LOCUS       NM_001368839            4821 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus MIA SH3 domain ER export factor 2 (Mia2), transcript
            variant 6, mRNA.
ACCESSION   NM_001368839
VERSION     NM_001368839.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4821)
  AUTHORS   Ma,T., Wang,Y., Yu,L., Liu,J., Wang,T., Sun,P., Feng,Y., Zhang,D.,
            Shi,L., He,K., Zhao,L. and Xu,Z.
  TITLE     Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and
            white matter development
  JOURNAL   iScience 27 (3), 109180 (2024)
   PUBMED   38439956
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4821)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4821)
  AUTHORS   Wang,X.T., Zhou,L., Cai,X.Y., Xu,F.X., Xu,Z.H., Li,X.Y. and Shen,Y.
  TITLE     Deletion of Mea6 in Cerebellar Granule Cells Impairs Synaptic
            Development and Motor Performance
  JOURNAL   Front Cell Dev Biol 8, 627146 (2021)
   PUBMED   33718348
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4821)
  AUTHORS   Jin,L., Chen,Y., Crossman,D.K., Datta,A., Vu,T., Mobley,J.A.,
            Basu,M.K., Scarduzio,M., Wang,H., Chang,C. and Datta,P.K.
  TITLE     STRAP regulates alternative splicing fidelity during lineage
            commitment of mouse embryonic stem cells
  JOURNAL   Nat Commun 11 (1), 5941 (2020)
   PUBMED   33230114
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4821)
  AUTHORS   Wang,X.T., Cai,X.Y., Xu,F.X., Zhou,L., Zheng,R., Ma,K.Y., Xu,Z.H.
            and Shen,Y.
  TITLE     MEA6 Deficiency Impairs Cerebellar Development and Motor
            Performance by Tethering Protein Trafficking
  JOURNAL   Front Cell Neurosci 13, 250 (2019)
   PUBMED   31244610
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4821)
  AUTHORS   Pitman,J.L., Bonnet,D.J., Curtiss,L.K. and Gekakis,N.
  TITLE     Reduced cholesterol and triglycerides in mice with a mutation in
            Mia2, a liver protein that localizes to ER exit sites
  JOURNAL   J Lipid Res 52 (10), 1775-1786 (2011)
   PUBMED   21807889
  REMARK    GeneRIF: Mia2 is a novel, hepatic, endoplasmic reticulum-to-Golgi
            trafficking protein that regulates cholesterol metabolism.
REFERENCE   7  (bases 1 to 4821)
  AUTHORS   Lin,S., Ikegami,M., Xu,Y., Bosserhoff,A.K., Malkinson,A.M. and
            Shannon,J.M.
  TITLE     Misexpression of MIA disrupts lung morphogenesis and causes
            neonatal death
  JOURNAL   Dev Biol 316 (2), 441-455 (2008)
   PUBMED   18342301
REFERENCE   8  (bases 1 to 4821)
  AUTHORS   Bosserhoff,A.K., Moser,M. and Buettner,R.
  TITLE     Characterization and expression pattern of the novel MIA homolog
            TANGO
  JOURNAL   Gene Expr Patterns 4 (4), 473-479 (2004)
   PUBMED   15183315
REFERENCE   9  (bases 1 to 4821)
  AUTHORS   Bosserhoff,A.K., Moser,M., Scholmerich,J., Buettner,R. and
            Hellerbrand,C.
  TITLE     Specific expression and regulation of the new melanoma inhibitory
            activity-related gene MIA2 in hepatocytes
  JOURNAL   J Biol Chem 278 (17), 15225-15231 (2003)
   PUBMED   12586826
REFERENCE   10 (bases 1 to 4821)
  AUTHORS   Moser,M., Bosserhoff,A.K., Hunziker,E.B., Sandell,L., Fassler,R.
            and Buettner,R.
  TITLE     Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient
            mice
  JOURNAL   Mol Cell Biol 22 (5), 1438-1445 (2002)
   PUBMED   11839810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132607.4.
            
            Summary: This gene encodes a protein that is involved in
            endoplasmic reticulum-to-Golgi trafficking and regulation of
            cholesterol metabolism. Three major classes of transcripts are
            generated from this gene- melanoma inhibitory activity 2-specific
            transcripts, cTAGE family member 5-specific transcripts and
            transcripts that include exons from both these transcript species.
            Additionally, alternative splicing in these transcripts results in
            multiple transcript variants encoding diverse isoforms. A mutation
            in this gene (couch-potato or cpto) may result in low levels of
            plasma cholesterol and triglycerides. [provided by RefSeq, Sep
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849380, SAMN00849381
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC132607.4         92836-93159
            325-458             AC132607.4         98716-98849
            459-545             AC132607.4         101720-101806
            546-1758            AC132607.4         105084-106296
            1759-1941           AC132607.4         116619-116801
            1942-2042           AC132607.4         116952-117052
            2043-2174           AC132607.4         133309-133440
            2175-2196           AC132607.4         134826-134847
            2197-2285           AC132607.4         134943-135031
            2286-2357           AC132607.4         141944-142015
            2358-2384           AC132607.4         143581-143607
            2385-2495           AC132607.4         144092-144202
            2496-2567           AC132607.4         145097-145168
            2568-2672           AC132607.4         146709-146813
            2673-2795           AC132607.4         151601-151723
            2796-2910           AC132607.4         155498-155612
            2911-2957           AC132607.4         156836-156882
            2958-3048           AC132607.4         157421-157511
            3049-3187           AC132607.4         160126-160264
            3188-3289           AC132607.4         166179-166280
            3290-3350           AC132607.4         167503-167563
            3351-3386           AC132607.4         168202-168237
            3387-3454           AC132607.4         169770-169837
            3455-3537           AC132607.4         171351-171433
            3538-3666           AC132607.4         173576-173704
            3667-3825           AC132607.4         177095-177253
            3826-3942           AC132607.4         181432-181548
            3943-4001           AC132607.4         182974-183032
            4002-4236           AC132607.4         185556-185790
            4237-4821           AC132607.4         186881-187465
FEATURES             Location/Qualifiers
     source          1..4821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 26.0 cM"
     gene            1..4821
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /note="MIA SH3 domain ER export factor 2"
                     /db_xref="GeneID:338320"
                     /db_xref="MGI:MGI:2159614"
     exon            1..324
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            325..458
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            459..545
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            546..1758
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1941
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2042
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2174
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2196
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2285
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2357
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2384
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2495
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2567
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2672
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2795
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2910
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..2957
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3048
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3187
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3289
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3350
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3386
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3454
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3537
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3666
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3825
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3942
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..4001
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            4002..4236
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     exon            4237..4821
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4531..4536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /note="hexamer: AATAAA"
     polyA_site      4553
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
     regulatory      4755..4760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /note="hexamer: AATAAA"
     polyA_site      4777
                     /gene="Mia2"
                     /gene_synonym="Ctage5; D12Bwg0579e; Mea6; Mgea; Mgea6"
                     /note="major polyA site"
ORIGIN      
        1 acctgactct gcagactgag accagagagt gttaatttct gaagctgggc cagcgcccca
       61 tcgggaaaat gtagctacga agggattgaa gaatacacag ctttttcctc ttgcgctacg
      121 gaagggagcg tcgcatgggc tgtttttctg gcatgcctgc cgcctaacat tctaacgctt
      181 gtccaggatc cttggtggct tgtttaggca tggcggaagt cagtgttcaa agaatccttc
      241 ttttggttgt ttctctggcc aagtgtctgg agggtacaaa gttgctggca caccttaaga
      301 agtgtggtga cttggaatgt gaaactttga tcagccgagt cttagccctg agagattaca
      361 caggacccga ctgtcggtac ctgaacttca ctacgggaga agagatatct gtttatgtta
      421 aacttggagg agacagagaa gatttgtggg caggaagcaa aggaaaagac tttggatttt
      481 ttcccagaga tgcagtcgag attgaagagg tgttcatatc tgaagaagtc gaaatgccaa
      541 ctaaatctga ctttctttgt cttcttggag aaggctacat atttggaagt gaacagagtg
      601 aattaaacag tgaagatgat gaagaacata tgtacccata tgaaaaagat gaagaccaaa
      661 actataatat atatgagggt gattttcagc cagaacctga cttatatgca gctgctgaag
      721 ggactttgtt ggaggaccaa attccagcat ccgaagctcc tgatgatttc cgattctcca
      781 gtgagtggaa ggcctgggaa ggggctggaa gccagggtgg aggggagcag gattacactg
      841 cagactctga ccaagacttg ccatccctca gtaagccaga aaggcaagga tggtttggcc
      901 tggggacaga agaagctgaa gagaaggttt tcgaatcaga tactgaacct acacaagaat
      961 tagcactaga agaggagagt gacctggaga aattacacag tggcgaaccc caagtggaac
     1021 ttgagcaaga gccaaaatca gagacattag aattcagttc agtgccggac gaagagtatg
     1081 agctagaatc tgagacggag agtatcctca aaccccaagc ttctggctgg tttggtgagg
     1141 gccttacaag ttatttaggt tttggaaatg aggaggcagg acttgagtta ttgtccaaag
     1201 aaagcaatcc accattacaa gatattccca gctctgttcc accagatgaa gaagtcccgg
     1261 ctccatgcag agaaatctca acagacaagg aagatgcagt cattaatgat agctcggttc
     1321 tcagtccaag ctggttttac tatggatttg gtatgctagg ctttacaaat gccgacgaag
     1381 acaacattgt ttcagacaaa ggagaaaatg aagatggtga ggtagataac ctcaaacatc
     1441 ctataggaag tgactttgac cctgaaaagg aacaagaaag gaaaatagta actgtggaaa
     1501 ccgaagacca ggcaggtaca gaaagcgtct tggagaagac agacgagtct ggttccatgc
     1561 agtatctgaa gaagttcttt gataatcctt ggggcttcca gagtctccca gaggacacag
     1621 aattaccatt ttccaaaaag atgctggatc aagatgatat agtagaaaat gacaaaattg
     1681 aagaactttc cactgaaaat tctcccacag gtagcatgaa agaccccgtg atgctggcga
     1741 gcagatacgt tctgtcagat atagactctg aagtggagtt acccatggaa gaacatgaag
     1801 gggtacattt caaaccctca tcttctaaaa ggaacgagga cgattcaaat tcctgggcgg
     1861 accctgaaga gctctctgtg gcacaaacag acgggtctgc ggaaggagcc ttgcttgata
     1921 cacagctagt ttctccaaaa gagcatgctg cagactttca gcttctgaag tatttactac
     1981 aaattgatgt ctacggtttc atgagctctg ctctttcacc aattgaaatt cttttagaaa
     2041 gtgttgtggc agcattgcct gaagatatga gagcagactt taatcccagt ggtttttcgt
     2101 tggaattggc agtatgtgtg ctttccgttg gactgcttgc cgtggtcttg tttctgtggc
     2161 gaggcttccg atcaattcga agccgatttt atgtggggag agaaaagaaa cttgctcttg
     2221 agctttctgc actaattgaa gaaaaatgta aactgcttga caaagtcagc attgttcaaa
     2281 aggagtatga aggcttagag tcatctttaa aggaggccag ctttgagaag gagtcaacag
     2341 aagcacaaag tttggagttt gttgaaggat cacaaatatc agaggccacc tatgaaaatc
     2401 tggaacaatc caaatctaaa cttgaagatg aaatactact cctagaggaa aagctggaag
     2461 aagagcgagc taaacattct gaacaagacg agctgatggc tgatatttca aaaaggatac
     2521 agtccctaga agatgaatca aaatctctca aatcgcaagt agctgaagcc aaaacaacct
     2581 ttagaatatt tgaaatcaat gaagagcgac tcaagggagc aataaaagat gccttgaatg
     2641 aaaattctca gcttcaggaa agccagaaac agcttttaca ggaaactgaa atgatgaaag
     2701 aacaagtgaa tgatctcgat aaacagaaag tggcattgga agagtccaga gcacaggcgg
     2761 aacaagctct gagtgagaag gagagtcaga ttgagactct ggtcacgagc ctgctaaaga
     2821 tgaaggattg ggctgctgtg cttggagaag cagatgatgg gaatctggac ttggacatga
     2881 agagtggcct agaaaacact gctgccttag ataatcagcc aaagggcgct ttgaagaagc
     2941 tgatttatgc agctaagtta aatgcttctt taaaagcctt ggaaggagaa cgaaatcaag
     3001 tttacactca gttatctgaa gtggatcaag taaaagaaga ccttacagag catatcaaaa
     3061 gtcttgagtc taaacaagca tctttgcagt cagaaaagac agagtttgaa agtgagagcc
     3121 agaaacttca gcagaaactg aaagtgataa ccgagctgta ccaagaaaat gaaatgaaac
     3181 ttcacaggaa attaacagta gaagaaaatt accgattaga gaaagaagaa aaactttcca
     3241 aagtagatga gaaaatcagc catgcgaccg aggagctgga gacctgcagg cagcgtgcca
     3301 aggatcttga agaagagctg gagagaacaa ttcattctta ccaggggcag gttatttctc
     3361 atgaaaaaaa agcacatgat aattggctgg cagctcggac tcttgaaaga aatctcaatg
     3421 atttaagaaa agaaaatgcc cacaacagac aaaaattaac tgaaacagag tttaaatttg
     3481 aacttttaga aaaagatcct tatgcacttg atgttccaaa cacagcattt ggcagagagc
     3541 actccccata tggtccctca ccattgggcc gacctccatc tgaaacgaga gcttttctct
     3601 ctcctccaac tttgttggag ggtccactaa gactctcacc tttgcttcca gggggaggag
     3661 gaagaggctc acgaggccct gagaaccttc tggaccatca gatgaacact gaaagaggag
     3721 agtcaagcta tgacagatta tctgatgctc ccagagcacc ttccgacagg tccctgtcac
     3781 ctccgtggga acaagatcga aggatgacag cccatccgcc accaggccaa ccatattctg
     3841 atccagctct acaaaggcaa gatcggtttt atcctaattc tggtagactc tctggaccag
     3901 cagaactcag aagttataat atgccctctt tggataaagt ggatgggcca gtaccctcag
     3961 aaatggagtc cagtggaaac ggtaccaaag ataatcttgg taactctaat gtgcctgatt
     4021 ctcctatccc tgctgaatgc gaagcagctg gccgtggctt cttccctcca ccctttcctc
     4081 cagtcagaga cccattgttt ccagtggatc caaggagcca gttcatgaga aggggcccct
     4141 ctttcccccc acctcctcca ggaagcatct atgcagctcc tcgagattat tttccaccaa
     4201 gggacttccc tggcccacca cttcctccgt tcccagggag aactgtgtac gcaccgaggg
     4261 gctttccacc ttaccttccc cccagagctg ggttcttccc cccaccccca catcctgaaa
     4321 gtagaagtga gctcccccca gacttgattc cgccttcaaa agagcctgca gctgaccctc
     4381 cagaaacaca ggaggcctga cagcgttacg tcttaccggc agtcatttcc gtctcatttt
     4441 cagtttaagt aactgctgtt acttatgtga ttatattttt gctcaaattg aagcttaatg
     4501 gaattataat tctcaggata gtattttgta aataaagatg atttaaatat gaatcttatg
     4561 ggtaaattat ttccatttta ttttattcta gatagtataa ctattttact ttgattacct
     4621 catctataat tatggtagtt ttatatatgt aatcttatag ttggggatat ctcaaactca
     4681 aaggctgtgt ctttatacca gggatgtgtt taccatggtt gtaggcaatg taaaagtaac
     4741 ttcatgttta atcaaataaa attttaattg atttaaagtc ttgtttggta ttaataataa
     4801 taaaactagc cagtttcctg t
//
