LOCUS       NM_001395864            5528 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus microtubule associated monooxygenase, calponin and LIM
            domain containing 2 (Mical2), transcript variant C, mRNA.
ACCESSION   NM_001395864 NM_027587
VERSION     NM_001395864.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5528)
  AUTHORS   Zhao,T., Xiao,T., Cao,D., Xia,W., Gao,L., Cheng,L., Zang,M., Li,X.
            and Xu,E.Y.
  TITLE     Sertoli cell PUMILIO proteins modulate mouse testis size through
            translational control of cell cycle regulators
  JOURNAL   Biol Reprod 107 (1), 135-147 (2022)
   PUBMED   35678316
REFERENCE   2  (bases 1 to 5528)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5528)
  AUTHORS   Jiang,F., Cao,J., Kong,R., Fang,L., Wang,B., Zhang,S., Yang,L. and
            Cao,X.
  TITLE     MICAL2 regulates myofibroblasts differentiation in epidural
            fibrosis via SRF/MRTF-A signaling pathway
  JOURNAL   Life Sci 269, 119045 (2021)
   PUBMED   33453238
  REMARK    GeneRIF: MICAL2 regulates myofibroblasts differentiation in
            epidural fibrosis via SRF/MRTF-A signaling pathway.
REFERENCE   4  (bases 1 to 5528)
  AUTHORS   Giarratana,N., Conti,F., La Rovere,R., Gijsbers,R., Carai,P.,
            Duelen,R., Vervliet,T., Bultynck,G., Ronzoni,F., Piciotti,R.,
            Costamagna,D., Fulle,S., Barravecchia,I., Angeloni,D., Torrente,Y.
            and Sampaolesi,M.
  TITLE     MICAL2 is essential for myogenic lineage commitment
  JOURNAL   Cell Death Dis 11 (8), 654 (2020)
   PUBMED   32811811
  REMARK    GeneRIF: MICAL2 is essential for myogenic lineage commitment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5528)
  AUTHORS   Tao,W., Sun,W., Zhu,H. and Zhang,J.
  TITLE     miR-205-5p suppresses pulmonary vascular smooth muscle cell
            proliferation by targeting MICAL2-mediated Erk1/2 signaling
  JOURNAL   Microvasc Res 124, 43-50 (2019)
   PUBMED   30853343
  REMARK    GeneRIF: In pulmonary artery hypertension miR-205-5p suppressed
            pulmonary artery smooth muscle cell proliferation by targeting
            MICAL2, which activated ERK1/2 signaling.
REFERENCE   6  (bases 1 to 5528)
  AUTHORS   Elsen,G.E., Hodge,R.D., Bedogni,F., Daza,R.A., Nelson,B.R.,
            Shiba,N., Reiner,S.L. and Hevner,R.F.
  TITLE     The protomap is propagated to cortical plate neurons through an
            Eomes-dependent intermediate map
  JOURNAL   Proc Natl Acad Sci U S A 110 (10), 4081-4086 (2013)
   PUBMED   23431145
REFERENCE   7  (bases 1 to 5528)
  AUTHORS   Miura,K.
  TITLE     ERK2-binding domain is required for phosphorylation of EBITEIN1, a
            potential downstream interactor of ERK2
  JOURNAL   Biochem Biophys Res Commun 375 (3), 367-371 (2008)
   PUBMED   18700133
  REMARK    GeneRIF: EBITEIN1 is a phosphoprotein and a downstream interactor
            of ERK2 that participates in the intracellular signal transduction
            pathway mediating the morphogenetic development of round spermatids
            into spermatozoa.
REFERENCE   8  (bases 1 to 5528)
  AUTHORS   Miura,K. and Imaki,J.
  TITLE     Identification of ERK2-binding domain of EBITEIN1, a novel
            ERK2-binding protein
  JOURNAL   Biochim Biophys Acta 1784 (9), 1319-1325 (2008)
   PUBMED   18590835
  REMARK    GeneRIF: Based on empirical and bioinformatic analyses, we propose
            two domains in EBITEIN1. One is the minimal sequence for binding
            ERK2 (EB domain) and the other is the EBITEIN1 C-terminal domain
            (ECT domain).
REFERENCE   9  (bases 1 to 5528)
  AUTHORS   Miura,K. and Imaki,J.
  TITLE     Molecular cloning of Ebitein1: a novel extracellular
            signal-regulated kinase 2-binding protein in testis
  JOURNAL   Biochem Biophys Res Commun 368 (2), 336-342 (2008)
   PUBMED   18241670
REFERENCE   10 (bases 1 to 5528)
  AUTHORS   Terman,J.R., Mao,T., Pasterkamp,R.J., Yu,H.H. and Kolodkin,A.L.
  TITLE     MICALs, a family of conserved flavoprotein oxidoreductases,
            function in plexin-mediated axonal repulsion
  JOURNAL   Cell 109 (7), 887-900 (2002)
   PUBMED   12110185
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166834.2, AC100153.10 and AC132392.3.
            
            On Aug 20, 2021 this sequence version replaced NM_027587.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC166834.2         1472-1657           c
            187-259             AC100153.10        75197-75269
            260-599             AC100153.10        111080-111419
            600-807             AC132392.3         149391-149598       c
            808-924             AC132392.3         146066-146182       c
            925-1026            AC132392.3         143659-143760       c
            1027-1182           AC132392.3         141715-141870       c
            1183-1283           AC132392.3         138114-138214       c
            1284-1541           AC132392.3         134543-134800       c
            1542-1657           AC132392.3         133359-133474       c
            1658-1784           AC132392.3         132453-132579       c
            1785-1875           AC132392.3         131750-131840       c
            1876-2023           AC132392.3         130523-130670       c
            2024-2223           AC132392.3         129509-129708       c
            2224-2330           AC132392.3         129105-129211       c
            2331-2399           AC132392.3         124466-124534       c
            2400-2543           AC132392.3         121147-121290       c
            2544-2730           AC132392.3         106278-106464       c
            2731-2819           AC132392.3         103704-103792       c
            2820-2922           AC132392.3         101759-101861       c
            2923-3103           AC132392.3         88043-88223         c
            3104-3282           AC132392.3         84728-84906         c
            3283-3357           AC132392.3         77097-77171         c
            3358-3503           AC132392.3         72758-72903         c
            3504-4785           AC132392.3         70949-72230         c
            4786-4877           AC132392.3         61829-61920         c
            4878-4958           AC132392.3         58312-58392         c
            4959-5052           AC132392.3         55621-55714         c
            5053-5152           AC132392.3         45527-45626         c
            5153-5226           AC132392.3         41723-41796         c
            5227-5528           AC132392.3         40082-40383         c
FEATURES             Location/Qualifiers
     source          1..5528
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 58.75 cM"
     gene            1..5528
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /note="microtubule associated monooxygenase, calponin and
                     LIM domain containing 2"
                     /db_xref="GeneID:320878"
                     /db_xref="MGI:MGI:2444947"
     exon            1..186
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            187..259
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            260..599
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..5411
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /EC_number="1.14.13.225"
                     /note="isoform C is encoded by transcript variant C;
                     protein MICAL-2; molecule interacting with CasL protein 2;
                     protein-methionine sulfoxide oxidase MICAL2; microtubule
                     associated monoxygenase, calponin and LIM domain
                     containing 2; mMical2; [F-actin]-methionine sulfoxide
                     oxidase MICAL2; [F-actin]-monooxygenase MICAL2; MICAL
                     C-terminal like; MICAL C-terminal-like protein-like;
                     mical-cL; ebitein1; ebitein-1; ERK2-binding testicular
                     protein 1"
                     /codon_start=1
                     /product="[F-actin]-monooxygenase MICAL2 isoform C"
                     /protein_id="NP_001382793.1"
                     /db_xref="GeneID:320878"
                     /db_xref="MGI:MGI:2444947"
                     /translation="MGENEDEKQAQASQVFENFVQATTCKGTLQAFNILTCLLDLDPL
                     DHRNFYSQLKSKVNTWKAKALWHKLDKRGSHKEYKRGKACSNTKCLIVGGGPCGLRTA
                     IELAYLGAKVVVVEKRDTFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIR
                     QLQLILFKVALMLGVEVHVNVEFVRVLEPPEDQENQKVGWRAEFLPADHALSDFEFDV
                     IIGADGHRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQ
                     DLKEETGIDLENIVYYKDSTHYFVMTAKKQSLLDKGVILNDYIDTEMLLCSENVNQDN
                     LLSYAREAADFATNYQLPSLDFAINHNGQPDVAMFDFTSMYASENAALMRERQAHQLL
                     VALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWDQGTPPLEVLAERESLYRLLPQ
                     TTPENINKNFEQYTLDPATRYPNLNLHCVRPHQVKHLYITKEMDRFPLERWGSVRRSV
                     SLSRRESDIRPNKLLTWCQQQTKGYQHVRVTDLTTSWRSGLALCAIIHSFRPELINFD
                     SLNEDDAVENNQLAFDVAKREFGILPVTTGKEMASTQEPDKLSMVMYLSKFYELFRGT
                     PLRPMDSWRKNYGENADFGLGKTFIQNNYLNLTLPRKRTPRVDTQTEENDMNKRRRQG
                     FNHLEELPSFSSRSLGSSQEYAKESGSQNKVKHMANQLLAKFEENTRNPSVVKQESPR
                     KAFPLSLGGRDTCYFCKKRVYMIERLSAEGHFFHQECFRCSVCSATLRLAAYAFDCDE
                     GKFYCKPHFVHCKTSSKQRKRRAELNQQREEEGTWQEQEAPRRDVPTESSCAVAAIST
                     PEGSPPDEPISPKKPKSVPEPNPRDVEAEATSPRPSEWTSVRISPGEDTVRQDVLAVR
                     VLVTSEDSSSDTESDYGSITAPCAGAYEERPQLPESPPLSKPLTRHISLRENLTQPVS
                     LLHEEPQALPALQRAHSLQSPTPSKYQNWRRRFQSNSTPMNQRAPSPPKEPPPPPSLS
                     SSSSLPSSFSSASVPGHTADDSSSPQVPAYNLHSPQISRGDVSPTPIYLRRARAQGIV
                     KEIPLYLPHSPMLESTEDCLVEPGRESLRSPEEISSSEGCQEARALGNTRSIQHPILG
                     KDQYLPNQNLALGAAGNPGDPREESRMGQPGGPELSKERKLGLKKLVLTEEQKNKLLD
                     WSDCTQEHKTGEQLSQESAENIRGGSLKPTCSSTLSQAVKEKLLSQKKALGGMRTPAV
                     KAPQEREVPPPKSPLKLIANAILRSLLHNSEAGKKTSPKPESKTLPRGQPHARSFSLR
                     KLGSSKDGDQQSPGRHMAKKASAFFSLASPTSKVAQASDLSLPNSILRSRSLPSRPSK
                     MFFSTTPHSKVEDVPTLLEKVSLQDATHSPKTGASHISSLGLKDKSFESFLQECKQRK
                     DIGDFFNSPKEEGPPGNRVPSLEKLVQPVGSTSMGQVAHPSSTGQDAHPVAPVTEATS
                     SPTSSSAEEEADSQLSLRIKEKILRRRRKLEKQSAKQEELKRLHKAQAIQRQLEEVEE
                     RQRTLAIQGVKLEKVLRGEADSGTQDEAQLLQEWFKLVLEKNKLMRYESELLIMAQEL
                     ELEDHQSRLEQKLRQKMLKDEGQKDENDLKEEQEIFEEMMQVIEQRNKLVDSLEEQRV
                     KERTQDQHFENFVLSRGCQLSRT"
     exon            600..807
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            808..924
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1026
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1182
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1283
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1541
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1657
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1784
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1875
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2023
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2223
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2330
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2399
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2543
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2730
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2819
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2922
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3103
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3282
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3357
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3503
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..4785
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            4786..4877
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            4878..4958
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            4959..5052
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            5053..5152
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            5153..5226
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     exon            5227..5528
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5505..5510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /note="hexamer: AATAAA"
     polyA_site      5528
                     /gene="Mical2"
                     /gene_synonym="4921517J23Rik; 5330438E18Rik; 9530064J02;
                     MICAL-2; Micalcl; mKIAA0750"
                     /note="major polyA site"
ORIGIN      
        1 gtgtcccaat cggatcctcc gcggctcaca gaaccgcagg cacccggccg gctcagcctg
       61 cgccgggccg cctcgctagc tccgggctcg gcaggcggcc cgctgggtcc cggatttctg
      121 cgccctcaga cagaggacaa gaaaggcagg tgttgacctg aggcctggag gcccgcgaga
      181 ccttgggtca aggagaagaa atgtggacat agaggctcct gacctcagaa acggaccagg
      241 gggttcctgc ttgcctgcgg tgtgatactt atccagccct ttatgctgac tcccgctgac
      301 ccctccacac cactgctcca cacagctccc gaaccatggg agagaatgaa gatgagaagc
      361 aggcgcaggc cagccaggtc ttcgagaact ttgtgcaagc taccacatgc aaagggaccc
      421 tccaggcctt caacatcctc acctgcctcc tggacctaga tccgctggac cataggaact
      481 tctactccca gctcaagtcc aaggtgaaca cctggaaggc caaagccctg tggcacaaac
      541 tggataagcg cggctcccac aaggagtaca agcgaggaaa agcctgctcg aacactaagt
      601 gtctcatcgt cggaggagga ccatgtggct tgcgcactgc cattgaactt gcctacctgg
      661 gagccaaagt ggttgtggtg gagaagaggg acaccttctc ccggaacaat gtcctgcacc
      721 tctggccctt cactatccat gacctgcggg gcctgggggc caagaagttc tatgggaaat
      781 tctgtgctgg ctccatcgac cacatcagta tccgacaact gcagcttatc ctcttcaagg
      841 tggccctgat gctgggagtg gaggtccacg tgaatgtgga gtttgtgagg gtgctggagc
      901 ctcctgaaga ccaagagaat caaaaagttg gatggcgggc agaattcctt cctgcagacc
      961 acgccctgtc tgactttgag tttgatgtca tcatcggtgc tgacggtcac aggaacacgc
     1021 tagaaggctt caggaggaaa gagttccgag ggaagctggc catcgccatc accgccaact
     1081 tcataaacag gaacagcaca gctgaggcca aggtggagga gatcagtggt gttgccttca
     1141 tcttcaacca gaagttcttc caggacctga aggaagaaac agggattgat ctcgagaaca
     1201 ttgtttacta taaggacagt acccactact ttgtcatgac agccaagaag cagagcctgc
     1261 tggacaaggg cgtcatcctt aatgactaca ttgacacaga gatgctgctg tgttcggaga
     1321 atgtgaacca ggacaacctg ctctcctacg ccagagaagc cgctgacttt gccaccaact
     1381 accagctgcc atccttagac tttgccatca atcacaacgg gcagcctgac gtggccatgt
     1441 tcgacttcac ctccatgtat gcctcagaga acgcagctct gatgcgtgag cgccaggcac
     1501 accagctgct cgtggctctt gtgggcgaca gcctgcttga gccattttgg cccatgggca
     1561 caggctgtgc ccgaggcttc ctggcagcct ttgacacggc atggatggtg aagagctggg
     1621 accagggcac ccctcccctg gaggtattag ctgaaagaga gagtctttac aggctgttac
     1681 ctcagacaac cccagagaac atcaacaaaa attttgagca gtacacattg gacccagcca
     1741 cgcggtaccc aaacctcaac ctgcactgcg tcaggcctca ccaggtgaag catttgtaca
     1801 tcactaagga gatggaccgc ttccctctcg agagatgggg ctcagtgagg agatctgtca
     1861 gcctctccag gcgggagtca gacatccggc ctaacaagct tttaacctgg tgccagcagc
     1921 agaccaaggg ttaccagcac gtcagagtca ctgacctgac cacatcctgg cgcagcggct
     1981 tggccctgtg tgccatcatc cacagcttcc ggccagagct gatcaacttt gactcgctga
     2041 atgaagatga cgctgtggag aacaaccaac tggcatttga tgtggccaag cgtgagtttg
     2101 ggatcctgcc tgtgaccaca ggcaaagaga tggcatctac ccaggagcca gacaagctca
     2161 gcatggtcat gtacctctcc aagttctatg agctcttccg gggcactcca ctgagaccca
     2221 tggattcctg gcgtaaaaac tatggagaaa atgctgactt tggcttgggc aaaacattca
     2281 ttcagaataa ctatctcaac ctcacattgc ccagaaagag gaccccacgg gtagacaccc
     2341 agactgaaga gaatgacatg aacaagaggc ggcgacaagg cttcaaccac ctggaagagc
     2401 tgccatcctt ctccagccgc agcctgggct ccagtcaaga gtatgctaaa gaaagtggca
     2461 gtcagaacaa ggtcaagcac atggccaatc agctgctagc caagtttgag gagaacactc
     2521 ggaacccttc agtcgtgaaa caggaatccc cgagaaaggc attccccctg agcctgggcg
     2581 gcagagacac ctgctacttt tgtaagaagc gtgtatacat gatagagcgg ctgagtgctg
     2641 agggccactt tttccaccaa gagtgcttcc gttgcagcgt ctgcagtgcc accctgcgcc
     2701 tggctgccta tgcctttgac tgcgatgaag gcaaatttta ctgcaagccc cattttgttc
     2761 actgcaaaac cagtagcaaa cagcgaaaga gacgggcaga gctgaatcag caaagagagg
     2821 aggaaggaac atggcaggag caggaagcac ctcggaggga tgtacccaca gaaagctctt
     2881 gtgcagtggc ggccatcagc acgccagaag gcagcccccc agatgagccc atctctccca
     2941 agaagccaaa gagtgtccct gagcccaacc ccagagacgt ggaggctgaa gccacctctc
     3001 ctcggccgtc tgaatggact tcagtgagga tcagccctgg ggaggataca gtcaggcagg
     3061 acgtgctggc tgtacgtgtc ctagtcacca gtgaggacag cagctctgat acagaatccg
     3121 actacggcag catcacagcc ccctgtgcag gggcctatga agaaagacct cagcttccag
     3181 aatccccacc tctatcaaag cccctaaccc ggcacatctc cctacgggag aacctgaccc
     3241 aaccagtctc tctgctacac gaagagccac aagctctgcc tgctctgcag cgggcccata
     3301 gcctccagtc tccaactcca agcaaatacc agaactggag aagaagattc cagtccaatt
     3361 caacacccat gaaccaaaga gcaccatcgc ctccaaagga gccgcctcct cctccatctt
     3421 tgtcttcttc atcttcccta ccatcttcat tttcttcagc cagtgtacct gggcacactg
     3481 cagacgattc ctcctctccc caggtgccag cttacaacct ccactcccca cagatctcca
     3541 gaggcgatgt cagccccact ccaatctacc tcagacgtgc cagggctcaa gggattgtga
     3601 aggaaattcc cctctacctg ccgcatagcc ccatgctaga gagcacagaa gactgcctgg
     3661 tcgagcccgg tagagaaagc ctcagaagtc ctgaggagat ctcctcttca gagggctgcc
     3721 aggaagcccg ggctcttgga aacaccagaa gcatacagca ccccatttta gggaaggacc
     3781 agtatttgcc caatcaaaac ctagctcttg gtgctgcagg gaaccctgga gacccgaggg
     3841 aggaatccag gatgggacaa ccaggtggac cagagctgtc caaagaaagg aagttgggct
     3901 tgaagaaatt agtcctcact gaggagcaga agaacaagtt gctagactgg agtgactgca
     3961 cccaggagca caagactggg gagcagctct ctcaggaaag tgctgagaac atcagaggtg
     4021 gtagcctgaa gccaacctgc tcttctaccc tctctcaggc ggtgaaagag aagctgctat
     4081 cccagaaaaa ggccctgggg gggatgcgta ccccagctgt caaagcacct caggagcgag
     4141 aggtgccccc acccaagtcc cccctgaagc tcatagcaaa tgccatcctt aggtctctgc
     4201 tccacaactc cgaagctgga aagaaaacca gccctaagcc agagtccaaa actttgccta
     4261 ggggccagcc acatgctcgt tcgttcagcc tccggaaact gggttccagt aaagatgggg
     4321 accagcagtc tccagggaga cacatggcca agaaggcttc agcattcttc tctctggctt
     4381 ctccaacatc taaggttgcc caagcctcag accttagcct tcccaactcc atcctccgca
     4441 gccggagttt accgagtcgt ccatccaaga tgttcttttc aaccacacct cacagcaagg
     4501 ttgaagatgt ccccacactc ctggagaaag tgagtttgca ggatgccact cacagtccaa
     4561 agacaggagc ctcacatatt tcttcccttg gcctcaaaga taaatccttt gagagttttc
     4621 tccaggaatg caaacaaaga aaggacattg gggacttctt taatagcccc aaggaggagg
     4681 ggccaccagg gaacagagtc ccatccttgg agaagttggt acagcctgtt ggcagcacct
     4741 ccatgggaca ggtggcacat ccttcttcca cagggcaaga tgcacaccct gtagctccag
     4801 tgacagaagc cacctcttct cccacctcgt cctctgcaga ggaagaagcc gactcccagc
     4861 tttccttaag gataaaggag aagatactca gaagaaggag gaagctggaa aagcagtcag
     4921 ctaagcaaga agaattgaaa agactccata aggctcaggc catccagaga caactagagg
     4981 aggtggagga gcggcagagg acattggcga tccagggcgt gaagctggag aaggtgctga
     5041 gaggagaagc agattcaggg acacaggatg aagcccagct tttgcaggaa tggtttaagc
     5101 tggttctgga gaagaataaa ttaatgcgat atgagtcgga gctactgatc atggcccaag
     5161 aactagaact agaagatcat cagagcagac tggagcagaa actacgacag aaaatgctca
     5221 aggatgaggg ccagaaagac gagaatgacc taaaggagga gcaagaaata ttcgaggaga
     5281 tgatgcaggt gattgagcaa agaaacaagc tcgtggattc cctagaggaa cagcgggtca
     5341 aagaaagaac ccaagaccaa cactttgaaa actttgttct ctccagaggc tgtcagctca
     5401 gcaggacttg aagtgccctt ccccgctgaa gccagagagc caagaacacc acactttccc
     5461 acccaggcac tgaatttaaa gcctactgcc ttaaaaataa taataataaa aaataatgat
     5521 gtctctta
//
