LOCUS       NM_174995                614 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus microsomal glutathione S-transferase 2 (Mgst2),
            transcript variant 1, mRNA.
ACCESSION   NM_174995
VERSION     NM_174995.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 614)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 614)
  AUTHORS   Veniaminova,N.A., Jia,Y.Y., Hartigan,A.M., Huyge,T.J., Tsai,S.Y.,
            Grachtchouk,M., Nakagawa,S., Dlugosz,A.A., Atwood,S.X. and
            Wong,S.Y.
  TITLE     Distinct mechanisms for sebaceous gland self-renewal and
            regeneration provide durability in response to injury
  JOURNAL   Cell Rep 42 (9), 113121 (2023)
   PUBMED   37715952
REFERENCE   3  (bases 1 to 614)
  AUTHORS   Dvash,E., Har-Tal,M., Barak,S., Meir,O. and Rubinstein,M.
  TITLE     Leukotriene C4 is the major trigger of stress-induced oxidative DNA
            damage
  JOURNAL   Nat Commun 6, 10112 (2015)
   PUBMED   26656251
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 614)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EH107642.1, AA794266.1, AV064608.1 and AI005961.1.
            
            On Jul 14, 2015 this sequence version replaced NM_174995.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX639527.1, BC132234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               EH107642.1         18-306              c
            290-363             AA794266.1         248-321
            364-427             AV064608.1         66-129
            428-614             AI005961.1         291-477
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 22.52 cM"
     gene            1..614
                     /gene="Mgst2"
                     /gene_synonym="GST2; MGST-II"
                     /note="microsomal glutathione S-transferase 2"
                     /db_xref="GeneID:211666"
                     /db_xref="MGI:MGI:2448481"
     exon            1..128
                     /gene="Mgst2"
                     /gene_synonym="GST2; MGST-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..514
                     /gene="Mgst2"
                     /gene_synonym="GST2; MGST-II"
                     /EC_number="2.5.1.18"
                     /EC_number="4.4.1.20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     microsomal GST-2; microsomal GST-II; glutathione
                     peroxidase MGST2; leukotriene C4 synthase MGST2;
                     microsomal glutathione S-transferase II"
                     /codon_start=1
                     /product="microsomal glutathione S-transferase 2 isoform
                     1"
                     /protein_id="NP_778160.2"
                     /db_xref="CCDS:CCDS38428.1"
                     /db_xref="GeneID:211666"
                     /db_xref="MGI:MGI:2448481"
                     /translation="MAGDSSLLAAVSLLSACQQSYFAWRVGRARLKHKIAPPAVTGPL
                     EFERIFRAQQNSLEFYPVFIVMLWMAGWYFNQVFAACLGLLYIYARHKYFWGYAEAAE
                     KRITGFRLSLGILTLLPVLAVLGVASRFLNEYLDFHVAKKLRKPF"
     exon            129..228
                     /gene="Mgst2"
                     /gene_synonym="GST2; MGST-II"
                     /inference="alignment:Splign:2.1.0"
     exon            229..299
                     /gene="Mgst2"
                     /gene_synonym="GST2; MGST-II"
                     /inference="alignment:Splign:2.1.0"
     exon            300..381
                     /gene="Mgst2"
                     /gene_synonym="GST2; MGST-II"
                     /inference="alignment:Splign:2.1.0"
     exon            382..602
                     /gene="Mgst2"
                     /gene_synonym="GST2; MGST-II"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcaccta tgctcttcat ctgacttcct acaaacagtt ctgtgaaaga gatcagagag
       61 tgaaagaaag atggccgggg attcaagcct gctggctgca gtctctcttc tctctgcctg
      121 tcagcaaagt tatttcgctt ggcgggtcgg acgagcaaga ctaaaacaca agattgcacc
      181 cccagcagtc acgggccctc tggaattcga gagaatattt cgtgcacagc aaaactcttt
      241 ggagttttat cctgtattca tcgtaatgct gtggatggct gggtggtact tcaatcaagt
      301 ttttgcagcc tgtctgggtc tcctgtacat atacgcccgt cacaagtatt tctggggcta
      361 tgccgaagcc gctgagaaaa ggatcaccgg tttccgactg agcctgggga ttttgacctt
      421 gctgcctgtc ctcgctgtcc tgggggtagc aagcagattc ctgaacgaat acctggactt
      481 tcatgttgcc aagaaactga ggaagccctt ctaagttttt ctcttccctt tcatgcttgt
      541 agaggccgtc actactctga aaacaataag atgtcatgtg ttaaataaaa cttttaaaac
      601 ttaaaaaaaa aaaa
//
