LOCUS       NM_029657               3290 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mahogunin, ring finger 1 (Mgrn1), transcript variant
            2, mRNA.
ACCESSION   NM_029657
VERSION     NM_029657.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3290)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3290)
  AUTHORS   Nakadate,K. and Kawakami,K.
  TITLE     Distribution and Localization of Mahogunin Ring Finger 1 in the
            Mouse Central Nervous System
  JOURNAL   Int J Mol Sci 23 (16), 8956 (2022)
   PUBMED   36012221
  REMARK    GeneRIF: Distribution and Localization of Mahogunin Ring Finger 1
            in the Mouse Central Nervous System.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3290)
  AUTHORS   Sires-Campos,J., Lambertos,A., Delevoye,C., Raposo,G.,
            Bennett,D.C., Sviderskaya,E., Jimenez-Cervantes,C., Olivares,C. and
            Garcia-Borron,J.C.
  TITLE     Mahogunin Ring Finger 1 regulates pigmentation by controlling the
            pH of melanosomes in melanocytes and melanoma cells
  JOURNAL   Cell Mol Life Sci 79 (1), 47 (2021)
   PUBMED   34921635
  REMARK    GeneRIF: Mahogunin Ring Finger 1 regulates pigmentation by
            controlling the pH of melanosomes in melanocytes and melanoma
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3290)
  AUTHORS   Kong,J.H., Young,C.B., Pusapati,G.V., Espinoza,F.H., Patel,C.B.,
            Beckert,F., Ho,S., Patel,B.B., Gabriel,G.C., Aravind,L.,
            Bazan,J.F., Gunn,T.M., Lo,C.W. and Rohatgi,R.
  TITLE     Gene-teratogen interactions influence the penetrance of birth
            defects by altering Hedgehog signaling strength
  JOURNAL   Development 148 (19) (2021)
   PUBMED   34486668
REFERENCE   5  (bases 1 to 3290)
  AUTHORS   Kong,J.H., Young,C.B., Pusapati,G.V., Patel,C.B., Ho,S.,
            Krishnan,A., Lin,J.I., Devine,W., Moreau de Bellaing,A.,
            Athni,T.S., Aravind,L., Gunn,T.M., Lo,C.W. and Rohatgi,R.
  TITLE     A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog
            Signaling and Heart Development
  JOURNAL   Dev Cell 55 (4), 432-449 (2020)
   PUBMED   32966817
REFERENCE   6  (bases 1 to 3290)
  AUTHORS   Bosma,G.C., Davisson,M.T., Ruetsch,N.R., Sweet,H.O., Shultz,L.D.
            and Bosma,M.J.
  TITLE     The mouse mutation severe combined immune deficiency (scid) is on
            chromosome 16
  JOURNAL   Immunogenetics 29 (1), 54-57 (1989)
   PUBMED   2908877
  REMARK    Erratum:[Immunogenetics 1989;29(3):224]
REFERENCE   7  (bases 1 to 3290)
  AUTHORS   Bosma,M., Schuler,W. and Bosma,G.
  TITLE     The scid mouse mutant
  JOURNAL   Curr Top Microbiol Immunol 137, 197-202 (1988)
   PUBMED   3416632
REFERENCE   8  (bases 1 to 3290)
  AUTHORS   Staeheli,P., Pravtcheva,D., Lundin,L.G., Acklin,M., Ruddle,F.,
            Lindenmann,J. and Haller,O.
  TITLE     Interferon-regulated influenza virus resistance gene Mx is
            localized on mouse chromosome 16
  JOURNAL   J Virol 58 (3), 967-969 (1986)
   PUBMED   2422403
REFERENCE   9  (bases 1 to 3290)
  AUTHORS   Epstein,R., Davisson,M., Lehmann,K., Akeson,E.C. and Cohn,M.
  TITLE     Position of Igl-1, md, and Bst loci on chromosome 16 of the mouse
  JOURNAL   Immunogenetics 23 (2), 78-83 (1986)
   PUBMED   3082752
REFERENCE   10 (bases 1 to 3290)
  AUTHORS   Epstein,R., Lehmann,K., Cohn,M., Buckler,C., Rowe,W. and
            Davisson,M.
  TITLE     Linkage of the Igl-1 structural and regulatory genes to Akv-2 on
            chromosome 16
  JOURNAL   Immunogenetics 19 (6), 527-537 (1984)
   PUBMED   6429038
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167018.4 and AK011747.2.
            
            On Nov 15, 2011 this sequence version replaced NM_029657.3.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region, but maintains the reading frame, compared to
            variant 1. The encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046830.1, AK088533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AC167018.4         54173-54380         c
            209-2215            AK011747.2         2-2008
            2216-3290           AC167018.4         2184-3258           c
FEATURES             Location/Qualifiers
     source          1..3290
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.48 cM"
     gene            1..3290
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /note="mahogunin, ring finger 1"
                     /db_xref="GeneID:17237"
                     /db_xref="MGI:MGI:2447670"
     exon            1..374
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1885
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable E3 ubiquitin-protein ligase MGRN1; mahogunin RING
                     finger protein 1; mahoganoid; RING-type E3 ubiquitin
                     transferase MGRN1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MGRN1 isoform 2"
                     /protein_id="NP_083933.1"
                     /db_xref="CCDS:CCDS49751.1"
                     /db_xref="GeneID:17237"
                     /db_xref="MGI:MGI:2447670"
                     /translation="MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKF
                     DTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKE
                     DADSPTEDGEKPRVLYSLEFTFDADARVAITIYCQAVEELVNGVAVYSCKNPSLQSET
                     VHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAH
                     VLLAAFEKHVDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSS
                     ECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPG
                     ALSPISFSPVLAQSVDHDEHSSSDSIPPGYEPISLLEALNGLRAVSPAIPSAPLYEEI
                     TYSGISDGLSQASCPLAGLDRIMESGLQKGKTQSKSPDSTLRSPSFPIHEEDEEKLSE
                     DSDAPLPPSGVELVLRESSSPESFGTEEGDEPSLKQGSRVPSIDDVLQDGSPQHHGCS
                     QPVPPADIYLPALGPESCSVGIEE"
     exon            375..493
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            494..582
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            583..729
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            730..847
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            848..914
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            915..964
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1012
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1081
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1241
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1351
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1578
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1702
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1745
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1844
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1889
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..3290
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3271..3276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /note="hexamer: AATAAA"
     polyA_site      3290
                     /gene="Mgrn1"
                     /gene_synonym="2610042J20Rik; md; mKIAA0544; nc"
                     /note="major polyA site"
ORIGIN      
        1 ggtggtggtg gtggtggtgg tggcaagctt gggaagcgta gtacgcaggc gcattggctg
       61 cctggcctgg actccatttc ccctggaact gcggggcggg ggcgggggcg gggcgccggg
      121 cctaggccgg ggcggccggg ggcgggggct gtggagaggt gccgcggcgg cggcggcggt
      181 ggcggcggtg ggtacgcgtt ggtgcggcct gttttgggcc atgtccgtgt gaggacgccg
      241 cagccgacaa cctctcctct ccggctggcc ggtagaaacg cgcaccatgg gctccatcct
      301 gagtcgccgc atcgcgggcg tagaggacat cgacatacag gccaactcgg cctatcgcta
      361 ccctccgaag tccggaaact actttgcttc gcattttttc atgggaggag agaaatttga
      421 cactccccat cctgaaggtt acctctttgg agagaacatg gacctgaact tcctgggcag
      481 tcgtccagtc cagtttccct atgtcacccc tgccccccat gagccagtga agacactgag
      541 gagcctggtg aacattcgca aagactctct ccggcttgtg aggtacaaag aagacgcaga
      601 cagccccacg gaggacggtg aaaagccccg cgtgctctac agtctggaat tcacctttga
      661 tgccgatgcc cgtgtggcta tcaccatcta ttgtcaggcg gtagaggagc tggtgaatgg
      721 cgtggcagtg tacagctgta agaacccttc tctgcaatct gagaccgtcc actacaagag
      781 aggcgttagc cagcagttct ccctgccttc tttcaagatt gacttctccg agtggaagga
      841 tgatgagctg aactttgacc tggaccgggg tgtgtttcca gtagtcatcc aggctgtggt
      901 ggacgaaggg gatgttgtgg aagtgactgg ccacgctcat gtgctcctgg ctgcctttga
      961 gaagcatgtg gatggcagct tctccgtgaa gccattaaag cagaagcaaa ttgtggaccg
     1021 ggtcagctac ctgctgcagg agatctacgg catcgagaac aagaacaacc aggagactaa
     1081 gccttctgat gatgagaaca gtgacaacag cagtgagtgt gtggtgtgcc tgtcagacct
     1141 gcgggacaca ctgatcctgc cctgccgaca cctgtgcctc tgcacttcct gtgctgacac
     1201 actgcggtac caggccaaca actgccccat ctgccggctg ccgttccgag cccttctgca
     1261 gatccgggct gtgcggaaga agccaggggc cctgtctccc atctccttca gccctgtctt
     1321 ggcccaaagt gtggaccacg atgagcactc tagttctgac agtatcccac ctggctatga
     1381 gcccatctcc ttgcttgagg cactcaatgg tctacgagct gtctccccgg ctatcccatc
     1441 agctcccctc tatgaggaaa tcacctactc aggcatctcg gacggtcttt cccaggccag
     1501 ttgtcccctt gctggacttg atcgaatcat ggaaagtggc ctacagaagg gcaagacaca
     1561 gagcaagtct ccagacagca ccctgcggtc tccatcattc cccatccatg aggaggacga
     1621 ggagaagctc tcagaggact cggatgctcc tctcccaccg agcggtgtgg agctggtact
     1681 gcgggagagc agctcccctg agagtttcgg aacagaggag ggagatgagc cgtccctaaa
     1741 gcaagggagc cgagtaccct ctattgatga tgtcctgcaa gatggcagtc cgcagcatca
     1801 tggttgcagc cagccagtcc ctcctgctga catctaccta ccagccctgg gtcctgagtc
     1861 gtgctctgtt ggtatagagg agtaagctgg atggtccacc tccatggaga cgccacacag
     1921 ccttggcacc accagctccc cctggcctct gctgagtggc tctagtcctg agcctggagt
     1981 tgctgagctg accccattct gaaagtctgg cttagcgggc aacacagagc cctcagcatc
     2041 ccaaacattg ccaggaggct tccctggacc ccagcgagac cctggcctct cttgtctgca
     2101 cgcctcatgt ggccactggg atttgagggt ccacagtgaa ccttgatcaa attgcacagt
     2161 gggttgttcc tccacacacc ctcctttttt tacggtcaat atatttgtaa atggtacaag
     2221 atgaaggaca acaactgtct ccatgggcca cgtgccctag aaggactctc cccaactgtc
     2281 aaagctaatg ctttgagcac ttagcaaacc agcataagag aatctaccca tggaatgttc
     2341 tggaaggtgg gcagtccagg ttacagttga tgaaggaaac agtgcctgtc tgcctctcat
     2401 gtgtgacccc aaggcagcca ggctgtcact gctgctgtca caggctgaca ccttacagat
     2461 gtcctgacca tgggtgaccc tcctcggagc gtccagatcc cctcctgctc tgctctatta
     2521 cctactagtg gtccctggca gctgtgggca aggcctgggt agtcagactg ttaacaccac
     2581 agtccttagc agtggtcaat gtccagttcc cccgcacagg tcctgcttca ctcacatcct
     2641 cacccgctgc caaggtggcg gtttgtgctt gcagggcagc actgcccacc acctgccagg
     2701 gaggagcctg agcagcttcc atagcagatc cgttgccagt tacctggcct gtaagcttct
     2761 tactgattga ttgtctaagg ctcctgtcag agcccaccta gaagcaggct cctagtgata
     2821 ctttgtttcc aaggcagaag tggcccatga gtggccccag agcagaggtg ccccaggcag
     2881 tgcagctccc tggtgggttg gtagagggac ctcagcttaa ggaactgccc tgccactcac
     2941 ccaggtgaca gcctgtagca gtgcatggag acccctttag gctcagggct gctcgagctc
     3001 tgactctaac cctgctcctt cctagcacag ctctgcacat ccatctctct ctcttgctga
     3061 atgcacatat gtgcacacat gtcagcatgt gcatgctcac tcccccactt ctcacctgcc
     3121 aacatcctgg cctctggccg tggcactggt gccagtactt tgaaagatgg ggtgcagcct
     3181 acacacttac ctgtctcaga ctcacatgta ctatcatctg atgtactctg attggctagt
     3241 ttgggttcat ttttactgta tatttatagt aataaaatca tgcagcaata
//
