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            126..287
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1560
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     calcium uptake protein 1, mitochondrial; calcium binding
                     atopy-related autoantigen 1"
                     /codon_start=1
                     /product="calcium uptake protein 1, mitochondrial isoform
                     3"
                     /protein_id="NP_659071.1"
                     /db_xref="CCDS:CCDS35909.1"
                     /db_xref="GeneID:216001"
                     /db_xref="MGI:MGI:2384909"
                     /translation="MFRLNTLSALAELAVGSRWYHGASQPTQTKRRLMLVAFLGASAV
                     TASTGLLWKKAHAESPPCVNSKKPDTEDKERNKDSGEVSSREGRAADAAAEPYPEDKK
                     KKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITP
                     NEKQPEHLGLDQYIIKRFDGKKIAQEREKFADEGSIFYSLGECGLISFSDYIFLTTVL
                     STPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGL
                     CSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRISERQFGGMLL
                     AYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGAS
                     LDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKP
                     KDMGFTRLMQAMWKCAQETAWDFALPK"
     exon            288..462
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..625
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..669
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..784
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..867
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1065
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1203
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1312
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1402
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..2358
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2327..2332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /note="hexamer: ATTATA"
     polyA_site      2347
                     /gene="Micu1"
                     /gene_synonym="C730016L05Rik; Calc; Cbara1"
                     /note="major polyA site"
ORIGIN      
        1 ggctaaggga gtcacgtgag agtgggcgga ggacgcagag cggggctccc cggcatttgc
       61 gtctctatgg ttgtcagagg tgggcggcat tctccgagtt gctgctaaag ctggagcgcg
      121 gacgggatgt ttcgtcttaa caccctttct gcgttggcag aactagctgt gggctctcgc
      181 tggtaccatg gggcatcaca gcccacacag accaaacgaa gattgatgct ggtggcgttc
      241 ctgggagcat ctgcagtgac tgcaagtacc ggtctcctgt ggaagaaggc tcacgcagaa
      301 tctccaccat gcgttaacag caagaagcct gacacagaag ataaagagag aaacaaagac
      361 agcggggaag tgtccagccg tgaaggaagg gctgcagatg ctgcggcaga gccttatcct
      421 gaggacaaga agaagaagcg ctctggattc agagacagaa aagtgatgga gtatgagaat
      481 cgaatccgag cctactccac accagacaaa attttccgat attttgccac cttgaaagta
      541 atcaacgaac ctggtgaaac cgaagtgttc atgactccgc aggactttgt gcgctccata
      601 acgcccaatg agaagcagcc agaacacttg ggcctggatc agtatataat aaagcgcttt
      661 gatggaaaga aaattgccca ggaacgagaa aaatttgctg atgaaggcag catcttctac
      721 agccttggag agtgtgggct catctccttc tctgactaca tcttcctcac aacagtcctc
      781 tccactcctc agagaaattt tgaaattgct ttcaagatgt ttgacttgaa tggagacgga
      841 gaggtagaca tggaggagtt tgagcaggtt cagagcatca ttcgctccca gaccagcatg
      901 ggcatgcgtc acagagaccg tccaaccact gggaacaccc tcaagtctgg cttatgttcg
      961 gccctcacga cctacttttt tggagctgat ctcaaaggga aactgaccat caaaaacttc
     1021 ctggaatttc agcgcaaact tcagcatgac gttctaaagc tggagtttga acgccatgac
     1081 ccggtagatg ggagaatctc tgagaggcag ttcgggggca tgctgctggc ctacagtgga
     1141 gtgcagtcca agaagctgac cgccatgcag agacagctga agaagcactt caaagatggg
     1201 aagggcctga ctttccagga ggtagagaac ttcttcactt tcctgaagaa cattaatgac
     1261 gtggacactg cactaagctt ttaccacatg gctggagcat ctcttgataa agtgaccatg
     1321 cagcaagtgg ccaggacagt ggcgaaggtc gaactctcgg accatgtgtg tgacgtggtg
     1381 ttcgcgctct ttgactgtga tggcaatggg gagctgagca acaaggagtt cgtttccatc
     1441 atgaagcagc ggctgatgag aggcctggag aagcccaagg acatgggctt cacccgcctc
     1501 atgcaggcca tgtggaaatg tgcccaagaa actgcctggg actttgctct gcccaaatag
     1561 tattcccacc tcctgcacct tagcaccctg caagccctgg agtggccctt catgctgctg
     1621 atgcatcggg agtggtgccc acctccccat ctttctggga gtaacctctg ggctcagccg
     1681 gcttccctct ccaccctgcc ctgaccccat cagtgttctg ctaggctctg agtctgcagt
     1741 cggatggaag gtcctaaaac aggactgagg cttcaaagta gagaccttag ttaactccct
     1801 tagcaagtgc cctgtgggtc agtgcaggag ccctcccaac cccggccagc ccgggaggga
     1861 ggcagctctg ctctgctctg acatctgtct ctcgctgtgg atttatagta gcaagaacac
     1921 tccctgccat tttcctcctg ctgtttttaa gctgcaagtt tggaaatgag ctggcaggcg
     1981 aaaggaagtg tgatgaatga taatgcagat gaccctggca ccctgagctg gcaggaagcc
     2041 tggccagagg agggtctgtg ttagccacca ggggctccag gaaggcactg tgcccccagc
     2101 agaatccaga ttccaagtgg ctgctttaag cagctctcca gaacttccca gctctgtggt
     2161 ttcctcccag gctccctgcg atgcctcctc tgggactctg cttcactaga gcaatggctg
     2221 agcccctgtc cctgtgtctc atcccctctc tatggacctg tggagcccag acccagctca
     2281 gagcctagct gccctctgtc taagacactc gtaaaatatc actttaatta tagcactttg
     2341 caggaaatac ccgcaaga
//
