LOCUS       NM_001369164            3985 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus mindbomb E3 ubiquitin protein ligase 2 (Mib2),
            transcript variant 7, mRNA.
ACCESSION   NM_001369164 XM_006539252
VERSION     NM_001369164.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3985)
  AUTHORS   Jin,Y., Sun,G., Li,J., Cheng,Q., Sun,H., Han,L., Guo,X., Zhu,S. and
            Wang,Q.
  TITLE     MIB2 Functions in Oocyte Meiosis by Modulating Chromatin
            Configuration
  JOURNAL   Mol Cell Proteomics 23 (8), 100813 (2024)
   PUBMED   39019259
  REMARK    GeneRIF: MIB2 Functions in Oocyte Meiosis by Modulating Chromatin
            Configuration.
REFERENCE   2  (bases 1 to 3985)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3985)
  AUTHORS   Li,R., Shao,J., Jin,Y.J., Kawase,H., Ong,Y.T., Troidl,K., Quan,Q.,
            Wang,L., Bonnavion,R., Wietelmann,A., Helmbacher,F., Potente,M.,
            Graumann,J., Wettschureck,N. and Offermanns,S.
  TITLE     Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ
            protein degradation via E3 ligase MIB2
  JOURNAL   Nat Commun 14 (1), 1980 (2023)
   PUBMED   37031213
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3985)
  AUTHORS   Yu,X., Li,W., Liu,H., Wang,X., Coarfa,C., Cheng,C., Yu,X., Zeng,Z.,
            Cao,Y., Young,K.H. and Li,Y.
  TITLE     PD-L1 translocation to the plasma membrane enables tumor immune
            evasion through MIB2 ubiquitination
  JOURNAL   J Clin Invest 133 (3), e160456 (2023)
   PUBMED   36719382
  REMARK    GeneRIF: PD-L1 translocation to the plasma membrane enables tumor
            immune evasion through MIB2 ubiquitination.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3985)
  AUTHORS   Chen,L.J., Zhang,N.N., Zhou,C.X., Yang,Z.X., Li,Y.R., Zhang,T.,
            Li,C.R., Wang,X., Wang,Y., Wang,Z.B., Xia,Z.R., Wang,Z.B.,
            Zhang,C.L., Guan,Y.C., Sun,Q.Y. and Zhang,D.
  TITLE     Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility
            through AKT activation
  JOURNAL   Cell Death Differ 29 (2), 366-380 (2022)
   PUBMED   34635817
REFERENCE   6  (bases 1 to 3985)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 3985)
  AUTHORS   Koo,B.K., Yoon,M.J., Yoon,K.J., Im,S.K., Kim,Y.Y., Kim,C.H.,
            Suh,P.G., Jan,Y.N. and Kong,Y.Y.
  TITLE     An obligatory role of mind bomb-1 in notch signaling of mammalian
            development
  JOURNAL   PLoS One 2 (11), e1221 (2007)
   PUBMED   18043734
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3985)
  AUTHORS   Wu,J.I., Rajendra,R., Barsi,J.C., Durfee,L., Benito,E., Gao,G.,
            Kuruvilla,M., Hrdlickova,R., Liss,A.S. and Artzt,K.
  TITLE     Targeted disruption of Mib2 causes exencephaly with a variable
            penetrance
  JOURNAL   Genesis 45 (11), 722-727 (2007)
   PUBMED   17987667
  REMARK    GeneRIF: created a targeted mutation of Mib2 and show that its
            phenotype is a variable penetrance, failure to close the cranial
            neural tube
REFERENCE   9  (bases 1 to 3985)
  AUTHORS   Koo,B.K., Yoon,K.J., Yoo,K.W., Lim,H.S., Song,R., So,J.H., Kim,C.H.
            and Kong,Y.Y.
  TITLE     Mind bomb-2 is an E3 ligase for Notch ligand
  JOURNAL   J Biol Chem 280 (23), 22335-22342 (2005)
   PUBMED   15824097
  REMARK    GeneRIF: Mib2 has functional similarities to Mib1, but might have
            distinct roles in Notch signaling as an E3 ubiquitin ligase
REFERENCE   10 (bases 1 to 3985)
  AUTHORS   Takeuchi,T., Heng,H.H., Ye,C.J., Liang,S.B., Iwata,J., Sonobe,H.
            and Ohtsuki,Y.
  TITLE     Down-regulation of a novel actin-binding molecule, skeletrophin, in
            malignant melanoma
  JOURNAL   Am J Pathol 163 (4), 1395-1404 (2003)
   PUBMED   14507647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627405.17.
            
            On Mar 21, 2019 this sequence version replaced XM_006539252.2.
            
            Transcript Variant: This variant (7), as well as variant 8, encodes
            the longest isoform (3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.892735.1,
                                           SRR13422598.1303149.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-646               AL627405.17        167011-167656       c
            647-802             AL627405.17        165451-165606       c
            803-1071            AL627405.17        159543-159811       c
            1072-1243           AL627405.17        159287-159458       c
            1244-1350           AL627405.17        158115-158221       c
            1351-1545           AL627405.17        157825-158019       c
            1546-1688           AL627405.17        157560-157702       c
            1689-1796           AL627405.17        157331-157438       c
            1797-1901           AL627405.17        156292-156396       c
            1902-2064           AL627405.17        156035-156197       c
            2065-2198           AL627405.17        155826-155959       c
            2199-2347           AL627405.17        155603-155751       c
            2348-2504           AL627405.17        155350-155506       c
            2505-2665           AL627405.17        155083-155243       c
            2666-2792           AL627405.17        154831-154957       c
            2793-3026           AL627405.17        154509-154742       c
            3027-3205           AL627405.17        153959-154137       c
            3206-3393           AL627405.17        153689-153876       c
            3394-3459           AL627405.17        153542-153607       c
            3460-3985           AL627405.17        152905-153430       c
FEATURES             Location/Qualifiers
     source          1..3985
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.86 cM"
     gene            1..3985
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /note="mindbomb E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:76580"
                     /db_xref="MGI:MGI:2679684"
     exon            1..646
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..802
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1071
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     CDS             825..3698
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 7; zinc
                     finger, ZZ type with ankyrin repeat domain 1; E3
                     ubiquitin-protein ligase MIB2; skeletrophin; dyslike; mind
                     bomb-2; dystrophin-like protein; mindbomb homolog 2;
                     RING-type E3 ubiquitin transferase MIB2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MIB2 isoform 3"
                     /protein_id="NP_001356093.1"
                     /db_xref="GeneID:76580"
                     /db_xref="MGI:MGI:2679684"
                     /translation="MDLDPHAGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGS
                     PSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGIRHPNIICDCCKKHGLRGM
                     RWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRPVTLSPRQGLPRIPLRGIFQG
                     AKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGK
                     VDLRCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCLLDTDVLRDMQ
                     EGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQFNHETRWTFHPGALTKHNSFWVGDVV
                     RVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVGGQRWTFSPSCL
                     VAYRPEEDANLDVAERARENKSSLSVALDKLRTQKSDPEHPGRLVVEAALGNVARALD
                     LLRRHPEQVDTKNQGRTALQVAAYLGQVELVRLLLQARASMDLPDDEGNTVLHYTAMG
                     NQPEATRVLLSAGCAVDARNGTRSTALHVAVQRGFLEVVKILCERGCDVNLPDAHADT
                     PLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVRKILARAR
                     QLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLG
                     LVPLLVDAGCSVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQLLSRLQASGL
                     PGCTELTVGAAVACFLALEGADVSYANHRGRSPLDLATEGRVLKALQGCAQRFRERQA
                     GGGGGVPPGPRHVLSTPNTVTNLHVSGTAGPEAAECLVCSELALLILFSPCQHRTVCE
                     ECARRMKKCIRCQVVISKKLRPDGSEVVNAIQVPGPPRQLVEELQSRYRQMEERITCP
                     ICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIFV"
     exon            1072..1243
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1350
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1545
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1688
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1796
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1901
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2064
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2198
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2347
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2504
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2665
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2792
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..3026
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3205
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3393
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3459
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3985
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3754..3759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /note="hexamer: TATAAA"
     polyA_site      3771
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
                     /note="major polyA site"
     polyA_site      3983
                     /gene="Mib2"
                     /gene_synonym="2210008I11Rik; skd; Zzank1"
ORIGIN      
        1 aaactacagc tcccggcaat ctgtgcggcg ccccgcgact gtagtcgggg agccgtggtg
       61 gggctccctg gtgggctagc gcaagagagg cggccttgct aaacactgtt agggggcgga
      121 ggacggcggg ctgcagctgg cgtctcggtg gcgagccgag gctccactgt cagcctctgc
      181 gctgctcagg ggcgggtatt cctgggccga acgagcgcgg aaactcttgg caagtggggg
      241 gccgggccgg gcgtcctccc agcgacgggg gcggtggcac ggggcctagg ggtcctgatc
      301 gtcctgacgg ggctgcggtt ttgttggctg acctcggccc ttcagcgcga cgggcttttg
      361 gtgcttctcc ccctggaccc agctcgtgcc cgttgcgcgt tctcggtgcg tgggggtgat
      421 gcagcgtgtc ccagccacca gacccatggg agctttttaa ggcgaccagc ggcctctgtc
      481 ccttctcaga tgttaactgc gtctcagcac ccctggccat aggtttggat ctcctggggc
      541 tttcagagag gaaggtcagc acggcggagg ccagtcccaa gtctccaagc atcagggctc
      601 ctgcccgatt ctcaaggcgg gtgggggaca ctggacctcc agacagcctg gctccctgac
      661 ttcctgtttg gtttgctgta ttctgtgttg gcaatggctg ctagtttctc acaggaagtt
      721 ttggtggctg agccaatttg tggcccagga agtagcaact aaatgcctgg gatgttgact
      781 aaaggcttct ttgtgtccta aggtctttga acaaccccct caccatggac ctggaccccc
      841 atgcaggtgt gcaggtgggc atgcgtgtgg tacgcggaat ggactggaaa tggggccagc
      901 aggatggagg tgagggcggt gtgggcaccg tggtggagct tggccgccat ggcagcccct
      961 cgacccccga ccgtacagtt gtcgttcagt gggaccaggg cacacgtacc aactatcgag
     1021 ctggctacca aggtgcccat gacctgttgc tctatgacaa cgcccaaatc ggtatccgcc
     1081 accccaatat catctgtgac tgctgcaaga aacatgggct tcggggcatg cgttggaagt
     1141 gccgcgtctg ctttgactat gacctctgca cacagtgcta catgcacaac aagcatgacc
     1201 tgacccatgc cttcgagcgc tatgagacat ctcactcacg cccggttacg ctgagccccc
     1261 gacagggcct ccctcggatc ccactgaggg gcatctttca aggagctaag gtggtacgag
     1321 gccctgactg ggaatggggc tcacaagatg gaggggaagg caagacaggt cgtgtggtgg
     1381 acatccgtgg ctgggatgtg gagacaggcc gaagtgtggc cagtgtgacg tgggcagatg
     1441 gaaccacgaa cgtgtaccga gtgggccaca agggcaaggt ggatctcaga tgtgttggtg
     1501 aggcagctgg cggcttttac tacaaggagc acctcccaaa gcttggcaag ccagcagagc
     1561 tgcagcgcag ggtgagtgct gatggccagc ccttccagcg tggggacaag gtcaagtgtc
     1621 tgctggacac agatgtccta agggatatgc aagaaggcca tggtggctgg aaccctagga
     1681 tggcagagtt tatcggacag atgggcaccg tgcaccgcat cacagaccgt ggggacgtgc
     1741 gtgtgcagtt caaccacgag acccgctgga ccttccaccc tggggctctc accaagcaca
     1801 acagcttctg ggtgggtgat gtggtccggg tcatcggtga ccttgacact gtgaagcgac
     1861 ttcaggccgg acatggtgaa tggaccgacg acatggctcc cgccctgggc cgagtgggga
     1921 aagtggtgaa ggtgtttgga gatggaaact tgcgtgtggc ggttggcggt cagcggtgga
     1981 ccttcagccc ctcttgccta gtggcctacc ggcctgagga agacgccaac ctggatgtgg
     2041 ctgagcgtgc cagagagaac aaaagctcac tgagtgtggc cctggacaag cttcggaccc
     2101 agaagagtga cccagagcac ccggggaggc tggtagtaga ggccgcacta ggaaatgtag
     2161 cccgggctct agatcttctg cggaggcatc cagagcaggt ggacaccaag aaccagggta
     2221 gaactgccct gcaggtggct gcttacctgg gccaggtaga gctggtgcgg ctgctgctgc
     2281 aggcaagagc aagtatggac ctgccggatg atgagggcaa cactgtgctg cactacacag
     2341 ccatggggaa ccagcctgag gccacaaggg tgctcctgag tgcagggtgt gcagtggatg
     2401 ctcggaatgg cacacgcagc acagccctac atgtggctgt acagaggggc ttcctagagg
     2461 tggtaaagat cctgtgtgaa cgtggttgtg atgtcaactt gccggatgcg catgcagaca
     2521 cacccctgca ttctgccatc tctgctggtg ctggtgccag cagcattgtt gaagtcctca
     2581 ccgaggtccc tggcatcgat gtcactgcta ccaatagcca gggcttcaca ctgctacacc
     2641 atgcatccct caagggccat gtgctagcag tcaggaagat tctggcaagg gcccggcagc
     2701 tggtggatgc caagaaggag gatggcttta ccgcactgca tctggcagcc ctcaacaacc
     2761 accgggaggt ggcccaggtc ctaatccgag agggtcgctg tgatgtgaat gtgcggaacc
     2821 ggaagcttca gtctccactt catctggctg tacagcaggc ccacctgggg ctggtaccgc
     2881 tgctagtgga cgcaggctgc agtgtcaaca cggaggacga ggagggtgac acggccctgc
     2941 atgtggcact acagcgtcac cagctgttgc cccttgtggc tgacagggct gggggagacc
     3001 cagggccctt gcagctgctg tcaaggctac aggcctcagg cctcccaggc tgcacagagt
     3061 tgactgtagg cgctgcagtg gcctgcttcc tggcgttgga gggtgctgat gtgagctacg
     3121 caaaccaccg cggccggagc ccactggacc tggccacaga gggccgagtg ctcaaggcct
     3181 tgcagggctg tgcccagcgc ttcagggagc gacaggcagg tggcggtggg ggtgtgcccc
     3241 cgggcccccg gcatgtgctg agtactccta acaccgtgac gaacctgcac gtgtctggca
     3301 cggcagggcc agaagctgcc gagtgcctgg tgtgctcgga gctggcattg ctaattctgt
     3361 tctcaccgtg tcagcaccgc acagtgtgtg aggagtgcgc tcgaaggatg aagaagtgta
     3421 tcaggtgcca ggtggtcatc agcaagaagc tccgcccaga cggctcagag gtggtaaatg
     3481 ccatccaggt gcccggcccg cctcggcaac tggtggagga gctacagagc cgctacaggc
     3541 agatggagga gcgcatcacc tgccccatct gcatcgacag ccacatccgc ctggtgttcc
     3601 agtgcggcca tggagcgtgc gcgccctgtg gcgccgcgct taacgcctgc cccatctgcc
     3661 gccagcccat ccgcgaccgc attcagatct tcgtgtgagc gcactccaca cgccgtggct
     3721 gatcgcagac cttccttcaa aacccctgta ttttataaaa agattatcgg actttgcttc
     3781 ctgttccttg cctaagggtg ttgggcaggc cccagagatc ctcaccgccc ctcccccgct
     3841 gcccaggccc caccccacgc cccgcccggc atcaggctcc agactgcctg gagatcagga
     3901 acgctctgga tgaggatgca gcccgccaaa agtgcgcgct ggctttggtt tgacacaaga
     3961 tggtccgtcc ggaaactcca aaagg
//
