LOCUS       NM_001270475            9448 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus microtubule associated monooxygenase, calponin and LIM
            domain containing 3 (Mical3), transcript variant 1, mRNA.
ACCESSION   NM_001270475
VERSION     NM_001270475.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9448)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 9448)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9448)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ105256.1, AK048201.1, BC090651.1, AK147803.1, BC043122.1,
            AK035932.1, BM899307.1 and AI845760.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                CJ105256.1         2-24
            24-2414             AK048201.1         2-2392
            2415-2756           BC090651.1         44-385
            2757-3101           AK147803.1         159-503
            3102-8845           BC043122.1         1-5744
            8846-9197           AK035932.1         2429-2780
            9198-9427           BM899307.1         19-248              c
            9428-9448           AI845760.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..9448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.03 cM"
     gene            1..9448
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /note="microtubule associated monooxygenase, calponin and
                     LIM domain containing 3"
                     /db_xref="GeneID:194401"
                     /db_xref="MGI:MGI:2442733"
     exon            1..253
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            254..592
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..6310
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /EC_number="1.14.13.225"
                     /note="isoform 1 is encoded by transcript variant 1;
                     flavoprotein oxidoreductase MICAL3; molecule interacting
                     with CasL protein 3; protein-methionine sulfoxide oxidase
                     MICAL3; [F-actin]-methionine sulfoxide oxidase MICAL3;
                     [F-actin]-monooxygenase MICAL3"
                     /codon_start=1
                     /product="[F-actin]-monooxygenase MICAL3 isoform 1"
                     /protein_id="NP_001257404.1"
                     /db_xref="CCDS:CCDS85152.1"
                     /db_xref="GeneID:194401"
                     /db_xref="MGI:MGI:2442733"
                     /translation="MEERKQETTNQAHVLFDRFVQATTCKGTLRAFQELCDHLELKPK
                     DYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTA
                     IDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIR
                     QLQLILLKVALILGIEIHVNVEFQGLVQPPEDQENERIGWRALVHPKTHPVSEYEFEV
                     IIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQ
                     ELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYTDTELLLSRENVDQEA
                     LLNYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMYASENAALVREQNGHQLL
                     VALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQ
                     TTPENVSKNFSQYSIDPVTRYPNININFLRPSQVRHLYDSGETKDIHLEMENMVNPRT
                     TPKLTRNESVARSSKLLGWCQRQTEGYSGVNVTDLTMSWKSGLALCAIIHRYRPDLID
                     FDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFK
                     DSLSSSDTLDLNAEEKAVLIASTKSPISFLSKLGQTISRKRSPKDKKEKDSDGAGKRR
                     KTSQSEEEEPPRSYKGERPTLVSTLTDRRMDAAVGNQNKVKYMATQLLAKFEENAPAQ
                     STGVRRQGSIKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTL
                     RLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKEVKGALQDGPTADANGL
                     ASVAASSAERSPGTSMNGLEEPSIAKRLRGTPERIELENYRRSVRQVEELEEVPEETQ
                     AEHNLSSVLDKGTEEDVASSSSESEMEEEEEEDDEDDHLPTSDLGGVPWKEAVRIHAL
                     LKGRSEEELEASKNFEPEEEEEEEEYEEEDEEYEEEEEEESSEAGNKRLQQIITAADP
                     LAIQADVHWTHIREREAEERMLPTSESSTSRAPLDEDDLEEDADSEPAETEGEAAEDG
                     DPGDTGAELDDQHWSDDIPSDAEAEHRLQSQAKVKAELELRVSENEEEKPSDAPKQEE
                     RGTSQVSSPSQPPEKQVGVFSPARSPGTEEAKSPLATKVKSPEEPLFPTPLLLREKPK
                     AEVPEEQKAVLSPIRSQPVALPEARSPTSPTSLQPESLLAPPTPPTPPPTQLPICSQP
                     QPSSDASIPSPTKSPIRFQPVPAKTSTPLTPLPVKSQGDPKDRLSGPLAVEEVLKRSD
                     LVEEFWMKSAEIRRSLGLTPVDRSKGSEPSLPSPASKPISLKSYSVDKSPQDEGLCLL
                     KPPSVPKRLGLPKSAGDQPPLLTPKSPSDKELRSSQEERRDLSSSSGLGLHDSSSNMK
                     TLGSQSFNTSDSTMLTPPSSPPPPPPPNEEPATLRRKPHQTFERREASIIPPPTPASF
                     MRPPREPAQPPREEVRKSFVESVDEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWSR
                     SEKLQAKENGRLPPLEQDVPPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMA
                     KQLSRMQAMEMVSSRSHTAQSQGKELGSESTRHPSLRGTQEPTLKHEATSEEILSPPS
                     DSGGPDGSVTSSEGSSGKSKKRSSLFSPRRNKKEKKTKGEARPPEKPSPGLPEDVVAK
                     PKSLWKSVFSGYKKDKKKKSDEKSCSSTPSSGATVDSGQRRASPMVRAELQLRRQLSF
                     SEDSDLSSDDILERSSQKSKREPRTYTEEELSAKLTRRVQKAARRQAKQEELKRLHRA
                     QIIQRQLEQVEEKQRQLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVR
                     YESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEGELSEEKKILNEMLEVVEQR
                     DSLVALLEEQRLREKEEDKDLEAAMLCKGFSLDWS"
     exon            593..800
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            801..917
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1019
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1175
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1276
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1534
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1650
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1777
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1874
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2022
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2219
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2332
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2395
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2569
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2756
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2845
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2933
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3129
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3374
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3512
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3623
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3770
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3853
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..5651
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            5652..5746
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            5747..5857
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            5858..5951
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            5952..6051
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            6052..6125
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     exon            6126..9432
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9225..9230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /note="hexamer: AATAAA"
     polyA_site      9264
                     /gene="Mical3"
                     /gene_synonym="C130040D16Rik; Mical-3; mKIAA1364"
                     /note="major polyA site"
ORIGIN      
        1 gagatgcagc ggtgagggag gacagacaga ggcagacccc gggttcttcg ttccttcttc
       61 gctgctccga tgaaagaagt gtgcctcggg gcttctgagt gagaaccttt gatgggattc
      121 tagctggaag gtggagtcac cacactcagg atgcatgcag ccacaacagc agcacctgtg
      181 tcctgaggac cagccaatct ggggaggcaa gctctcaccg gcgaggaaga tgcgggtgtg
      241 aagccccaag tccattaagg tgacagtgcc aggtggatca gcaccattcc accgcccctc
      301 cgtggagctg tgccaagagt aggggaacat ggaggagagg aagcaggaga caacgaacca
      361 agctcacgtc ctctttgacc gctttgtcca ggccaccacc tgcaagggga ccctcagggc
      421 cttccaagag ctctgtgacc acctggagct gaagcccaag gactaccggt ccttctacca
      481 caagctcaag tccaagctca actactggaa ggccaaagcc ctctgggcca aattggacaa
      541 gcggggcagt cacaaagact acaaaaaggg caaagcctgc accaacacaa agtgtctcat
      601 cattggagct ggcccctgtg ggctgcgcac agccatcgac ttgtccttgt tgggagccaa
      661 ggtggttgtt attgaaaagc gagatgcctt ctcccgcaac aatgtcttac atctctggcc
      721 cttcaccata cacgatctcc gaggcctggg tgccaagaaa ttctacggca agttctgtgc
      781 cggagccatc gaccatatca gtatccgtca gctccagcta atcctcttga aggtagcctt
      841 gatcttgggc attgagatcc atgtcaatgt ggaattccaa ggacttgttc agcctcccga
      901 ggaccaagag aatgaacgga taggatggcg agcattggtg caccccaaaa ctcatcctgt
      961 atcagaatat gaatttgaag ttatcatcgg tggagatggg cgtaggaaca ccttggaagg
     1021 atttcgtcga aaagaatttc gtggcaagct agccattgcc attacagcaa attttatcaa
     1081 ccgcaacaca accgcagagg ccaaagtgga ggagattagt ggcgtggctt ttatattcaa
     1141 ccaaaaattt ttccaggagc tgagagaagc cacaggtatt gacttagaga acatcgtcta
     1201 ctacaaagat gacacacact actttgtcat gacggccaaa aagcagagtt tgctggacaa
     1261 gggggtgatc ctgcatgact acacagacac ggagctgttg ctttcccggg agaacgtgga
     1321 ccaggaggcc ctgctgaact atgcccggga ggccgcagac ttctctaccc agcagcagct
     1381 gccttctctg gatttcgcca tcaatcacta cgggcagcca gacgtggcca tgtttgactt
     1441 tacctgcatg tacgcctctg aaaatgccgc cttggtccgg gaacagaacg gacaccagtt
     1501 actagtagct ttggttggag acagcctcct ggagcctttc tggccaatgg ggacaggaat
     1561 agcccggggc tttctggctg ctatggactc tgcctggatg gtacgaagct ggtctctggg
     1621 caccagcccc ttggaagtcc tggcagaaag ggaaagcatt tataggttgc tgcctcagac
     1681 cacccctgag aacgtgagca aaaacttcag ccaatatagc atcgaccctg tcactaggta
     1741 tcccaatatc aacatcaact tcctcaggcc aagccaggtg cgccatttat acgatagcgg
     1801 agaaacaaaa gatatccacc tggaaatgga gaacatggtg aatccccgaa ccactcccaa
     1861 gctgactcgc aacgagtctg tagctcgttc aagcaaactg ctggggtggt gccaaaggca
     1921 gacagaaggc tattcaggag tcaatgtgac agatctcact atgtcttgga aaagtggcct
     1981 ggccctgtgt gcgatcatcc acagataccg ccccgatcta atagactttg attctttgga
     2041 tgagcaaaac gtggagaaga ataatcagct ggcctttgac atcgctgaga aggaactggg
     2101 tatctctccc atcatgacgg gcaaggagat ggcttcggtc ggggagccag acaagctgtc
     2161 catggtgatg tacctcacgc agttctacga gatgttcaag gactcgctct cctccagcga
     2221 caccctcgac ctgaatgcag aggagaaagc cgtcctgata gccagcacca aatcccccat
     2281 ctccttcctg agcaaactcg gacagaccat ctctcggaag cgttcgccca aggataaaaa
     2341 agaaaaggac tcagatgggg ctggaaagag gagaaaaacc agtcagtcag aggaggagga
     2401 gcctccccgg agctacaaag gagaaagacc gaccctggtg agcaccctga cggacagacg
     2461 gatggatgct gccgttggga accagaacaa agtgaagtac atggcgaccc agctgctggc
     2521 caagtttgaa gagaacgcac ctgctcagtc cactggtgtg aggagacagg gctccataaa
     2581 gaaagagttc ccgcagaact tggggggcag cgacacgtgc tatttctgcc aaaagcgggt
     2641 ctacgtgatg gagaggctga gcgccgaggg caagttcttc catcgaagct gcttcaagtg
     2701 tgagtactgt gccaccacgc tgcgcctatc agcctacgcc tacgacatcg aggatggcaa
     2761 attctactgt aagccgcact actgttaccg actatctggc tacgcgcaaa ggaagaggcc
     2821 agcggtggct cctctgtctg gaaaggaagt caaaggagcc ctgcaggatg gccccactgc
     2881 agatgcaaat ggactggcca gcgttgccgc cagctcagcc gagagaagtc caggtaccag
     2941 catgaacggc ctggaggagc ccagcattgc caaaaggctg aggggcaccc ccgagaggat
     3001 cgagctggag aactaccgcc gatctgtgag gcaggtggag gagctggagg aggtacccga
     3061 ggagacacag gccgagcata acctgagcag cgtcttagac aaaggcaccg aagaggatgt
     3121 ggccagcagc agttctgagt cggagatgga ggaggaggaa gaggaagatg acgaagatga
     3181 tcatctcccc acctctgacc tgggcggggt tccctggaag gaggcagtca ggatccatgc
     3241 ccttctgaag ggaaggagtg aagaggagct ggaagcctcc aagaacttcg agcccgagga
     3301 agaagaagag gaggaggaat acgaagaaga ggatgaagag tatgaggagg aggaagagga
     3361 ggaatccagt gaagccggga acaagaggct gcagcagatc ataaccgcag cggatccctt
     3421 ggcgatccag gctgatgtgc actggacaca catccgtgag agagaggcag aggagaggat
     3481 gctcccaacc tctgagtcct ccacttctag agctcctcta gatgaggatg acctagaaga
     3541 ggacgcggac tctgagccag cagagactga aggggaagcc gcggaggatg gggaccctgg
     3601 agacaccggt gctgaactgg atgatcagca ctggtctgac gacatccctt ctgatgctga
     3661 agcggagcat cgcttacaga gccaggccaa ggtgaaagca gagctggagc tgagagtatc
     3721 ggaaaacgag gaagagaagc catctgatgc gccaaagcaa gaggagagag gtacttccca
     3781 agtctccagc cctagccagc cacctgagaa acaagttggt gtgttctccc cagctcgcag
     3841 ccctgggaca gaggaggcca aatccccact tgccaccaag gtaaagtccc ccgaggagcc
     3901 acttttcccc acgcctctgc tcctcagaga aaagcccaaa gctgaagtcc ctgaagaaca
     3961 gaaagctgta ctctcgccca tccggtcaca gcctgtggcc ctgccagaag ccagatcacc
     4021 tacctcaccc accagcttac agccagagtc tctgttggcc cctcccactc ctcccacacc
     4081 tccccccacc caactcccca tctgttccca acctcagccc tcctcggatg cctccatccc
     4141 atcgcccacc aagtccccca tacgcttcca gccagttcca gccaaaacat ccacacccct
     4201 caccccactc cccgtgaaga gccaaggaga ccccaaagac agactgagtg gccccctggc
     4261 tgtggaggag gtcttaaagc ggagtgatct ggtggaagaa ttctggatga agagtgctga
     4321 gatccgccgc agcctgggcc ttactcccgt ggaccggagc aaggggtcag agcccagcct
     4381 cccctcccct gcctcgaagc caatatccct aaagtcctac tcagttgaca agtcacctca
     4441 ggatgagggt ctctgccttc tgaaacctcc atcggttcct aaaaggttgg gcctaccaaa
     4501 gtcagccggt gaccagcccc cactgctgac cccaaagtcg ccctccgaca aggagctgag
     4561 gagcagccag gaggagcgaa gggacctgtc cagcagctca ggcctgggcc tccatgatag
     4621 ctcctccaac atgaagacct tgggcagcca gagcttcaac acctcggact ccaccatgct
     4681 caccccacct tccagcccac ccccaccccc accccccaac gaggagcctg caacccttcg
     4741 aaggaaaccc catcagactt ttgagcgcag ggaggcctca attatccccc ctcccacccc
     4801 tgcctcattc atgcggcccc cacgggagcc ggcccagccc cccagggagg aggttcggaa
     4861 gtccttcgtg gagagtgtgg atgagatccc ctttgccgac gatgtggagg acacttacga
     4921 tgataagacg gaggactcca gtctgcagga gaagttcttc acaccccctt cctgctggtc
     4981 ccgctcggag aagctccagg ccaaggagaa cgggcgactc ccacccctgg agcaggacgt
     5041 gccaccacag aaaagggggc tgcccctggt ctccgcggaa gccaaggagc tggccgagga
     5101 gcgcatgcgc gcccgggaga agtctgtgaa gagccaggca ctgcgagatg ccatggccaa
     5161 acagctgagc cggatgcagg ccatggagat ggtgtcctcc aggtcccaca cggcacaatc
     5221 gcagggcaag gaactaggat ccgagtccac cagacaccca agcctccgag gcacccagga
     5281 gcccaccctg aagcatgaag ccaccagcga agagatcctc tcccctccgt cagactcagg
     5341 aggccccgat ggctccgtca cctcatctga gggctccagt ggaaagagca aaaagaggtc
     5401 gtcgctcttc tccccccgca ggaataagaa agagaagaaa accaaagggg aagcccggcc
     5461 ccccgagaaa cccagcccag gcctcccaga agatgtggta gccaagccca agtccctgtg
     5521 gaaatctgtc ttctctgggt acaagaagga caagaagaaa aagagcgacg agaaatcgtg
     5581 ttccagcacg ccgtccagtg gcgccacggt ggactccggc cagcgcaggg cgtctccaat
     5641 ggtgagagca gagctgcagc tccgccgcca gctgagtttc tcagaggact cagacctgtc
     5701 cagtgatgac atccttgaga ggtcttccca gaagtccaag cgagagccca gaacctacac
     5761 agaggaggag ctgagtgcca agctgacgag gcgtgtgcag aaggcggctc ggagacaggc
     5821 taagcaggag gaactgaagc ggctgcaccg agcccagatc atccagcggc aactggagca
     5881 agtggaagag aaacagaggc agctggagga gaggggcgtt gcagtagaga aggctcttcg
     5941 aggagaagca ggcatgggca aaaaggatga ccccaagctg atgcaggagt ggttcaagct
     6001 ggtgcaggag aagaacgcaa tggtgcgcta cgagtcggag ctgatgattt ttgcccggga
     6061 gctggagctg gaagaccggc agagccgact acagcaggag ctgagggagc ggatggccgt
     6121 ggaagatcac ctgaagaccg agggggagct ttcagaggag aagaagatcc tgaacgagat
     6181 gctggaggtg gtggagcaga gagactcgct ggtggccctg ctggaggagc agcgactgcg
     6241 ggagaaagag gaggacaagg acctggaggc cgccatgcta tgcaaaggct tcagcctgga
     6301 ctggtcctga gcccgcctgc cattgtgtct ggtagattgg cacccacctg acccggctgc
     6361 gttctcccaa accaccggat tcaggttcag aagaggcctg gcatccctgg agaagccgtg
     6421 ctcagacacc atgccgtggg aaaaccccag gtgaggggta tcatctgagg tgacaacacc
     6481 tctgaggaga ggcaccttcc cccaccccag acttcccact caggagggag gagatgggtg
     6541 tgtttgatgt gtgccccagg gggaaaacgc cttcaggtct atgagggctt gctgcctggc
     6601 acctctttca agtggctcct cttcagagcc actgccacca cagagcacct gcagagcaga
     6661 gcagccattg ccctcatgct ccctgaagca ccaccaaaga aagtacagag gcaccttcag
     6721 gaaagggctg tggatggaga tccagcaggg acaacccccc acaggggtaa tgctcaccct
     6781 gtcggggcag gggaagtagg caggttcatt atgcaagtca ggagggcgca ggaggggcct
     6841 gcccccccac acactggatc cccagtggcc aagtgccccg ggcctttcac atggacagtg
     6901 gcctgaagcc cgtggattgc tgtgttttgc ttttagttca caaccatttt gacactggaa
     6961 agtattgact ttgggagagc tgaaggaagc cctacctgtc aacccctccc ccaaccccac
     7021 tacttttgac cgagaggcgc agtccctggt cagcacccac atctgtacag gagatggctc
     7081 tccttggtgt tttcctgtgt ttgcacattg aaacgagact gacagcctgg ccagacactc
     7141 agccacttcg gacccttttt ttttttttgt caattaactt atttttttaa tacttgaaag
     7201 tgagcaatgt cattttttta tacctttact aagagacact gcctgtcacc tgcgcgtggg
     7261 agtggcaaga aggtctttgt acatcccatg caacctgatg caaaattgcc ctgattcttg
     7321 ttacacgcat ctatttatta gccttcttaa tagtgttacc gacctgcttg gcaccaggga
     7381 gcagcccagg gccctgtggg tccttgttca cagctttgcc gtcccctcct ctacccggca
     7441 ccctgttcct gttgccactg gacttttcca ggagaatagc ctctctgtat ggatgcattt
     7501 cggagccagg aggccaggcc tcgagacagg ttgttctggt cttttgggaa tcttggctct
     7561 gtggacccca ctttgtccaa ttttgctgcc aaggttttac ctcctgtaca tatgttaaag
     7621 gttgaggcta gcccctcttc atgcttgctg ggaccaagta gagtgtgatg ctcagcccca
     7681 gctagacagg aacatgtgtg ctggtctcac ctcaacatac cggccactcc aatcttctct
     7741 gcctatatca ggattttctt ggcctggcag gagccagtca gcaccatgta actagatcca
     7801 taagccaagc tgttcatttc tcatggttca gccagagacc agcagttgga gccagggtgc
     7861 ttctccttca aaacagcagc cacctatgga ccagtccatt ggtaccatac caatctggaa
     7921 agggcacgcc agctgggcct gtgggagggg ccagtgcaga caacagccaa gggcccacac
     7981 tgaccctgga ctccccgtgg gaaccacact gtgcctcaac ttgaacatcc atccacccaa
     8041 ctccagagga gcaaacagct atcttacttc tcaccttgcg caaaagctgc catctctcct
     8101 gtggaaaccc agatgtgctg ctagcaaccg ccacagcgct gacgtcatca cttcctggac
     8161 tctgatatgg cggcatcgct atttttattc catcagagga ggatgttctg gattctattt
     8221 tcaaccacaa tctgccaatc aaactggact ttggacagga ccttcatcgc ctgtgtggcc
     8281 ttctccttga ccctgtcctc ctctgcagtg ccaccggcgg caatcccacg cagctcagcc
     8341 ctgtcattcc tgctaaccca gaacaaggaa accatttccc gagcgactca agaaggatgc
     8401 aggggcacgc tgcatctcta gctgcctctc agagctctgc accagatgtt cccttccacc
     8461 tctgtcctgg tcagccatga cgtgttgatc tctccaaagc acacgctgct tccagtgaaa
     8521 gtgggcagaa cacttcgcag gagggcctca gaaatccacc agccttggga gacgtcccgc
     8581 agttctccag tcgtgacgac acgaggactt cagaatccca cagagcactt ttttttttag
     8641 gctaccagtt tgtaaccact agtttgcagt tgatttcagt ggcccgggaa cgagacgcga
     8701 agtgttctcc acctctggaa atgcatacag ctctggtcat gcgttcttcc caggaattat
     8761 gtcttcactt gaaggcaggg aagagaggga tgtatacact tcatccacac atacagtgct
     8821 agagtgcttt tgagtaaacc caaactcaag gctaaggaca gtacatgagg ctctaacctc
     8881 tgtccctgga gcgcaagcag aaggcagccc gtggctccca aagaagagcg tggccaaccc
     8941 aggttctgac cctgctcagt tgatatctct gcctccaaca gccatcctta acgtaatttt
     9001 gaccagcaga tgtagacttt aaaaaataag acatatgtca ctgggacagg agagtagagg
     9061 tgggggcaac aaatcttggg ggcgctggga ctatagctca gtggtagaat gtgtgttcag
     9121 catgcataag acccacggtt caacccccag taccacattt aaaaattttt ttcttttgaa
     9181 agatggtaac atgacccaca agagggaatg gctggtttat gcgcaataaa gttttgtttt
     9241 gtttcggttt tttttttaaa gaaatgaaaa atgtatttct gaagtcattg ttctgctctt
     9301 ggcattgagc taaggcatac ttagcacctt cctttcaggt gagtgatact gaacacaaat
     9361 catttggtga ttatcagtga gtgtatgcag acaaggattc tcagagaata gagcttttca
     9421 tttggtttgt gaaaaaaaaa aaaaaaaa
//
