LOCUS       NM_019394                583 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus MIA SH3 domain containing (Mia), mRNA.
ACCESSION   NM_019394
VERSION     NM_019394.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 583)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   2  (bases 1 to 583)
  AUTHORS   Staebler,S., Lichtblau,A., Gurbiel,S., Schubert,T., Riechers,A.,
            Rottensteiner-Brandl,U. and Bosserhoff,A.
  TITLE     MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying
            Target for Osteoarthritis Therapy
  JOURNAL   Cells 12 (2), 229 (2023)
   PUBMED   36672165
  REMARK    GeneRIF: MIA/CD-RAP Regulates MMP13 and Is a Potential New
            Disease-Modifying Target for Osteoarthritis Therapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 583)
  AUTHORS   Schneider,A.J., Gawdzik,J., Vezina,C.M., Baker,T.R. and
            Peterson,R.E.
  TITLE     Sox9 in mouse urogenital sinus epithelium mediates elongation of
            prostatic buds and expression of genes involved in epithelial cell
            migration
  JOURNAL   Gene Expr Patterns 34, 119075 (2019)
   PUBMED   31669249
REFERENCE   4  (bases 1 to 583)
  AUTHORS   Feuerer,L., Lamm,S., Henz,I., Kappelmann-Fenzl,M., Haferkamp,S.,
            Meierjohann,S., Hellerbrand,C., Kuphal,S. and Bosserhoff,A.K.
  TITLE     Role of melanoma inhibitory activity in melanocyte senescence
  JOURNAL   Pigment Cell Melanoma Res 32 (6), 777-791 (2019)
   PUBMED   31172672
  REMARK    GeneRIF: MIA is a regulator of cellular senescence in human and
            murine melanocytes.
REFERENCE   5  (bases 1 to 583)
  AUTHORS   Watson,L., Keatinge,M., Gegg,M., Bai,Q., Sandulescu,M.C., Vardi,A.,
            Futerman,A.H., Schapira,A.H.V., Burton,E.A. and Bandmann,O.
  TITLE     Ablation of the pro-inflammatory master regulator miR-155 does not
            mitigate neuroinflammation or neurodegeneration in a vertebrate
            model of Gaucher's disease
  JOURNAL   Neurobiol Dis 127, 563-569 (2019)
   PUBMED   30981829
REFERENCE   6  (bases 1 to 583)
  AUTHORS   Xie,W.F., Zhang,X. and Sandell,L.J.
  TITLE     The 2.2-kb promoter of cartilage-derived retinoic acid-sensitive
            protein controls gene expression in cartilage and embryonic mammary
            buds of transgenic mice
  JOURNAL   Matrix Biol 19 (6), 501-509 (2000)
   PUBMED   11068204
REFERENCE   7  (bases 1 to 583)
  AUTHORS   Golob,M., Buettner,R. and Bosserhoff,A.K.
  TITLE     Characterization of a transcription factor binding site,
            specifically activating MIA transcription in melanoma
  JOURNAL   J Invest Dermatol 115 (1), 42-47 (2000)
   PUBMED   10886506
REFERENCE   8  (bases 1 to 583)
  AUTHORS   Bosserhoff,A.K., Kondo,S., Moser,M., Dietz,U.H., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Buettner,R. and Sandell,L.J.
  TITLE     Mouse CD-RAP/MIA gene: structure, chromosomal localization, and
            expression in cartilage and chondrosarcoma
  JOURNAL   Dev Dyn 208 (4), 516-525 (1997)
   PUBMED   9097023
REFERENCE   9  (bases 1 to 583)
  AUTHORS   Dietz,U.H. and Sandell,L.J.
  TITLE     Cloning of a retinoic acid-sensitive mRNA expressed in cartilage
            and during chondrogenesis
  JOURNAL   J Biol Chem 271 (6), 3311-3316 (1996)
   PUBMED   8621736
REFERENCE   10 (bases 1 to 583)
  AUTHORS   Blesch,A., Bosserhoff,A.K., Apfel,R., Behl,C., Hessdoerfer,B.,
            Schmitt,A., Jachimczak,P., Lottspeich,F., Buettner,R. and
            Bogdahn,U.
  TITLE     Cloning of a novel malignant melanoma-derived growth-regulatory
            protein, MIA
  JOURNAL   Cancer Res 54 (21), 5695-5701 (1994)
   PUBMED   7923218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE864464.1, CK794645.1 and AW047492.1.
            
            On Dec 11, 2007 this sequence version replaced NM_019394.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI851688.1, CK794645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BE864464.1         1-6
            7-564               CK794645.1         1-558
            565-583             AW047492.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.84 cM"
     gene            1..583
                     /gene="Mia"
                     /gene_synonym="CD-RAP; Cdrap; Mia1"
                     /note="MIA SH3 domain containing"
                     /db_xref="GeneID:12587"
                     /db_xref="MGI:MGI:109615"
     exon            1..228
                     /gene="Mia"
                     /gene_synonym="CD-RAP; Cdrap; Mia1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..497
                     /gene="Mia"
                     /gene_synonym="CD-RAP; Cdrap; Mia1"
                     /note="melanoma-derived growth regulatory protein;
                     melanoma inhibitory activity protein; cartilage-derived
                     retinoic acid-sensitive protein; melanoma inhibitory
                     activity 1"
                     /codon_start=1
                     /product="melanoma-derived growth regulatory protein
                     precursor"
                     /protein_id="NP_062267.2"
                     /db_xref="CCDS:CCDS21013.1"
                     /db_xref="GeneID:12587"
                     /db_xref="MGI:MGI:109615"
                     /translation="MVWSPVLLGIVVLSVFSGPSRADRAMPKLADWKLCADEECSHPI
                     SMAVALQDYVAPDCRFLTIYRGQVVYVFSKLKGRGRLFWGGSVQGGYYGDLAARLGYF
                     PSSIVREDLTLKPGKIDMKTDQWDFYCQ"
     exon            229..362
                     /gene="Mia"
                     /gene_synonym="CD-RAP; Cdrap; Mia1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..473
                     /gene="Mia"
                     /gene_synonym="CD-RAP; Cdrap; Mia1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..567
                     /gene="Mia"
                     /gene_synonym="CD-RAP; Cdrap; Mia1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      544..549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mia"
                     /gene_synonym="CD-RAP; Cdrap; Mia1"
                     /note="hexamer: AATACA"
     polyA_site      567
                     /gene="Mia"
                     /gene_synonym="CD-RAP; Cdrap; Mia1"
                     /note="major polyA site"
ORIGIN      
        1 gcggagacag gatcgagaac acaggtttcc ttgatattca gcctggaagg agggcaggag
       61 gagcccagag acctcgttct tcacttggtc attctcagtc catgatggtg tggtccccag
      121 tgctccttgg catcgtcgtc ttgtctgttt tttcagggcc tagcagggct gatcgagcta
      181 tgcccaagct ggctgactgg aagctgtgtg cggacgagga atgcagccat cctatctcca
      241 tggctgtggc cctccaggac tacgtggccc ctgattgccg cttcttgact atatataggg
      301 gccaagtggt gtatgtcttc tccaagttga agggccgtgg gcgccttttc tggggaggca
      361 gtgttcaggg aggttactat ggagacctgg cagcccgcct gggctatttc cccagtagca
      421 ttgtccggga ggacctgact ctgaaacctg gcaaaattga tatgaagacc gatcaatggg
      481 atttctactg ccagtgagct cagcctaccg ctatccctgc agttaccctt ccggctctat
      541 gcaaatacag cagccaatgg caaactaaaa aaaaaaaaaa aaa
//
