LOCUS       NM_138315               3563 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus microtubule associated monooxygenase, calponin and LIM
            domain containing 1 (Mical1), transcript variant 1, mRNA.
ACCESSION   NM_138315
VERSION     NM_138315.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3563)
  AUTHORS   Micovic,K., Canuel,A., Remtulla,A., Chuyen,A., Byrsan,M.,
            McGarry,D.J. and Olson,M.F.
  TITLE     Mical1 deletion in tyrosinase expressing cells affects mouse
            running gaits
  JOURNAL   Genes Brain Behav 23 (5), e70004 (2024)
   PUBMED   39344934
  REMARK    GeneRIF: Mical1 deletion in tyrosinase expressing cells affects
            mouse running gaits.
REFERENCE   2  (bases 1 to 3563)
  AUTHORS   Xu,C., Mao,L., Tian,H., Lin,S., Zhao,X., Lin,J., Li,D., Li,X. and
            Mei,X.
  TITLE     MICAL1 (molecule interacting with CasL 1) protects oligodendrocyte
            cells from oxidative injury through regulating apoptosis, autophagy
            in spinal cord injury
  JOURNAL   Neurosci Lett 750, 135712 (2021)
   PUBMED   33647394
  REMARK    GeneRIF: MICAL1 (molecule interacting with CasL 1) protects
            oligodendrocyte cells from oxidative injury through regulating
            apoptosis, autophagy in spinal cord injury.
REFERENCE   3  (bases 1 to 3563)
  AUTHORS   Niu,F., Sun,K., Wei,W., Yu,C. and Wei,Z.
  TITLE     F-actin disassembly factor MICAL1 binding to Myosin Va mediates
            cargo unloading during cytokinesis
  JOURNAL   Sci Adv 6 (45) (2020)
   PUBMED   33158857
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3563)
  AUTHORS   Konstantinidis,K., Bezzerides,V.J., Lai,L., Isbell,H.M., Wei,A.C.,
            Wu,Y., Viswanathan,M.C., Blum,I.D., Granger,J.M., Heims-Waldron,D.,
            Zhang,D., Luczak,E.D., Murphy,K.R., Lu,F., Gratz,D.H., Manta,B.,
            Wang,Q., Wang,Q., Kolodkin,A.L., Gladyshev,V.N., Hund,T.J.,
            Pu,W.T., Wu,M.N., Cammarato,A., Bianchet,M.A., Shea,M.A.,
            Levine,R.L. and Anderson,M.E.
  TITLE     MICAL1 constrains cardiac stress responses and protects against
            disease by oxidizing CaMKII
  JOURNAL   J Clin Invest 130 (9), 4663-4678 (2020)
   PUBMED   32749237
  REMARK    GeneRIF: MICAL1 constrains cardiac stress responses and protects
            against disease by oxidizing CaMKII.
REFERENCE   5  (bases 1 to 3563)
  AUTHORS   Alqassim,S.S., Urquiza,M., Borgnia,E., Nagib,M., Amzel,L.M. and
            Bianchet,M.A.
  TITLE     Modulation of MICAL Monooxygenase Activity by its Calponin Homology
            Domain: Structural and Mechanistic Insights
  JOURNAL   Sci Rep 6, 22176 (2016)
   PUBMED   26935886
  REMARK    GeneRIF: esults suggest that the CH domain, which is loosely
            connected to the MO domain by a flexible linker and is far away
            from the catalytic site, couples F-actin to the enhancement of
            redox activity of MICALMO-CH by a cooperative mechanism involving a
            trans interaction between adjacently bound molecules.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3563)
  AUTHORS   Zhou,Y., Adolfs,Y., Pijnappel,W.W., Fuller,S.J., Van der
            Schors,R.C., Li,K.W., Sugden,P.H., Smit,A.B., Hergovich,A. and
            Pasterkamp,R.J.
  TITLE     MICAL-1 is a negative regulator of MST-NDR kinase signaling and
            apoptosis
  JOURNAL   Mol Cell Biol 31 (17), 3603-3615 (2011)
   PUBMED   21730291
  REMARK    GeneRIF: Findings show a biological role for MICAL-1 in apoptosis
            and define a novel negative regulatory mechanism of MST-NDR
            signaling.
REFERENCE   7  (bases 1 to 3563)
  AUTHORS   Morinaka,A., Yamada,M., Itofusa,R., Funato,Y., Yoshimura,Y.,
            Nakamura,F., Yoshimura,T., Kaibuchi,K., Goshima,Y., Hoshino,M.,
            Kamiguchi,H. and Miki,H.
  TITLE     Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2
            and growth cone collapse
  JOURNAL   Sci Signal 4 (170), ra26 (2011)
   PUBMED   21521879
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3563)
  AUTHORS   Yamamura,R., Nishimura,N., Nakatsuji,H., Arase,S. and Sasaki,T.
  TITLE     The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates
            the assembly of tight junctions and adherens junctions
  JOURNAL   Mol Biol Cell 19 (3), 971-983 (2008)
   PUBMED   18094055
REFERENCE   9  (bases 1 to 3563)
  AUTHORS   Nadella,M., Bianchet,M.A., Gabelli,S.B., Barrila,J. and Amzel,L.M.
  TITLE     Structure and activity of the axon guidance protein MICAL
  JOURNAL   Proc Natl Acad Sci U S A 102 (46), 16830-16835 (2005)
   PUBMED   16275926
REFERENCE   10 (bases 1 to 3563)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK171411.1, AK171429.1 and AC153360.6.
            
            On Aug 26, 2009 this sequence version replaced NM_138315.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034682.1, AK170881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2454              AK171411.1         2-2455
            2455-3511           AK171429.1         2434-3490
            3512-3563           AC153360.6         211462-211513
FEATURES             Location/Qualifiers
     source          1..3563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.41 cM"
     gene            1..3563
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /note="microtubule associated monooxygenase, calponin and
                     LIM domain containing 1"
                     /db_xref="GeneID:171580"
                     /db_xref="MGI:MGI:2385847"
     exon            1..227
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            228..532
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            533..740
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            741..845
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            846..950
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1106
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1207
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1465
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1581
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1708
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1790
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1935
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2126
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2212
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2302
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2459
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2536
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2807
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2908
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3022
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3116
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3216
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3290
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3563
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3541..3546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /note="hexamer: AATAAA"
     polyA_site      3563
                     /gene="Mical1"
                     /gene_synonym="MICAL; MICAL-1; Nical"
                     /note="major polyA site"
ORIGIN      
        1 aggcgtgggc gggacccagg ctgtccccag aggaggactg cggagtacgg aggttcggag
       61 taagtcttcc tctgtgctct gcgctggcgc tgcggtccaa actctttgga actccccggt
      121 ttctgccacc aggcatctct tgctttccct gcgccacccc ttcctctgcc cctaggcctg
      181 ggacaccctt ccgacaggaa gcggctcttc cagccccaga aacgctgaca ctgggttttc
      241 tcccagctgc tcctgctgtc aacaggggcc ctacatggca tcacccgcct ccaccaaccc
      301 agcacatgac cactttgaga cctttgtgca ggcacagctg tgccaggatg tactgagtag
      361 ctttcagggg ctctgtagag ccctgggagt ggagtctggt gggggattgt cccagtacca
      421 caagatcaag gcccagctca actactggag tgccaagtca ctgtgggcca agttggacaa
      481 gagagcgagc cagcctgtgt accagcaagg ccaggcctgt accaacacca agtgtctcgt
      541 ggtaggtgcc gggccttgcg gacttcgggc tgctgtggag ttggcactgt taggtgcccg
      601 agtggtactt gtggaaaagc gtatcaagtt ctctaggcac aatgtgctcc atctctggcc
      661 cttcaccatc catgaccttc gggcacttgg ggccaagaag ttctacgggc gcttctgtac
      721 tggcaccctg gaccatatca gcatccgaca gcttcagctg cttctactga aggtggcctt
      781 actgttgggg gtggagattc actggggcgt caaattcact ggcctccagc cccctcccag
      841 aaaagggagt ggctggcgtg ctcagctcca gcccaacccc ccagcccaac tggccagcta
      901 tgagtttgat gtcctcatct cagctgcagg aggcaaattt gtccctgaag gcttcactat
      961 acgagagatg cgtggcaaac tggccattgg catcacagcc aactttgtga atgggcgcac
     1021 ggtggaggag acacaggtgc cggagatcag tggtgtagct cgaatctaca accaaaaatt
     1081 cttccagagc ctgctcaaag ccacaggtat tgatctggag aacattgtat actacaaaga
     1141 cgagacccac tactttgtga tgacagccaa gaagcagtgc ctgctgaggc tgggggtgct
     1201 gcgccaggac ttgtcagaga ctgatcagct gctgggcaaa gctaatgtgg taccggaggc
     1261 tctgcagcgc tttgccagag cagcggctga cttcgccaca catggcaagc ttgggaaact
     1321 ggagtttgct caggatgcac gcgggcggcc tgatgtggcg gccttcgact tcacaagcat
     1381 gatgcgggca gagagttccg ctcgtgtcca agaaaagcat ggtgctcgcc tactgctggg
     1441 gctggtgggg gactgcctag tggagccctt ctggcctctg ggcactggag tagcccgagg
     1501 cttcttggca gccttcgatg cagcctggat ggtgaagcgg tgggcagagg gcgctgggcc
     1561 gctagaggtg ttggctgaac gcgagagctt gtaccagctt ctgtcacaaa catcccccga
     1621 gaatatgcat cgaaatgtag cccagtatgg gttggaccct gccacccgat accccaacct
     1681 gaacctccgg gctgtaaccc ccaatcaggt acaggacctc tatgatatga tggacaagga
     1741 gcatgctcag aggaagagtg acgagccgga ttccaggaag acaaccacag ggtccgcagg
     1801 cacggaggag cttctgcact ggtgccagga gcagacagct ggctttcctg gagtccatgt
     1861 cactgacttt tcttcctcgt gggctgatgg gctagctctg tgtgccctgg tacaccacct
     1921 acagcctggc ctgctggaac cctcggagct gcagggcatg ggagctctag aagccactac
     1981 ctgggcactg agggtggcag aacatgagct aggcatcaca ccagtgttgt ctgcacaggc
     2041 agtcatggct ggcagtgacc cactgggtct cattgcctac ctcagccact tccacagtgc
     2101 cttcaagaac acgagccaca gctcaggcct tgtcagccag ccctctggaa cccccagtgc
     2161 tatacttttc cttggcaaac tccagaggag cctacaacgg acccgcgcca aggtagacga
     2221 ggagactccg agcactgagg agccgcctgt ctccgagccc agtatgtctc caaacactcc
     2281 agagctctct gaacaccagg aggctggggc agaggagctg tgtgaactct gtgggaaaca
     2341 tctgtacatc ctagaacgct tctgtgtgga tggccatttc tttcaccgga gctgcttctg
     2401 ctgccatacc tgtgaggcca cattgtggcc aggtggctat gggcaacatc caggagatgg
     2461 acatttctac tgtctccagc acctacccca ggaggaccaa aaggaggctg acaacaatgg
     2521 aagtctggag agccaggagc tcccaacacc aggagacagc aacatgcagc cagacccctc
     2581 ctctcctcct gtgacgaggg tcagccctgt cccaagcccc agccagcctg cacgtcggct
     2641 gatccggctc tccagtttag aacgcctacg gctgtcctcc ctgaatatca tccctgactc
     2701 aggagcggag cctcctccca aacccccaag gagctgctca gacttggccc gagaatccct
     2761 gaagagcagc tttgtgggct ggggtgtgcc agtccaagca ccacaagttc ctgaagccat
     2821 agagaaaggg gatgatgagg aggaggaaga ggaagaagag gaggaggagg aggagccact
     2881 gccacctttg gagccagagt tggagcagac tctgctgacc ttggccaaga acccaggtgc
     2941 catgactaag tacccaacgt ggcgtcgaac cctcatgcgc cgtgccaaag aggaggagat
     3001 gaagaggttt tgcaaggccc aggccatcca gcgaagactg aacgagattg aggccactat
     3061 gcgggagctg gaggccgaag gcacgaagct ggagctggcc ttgaggaaag agagtagctc
     3121 tccagaacag cagaagaaac tctggctgga tcagctgcta cggctcattc agaagaagaa
     3181 cagcctagtg actgaagagg ccgagctcat gatcacggtg caggagctgg atctggaaga
     3241 gaagcagcgg cagctagacc acgagttgcg gggctacatg aatcgggaag aaactatgaa
     3301 gacagaggcc gacctgcagt ctgagaacca ggtcctaagg aagctgttgg aggtggtgaa
     3361 ccagcgggat gctctgatcc aattccagga ggaacggagg ctcagagaga tgcctgcata
     3421 gatgggagcc cagggctaga agatgatggt tagctgcctc cctgccccgt aagcaagaca
     3481 ccatcacaag ggctgtacct ccgccatctg gactgcttag tcagaggctt cgttgtttac
     3541 aataaaagga ttatgaccat gaa
//
