LOCUS       NM_001410533            3700 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus monoglyceride lipase (Mgll), transcript variant 5,
            mRNA.
ACCESSION   NM_001410533 XM_036166101
VERSION     NM_001410533.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3700)
  AUTHORS   Morales-Soto,W., Thomasi,B. and Gulbransen,B.D.
  TITLE     Endocannabinoids regulate enteric neuron-glia networks and visceral
            hypersensitivity following inflammation through a glial-dependent
            mechanism
  JOURNAL   Glia 72 (11), 2095-2114 (2024)
   PUBMED   39132860
REFERENCE   2  (bases 1 to 3700)
  AUTHORS   Madsen,S., Delgado,A.C., Cadilhac,C., Maillard,V., Battiston,F.,
            Igelbuscher,C.M., De Neck,S., Magrinelli,E., Jabaudon,D.,
            Telley,L., Doetsch,F. and Knobloch,M.
  TITLE     A fluorescent perilipin 2 knock-in mouse model reveals a high
            abundance of lipid droplets in the developing and adult brain
  JOURNAL   Nat Commun 15 (1), 5489 (2024)
   PUBMED   38942786
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3700)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3700)
  AUTHORS   Zhou,S., Ling,X., Zhu,J., Liang,Y., Feng,Q., Xie,C., Li,J.,
            Chen,Q., Chen,S., Miao,J., Zhang,M., Li,Z., Shen,W., Li,X., Wu,Q.,
            Wang,X., Liu,R., Wang,C., Hou,F.F., Kong,Y., Liu,Y. and Zhou,L.
  TITLE     MAGL protects against renal fibrosis through inhibiting tubular
            cell lipotoxicity
  JOURNAL   Theranostics 14 (4), 1583-1601 (2024)
   PUBMED   38389852
  REMARK    GeneRIF: MAGL protects against renal fibrosis through inhibiting
            tubular cell lipotoxicity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3700)
  AUTHORS   Comelli,F., Giagnoni,G., Bettoni,I., Colleoni,M. and Costa,B.
  TITLE     The inhibition of monoacylglycerol lipase by URB602 showed an
            anti-inflammatory and anti-nociceptive effect in a murine model of
            acute inflammation
  JOURNAL   Br J Pharmacol 152 (5), 787-794 (2007)
   PUBMED   17700715
REFERENCE   6  (bases 1 to 3700)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   7  (bases 1 to 3700)
  AUTHORS   Sacksteder,C.A., Qian,W.J., Knyushko,T.V., Wang,H., Chin,M.H.,
            Lacan,G., Melega,W.P., Camp,D.G. 2nd, Smith,R.D., Smith,D.J.,
            Squier,T.C. and Bigelow,D.J.
  TITLE     Endogenously nitrated proteins in mouse brain: links to
            neurodegenerative disease
  JOURNAL   Biochemistry 45 (26), 8009-8022 (2006)
   PUBMED   16800626
REFERENCE   8  (bases 1 to 3700)
  AUTHORS   Walter,L., Dinh,T. and Stella,N.
  TITLE     ATP induces a rapid and pronounced increase in
            2-arachidonoylglycerol production by astrocytes, a response limited
            by monoacylglycerol lipase
  JOURNAL   J Neurosci 24 (37), 8068-8074 (2004)
   PUBMED   15371507
  REMARK    GeneRIF: Astrocytes express monoacylglycerol lipase, the main
            hydrolyzing enzyme of 2-arachidonoylglycerol. Pharmacological
            inhibition of MGL potentiates ATP-induced 2-AG production.
REFERENCE   9  (bases 1 to 3700)
  AUTHORS   Karlsson,M., Reue,K., Xia,Y.R., Lusis,A.J., Langin,D., Tornqvist,H.
            and Holm,C.
  TITLE     Exon-intron organization and chromosomal localization of the mouse
            monoglyceride lipase gene
  JOURNAL   Gene 272 (1-2), 11-18 (2001)
   PUBMED   11470505
REFERENCE   10 (bases 1 to 3700)
  AUTHORS   Karlsson,M., Contreras,J.A., Hellman,U., Tornqvist,H. and Holm,C.
  TITLE     cDNA cloning, tissue distribution, and identification of the
            catalytic triad of monoglyceride lipase. Evolutionary relationship
            to esterases, lysophospholipases, and haloperoxidases
  JOURNAL   J Biol Chem 272 (43), 27218-27223 (1997)
   PUBMED   9341166
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153860.4 and AC153923.4.
            
            On Aug 10, 2022 this sequence version replaced XM_036166101.1.
            
            Summary: This gene encodes a monoglyceride lipase, which catalyzes
            the hydrolysis of monoglycerides into fatty acids and glycerol.
            This enzyme is also thought to hydrolyze the endocannabinoid
            2-arachidonoylglycerol. Alternatively spliced transcript variants
            have been described. [provided by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR2844020.683122.1,
                                           SRR5189682.62384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC153860.4         54181-54282         c
            103-247             AC153860.4         52907-53051         c
            248-354             AC153860.4         14050-14156         c
            355-491             AC153923.4         134327-134463
            492-602             AC153923.4         135652-135762
            603-686             AC153923.4         140196-140279
            687-776             AC153923.4         144890-144979
            777-992             AC153923.4         149507-149722
            993-3700            AC153923.4         151967-154674
FEATURES             Location/Qualifiers
     source          1..3700
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.51 cM"
     gene            1..3700
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /note="monoglyceride lipase"
                     /db_xref="GeneID:23945"
                     /db_xref="MGI:MGI:1346042"
     exon            1..102
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /inference="alignment:Splign:2.1.0"
     exon            103..247
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1118
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /EC_number="3.1.1.23"
                     /note="isoform e is encoded by transcript variant 5;
                     monoacylglycerol lipase"
                     /codon_start=1
                     /product="monoglyceride lipase isoform e"
                     /protein_id="NP_001397462.1"
                     /db_xref="GeneID:23945"
                     /db_xref="MGI:MGI:1346042"
                     /translation="MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKAL
                     IFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQ
                     HVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLK
                     DKLHITKTSLEKAAEVSVTWIPYAFHLWVLAAKLLNFVLPNMTLGRIDSSVLSRNKSE
                     VDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAY
                     LLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP"
     exon            248..354
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /inference="alignment:Splign:2.1.0"
     exon            355..491
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /inference="alignment:Splign:2.1.0"
     exon            492..602
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /inference="alignment:Splign:2.1.0"
     exon            603..686
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /inference="alignment:Splign:2.1.0"
     exon            687..776
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /inference="alignment:Splign:2.1.0"
     exon            777..992
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /inference="alignment:Splign:2.1.0"
     exon            993..3700
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3678..3683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /note="hexamer: AATAAA"
     polyA_site      3700
                     /gene="Mgll"
                     /gene_synonym="Magl; Mgl"
                     /note="major polyA site"
ORIGIN      
        1 atcgctgcgc agccggccgc gcgcagtagt ctggctctag cccgccgcag acccggaccc
       61 gcgtggtgct cggggaacgt gacagcggcg ctcgtggccc ggggcctaaa gacccctgca
      121 ggatgcctga ggcaagttca cccaggcgaa ctccacagaa tgttccctac caggacctgc
      181 ctcacctggt caatgcagac ggacagtacc tcttttgtag atactggaag cccagtggca
      241 cacccaaggc cctcatcttt gtgtcccatg gagctgggga acactgtggc cgttatgatg
      301 agctggctca tatgttgaag gggctggaca tgctggtatt tgcccatgac catgttggcc
      361 atgggcagag tgagggagag aggatggtgg tgtcggactt ccaagttttt gtcagagatg
      421 tgctgcaaca cgtggacacc atccagaagg actaccccga cgtccccatc ttcctcctgg
      481 gccactccat gggcggtgcc atctccatcc tagtggctgc agagaggcca acctactttt
      541 ctggcatggt cctgatttca cctctggtcc ttgccaatcc ggaatctgca tcgactttga
      601 aggacaaatt gcacatcacg aagacctctc ttgagaaggc tgccgaagtg tcagtgactt
      661 ggatcccgta tgctttccac ctgtgggtcc ttgctgccaa actgctcaat tttgtcctgc
      721 caaatatgac cttggggcgc attgactcca gcgtgctgtc tcggaacaag tcggaggttg
      781 acctgtacaa ctctgaccca ctcgtctgcc gagcagggct gaaggtgtgc tttggcatac
      841 agctgctgaa tgccgtcgca agagtggagc gagcaatgcc caggctgaca ctgccattcc
      901 tgctgctgca gggttctgct gaccggcttt gcgacagcaa aggtgcctac ctgctcatgg
      961 aatcatcccg gagtcaggac aaaacactca agatgtatga aggtgcctat cacgtcctcc
     1021 acagggagct tccggaagtg accaactccg tcctccatga agtaaactcg tgggtgtctc
     1081 acaggatagc agcagcagga gctgggtgtc caccctgaac atgctggcca ggcaaccagc
     1141 tcatggtctg gggggaggca ggcagaggaa gggcagtgct ggctggctca aaaaaaaaaa
     1201 aaaaaatcac aaattggagg aacccttagt accctagtgc aacttgcttt gggaaaaaaa
     1261 aaaaggatca tttgtcatat agatggctac tggccactga tctactacct taaggagcag
     1321 gcactttatg aaggagggag tatattttct acacagagac tgtgtggaaa tatcctttga
     1381 attaaaaaaa aaaaaaaaaa aaaaaagcaa agcagcattg cccacctctc ccagctcctg
     1441 tggggttcgg ggactctctg gcagtcccag atcccagtct gcaataatca gaggtctctt
     1501 tcctcctgaa ccaagtcctc tctgactggc tgtcctctgg catatgatga ggtggcctgt
     1561 atccccacag ctagctccct agcaggctca tgtgcccctc caaggcactt cctcaaaacg
     1621 ggcaactacc ctatgacctg gtcagcgact tttcagatgg aagccaggct gggggaaggg
     1681 aaggtggccc caaatagctc ttctccccca cacaactccc ccctcccacc ctgctgggag
     1741 tttggtcacc cacagcatgt tgtatgtatt tagaaaggca ccttttctca ggtcactaag
     1801 tactccatgc tgaggagggt ggctttgaag ataattgttt aatatatata tggtatattc
     1861 taaattaaag attatatggg tgggtgggta aagcctaggc ggctttggag gaaccagtac
     1921 ccccacacag ggtcggtctg ccgaggaccc agccccctaa ttgaggacta gttggctctc
     1981 ctggcagaga agacacaggg tggaggactg tggccctggg tggtccctct gtccagagcc
     2041 actaggagtt gcttgccagt agcacagcta cctctggtgg taggagagac tcccatggag
     2101 ccaccacggt gctggctgcc tgccaggggc agcacagagc acttcaatga ctaccggcag
     2161 acaaggacca cagctgtctg caccccatgc cagactgcag caggatggcc cagccaggcc
     2221 tcagagaggc tcccctgaag cagtgaaacc caagccccct gtcctctcag gtgcccgcct
     2281 gaaggcctcc cccaggcctc acttagcgcc agcaataact ggggctcact gctctcttgg
     2341 agcactcact gctctcctgg agcacttcta tctttacgga gggccttgct gttacctcag
     2401 gagtcctgtc gatgcatgta gaaccctgga aaggggcact gctgccaagg agagctgcct
     2461 ggctgctgga aggggtgggt gggcctccag gaaggtggga tccaagtgtc ctttctggag
     2521 ttgattctag gtcctgggaa gggccctctg ccccctctgg tgaccctgac catgcatagc
     2581 agtcagaggc tggccaccta ctataggtca taaggtcact gtgcccctca acagggccca
     2641 agcactgcat gcagggaagg aagggcccag gagctgtcca gagccccctc ttagctctcc
     2701 ttctgtttag aaaatgaaga cagaaagagt gtgggaagag gggcagccag cactccctcc
     2761 tgctcaggga accctggaca gcagtggacg ggcatggggt attttggctc tccattaagt
     2821 taaaaccatt ccagactact gtgctcagat ctgtgactct caccaggagc cacccaaggc
     2881 tgctcccaaa agcacactga caatgccact tttccaaacc aaacgccagc tggcggcttt
     2941 catgcatgac atcatttaga gatgcatttg tatctggtta aagaaccact aacactaaaa
     3001 cccaggggtg ggatgatcag aagttaagac tgtcttgtga agcctgtaag agtcatgtta
     3061 agagtcatgt ccctgcatga cagcaccggg gctccctctg tagagagcta ggccagtctc
     3121 gtcagactcc gcccctgtca ctggaggaag cctgaccagc agggcttcac agtcaccccc
     3181 atcaccacag gatgcagagg aattggggta cggaaaaaat gctaggacac acaaggctcg
     3241 gcctgaagaa ggtggaagcc agcaagaaac cgccgatggt cctcccccgg gtgaaggagg
     3301 ggagccagaa cccgcaagaa cagagcatct gtgggctttt ccaacaacca tggacttagg
     3361 gcctgaaaag ctttttagaa ggtgccacct gcaggcagtg gaacatctca accactaagc
     3421 cccagttcct tagagatagg ggaacagcct ccctccacca tgtgagcatc gggggagtgc
     3481 tctgctcaca tcctgcctct gggccacctc acacttccct ttctctcctg attgctaatg
     3541 taactttcta aggatcacag tgggtcactg gtttgtcact gtcactgcgc ccagtcactc
     3601 cccacgtata ctcctagtgg ggaacctgta tcggcttaga attactaaag aagccaatgt
     3661 gcactacagc tcaccgtaat aaaaaccacg tgcttttgga
//
