LOCUS       NM_177389               6933 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus MIA SH3 domain ER export factor 3 (Mia3), mRNA.
ACCESSION   NM_177389 XM_001005685
VERSION     NM_177389.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6933)
  AUTHORS   Lei,Y., Xu,J., Li,M., Meng,T., Chen,M., Yang,Y., Li,H., Zhuang,T.
            and Zuo,J.
  TITLE     MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal
            Formation by Restoring BAT-Like PVAT and Decreasing VSMC
            Proliferation and Migration
  JOURNAL   Front Endocrinol (Lausanne) 12, 748216 (2021)
   PUBMED   34858331
  REMARK    GeneRIF: MIA SH3 Domain ER Export Factor 3 Deficiency Prevents
            Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC
            Proliferation and Migration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6933)
  AUTHORS   Wilson,D.G., Phamluong,K., Li,L., Sun,M., Cao,T.C., Liu,P.S.,
            Modrusan,Z., Sandoval,W.N., Rangell,L., Carano,R.A., Peterson,A.S.
            and Solloway,M.J.
  TITLE     Global defects in collagen secretion in a Mia3/TANGO1 knockout
            mouse
  JOURNAL   J Cell Biol 193 (5), 935-951 (2011)
   PUBMED   21606205
  REMARK    GeneRIF: Mia3's role in protein secretion is much broader than
            previously realized, and it may, in fact, be required for the
            efficient secretion of all collagen molecules in higher organisms
            Erratum:[J Cell Biol. 2011 Jul 25;194(2):347]
REFERENCE   3  (bases 1 to 6933)
  AUTHORS   Bosserhoff,A.K., Moser,M. and Buettner,R.
  TITLE     Characterization and expression pattern of the novel MIA homolog
            TANGO
  JOURNAL   Gene Expr Patterns 4 (4), 473-479 (2004)
   PUBMED   15183315
  REMARK    GeneRIF: revealed very broad TANGO expression patterns in contrast
            to the highly restricted expression patterns previously determined
            for the other members of the MIA gene family
REFERENCE   4  (bases 1 to 6933)
  AUTHORS   Moser,M., Bosserhoff,A.K., Hunziker,E.B., Sandell,L., Fassler,R.
            and Buettner,R.
  TITLE     Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient
            mice
  JOURNAL   Mol Cell Biol 22 (5), 1438-1445 (2002)
   PUBMED   11839810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AEKQ02108037.1, AEKQ02108038.1 and CAAA01083531.1.
            
            On Jul 30, 2020 this sequence version replaced NM_177389.3.
            
            Sequence Note: This RefSeq record was created from transcript data
            from C57BL/6J and C576J/6NCrl because no single transcript from the
            same strain was available for the full length of the gene. The
            extent of this transcript is supported by transcript alignments and
            orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.1389.1,
                                           SRR10223969.1301.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AEKQ02108037.1     7091-7259
            170-303             AEKQ02108037.1     10876-11009
            304-390             AEKQ02108037.1     14522-14608
            391-3145            AEKQ02108037.1     17638-20392
            3146-3451           AEKQ02108037.1     22514-22819
            3452-3594           AEKQ02108037.1     25448-25590
            3595-3726           AEKQ02108037.1     32191-32322
            3727-3748           AEKQ02108038.1     2336-2357
            3749-3837           AEKQ02108038.1     3062-3150
            3838-3915           AEKQ02108038.1     3383-3460
            3916-4026           AEKQ02108038.1     3554-3664
            4027-4098           AEKQ02108038.1     5198-5269
            4099-4203           AEKQ02108038.1     5692-5796
            4204-4326           AEKQ02108038.1     6563-6685
            4327-4438           AEKQ02108038.1     6764-6875
            4439-4494           AEKQ02108038.1     7678-7733
            4495-4585           AEKQ02108038.1     7822-7912
            4586-4724           AEKQ02108038.1     8068-8206
            4725-4826           AEKQ02108038.1     9389-9490
            4827-4887           AEKQ02108038.1     10622-10682
            4888-4923           AEKQ02108038.1     10804-10839
            4924-4991           AEKQ02108038.1     10944-11011
            4992-5092           AEKQ02108038.1     11123-11223
            5093-5230           AEKQ02108038.1     11381-11518
            5231-5299           AEKQ02108038.1     12324-12392
            5300-5373           AEKQ02108038.1     12496-12569
            5374-5515           AEKQ02108038.1     13970-14111
            5516-6190           AEKQ02108038.1     14662-15336
            6191-6933           CAAA01083531.1     5737-6479           c
FEATURES             Location/Qualifiers
     source          1..6933
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..6933
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /note="MIA SH3 domain ER export factor 3"
                     /db_xref="GeneID:338366"
                     /db_xref="MGI:MGI:2443183"
     exon            1..169
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..5829
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /note="melanoma inhibitory activity protein 3; transport
                     and Golgi organization protein 1 homolog; melanoma
                     inhibitory activity 3"
                     /codon_start=1
                     /product="transport and Golgi organization protein 1
                     homolog precursor"
                     /protein_id="NP_796363.3"
                     /db_xref="GeneID:338366"
                     /db_xref="MGI:MGI:2443183"
                     /translation="MAAAPGLLFWLFVLGALWWVPGQSDLSHGRRFSDLKVCGDEECS
                     MLMYRGKALEDFTGPDCRFVNFKKGDDVYVYYKLAGGSLELWAGSVEHSFGYFPKDLI
                     KVLHKYTEEELHIPADETDFVCFEGGRDDFNSYNVEELLGSLELEDSVPEESKKAEEV
                     SQHREKSPEESRGRELDPVPEPEAFRADSEDGEGAFSESTEGLQGQPSAQESHPHTSG
                     PAANAQGVQSSLDTFEEILHDKLKVPGSESRTGNSSPASVEREKTDAYKVLKTEMSLD
                     LKTKFGSTADALVSDDEATRLVTSLEDGFDEALDAEYYPMEEEEEVEEDADSSDELPL
                     LTFSDKDEKVPGKPMIEKYLTDKDPNLSEEDKVEPPTWGDAFFSIVTGGEGKPGVVDL
                     ERSIEEEEDVSVSSSHQRKPQPAAGYTDSEDEGDDLFVEEPKTNDVKDSETDPELVIT
                     GEEKDIQESRKGLVQPESQSEDAKSETASAYRLQGSKLNPLSAAEKGRDFTLKAVFEK
                     KENGLKESVIHISKETLHEDKTREIQRDSLESELVHRALGSSVTENNKPKSLGVAPLL
                     GNNKPDASKDSTEVPDGSVSGPKAGQQEGFLEPGLKTQHQPRFSPPEETGPSRELGGK
                     VPISGRNLSWQQEQDVAAVVGKHANEKTGFPEEESREDGTDAEQARAIRRPQEAESPE
                     VLSVQPGRPDEEEEEEEGDNYPPEGLMEDENAVSAQQSRENSPSARDGRSDMNSQVFE
                     KVILGTLNLNTEKTKQPANMILETGQESETTSEEAGDVGKESGHSVVVDSEESHLADM
                     RAQRPSQVHGLRDETAAQTPGSGEAVLSKNPNDLQKDNPEEELVNTLGLEDPGVGEIS
                     EGEPEDTKEFGVSESQGTDAEDLRDDPSRQATPEIPDIVLKSIREDLPIINSFFKDDQ
                     QSLHRFLKYFDVRELEGLLEDMSIRLRSAHQNSLPYNMEKVLDKVFRASESRILSMAE
                     KMLDTGVAKNRDLGSKESSPLEEAEVLDDIQDLIYFVRYQYSGVETAPLVTPPPPEEG
                     WARPGEERQPPQQDSLPQENTGDLSVQPPEEPELSDQPVTSVQPPEEPELSDQPVTSV
                     QPPEEPELSDQPVTSVQPPEEPELSDQPVTGYTSTSEVSQKPDTKKDIDLGPVMEGGP
                     VGAGDVQKQLETIAEEPAAVPPLESAFGSLYAFILYLSKMLLATLPDNVQPGPDFYGL
                     PWQPVIITAVLGIVSFAIFSWRTILVVKSRVYQVTEKQISEKLENIKKENAELMQKLS
                     SYEQKIKESKKYVQETKKQNMILSDEAVKYKDKIKILEETNVSLGDKAKSLRLQLESE
                     REQNVKNQDLILENKKSIEKLKDVISMNASELSEVQVALNEAKLSEENVKSECHRVQE
                     ENARLKKKKEQLQQQVEEWSKSHAELTEQIKSFEKSQEDLEIALTHKDDNISALTNCI
                     TQLNRLECELESEDPDKGGNESDDLANGETGGDRSEKIRNRIKQMMDVSRTQTAVSIV
                     EEDLKLLQLKLRASMSTKCNLEDQIKKLEDDRSSLQTAKAGLEDECKTLRQKVEILNE
                     LYQQKEMALQKKLSQEEYERQDREQRLTAADEKVVLAAEEVKTYKRRIEEMEEELQKT
                     ERSFKNQIAAHEKKAHDNWLKARAAERAMAEEKREAANLRHKLLEMTQKMAMRQDEPV
                     IVKPMPGRPNTQNPPRRGLLSQNGSFGPSPVSGGECSPPLPAEPPGRPLSATLSRRDT
                     PRSEFGSLDRHLPRPRWPSEASGKHSASDPGPAPVVNSSSRSSSPAKAVDEGKVNMAP
                     KGPPPFPGVPLMGGPVPPPIRYGPPPQLCGGPFGPRPLPPPFVPGMHPPLGVREYAPG
                     VLPGKRDLPLDPREFLPGHTPFRPPGSLGPREFFIPGTRLPPPTHGPQEYPPPPPAVR
                     DSLPSGPREEAKPASPSSVQDRSQASKPTP"
     exon            170..303
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..390
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..3145
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3451
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3594
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..3726
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3748
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..3837
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..3915
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3916..4026
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4027..4098
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..4203
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4204..4326
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4327..4438
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4439..4494
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4585
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4586..4724
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4725..4826
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4827..4887
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4888..4923
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4924..4991
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4992..5092
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5093..5230
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5231..5299
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5300..5373
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5374..5515
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5516..6933
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6320..6325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /note="hexamer: CATAAA"
     polyA_site      6342
                     /gene="Mia3"
                     /gene_synonym="9130229H14Rik; A930039G15Rik;
                     B230399H06Rik; Gm1525; Tango; TANGO1"
                     /note="major polyA site"
ORIGIN      
        1 ggcctccgcg tcacccgggc ccgcggtggc cacaacatgg ctgcggcgcc ggggctgctc
       61 ttctggctgt tcgtgctggg ggcgctctgg tgggtcccgg gccagtcgga tctcagccac
      121 ggacggcgtt tctcggacct caaagtgtgc ggggacgaag agtgcagcat gttaatgtac
      181 cgtgggaaag ctcttgaaga cttcacgggc cctgattgtc gttttgtgaa ttttaaaaaa
      241 ggtgacgatg tatatgtcta ctacaaactg gcagggggat cccttgaact ttgggctgga
      301 agtgttgaac acagttttgg atattttcca aaagatttga tcaaggtact tcataaatac
      361 acggaagaag agctacatat tccagcagat gagacagact ttgtctgctt tgaaggagga
      421 agagatgatt ttaatagtta taatgtagaa gagcttttag gatctttgga actggaggac
      481 tctgtacctg aagagtcgaa gaaagctgaa gaagtttctc agcacagaga gaaatctcct
      541 gaggagtctc gggggcgtga acttgaccct gtgcctgagc ccgaggcatt cagagctgat
      601 tcagaggatg gagaaggtgc tttctcagag agcaccgagg ggctgcaggg acagccctca
      661 gctcaggaga gccaccctca caccagcggt cctgcggcta acgctcaggg agtgcagtct
      721 tcgttggaca cttttgaaga aattctgcac gataaattga aagtgccggg aagcgaaagc
      781 agaactggca atagttctcc tgcctcggtg gagcgggaga agacagatgc ttacaaagtc
      841 ctgaaaacag aaatgagtct tgacctgaaa accaagtttg gctcaactgc cgacgccctt
      901 gtgtctgacg acgaggcaac cagactggtc acttcattag aagacggctt cgatgaagcg
      961 ctggatgctg agtattaccc gatggaggag gaggaggagg tagaggagga tgcagacagc
     1021 tctgatgagc taccattact aaccttctca gacaaagatg agaaagtccc cgggaagccc
     1081 atgatagaga aatatttaac agataaggat ccgaatttga gtgaagagga taaagttgaa
     1141 ccccctacct ggggggatgc ttttttttct attgtcacag gaggtgaagg gaaaccaggt
     1201 gtggtggatt tagaaagatc tatcgaggag gaggaagatg tgtcagtttc atctagccat
     1261 cagaggaagc cacagccagc agctggctat acagacagtg aggatgaagg tgacgatctt
     1321 tttgtagaag agcccaaaac aaatgatgta aaggactcag aaacagaccc agaacttgtc
     1381 attacaggag aagaaaagga catccaggaa tccaggaaag gcctggtaca gcctgagtca
     1441 caatcagagg atgccaagtc agaaacggcg agcgcttatc gtcttcaggg tagcaagctc
     1501 aaccctctgt cagctgctga aaagggcaga gactttacac taaaagccgt ctttgaaaaa
     1561 aaagaaaatg gcctaaaaga atcagttatc catatctcaa aggaaacact acatgaagac
     1621 aagaccagag agatccagag agacagcttg gagagtgaat tggtacacag agctttaggg
     1681 agttcagtga cagaaaataa caagcccaaa tccttgggtg ttgcaccact cttgggaaat
     1741 aacaagcccg atgcatccaa agacagtaca gaggtcccag acggttccgt cagtggacca
     1801 aaagcaggcc agcaggaggg atttctagaa ccaggtctta aaactcagca ccaacctaga
     1861 ttctcccctc cagaggaaac tggtccctca agagaactgg ggggaaaagt tcctatttcg
     1921 ggaagaaatc tttcttggca gcaagagcaa gacgtagctg ctgtagtcgg taagcatgcg
     1981 aatgagaaga cagggtttcc ggaggaagag agcagggaag acgggacaga tgcggagcaa
     2041 gccagggcca tacgaaggcc acaggaggct gagagcccgg aagtgctgag tgtccaacct
     2101 ggaaggccag acgaggagga ggaggaggaa gagggcgaca actatccccc cgaggggctg
     2161 atggaggatg aaaatgctgt gagcgcacag cagtctagag aaaattcccc cagcgctcgc
     2221 gacgggaggt cagatatgaa ttctcaagtt tttgaaaaag taattttggg gacccttaat
     2281 cttaacactg aaaaaaccaa acaaccagct aatatgattt tggagactgg acaagagagt
     2341 gaaaccacat ccgaagaggc aggtgacgtg ggcaaggagt caggtcacag tgtggtggtg
     2401 gacagtgaag aaagccatct ggcagatatg agagcccaga gaccctctca agtccacggc
     2461 cttcgtgacg agacagcagc tcagactccc ggctccgggg aagctgttct gagtaaaaat
     2521 cctaatgacc tacaaaaaga caacccagag gaagaactgg tcaacacctt gggacttgaa
     2581 gaccctggcg taggagaaat ctcagaaggg gagccggaag ataccaagga gtttggagtc
     2641 tcagaaagcc aggggactga tgctgaagac cttagggatg acccatcccg gcaagctaca
     2701 ccggaaattc ctgacatagt gctcaagagt ataagggaag acttgcctat cataaacagc
     2761 ttcttcaagg acgaccaaca gtccctgcat cgtttcctga agtacttcga tgttcgtgag
     2821 ctggagggct tgcttgaaga catgtcgata aggctgagat cagcgcacca gaacagcctg
     2881 ccgtacaaca tggagaaagt cctagataaa gtcttccgtg cctctgagtc acgaattcta
     2941 agtatggcgg agaaaatgct tgatacggga gtggccaaaa atagggacct gggctccaaa
     3001 gagagcagtc cgttggaaga agccgaggtg ttggatgaca tacaagacct gatctatttt
     3061 gtcaggtacc aatactctgg agtggagact gccccattag tcacacctcc acctccggag
     3121 gaaggctggg ccagaccagg agaagagaga cagccacccc agcaagacag cttaccacaa
     3181 gaaaacacag gagacctcag tgtgcagcct ccagaagagc ctgagctctc ggatcaacct
     3241 gtgaccagtg tgcagcctcc agaagagcct gagctctcgg atcaacctgt gaccagtgtg
     3301 cagcctccag aagagcctga gctctcggat caacctgtga ccagtgtgca gcctccagaa
     3361 gagcctgagc tctcggatca acctgtgact gggtacacaa gtacctcaga ggtatcacag
     3421 aagccagata ccaagaaaga catagatcta ggtcctgtaa tggaaggtgg tcctgttggg
     3481 gctggagatg tacaaaagca actagagaca attgcagagg agccagcagc tgtcccacct
     3541 ctggaaagtg catttggttc cctctatgcc ttcatccttt atttaagtaa gatgctcctt
     3601 gccacgttgc ctgacaatgt tcagcctggc cctgactttt acggactgcc ctggcaacct
     3661 gtgatcatta ctgcagtctt gggaattgtt tcatttgcaa ttttctcctg gagaactatt
     3721 cttgttgtaa agagtagagt atatcaagtt actgagaaac aaatttctga aaagttggag
     3781 aatatcaaga aagaaaatgc agaacttatg caaaaattgt caagttatga acaaaagatc
     3841 aaggagtcaa agaagtatgt tcaagaaacc aagaaacaaa acatgattct ctccgatgaa
     3901 gctgttaaat ataaggataa aatcaagatc cttgaagaaa ctaatgtaag tttgggtgac
     3961 aaagccaaaa gccttcgtct tcagttagag tctgagaggg agcagaacgt caagaaccag
     4021 gacctgatac tggaaaacaa gaaatctatt gagaagttga aggatgtcat ctcaatgaat
     4081 gcatcagaac tttcagaggt tcaagttgcc cttaatgaag ccaagctcag tgaagagaat
     4141 gtaaaatctg agtgccatcg ggttcaagaa gaaaatgcca ggcttaagaa gaagaaagag
     4201 cagttgcagc agcaggtaga agagtggagt aaatcgcatg ccgagctcac tgaacagatc
     4261 aagtcatttg agaagtccca ggaagacttg gaaatagctc tgactcacaa agacgacaat
     4321 attagtgctt tgactaattg catcacacag ctgaatcggt tagaatgtga acttgaatct
     4381 gaggatccag ataaaggagg aaatgagtca gatgatctgg ccaatggaga aacgggaggt
     4441 gaccggagcg agaagataag aaatagaatt aagcagatga tggacgtctc tcggacacaa
     4501 actgcagtct caatagttga agaggatcta aaacttttac agcttaagct aagagcatcg
     4561 atgtccacta aatgtaacct ggaagaccaa atcaagaaat tagaagatga ccgcagctcg
     4621 ctgcagactg ctaaagctgg gttggaagac gagtgcaaaa ctctgaggca gaaagtggag
     4681 atcctgaatg agctgtacca gcagaaggag atggcgctgc agaagaaact gagtcaagaa
     4741 gagtatgagc ggcaagacag agagcagagg ctcacggcgg ccgatgagaa ggtggttctg
     4801 gctgcagagg aagtgaaaac gtacaagcgg cgaatcgaag aaatggaaga agaattacag
     4861 aaaacagaac gttcatttaa aaaccagatt gctgctcatg agaagaaagc tcatgataat
     4921 tggctcaaag ctcgtgctgc agagagagcc atggcagagg agaagagaga agctgctaac
     4981 ttaaggcaca aattactgga aatgactcaa aagatggcaa tgaggcaaga tgagcccgtg
     5041 attgtaaagc cgatgccagg aagaccgaac acacagaacc ctccccggcg aggtctgctg
     5101 agccagaatg gctcttttgg cccatcccct gtgagtggtg gggaatgctc ccctccccta
     5161 ccagcagagc cgcctgggag acctctctct gccacactca gtcgaagaga cactcctaga
     5221 agtgaatttg ggtcactgga caggcattta cctcgccctc gatggccatc agaggcatct
     5281 ggcaaacact ctgcttctga cccgggtccc gctcctgtgg tgaacagcag ctccaggagc
     5341 tcttctcccg ctaaggccgt ggatgagggc aaggttaata tggctcccaa agggccgcct
     5401 ccatttccag gggtgcctct catgggaggc ccagtgccac cacccatacg atatggacca
     5461 cctccccagc tatgtggtgg gccttttggg cctcgcccac ttcctccacc atttgttcca
     5521 ggcatgcatc caccactagg cgtaagagaa tatgcaccag gtgttctgcc tgggaaacgg
     5581 gacctgcctc ttgatcctcg ggaattttta ccaggacata caccatttag acctccaggt
     5641 tcactcggtc caagagagtt ctttattcct ggtacccgat taccacctcc aacccatggt
     5701 cctcaggaat acccaccacc accacctgct gtaagagact cactgccttc aggcccgaga
     5761 gaggaagcca aacctgcctc tccaagcagt gtccaggacc gctcacaggc ttcaaagccc
     5821 accccctgac tttgacctct atcgatgagt cagagaggaa gtggacagtg cgttattcat
     5881 tacagcaaag gatttcgttg gcatcaaaat ctaagtttgt tttacaaaga ttgtttttag
     5941 tactaagctg ccttggcagt ttgcattttt gagccaaaca aaaatatatt attttccctt
     6001 ctaagtaaaa aaaaaaaaaa aatcacctct taagctagaa tatccttcaa actttgaaat
     6061 gtgcaataaa gaatacctgt gtttagttca tgtagcatat gtaatgattg ctaaatgatt
     6121 tagaatatca agtatgaaca tttcctgtgg aaatgcttta agaacacgta tttccatggc
     6181 cttggtttag tgtatgccag ctgatttgag caaggtgttt acagctccat ttgtgtctca
     6241 aagactgtta cgctaaaaag aaaagtttac tcaaggatca taaactgtcc cgttgctaaa
     6301 gttctttgta gtaatagttc ataaacttgg tttattactg tttcccagtg tctgctgatt
     6361 ctttgggttg ctctgagaca tgcatcattt gggaaacctg acaactatac ttctggaact
     6421 acagtggtgg gctgtgtaca tcccatgtga caatgttgag ttctccttca aagtcatcag
     6481 tgagctctac caggaatttc ctcttctttt tttcctcttc ttttcttgtt ttaaaaaaag
     6541 atttatttat ttattatata tgagtacagt gtagctgtct tcagacacac cataagaggg
     6601 cgccagatct cattgcagat ggttgtgagc caccatgtga ttgctgggat ttgaactcgg
     6661 gacctttgga agaacagtca gtgctcttaa ccgctgagcc atctctccaa ccccctctct
     6721 gctttcaaat aagccagagg ccccactcat tctagatgac tgccctttct tggtgctcat
     6781 agcttgagaa tgaatgaatt tgtactacta tcaagaatta tttggagtgg gtgtggtggc
     6841 tcacatcttt aatcccagca cctgagaggc aaaggcaggc atatatctga gttccaggac
     6901 agccagagct acatagaatc tgtctcaaaa act
//
