LOCUS       NM_019946                956 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus microsomal glutathione S-transferase 1 (Mgst1),
            transcript variant 1, mRNA.
ACCESSION   NM_019946
VERSION     NM_019946.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 956)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 956)
  AUTHORS   Zhang,J., Ye,Z.W., Brautigam,L., Chakraborty,P., Luo,Z.,
            Culpepper,J., Aslam,M., Zhang,L., Johansson,K., Haeggstrom,J.Z.,
            Xu,J., Olsson,M., Townsend,D.M., Mehrotra,S., Morgenstern,R. and
            Tew,K.D.
  TITLE     A role for microsomal glutathione transferase 1 in melanin
            biosynthesis and melanoma progression
  JOURNAL   J Biol Chem 299 (8), 104920 (2023)
   PUBMED   37321450
  REMARK    GeneRIF: A role for microsomal glutathione transferase 1 in melanin
            biosynthesis and melanoma progression.
REFERENCE   3  (bases 1 to 956)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 956)
  AUTHORS   Lopez-Tello,J., Perez-Garcia,V., Khaira,J., Kusinski,L.C.,
            Cooper,W.N., Andreani,A., Grant,I., Fernandez de Liger,E.,
            Lam,B.Y., Hemberger,M., Sandovici,I., Constancia,M. and
            Sferruzzi-Perri,A.N.
  TITLE     Fetal and trophoblast PI3K p110alpha have distinct roles in
            regulating resource supply to the growing fetus in mice
  JOURNAL   Elife 8, e45282 (2019)
   PUBMED   31241463
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 956)
  AUTHORS   Brautigam,L., Zhang,J., Dreij,K., Spahiu,L., Holmgren,A., Abe,H.,
            Tew,K.D., Townsend,D.M., Kelner,M.J., Morgenstern,R. and
            Johansson,K.
  TITLE     MGST1, a GSH transferase/peroxidase essential for development and
            hematopoietic stem cell differentiation
  JOURNAL   Redox Biol 17, 171-179 (2018)
   PUBMED   29702404
  REMARK    GeneRIF: The impact of MGST1 on hematopoiesis was also shown in
            hematopoietic stem/progenitor cells (HSPC) isolated from mice,
            where it was expressed at high levels. Upon promoting HSPC
            differentiation, lentiviral shRNA MGST1 knockdown significantly
            reduced differentiated, dedicated cells of the hematopoietic
            system.
REFERENCE   6  (bases 1 to 956)
  AUTHORS   Mavis,C.K., Morey Kinney,S.R., Foster,B.A. and Karpf,A.R.
  TITLE     Expression level and DNA methylation status of
            glutathione-S-transferase genes in normal murine prostate and TRAMP
            tumors
  JOURNAL   Prostate 69 (12), 1312-1324 (2009)
   PUBMED   19444856
  REMARK    GeneRIF: Gst genes are extensively downregulated in primary but not
            metastatic TRAMP tumors.
REFERENCE   7  (bases 1 to 956)
  AUTHORS   Svensson,P., Williams,C., Lundeberg,J., Ryden,P., Bergqvist,I. and
            Edlund,H.
  TITLE     Gene array identification of Ipf1/Pdx1-/- regulated genes in
            pancreatic progenitor cells
  JOURNAL   BMC Dev Biol 7, 129 (2007)
   PUBMED   18036209
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 956)
  AUTHORS   Maeda,A., Crabb,J.W. and Palczewski,K.
  TITLE     Microsomal glutathione S-transferase 1 in the retinal pigment
            epithelium: protection against oxidative stress and a potential
            role in aging
  JOURNAL   Biochemistry 44 (2), 480-489 (2005)
   PUBMED   15641772
  REMARK    GeneRIF: MGST1 is a dominant, highly expressed enzyme in mouse
            retinal pigment epithelium (RPE) microsomes that displays an
            important protective function against oxidative insult in the RPE
            that decreases with age.
REFERENCE   9  (bases 1 to 956)
  AUTHORS   Kelner,M.J., Bagnell,R.D. and Morgenstern,R.
  TITLE     Structural organization of the murine microsomal glutathione
            S-transferase gene (MGST1) from the 129/SvJ strain: identification
            of the promoter region and a comprehensive examination of tissue
            expression
  JOURNAL   Biochim Biophys Acta 1678 (2-3), 163-169 (2004)
   PUBMED   15157743
  REMARK    GeneRIF: identification of the promoter region and a comprehensive
            examination of tissue expression of MGST1
REFERENCE   10 (bases 1 to 956)
  AUTHORS   Raza,H., Mullick,J., John,A., Bhagwat,S.V. and Avadhani,N.G.
  TITLE     Cloning, characterisation and bacterial expression of full length
            cDNA for the mouse liver microsomal glutathione S-transferase
  JOURNAL   Oncol Rep 7 (3), 645-649 (2000)
   PUBMED   10767383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121849.3, AK005122.1 and AC131766.4.
            
            On Mar 19, 2018 this sequence version replaced NM_019946.4.
            
            Transcript Variant: This variant (1) encodes the shorter isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV054825.1, BG518773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC121849.3         189856-189865
            11-953              AK005122.1         2-944
            954-956             AC131766.4         115236-115238       c
FEATURES             Location/Qualifiers
     source          1..956
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 68.4 cM"
     gene            1..956
                     /gene="Mgst1"
                     /gene_synonym="1500002K10Rik; Gst"
                     /note="microsomal glutathione S-transferase 1"
                     /db_xref="GeneID:56615"
                     /db_xref="MGI:MGI:1913850"
     exon            1..80
                     /gene="Mgst1"
                     /gene_synonym="1500002K10Rik; Gst"
                     /inference="alignment:Splign:2.1.0"
     exon            81..237
                     /gene="Mgst1"
                     /gene_synonym="1500002K10Rik; Gst"
                     /inference="alignment:Splign:2.1.0"
     exon            238..332
                     /gene="Mgst1"
                     /gene_synonym="1500002K10Rik; Gst"
                     /inference="alignment:Splign:2.1.0"
     exon            333..956
                     /gene="Mgst1"
                     /gene_synonym="1500002K10Rik; Gst"
                     /inference="alignment:Splign:2.1.0"
     regulatory      935..940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mgst1"
                     /gene_synonym="1500002K10Rik; Gst"
                     /note="hexamer: ATTAAA"
     polyA_site      956
                     /gene="Mgst1"
                     /gene_synonym="1500002K10Rik; Gst"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgggtc ctgttggtga aaagtcccag aagtgcacag gctcggcagg acaacttgca
       61 gcccttctcc ctggattcag tcatttgaag actgagacca agattggaag catggccgac
      121 ctcaggcagc tcatggacaa tgaggtgttg atggccttta cctcctatgc aacgatcatt
      181 cttaccaaga tgatgttcat gagctctgcg accgcattcc agaggataac caacaaggtt
      241 tttgccaacc cagaagactg cgctggcttt ggcaagggag agaatgccaa gaagtttgtt
      301 cgcactgacg agaaggtgga acgcgtgcgc agagcccacc tgaatgatct tgaaaacatc
      361 gttccctttc tcggcatcgg cctcctgtac tccctgagtg gaccagatct ctctacagcc
      421 ctcatgcact tcagaatctt tgtaggtgct cggatctacc acaccattgc ttacttgact
      481 ccccttcctc agccaaacag gggcttggca ttttttgttg gctatggagt tactttgtca
      541 atggcttaca ggctgctaag gagcagactg tacttgtaaa gagaattgtg atcttcacct
      601 tctaattgat tctttttaaa aaaagaattc ctatattttc agtggattca aactctttct
      661 gaggttttaa tgcgtgaaag gagcagagaa attaggaatc agggaaaatt cagttaaaag
      721 actagcatca gtaggctcta ttcttttgta tttgggttag aaatttaata taatcagcct
      781 taactatgtt gtctaactcc taaagtactt tgttataaag tcttgatttc atcataattt
      841 gttacatttg tctatatttc ctacggtgca tctataaaga gtgcacacac ctatgggaaa
      901 cctaggtttc attatagctg aagtagacac atgaattaaa aacattacaa atgaaa
//
