LOCUS       NM_145137               1550 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus macrophage galactose N-acetyl-galactosamine specific
            lectin 2 (Mgl2), mRNA.
ACCESSION   NM_145137
VERSION     NM_145137.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1550)
  AUTHORS   Mickael,C., Sanders,L.A., Lee,M.H., Kumar,R.,
            Fonseca-Balladares,D., Gandjeva,A., Cautivo-Reyes,K., Kassa,B.,
            Kumar,S., Irwin,D., Swindle,D., Phang,T., Stearman,R.S.,
            Molofsky,A.B., McKee,A.S., Stenmark,K.R., Graham,B.B. and
            Tuder,R.M.
  TITLE     Classical dendritic cells contribute to hypoxia-induced pulmonary
            hypertension
  JOURNAL   FASEB J 38 (16), e70015 (2024)
   PUBMED   39212294
REFERENCE   2  (bases 1 to 1550)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1550)
  AUTHORS   Wang,C., Zhao,Q., Chen,C., Li,J., Zhang,J., Qu,S., Tang,H., Zeng,H.
            and Zhang,Y.
  TITLE     CD301b+ macrophage: the new booster for activating bone
            regeneration in periodontitis treatment
  JOURNAL   Int J Oral Sci 15 (1), 19 (2023)
   PUBMED   37198150
  REMARK    GeneRIF: CD301b[+] macrophage: the new booster for activating bone
            regeneration in periodontitis treatment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1550)
  AUTHORS   Costa,M., da Costa,V., Lores,P., Landeira,M.,
            Rodriguez-Zraquia,S.A., Festari,M.F. and Freire,T.
  TITLE     Macrophage Gal/GalNAc lectin 2 (MGL2)+ peritoneal antigen
            presenting cells during Fasciola hepatica infection are essential
            for regulatory T cell induction
  JOURNAL   Sci Rep 12 (1), 17661 (2022)
   PUBMED   36271272
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1550)
  AUTHORS   Ryu,S.H., Shin,H.S., Eum,H.H., Park,J.S., Choi,W., Na,H.Y., In,H.,
            Kim,T.G., Park,S., Hwang,S., Sohn,M., Kim,E.D., Seo,K.Y., Lee,H.O.,
            Lee,M.G., Chu,M.K. and Park,C.G.
  TITLE     Granulocyte Macrophage-Colony Stimulating Factor Produces a Splenic
            Subset of Monocyte-Derived Dendritic Cells That Efficiently
            Polarize T Helper Type 2 Cells in Response to Blood-Borne Antigen
  JOURNAL   Front Immunol 12, 767037 (2022)
   PUBMED   35069539
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1550)
  AUTHORS   Singh,S.K., Streng-Ouwehand,I., Litjens,M., Weelij,D.R.,
            Garcia-Vallejo,J.J., van Vliet,S.J., Saeland,E. and van Kooyk,Y.
  TITLE     Characterization of murine MGL1 and MGL2 C-type lectins: distinct
            glycan specificities and tumor binding properties
  JOURNAL   Mol Immunol 46 (6), 1240-1249 (2009)
   PUBMED   19162326
REFERENCE   7  (bases 1 to 1550)
  AUTHORS   Kumamoto,Y., Denda-Nagai,K., Aida,S., Higashi,N. and Irimura,T.
  TITLE     MGL2 Dermal dendritic cells are sufficient to initiate contact
            hypersensitivity in vivo
  JOURNAL   PLoS One 4 (5), e5619 (2009)
   PUBMED   19440334
  REMARK    GeneRIF: The results demonstrated the availability of MGL2 as a
            novel marker for DDCs and suggested the contribution of MGL2(+)
            DDCs for initiating CHS.
REFERENCE   8  (bases 1 to 1550)
  AUTHORS   Oo-Puthinan,S., Maenuma,K., Sakakura,M., Denda-Nagai,K., Tsuiji,M.,
            Shimada,I., Nakamura-Tsuruta,S., Hirabayashi,J., Bovin,N.V. and
            Irimura,T.
  TITLE     The amino acids involved in the distinct carbohydrate specificities
            between macrophage galactose-type C-type lectins 1 and 2 (CD301a
            and b) of mice
  JOURNAL   Biochim Biophys Acta 1780 (2), 89-100 (2008)
   PUBMED   18053814
  REMARK    GeneRIF: Mutations of MGL2 CRD at Leu, Arg, Arg, and Tyr at
            positions 61, 89, 115 and 125 were implicated in the preference for
            beta-GalNAc.
REFERENCE   9  (bases 1 to 1550)
  AUTHORS   Raes,G., Brys,L., Dahal,B.K., Brandt,J., Grooten,J., Brombacher,F.,
            Vanham,G., Noel,W., Bogaert,P., Boonefaes,T., Kindt,A., Van den
            Bergh,R., Leenen,P.J., De Baetselier,P. and Ghassabeh,G.H.
  TITLE     Macrophage galactose-type C-type lectins as novel markers for
            alternatively activated macrophages elicited by parasitic
            infections and allergic airway inflammation
  JOURNAL   J Leukoc Biol 77 (3), 321-327 (2005)
   PUBMED   15591125
  REMARK    GeneRIF: The mMGL2 protein is induced in diverse populations of
            aaMF, including peritoneal macrophages elicited during infection
            with the protozoan Trypanosoma brucei brucei or the Helminth Taenia
            crassiceps and alveolar macrophages elicited.
REFERENCE   10 (bases 1 to 1550)
  AUTHORS   Tsuiji,M., Fujimori,M., Ohashi,Y., Higashi,N., Onami,T.M.,
            Hedrick,S.M. and Irimura,T.
  TITLE     Molecular cloning and characterization of a novel mouse macrophage
            C-type lectin, mMGL2, which has a distinct carbohydrate specificity
            from mMGL1
  JOURNAL   J Biol Chem 277 (32), 28892-28901 (2002)
   PUBMED   12016228
  REMARK    GeneRIF: Molecular cloning and expression of mMGL2
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY198732.1, BC106833.1 and BY544307.1.
            
            On Sep 23, 2006 this sequence version replaced NM_145137.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY103461.1, SRR5189679.65138.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BY198732.1         3-76
            75-1386             BC106833.1         1-1312
            1387-1550           BY544307.1         291-454
FEATURES             Location/Qualifiers
     source          1..1550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..1550
                     /gene="Mgl2"
                     /gene_synonym="CD301b"
                     /note="macrophage galactose N-acetyl-galactosamine
                     specific lectin 2"
                     /db_xref="GeneID:216864"
                     /db_xref="MGI:MGI:2385729"
     exon            1..86
                     /gene="Mgl2"
                     /gene_synonym="CD301b"
                     /inference="alignment:Splign:2.1.0"
     exon            87..231
                     /gene="Mgl2"
                     /gene_synonym="CD301b"
                     /inference="alignment:Splign:2.1.0"
     exon            232..342
                     /gene="Mgl2"
                     /gene_synonym="CD301b"
                     /inference="alignment:Splign:2.1.0"
     exon            343..438
                     /gene="Mgl2"
                     /gene_synonym="CD301b"
                     /inference="alignment:Splign:2.1.0"
     exon            439..510
                     /gene="Mgl2"
                     /gene_synonym="CD301b"
                     /inference="alignment:Splign:2.1.0"
     exon            511..582
                     /gene="Mgl2"
                     /gene_synonym="CD301b"
                     /inference="alignment:Splign:2.1.0"
     exon            583..669
                     /gene="Mgl2"
                     /gene_synonym="CD301b"
                     /inference="alignment:Splign:2.1.0"
     exon            670..821
                     /gene="Mgl2"
                     /gene_synonym="CD301b"
                     /inference="alignment:Splign:2.1.0"
     exon            822..928
                     /gene="Mgl2"
                     /gene_synonym="CD301b"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1550
                     /gene="Mgl2"
                     /gene_synonym="CD301b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accaaccctc cgggatatag ttctccaccc cgactgagtt ctcgcctctg gtcattgctg
       61 cacagggaag ccaagacttc acacagttct gattgtccca gaagccttgc gtttgtcaaa
      121 acatgacaat gagatatgaa aacttccaga acttggagcg ggaagagaaa aaccaggaga
      181 tgagaaatgg tgacaagaaa ggaggaatgg agtctccaaa gtttgctcta attccttccc
      241 agtccttcct gtggcgcatc ctctcttgga cccacctcct cctgttctcc ctgggcctca
      301 gcctcctgct actggtggtc atctccgtga ttggatccca aaattcccag ttaaggaggg
      361 acctaggcac cctaagagcc attttagaca acaccacctc caagataaag gctgaattcc
      421 agtccctgga ctccagggct gacaacttcg aaaaagggat cagttctctg aaagtggatg
      481 tggaggatca caggcaggaa ctgcaggcag gccgagactt gagccagaag gtgacttctc
      541 tggagagcac actggagaag agggagcagg ctctcaaaac agatctgtct gatttaaccg
      601 accatgtaca acagctggag acagacttga aggccttgac gtgccagctg gccaacctca
      661 agaacaatgg ctcggaagtg gcctgctgcc cgcttcactg gacggagcat gaaggcagct
      721 gctattggtt ctctgagtct gagaagtcgt ggcctgaagc tgacaagtac tgccggctgg
      781 agaattctca cctggtggtg gtcaactccc tggaggagca gaattttcta cagaatcgct
      841 tagccaatgt gcttagctgg atgggcctaa cggaccaaaa tgggccctgg cgatgggtgg
      901 atgggaccga ctttgacaaa ggtttcaaga attggaggcc actgcagccg gataactggc
      961 atggacatat gctaggtgga ggcgaggact gtgcccactt ttcttacgat ggtcgttgga
     1021 atgacgatgt ctgccagagg cattaccatt ggatctgtga aacagagctg ggcaaagcca
     1081 gctcagccca ctccccacaa cttatagcct cagttccata agcctcagat acctgacgtt
     1141 ggtaatcact ctatcttggt atctccacca tctgggggag gggtgttttt tgctagtact
     1201 ttaaggggta gataaaggat ggtatctgag gaatgtgtta tggtgattag aaagctgaca
     1261 ctgtgtacag tgttcagcct gtgattgtca agtaattttt tagagtaaaa agaaagaaat
     1321 ataggggggc tgtgtagtct cccctccccc agcctgaaac ctgcttgctc aggggtggag
     1381 cttcctgctc attcgttcta tcacgcccac tgttggaacc tgccactttg ctgttcagag
     1441 ccacacacgt gctcaccttt ctactggacc agagattatt cggcgggaat cgggtcccct
     1501 cctccttcct tcataactag tgtcgcaaca ataaaatttg agctttaatc
//
