LOCUS       NM_025569               1097 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus microsomal glutathione S-transferase 3 (Mgst3), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_025569
VERSION     NM_025569.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1097)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1097)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1097)
  AUTHORS   Yao,Y., Liu,Q., Adrianto,I., Wu,X., Glassbrook,J., Khalasawi,N.,
            Yin,C., Yi,Q., Dong,Z., Geissmann,F., Zhou,L. and Mi,Q.S.
  TITLE     Histone deacetylase 3 controls lung alveolar macrophage development
            and homeostasis
  JOURNAL   Nat Commun 11 (1), 3822 (2020)
   PUBMED   32732898
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1097)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1097)
  AUTHORS   Wu,Y., Wei,F.Y., Kawarada,L., Suzuki,T., Araki,K., Komohara,Y.,
            Fujimura,A., Kaitsuka,T., Takeya,M., Oike,Y., Suzuki,T. and
            Tomizawa,K.
  TITLE     Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is
            Required for Mitochondrial Translation and Is Involved in
            Reversible Infantile Liver Injury
  JOURNAL   PLoS Genet 12 (9), e1006355 (2016)
   PUBMED   27689697
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1097)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   7  (bases 1 to 1097)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   8  (bases 1 to 1097)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   9  (bases 1 to 1097)
  AUTHORS   Hitzemann,R., Reed,C., Malmanger,B., Lawler,M., Hitzemann,B.,
            Cunningham,B., McWeeney,S., Belknap,J., Harrington,C., Buck,K.,
            Phillips,T. and Crabbe,J.
  TITLE     On the integration of alcohol-related quantitative trait loci and
            gene expression analyses
  JOURNAL   Alcohol Clin Exp Res 28 (10), 1437-1448 (2004)
   PUBMED   15597075
  REMARK    Erratum:[Alcohol Clin Exp Res. 2004 Dec;28(12):1930]
REFERENCE   10 (bases 1 to 1097)
  AUTHORS   Cheung,C.C., Martin,I.C., Zenger,K.R., Donald,J.A., Thomson,P.C.,
            Moran,C. and Buckley,M.F.
  TITLE     Quantitative trait loci for steady-state platelet count in mice
  JOURNAL   Mamm Genome 15 (10), 784-797 (2004)
   PUBMED   15520881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113970.8 and AK003246.1.
            
            On Feb 1, 2019 this sequence version replaced NM_025569.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.736548.1, BM933254.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC113970.8         154220-154263       c
            45-679              AK003246.1         1-635
            680-1097            AC113970.8         132388-132805       c
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 74.76 cM"
     gene            1..1097
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
                     /note="microsomal glutathione S-transferase 3"
                     /db_xref="GeneID:66447"
                     /db_xref="MGI:MGI:1913697"
     exon            1..91
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
                     /inference="alignment:Splign:2.1.0"
     exon            92..215
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..560
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
                     /EC_number="4.4.1.20"
                     /note="microsomal GST-3; microsomal GST-III; glutathione
                     peroxidase MGST3; microsomal glutathione S-transferase
                     III; LTC4 synthase MGST3"
                     /codon_start=1
                     /product="glutathione S-transferase 3, mitochondrial"
                     /protein_id="NP_079845.1"
                     /db_xref="CCDS:CCDS15457.1"
                     /db_xref="GeneID:66447"
                     /db_xref="MGI:MGI:1913697"
                     /translation="MAVLSKEYGFVLLTGAASFVMVLHLAINVGKARKKYKVEYPVMY
                     STDPENGHMFNCIQRAHQNTLEVYPPFLFFLTVGGVYHPRIASGLGLAWIIGRVLYAY
                     GYYTGDPSKRYRGAVGSLALFALMGTTVCSAFQHLGWIRPGLGYGSRSCHH"
     exon            216..289
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
                     /inference="alignment:Splign:2.1.0"
     exon            290..347
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
                     /inference="alignment:Splign:2.1.0"
     exon            348..420
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
                     /inference="alignment:Splign:2.1.0"
     exon            421..1097
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
                     /inference="alignment:Splign:2.1.0"
     regulatory      647..652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
                     /note="hexamer: AATAAA"
     polyA_site      682
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
                     /note="major polyA site"
     regulatory      1077..1082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
                     /note="hexamer: AATAAA"
     polyA_site      1097
                     /gene="Mgst3"
                     /gene_synonym="2010012L10Rik; 2010306B17Rik;
                     2700004G04Rik; GST-III"
ORIGIN      
        1 ggagtggggc gggtcctgcg ggacagctag agccgcacct aggcactgct gtgcttctca
       61 ggtctgtacc aggcgcacga aggtgagcca gagccaagat ggctgtcctc tctaaggagt
      121 atggatttgt gcttctcact ggtgctgcca gctttgtgat ggtgctccac ctagccatca
      181 acgtgggcaa agcccgcaag aagtacaagg tagagtaccc tgtcatgtac agcacagatc
      241 ctgagaacgg gcatatgttc aactgcattc agcgcgccca ccagaacacg ttggaggtgt
      301 accctccctt cctgtttttc ctaacggtgg gaggtgttta ccacccgcgc atagcttctg
      361 gcctgggcct ggcctggatt attgggcgag tcctttacgc atatggctac tacacaggag
      421 accctagcaa gcggtatcga ggagccgtgg gctctcttgc cctctttgcc ctgatgggca
      481 ccaccgtgtg ctctgctttc cagcatctcg gctggatcag accaggctta ggctacgggt
      541 ccagatcctg ccaccactga ggtgtggagg gccttccgac tctcactcac ctccagcgac
      601 tcaccctgat ttccagttgc actggttttt tttttttttt taatataata aaaacttatc
      661 tggcatcagc ctcataccta aagctcctgc ctgcatctct ttctgagagt cttagtgaaa
      721 taatggtgcc atttctaccc attacgagca aagctgtgag cgcaccccac ccccaccccc
      781 gcgacacagt ctgtgaatcg gtgatgaagt catggtgatg aggacggaaa aattcatcct
      841 cggctctagt tcaaagtacc gcttgatgct aataattaac ggtatggact tttttttttt
      901 aatctattga agattgttta tgttgcttaa aaggttaagt aatgagctca gtcacatgag
      961 caggtaacga cgcttgtcac aaagcctgat ggccatgtgt tgatctggct cccacaagtt
     1021 agcccctgac ctctacgcgt gcactgtatg tcgcacacgt atgtaacacc tatacaaata
     1081 aacgttaact gtttaaa
//
